Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	6129
Gene name	Ribosomal protein L7
Gene symbol	RPL7
Synonyms (NCBI Gene)	L7humL7-1uL30
Chromosome	8
Chromosome location	8q21.11
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT050872	hsa-miR-17-5p	CLASH	23622248
MIRT048570	hsa-miR-100-5p	CLASH	23622248
MIRT045839	hsa-miR-132-3p	CLASH	23622248
MIRT044249	hsa-miR-106b-5p	CLASH	23622248
MIRT040053	hsa-miR-615-3p	CLASH	23622248
MIRT515389	hsa-miR-5692a	PAR-CLIP	23446348
MIRT515388	hsa-miR-452-5p	PAR-CLIP	23446348
MIRT515387	hsa-miR-4676-3p	PAR-CLIP	23446348
MIRT515386	hsa-miR-892c-3p	PAR-CLIP	23446348
MIRT515385	hsa-miR-2278	PAR-CLIP	23446348
MIRT515384	hsa-miR-2681-3p	PAR-CLIP	23446348
MIRT515383	hsa-miR-205-3p	PAR-CLIP	23446348
MIRT515382	hsa-miR-3622a-3p	PAR-CLIP	23446348
MIRT515381	hsa-miR-3622b-3p	PAR-CLIP	23446348
MIRT515380	hsa-miR-4650-3p	PAR-CLIP	23446348
MIRT515379	hsa-miR-3529-5p	PAR-CLIP	23446348
MIRT515378	hsa-miR-379-5p	PAR-CLIP	23446348
MIRT515377	hsa-miR-4451	PAR-CLIP	23446348
MIRT515376	hsa-miR-4477a	PAR-CLIP	23446348
MIRT515389	hsa-miR-5692a	PAR-CLIP	23446348
MIRT515388	hsa-miR-452-5p	PAR-CLIP	23446348
MIRT515387	hsa-miR-4676-3p	PAR-CLIP	23446348
MIRT515386	hsa-miR-892c-3p	PAR-CLIP	23446348
MIRT515385	hsa-miR-2278	PAR-CLIP	23446348
MIRT515384	hsa-miR-2681-3p	PAR-CLIP	23446348
MIRT515383	hsa-miR-205-3p	PAR-CLIP	23446348
MIRT515382	hsa-miR-3622a-3p	PAR-CLIP	23446348
MIRT515381	hsa-miR-3622b-3p	PAR-CLIP	23446348
MIRT515380	hsa-miR-4650-3p	PAR-CLIP	23446348
MIRT515379	hsa-miR-3529-5p	PAR-CLIP	23446348
MIRT515378	hsa-miR-379-5p	PAR-CLIP	23446348
MIRT515377	hsa-miR-4451	PAR-CLIP	23446348
MIRT515376	hsa-miR-4477a	PAR-CLIP	23446348
MIRT1316999	hsa-miR-452	CLIP-seq
MIRT2318730	hsa-miR-2681	CLIP-seq
MIRT2318731	hsa-miR-3529	CLIP-seq
MIRT2318732	hsa-miR-379	CLIP-seq
MIRT1316999	hsa-miR-452	CLIP-seq
MIRT1316999	hsa-miR-452	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003677	Function	DNA binding	IDA	8441630
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	8441630
GO:0003729	Function	MRNA binding	IDA	8441630
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IMP	18697920
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	8360149
GO:0005515	Function	Protein binding	IPI	18274552, 20828572, 24965446, 25854864
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005730	Component	Nucleolus	HDA	16791210
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	HDA	16791210
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006364	Process	RRNA processing	IMP	18697920
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	8360149
GO:0014069	Component	Postsynaptic density	EXP	21170055
GO:0014069	Component	Postsynaptic density	IDA	21170055
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS	8360149
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0042273	Process	Ribosomal large subunit biogenesis	IMP	18697920
GO:0042802	Function	Identical protein binding	IPI	8441630
GO:1990904	Component	Ribonucleoprotein complex	IDA	18809582
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
604166	10363	ENSG00000147604

P18124

Protein name

Large ribosomal subunit protein uL30 (60S ribosomal protein L7)

Protein function

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08079	Ribosomal_L30_N	14 → 85	Ribosomal L30 N-terminal domain	Domain
PF00327	Ribosomal_L30	90 → 140	Ribosomal protein L30p/L7e	Domain

Sequence

MEGVEEKKKEVPAVPETLKKKRRNFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKE
YRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNG
TFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLG
KYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQI
NRLIRRMN

Sequence length

248

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

RPL7 (ribosomal protein L7)