Gene Gene information from NCBI Gene database.
Entrez ID 6138
Gene name Ribosomal protein L15
Gene symbol RPL15
Synonyms (NCBI Gene)
DBA12EC45L15RPL10RPLY10RPYL10eL15
Chromosome 3
Chromosome location 3p24.2
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of
miRNA miRNA information provided by mirtarbase database.
968
miRTarBase ID miRNA Experiments Reference
MIRT025638 hsa-miR-7-5p Microarray 19073608
MIRT025638 hsa-miR-7-5p Microarray 17612493
MIRT049215 hsa-miR-92a-3p CLASH 23622248
MIRT048511 hsa-miR-100-5p CLASH 23622248
MIRT047531 hsa-miR-10a-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
GO ID Ontology Definition Evidence Reference
GO:0002181 Process Cytoplasmic translation IBA
GO:0002181 Process Cytoplasmic translation IC 23636399
GO:0002181 Process Cytoplasmic translation NAS 25901680
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604174 10306 ENSG00000174748
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61313
Protein name Large ribosomal subunit protein eL15 (60S ribosomal protein L15)
Protein function Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
PDB 4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ , 8FL2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00827 Ribosomal_L15e 2 191 Ribosomal L15 Family
Sequence
Sequence length 204
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Ribosome
Coronavirus disease - COVID-19
  L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
47
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Diamond-Blackfan anemia 12 Pathogenic; Likely pathogenic rs2471215139, rs2471221205, rs2471214687, rs2471214224, rs370700905, rs1704930969 RCV002290331
RCV003228754
RCV003228755
RCV003228756
RCV003228757
RCV001089984
RPL15-related disorder Pathogenic rs2471221205 RCV003973781
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs7616185 RCV005924685
Cervical cancer Likely benign; Conflicting classifications of pathogenicity rs769264177, rs193020435, rs369956511 RCV005922543
RCV005933150
RCV005897353
Chronic lymphocytic leukemia/small lymphocytic lymphoma Benign rs7616185 RCV005924689
Clear cell carcinoma of kidney Benign; Likely benign rs35629664 RCV005899898
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 22491060
Alzheimer Disease Associate 27050411, 35766008
Anemia Diamond Blackfan Associate 23812780, 29599205
Brain Diseases Associate 27050411
Carcinogenesis Associate 31523176
Carcinoma Renal Cell Associate 24977159
Carcinoma Squamous Cell Associate 22491060
Colorectal Neoplasms Stimulate 31523176
COVID 19 Associate 38327202
Hydrops Fetalis Associate 29599205