Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6136
Gene name Gene Name - the full gene name approved by the HGNC.	Ribosomal protein L12
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RPL12
Synonyms (NCBI Gene) Gene synonyms aliases	L12, uL11
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9q33.3
Summary Summary of gene provided in NCBI Entrez Gene.	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT031402	hsa-miR-16-5p	Proteomics	18668040
MIRT051997	hsa-let-7b-5p	CLASH	23622248
MIRT051475	hsa-let-7e-5p	CLASH	23622248
MIRT046988	hsa-miR-218-5p	CLASH	23622248
MIRT046650	hsa-miR-222-3p	CLASH	23622248
MIRT046558	hsa-let-7g-5p	CLASH	23622248
MIRT041418	hsa-miR-193b-3p	CLASH	23622248
MIRT682960	hsa-miR-141-3p	HITS-CLIP	23706177
MIRT682959	hsa-miR-200a-3p	HITS-CLIP	23706177
MIRT682958	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT682957	hsa-miR-335-5p	HITS-CLIP	23706177
MIRT682956	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT682955	hsa-miR-939-3p	HITS-CLIP	23706177
MIRT682954	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT682953	hsa-miR-4793-3p	HITS-CLIP	23706177
MIRT682952	hsa-miR-1285-3p	HITS-CLIP	23706177
MIRT682951	hsa-miR-3187-5p	HITS-CLIP	23706177
MIRT682950	hsa-miR-5189-5p	HITS-CLIP	23706177
MIRT682949	hsa-miR-612	HITS-CLIP	23706177
MIRT682948	hsa-miR-6860	HITS-CLIP	23706177
MIRT682947	hsa-miR-661	HITS-CLIP	23706177
MIRT682946	hsa-miR-31-5p	HITS-CLIP	23706177
MIRT682945	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT682944	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT682943	hsa-miR-7703	HITS-CLIP	23706177
MIRT682942	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT446160	hsa-miR-134-3p	PAR-CLIP	22100165
MIRT446159	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT446158	hsa-miR-873-3p	PAR-CLIP	22100165
MIRT446157	hsa-miR-4747-5p	PAR-CLIP	22100165
MIRT446156	hsa-miR-5196-5p	PAR-CLIP	22100165
MIRT446155	hsa-miR-4648	PAR-CLIP	22100165
MIRT446154	hsa-miR-1233-5p	PAR-CLIP	22100165
MIRT446153	hsa-miR-6778-5p	PAR-CLIP	22100165
MIRT446152	hsa-miR-4654	PAR-CLIP	22100165
MIRT446150	hsa-miR-4769-5p	PAR-CLIP	22100165
MIRT446151	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT446149	hsa-miR-3672	PAR-CLIP	22100165
MIRT446148	hsa-miR-6864-3p	PAR-CLIP	22100165
MIRT446149	hsa-miR-3672	PAR-CLIP	27292025
MIRT446148	hsa-miR-6864-3p	PAR-CLIP	27292025
MIRT682960	hsa-miR-141-3p	HITS-CLIP	23706177
MIRT682959	hsa-miR-200a-3p	HITS-CLIP	23706177
MIRT682958	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT682957	hsa-miR-335-5p	HITS-CLIP	23706177
MIRT682956	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT682955	hsa-miR-939-3p	HITS-CLIP	23706177
MIRT682954	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT682953	hsa-miR-4793-3p	HITS-CLIP	23706177
MIRT682952	hsa-miR-1285-3p	HITS-CLIP	23706177
MIRT682951	hsa-miR-3187-5p	HITS-CLIP	23706177
MIRT682950	hsa-miR-5189-5p	HITS-CLIP	23706177
MIRT682949	hsa-miR-612	HITS-CLIP	23706177
MIRT682948	hsa-miR-6860	HITS-CLIP	23706177
MIRT682947	hsa-miR-661	HITS-CLIP	23706177
MIRT682946	hsa-miR-31-5p	HITS-CLIP	23706177
MIRT682945	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT682944	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT682943	hsa-miR-7703	HITS-CLIP	23706177
MIRT682942	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT446160	hsa-miR-134-3p	PAR-CLIP	22100165
MIRT446159	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT446158	hsa-miR-873-3p	PAR-CLIP	22100165
MIRT446157	hsa-miR-4747-5p	PAR-CLIP	22100165
MIRT446156	hsa-miR-5196-5p	PAR-CLIP	22100165
MIRT446155	hsa-miR-4648	PAR-CLIP	22100165
MIRT446154	hsa-miR-1233-5p	PAR-CLIP	22100165
MIRT446153	hsa-miR-6778-5p	PAR-CLIP	22100165
MIRT446152	hsa-miR-4654	PAR-CLIP	22100165
MIRT446150	hsa-miR-4769-5p	PAR-CLIP	22100165
MIRT446151	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT446149	hsa-miR-3672	PAR-CLIP	22100165
MIRT446148	hsa-miR-6864-3p	PAR-CLIP	22100165
MIRT1315858	hsa-miR-105	CLIP-seq
MIRT1315859	hsa-miR-203	CLIP-seq
MIRT1315860	hsa-miR-4307	CLIP-seq
MIRT1315861	hsa-miR-501-5p	CLIP-seq
MIRT1315858	hsa-miR-105	CLIP-seq
MIRT1315859	hsa-miR-203	CLIP-seq
MIRT1315861	hsa-miR-501-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005515	Function	Protein binding	IPI	22314232
GO:0005829	Component	Cytosol	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IBA	21873635
GO:0006412	Process	Translation	NAS	12962325
GO:0006413	Process	Translational initiation	TAS
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0014069	Component	Postsynaptic density	EXP	21170055
GO:0014069	Component	Postsynaptic density	IDA	21170055
GO:0015934	Component	Large ribosomal subunit	IBA	21873635
GO:0016020	Component	Membrane	HDA	19946888
GO:0019083	Process	Viral transcription	TAS
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA	21873635
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070180	Function	Large ribosomal subunit rRNA binding	IBA	21873635

MIM	HGNC	e!Ensembl
180475	10302	ENSG00000197958

Protein

UniProt ID

P30050

Protein name

Large ribosomal subunit protein uL11 (60S ribosomal protein L12)

Protein function

Component of the large ribosomal subunit (PubMed:25901680). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:25901680). Binds directly to 26S ribosomal RNA (PubMed:25901680). {ECO:00

PDB

4V6X , 5A8L , 5AJ0 , 6OLG , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7VB2 , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ , 8FL0 , 8FL2 , 8FL3 , 8FL4 , 8FL6 , 8FL7 , 8FL9 , 8FLA , 8FLB , 8FLC , 8G5Z , 8G60 , 8G6J , 8IDT , 8IDY , 8INE , 8INF , 8INK , 8IPD , 8IPX , 8IPY , 8IR1 , 8IR3 , 8K2C , 8RL2 , 8UKB , 8XSX , 8XSY , 8XSZ , 8YOO , 8YOP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03946	Ribosomal_L11_N	3 → 69	Ribosomal protein L11, N-terminal domain	Domain
PF00298	Ribosomal_L11	73 → 143	Ribosomal protein L11, RNA binding domain	Domain

Sequence

MPPKFDPNEIKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGDWKGLRITV
KLTIQNRQAQIEVVPSASALIIKALKEPPRDRKKQKNIKHSGNITFDEIVNIARQMRHRS
LARELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSGAVECPAS

Sequence length

165

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	35766008
Diabetic Nephropathies	Associate	37526061
Growth Disorders	Associate	23603806
Microsatellite Instability	Associate	30664178
Mitochondrial Diseases	Associate	23603806
Nervous System Diseases	Associate	23603806
Stomach Neoplasms	Associate	18505066, 22468085

RPL12 (ribosomal protein L12)