Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6133
Gene name	Ribosomal protein L9
Gene symbol	RPL9
Synonyms (NCBI Gene)	L9NPC-A-16uL6
Chromosome	4
Chromosome location	4p14
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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Show/Hide all (202)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031465	hsa-miR-16-5p	Proteomics	18668040
MIRT052396	hsa-let-7a-5p	CLASH	23622248
MIRT050666	hsa-miR-18a-5p	CLASH	23622248
MIRT048764	hsa-miR-93-5p	CLASH	23622248
MIRT045745	hsa-miR-125a-5p	CLASH	23622248
MIRT045207	hsa-miR-186-5p	CLASH	23622248
MIRT044491	hsa-miR-320a	CLASH	23622248
MIRT041211	hsa-miR-193b-3p	CLASH	23622248
MIRT041007	hsa-miR-505-3p	CLASH	23622248
MIRT039617	hsa-miR-615-3p	CLASH	23622248
MIRT504658	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT504657	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT504656	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT504655	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT504654	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT504653	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT551671	hsa-miR-5697	PAR-CLIP	20371350
MIRT504651	hsa-miR-4457	PAR-CLIP	20371350
MIRT504652	hsa-miR-125b-2-3p	PAR-CLIP	20371350
MIRT504649	hsa-miR-4729	PAR-CLIP	20371350
MIRT504650	hsa-miR-7112-3p	PAR-CLIP	20371350
MIRT504648	hsa-miR-4711-5p	PAR-CLIP	20371350
MIRT504647	hsa-miR-137	PAR-CLIP	20371350
MIRT504646	hsa-miR-513b-5p	PAR-CLIP	20371350
MIRT504644	hsa-miR-5696	PAR-CLIP	20371350
MIRT504658	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT504657	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT504656	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT504655	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT504654	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT504653	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT504651	hsa-miR-4457	PAR-CLIP	20371350
MIRT504652	hsa-miR-125b-2-3p	PAR-CLIP	20371350
MIRT504649	hsa-miR-4729	PAR-CLIP	20371350
MIRT504650	hsa-miR-7112-3p	PAR-CLIP	20371350
MIRT504648	hsa-miR-4711-5p	PAR-CLIP	20371350
MIRT504647	hsa-miR-137	PAR-CLIP	20371350
MIRT504646	hsa-miR-513b-5p	PAR-CLIP	20371350
MIRT504644	hsa-miR-5696	PAR-CLIP	20371350
MIRT504658	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT504657	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT504656	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT504655	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT504654	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT504653	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT551671	hsa-miR-5697	PAR-CLIP	21572407
MIRT504651	hsa-miR-4457	PAR-CLIP	21572407
MIRT504652	hsa-miR-125b-2-3p	PAR-CLIP	21572407
MIRT504649	hsa-miR-4729	PAR-CLIP	21572407
MIRT504650	hsa-miR-7112-3p	PAR-CLIP	21572407
MIRT504648	hsa-miR-4711-5p	PAR-CLIP	21572407
MIRT504647	hsa-miR-137	PAR-CLIP	21572407
MIRT504646	hsa-miR-513b-5p	PAR-CLIP	21572407
MIRT504644	hsa-miR-5696	PAR-CLIP	21572407
MIRT504658	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT504657	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT504656	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT504655	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT504654	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT504653	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT504651	hsa-miR-4457	PAR-CLIP	21572407
MIRT504652	hsa-miR-125b-2-3p	PAR-CLIP	21572407
MIRT504649	hsa-miR-4729	PAR-CLIP	21572407
MIRT504650	hsa-miR-7112-3p	PAR-CLIP	21572407
MIRT504648	hsa-miR-4711-5p	PAR-CLIP	21572407
MIRT504647	hsa-miR-137	PAR-CLIP	21572407
MIRT504646	hsa-miR-513b-5p	PAR-CLIP	21572407
MIRT504644	hsa-miR-5696	PAR-CLIP	21572407
MIRT504658	hsa-miR-25-3p	PAR-CLIP	23446348
MIRT504657	hsa-miR-32-5p	PAR-CLIP	23446348
MIRT504656	hsa-miR-363-3p	PAR-CLIP	23446348
MIRT504655	hsa-miR-367-3p	PAR-CLIP	23446348
MIRT504654	hsa-miR-92a-3p	PAR-CLIP	23446348
MIRT504653	hsa-miR-92b-3p	PAR-CLIP	23446348
MIRT504651	hsa-miR-4457	PAR-CLIP	23446348
MIRT504652	hsa-miR-125b-2-3p	PAR-CLIP	23446348
MIRT504649	hsa-miR-4729	PAR-CLIP	23446348
MIRT504650	hsa-miR-7112-3p	PAR-CLIP	23446348
MIRT504648	hsa-miR-4711-5p	PAR-CLIP	23446348
MIRT504647	hsa-miR-137	PAR-CLIP	23446348
MIRT504646	hsa-miR-513b-5p	PAR-CLIP	23446348
MIRT504644	hsa-miR-5696	PAR-CLIP	23446348
MIRT504658	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT504657	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT504656	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT504655	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT504654	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT504653	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT551671	hsa-miR-5697	PAR-CLIP	20371350
MIRT504651	hsa-miR-4457	PAR-CLIP	20371350
MIRT504652	hsa-miR-125b-2-3p	PAR-CLIP	20371350
MIRT504649	hsa-miR-4729	PAR-CLIP	20371350
MIRT504650	hsa-miR-7112-3p	PAR-CLIP	20371350
MIRT504648	hsa-miR-4711-5p	PAR-CLIP	20371350
MIRT504647	hsa-miR-137	PAR-CLIP	20371350
MIRT504646	hsa-miR-513b-5p	PAR-CLIP	20371350
MIRT504644	hsa-miR-5696	PAR-CLIP	20371350
MIRT504658	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT504657	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT504656	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT504655	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT504654	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT504653	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT504651	hsa-miR-4457	PAR-CLIP	20371350
MIRT504652	hsa-miR-125b-2-3p	PAR-CLIP	20371350
MIRT504649	hsa-miR-4729	PAR-CLIP	20371350
MIRT504650	hsa-miR-7112-3p	PAR-CLIP	20371350
MIRT504648	hsa-miR-4711-5p	PAR-CLIP	20371350
MIRT504647	hsa-miR-137	PAR-CLIP	20371350
MIRT504646	hsa-miR-513b-5p	PAR-CLIP	20371350
MIRT504644	hsa-miR-5696	PAR-CLIP	20371350
MIRT504658	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT504657	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT504656	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT504655	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT504654	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT504653	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT551671	hsa-miR-5697	PAR-CLIP	21572407
MIRT504651	hsa-miR-4457	PAR-CLIP	21572407
MIRT504652	hsa-miR-125b-2-3p	PAR-CLIP	21572407
MIRT504649	hsa-miR-4729	PAR-CLIP	21572407
MIRT504650	hsa-miR-7112-3p	PAR-CLIP	21572407
MIRT504648	hsa-miR-4711-5p	PAR-CLIP	21572407
MIRT504647	hsa-miR-137	PAR-CLIP	21572407
MIRT504646	hsa-miR-513b-5p	PAR-CLIP	21572407
MIRT504644	hsa-miR-5696	PAR-CLIP	21572407
MIRT504658	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT504657	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT504656	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT504655	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT504654	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT504653	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT504651	hsa-miR-4457	PAR-CLIP	21572407
MIRT504652	hsa-miR-125b-2-3p	PAR-CLIP	21572407
MIRT504649	hsa-miR-4729	PAR-CLIP	21572407
MIRT504650	hsa-miR-7112-3p	PAR-CLIP	21572407
MIRT504648	hsa-miR-4711-5p	PAR-CLIP	21572407
MIRT504647	hsa-miR-137	PAR-CLIP	21572407
MIRT504646	hsa-miR-513b-5p	PAR-CLIP	21572407
MIRT504644	hsa-miR-5696	PAR-CLIP	21572407
MIRT504658	hsa-miR-25-3p	PAR-CLIP	23446348
MIRT504657	hsa-miR-32-5p	PAR-CLIP	23446348
MIRT504656	hsa-miR-363-3p	PAR-CLIP	23446348
MIRT504655	hsa-miR-367-3p	PAR-CLIP	23446348
MIRT504654	hsa-miR-92a-3p	PAR-CLIP	23446348
MIRT504653	hsa-miR-92b-3p	PAR-CLIP	23446348
MIRT504651	hsa-miR-4457	PAR-CLIP	23446348
MIRT504652	hsa-miR-125b-2-3p	PAR-CLIP	23446348
MIRT504649	hsa-miR-4729	PAR-CLIP	23446348
MIRT504650	hsa-miR-7112-3p	PAR-CLIP	23446348
MIRT504648	hsa-miR-4711-5p	PAR-CLIP	23446348
MIRT504647	hsa-miR-137	PAR-CLIP	23446348
MIRT504646	hsa-miR-513b-5p	PAR-CLIP	23446348
MIRT504644	hsa-miR-5696	PAR-CLIP	23446348
MIRT1317054	hsa-miR-25	CLIP-seq
MIRT1317055	hsa-miR-3126-3p	CLIP-seq
MIRT1317056	hsa-miR-3128	CLIP-seq
MIRT1317057	hsa-miR-32	CLIP-seq
MIRT1317058	hsa-miR-363	CLIP-seq
MIRT1317059	hsa-miR-367	CLIP-seq
MIRT1317060	hsa-miR-4642	CLIP-seq
MIRT1317061	hsa-miR-4720-5p	CLIP-seq
MIRT1317062	hsa-miR-4778-3p	CLIP-seq
MIRT1317063	hsa-miR-4799-3p	CLIP-seq
MIRT1317064	hsa-miR-513b	CLIP-seq
MIRT1317065	hsa-miR-595	CLIP-seq
MIRT1317066	hsa-miR-92a	CLIP-seq
MIRT1317067	hsa-miR-92b	CLIP-seq
MIRT1317054	hsa-miR-25	CLIP-seq
MIRT1317055	hsa-miR-3126-3p	CLIP-seq
MIRT1317056	hsa-miR-3128	CLIP-seq
MIRT1317057	hsa-miR-32	CLIP-seq
MIRT1317058	hsa-miR-363	CLIP-seq
MIRT1317059	hsa-miR-367	CLIP-seq
MIRT1317060	hsa-miR-4642	CLIP-seq
MIRT1317061	hsa-miR-4720-5p	CLIP-seq
MIRT1317062	hsa-miR-4778-3p	CLIP-seq
MIRT1317063	hsa-miR-4799-3p	CLIP-seq
MIRT1317064	hsa-miR-513b	CLIP-seq
MIRT1317065	hsa-miR-595	CLIP-seq
MIRT1317066	hsa-miR-92a	CLIP-seq
MIRT1317067	hsa-miR-92b	CLIP-seq
MIRT1317054	hsa-miR-25	CLIP-seq
MIRT1317055	hsa-miR-3126-3p	CLIP-seq
MIRT1317056	hsa-miR-3128	CLIP-seq
MIRT2318761	hsa-miR-3137	CLIP-seq
MIRT1317057	hsa-miR-32	CLIP-seq
MIRT1317058	hsa-miR-363	CLIP-seq
MIRT1317059	hsa-miR-367	CLIP-seq
MIRT2318762	hsa-miR-3686	CLIP-seq
MIRT1317060	hsa-miR-4642	CLIP-seq
MIRT2318763	hsa-miR-4652-3p	CLIP-seq
MIRT2318764	hsa-miR-4676-5p	CLIP-seq
MIRT1317061	hsa-miR-4720-5p	CLIP-seq
MIRT1317062	hsa-miR-4778-3p	CLIP-seq
MIRT1317063	hsa-miR-4799-3p	CLIP-seq
MIRT1317064	hsa-miR-513b	CLIP-seq
MIRT2318765	hsa-miR-575	CLIP-seq
MIRT1317065	hsa-miR-595	CLIP-seq
MIRT2318766	hsa-miR-618	CLIP-seq
MIRT1317066	hsa-miR-92a	CLIP-seq
MIRT1317067	hsa-miR-92b	CLIP-seq

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IBA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	TAS	8597601
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	8597601
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 28514442, 32296183, 33961781, 37776851
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005840	Component	Ribosome	TAS	8597601
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	8597601
GO:0016020	Component	Membrane	HDA	19946888
GO:0019843	Function	RRNA binding	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
603686	10369	ENSG00000163682

P32969

Protein name

Large ribosomal subunit protein uL6 (60S ribosomal protein L9)

Protein function

Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399

PDB

2CQL , 4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ , 8FL0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00347	Ribosomal_L6	12 → 87	Ribosomal protein L6	Domain
PF00347	Ribosomal_L6	99 → 178	Ribosomal protein L6	Domain

Sequence

MKTILSNQTVDIPENVDITLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKW
WGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGE
KYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIY
VSEKGTVQQADE

Sequence length

192

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Unknown Diseases (13)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cholangiocarcinoma	Benign	rs142648868	RCV005869936
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign	rs142648868	RCV005869937
Colon adenocarcinoma	Benign	rs142648868	RCV005869926
Colorectal cancer	Benign	rs142648868	RCV005869933
Familial pancreatic carcinoma	Benign	rs142648868	RCV005869931
Gastric cancer	Benign	rs142648868	RCV005869934
Lymphoma	Benign	rs142648868	RCV005869935
Malignant lymphoma, large B-cell, diffuse	Benign	rs142648868	RCV005869932
Malignant tumor of esophagus	Benign	rs142648868	RCV005869927
Nonpapillary renal cell carcinoma	Benign	rs142648868	RCV005869928
Ovarian cancer	Benign	rs142648868	RCV005869929
RPL9-related disorder	Likely benign	rs192165699	RCV003944161
Uveal melanoma	Benign	rs142648868	RCV005869930

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Anemia Diamond Blackfan	Associate	31799629
Carcinoma Hepatocellular	Associate	36378050, 38639179
HIV Infections	Associate	32579550
Infertility Male	Associate	36369953
Irritable Bowel Syndrome	Associate	24200957
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	37774059
Metabolic Syndrome	Associate	34714849
Neoplasms	Associate	31799629
Systemic Vasculitis	Associate	25410188
Thromboangiitis Obliterans	Associate	38275601
Thrombosis	Associate	34483448
Venous Thromboembolism	Associate	29620629

RPL9 (ribosomal protein L9)