Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6139
Gene name	Ribosomal protein L17
Gene symbol	RPL17
Synonyms (NCBI Gene)	DBA22L17PD-1RPL23uL22
Chromosome	18
Chromosome location	18q21.1
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

Show/Hide all (8)

miRTarBase ID	miRNA	Experiments	Reference
MIRT439744	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT439742	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439744	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT726689	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT726687	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT726688	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT726686	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT439742	hsa-miR-20a-5p	HITS-CLIP	22473208

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IBA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005515	Function	Protein binding	IPI	24965446
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0015934	Component	Large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022626	Component	Cytosolic ribosome	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
603661	10307	ENSG00000265681

P18621

Protein name

Large ribosomal subunit protein uL22 (60S ribosomal protein L17) (60S ribosomal protein L23) (PD-1)

Protein function

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669

PDB

4UG0 , 4V6X , 5A8L , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00237	Ribosomal_L22	17 → 151	Ribosomal protein L22p/L17e	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in pancreas, lung, colon, cystic duct, gall bladder, kidney and liver. Expressed at high levels in the well differentiated pancreatic tumor cell lines HPAF, COLO 357 and Capan-1, the moderately differentiated pancreatic tumor

Sequence

MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLQKQCVPF
RRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVN
KAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKL
MARE

Sequence length

184

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Diamond-Blackfan anemia	Uncertain significance	rs753489644	RCV004691642

Show/Hide Text Mining Associations (21)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Inhibit	26650044
Alzheimer Disease	Associate	37438770, 37545529
Carcinoma Hepatocellular	Associate	34732136
Cholangiocarcinoma	Associate	34871464
Colonic Neoplasms	Associate	35712285
COVID 19	Associate	33138195, 36509426, 37153620
Disease	Associate	37153620
Down Syndrome	Associate	28717645
Hereditary Breast and Ovarian Cancer Syndrome	Associate	30206415
Infections	Associate	36509426
Intervertebral Disc Degeneration	Associate	31124977
Lymphoma Large Cell Anaplastic	Associate	30206415
Multiple Sclerosis Relapsing Remitting	Inhibit	35328606
Myocardial Ischemia	Associate	40620566
Ovarian Neoplasms	Associate	23354626
Spondylitis Ankylosing	Associate	34521416
Still's Disease Adult Onset	Associate	37153620
Stomach Neoplasms	Associate	27097946
Trisomy 18 Syndrome	Associate	28717645
Uterine Cervical Neoplasms	Associate	28754129
Virus Diseases	Associate	36509426

RPL17 (ribosomal protein L17)