Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6125
Gene name	Ribosomal protein L5
Gene symbol	RPL5
Synonyms (NCBI Gene)	L5MSTP030PPP1R135uL18
Chromosome	1
Chromosome location	1p22.1
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of

Show/Hide all (59)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031631	hsa-miR-16-5p	Proteomics	18668040
MIRT048387	hsa-miR-100-5p	CLASH	23622248
MIRT047180	hsa-miR-182-5p	CLASH	23622248
MIRT045009	hsa-miR-186-5p	CLASH	23622248
MIRT045009	hsa-miR-186-5p	CLASH	23622248
MIRT043744	hsa-miR-328-3p	CLASH	23622248
MIRT041938	hsa-miR-484	CLASH	23622248
MIRT040235	hsa-miR-615-3p	CLASH	23622248
MIRT038731	hsa-miR-93-3p	CLASH	23622248
MIRT367234	hsa-miR-548c-3p	HITS-CLIP	21572407
MIRT516264	hsa-miR-3200-5p	HITS-CLIP	21572407
MIRT516263	hsa-miR-4766-5p	HITS-CLIP	21572407
MIRT516262	hsa-miR-1206	HITS-CLIP	21572407
MIRT516261	hsa-miR-6853-3p	HITS-CLIP	21572407
MIRT516260	hsa-miR-4795-3p	HITS-CLIP	21572407
MIRT367234	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT516264	hsa-miR-3200-5p	PAR-CLIP	20371350
MIRT516263	hsa-miR-4766-5p	PAR-CLIP	20371350
MIRT516262	hsa-miR-1206	PAR-CLIP	20371350
MIRT516261	hsa-miR-6853-3p	PAR-CLIP	20371350
MIRT516260	hsa-miR-4795-3p	PAR-CLIP	20371350
MIRT367234	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT516264	hsa-miR-3200-5p	PAR-CLIP	20371350
MIRT516263	hsa-miR-4766-5p	PAR-CLIP	20371350
MIRT516262	hsa-miR-1206	PAR-CLIP	20371350
MIRT516261	hsa-miR-6853-3p	PAR-CLIP	20371350
MIRT516260	hsa-miR-4795-3p	PAR-CLIP	20371350
MIRT367234	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT516264	hsa-miR-3200-5p	PAR-CLIP	23446348
MIRT516263	hsa-miR-4766-5p	PAR-CLIP	23446348
MIRT516262	hsa-miR-1206	PAR-CLIP	23446348
MIRT516261	hsa-miR-6853-3p	PAR-CLIP	23446348
MIRT516260	hsa-miR-4795-3p	PAR-CLIP	23446348
MIRT439736	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT439736	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT367234	hsa-miR-548c-3p	HITS-CLIP	21572407
MIRT516264	hsa-miR-3200-5p	HITS-CLIP	21572407
MIRT516263	hsa-miR-4766-5p	HITS-CLIP	21572407
MIRT516262	hsa-miR-1206	HITS-CLIP	21572407
MIRT516261	hsa-miR-6853-3p	HITS-CLIP	21572407
MIRT516260	hsa-miR-4795-3p	HITS-CLIP	21572407
MIRT367234	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT516264	hsa-miR-3200-5p	PAR-CLIP	20371350
MIRT516263	hsa-miR-4766-5p	PAR-CLIP	20371350
MIRT516262	hsa-miR-1206	PAR-CLIP	20371350
MIRT516261	hsa-miR-6853-3p	PAR-CLIP	20371350
MIRT516260	hsa-miR-4795-3p	PAR-CLIP	20371350
MIRT367234	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT516264	hsa-miR-3200-5p	PAR-CLIP	20371350
MIRT516263	hsa-miR-4766-5p	PAR-CLIP	20371350
MIRT516262	hsa-miR-1206	PAR-CLIP	20371350
MIRT516261	hsa-miR-6853-3p	PAR-CLIP	20371350
MIRT516260	hsa-miR-4795-3p	PAR-CLIP	20371350
MIRT367234	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT516264	hsa-miR-3200-5p	PAR-CLIP	23446348
MIRT516263	hsa-miR-4766-5p	PAR-CLIP	23446348
MIRT516262	hsa-miR-1206	PAR-CLIP	23446348
MIRT516261	hsa-miR-6853-3p	PAR-CLIP	23446348
MIRT516260	hsa-miR-4795-3p	PAR-CLIP	23446348

Show/Hide all (61)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000027	Process	Ribosomal large subunit assembly	IBA
GO:0000027	Process	Ribosomal large subunit assembly	IMP	24120868
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	7772601
GO:0003730	Function	MRNA 3'-UTR binding	IDA	16213212
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	IMP	18697920
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	7772601
GO:0005515	Function	Protein binding	IPI	9465063, 9687515, 12054647, 15314173, 15469983, 16648475, 17110929, 17373842, 18560357, 20434207, 20926688, 21399665, 21900206, 28514442, 30021884, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	9687515
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	24120868
GO:0005730	Component	Nucleolus	HDA	16791210
GO:0005730	Component	Nucleolus	IDA	15469983, 24120868
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	HDA	16791210
GO:0005737	Component	Cytoplasm	IDA	15314173, 15469983
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006364	Process	RRNA processing	IMP	18697920
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	7772601
GO:0008097	Function	5S rRNA binding	IBA
GO:0008097	Function	5S rRNA binding	IDA	18560357
GO:0008097	Function	5S rRNA binding	IEA
GO:0010628	Process	Positive regulation of gene expression	IDA	18560357
GO:0016020	Component	Membrane	HDA	19946888
GO:0019843	Function	RRNA binding	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS	7772601
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	18560357
GO:0032991	Component	Protein-containing complex	IDA	15314173
GO:0042273	Process	Ribosomal large subunit biogenesis	IMP	18697920
GO:0045727	Process	Positive regulation of translation	IDA	16213212
GO:0048027	Function	MRNA 5'-UTR binding	IDA	16213212
GO:0050821	Process	Protein stabilization	IMP	18560357
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	IMP	24120868
GO:1904667	Process	Negative regulation of ubiquitin protein ligase activity	IDA	18560357
GO:1990904	Component	Ribonucleoprotein complex	IDA	18809582
GO:1990904	Component	Ribonucleoprotein complex	IEA
GO:1990948	Function	Ubiquitin ligase inhibitor activity	IDA	18560357
GO:2000059	Process	Negative regulation of ubiquitin-dependent protein catabolic process	IDA	18560357
GO:2000435	Process	Negative regulation of protein neddylation	IDA	18560357

MIM	HGNC	e!Ensembl
603634	10360	ENSG00000122406

P46777

Protein name

Large ribosomal subunit protein uL18 (60S ribosomal protein L5)

Protein function

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8BGU , 8FL0 , 8FL2 , 8FL3 , 8FL4 , 8FL6 , 8FL7 , 8FL9 , 8FLA , 8FLB , 8FLC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17144	Ribosomal_L5e	14 → 176	Ribosomal large subunit proteins 60S L5, and 50S L18	Family
PF14204	Ribosomal_L18_c	192 → 283	Ribosomal L18 C-terminal region	Domain

Sequence

MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDI
ICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYE
GQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRF
PGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMY
KKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES

Sequence length

297

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

419

Show/Hide Causal Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Diamond-Blackfan anemia	Likely pathogenic; Pathogenic	rs1686989669, rs2100672432, rs2100677043, rs587777117, rs2100685111, rs2100685034, rs2100676852, rs2100688383, rs2524457676, rs138710531, rs1190811369, rs148673599, rs2524462266, rs2524447751, rs2524448276 View all (31 more)	RCV001377843 RCV001380814 RCV001387662 RCV002444558 RCV001971307 RCV002035339 RCV002045961 RCV001924534 RCV002355543 RCV002375646 RCV002333052 RCV002340604 RCV002353824 RCV002360149 RCV002434901 RCV002371533 RCV002385015 RCV002404073 RCV002428225 RCV002428991 RCV002428467 RCV005098433 RCV003072754 RCV002648164 RCV002664165 RCV002871157 RCV002885333 RCV001217229 RCV000229721 RCV003508732 RCV003507822 RCV003616280 RCV003615722 RCV005090723 RCV000466439 RCV000543851 RCV000691755 RCV000694413 RCV000702906 RCV000691705 RCV000822654 RCV000805012 RCV000819548 RCV001044815 RCV001056294 RCV005093454 RCV001239349
Diamond-Blackfan anemia 1	Pathogenic	rs1558284033	RCV000761557
Diamond-Blackfan anemia 6	Pathogenic; Likely pathogenic	rs1687123286, rs587777117, rs587777118, rs2100677045, rs2100685111, rs2100688414, rs2100676969, rs1394064043, rs2524458087, rs2524448581, rs2524440268, rs121434405, rs1571026775, rs142156224, rs2524452489 View all (6 more)	RCV001332618 RCV000087038 RCV000087039 RCV001783692 RCV004594615 RCV002052118 RCV002053872 RCV002283677 RCV002283945 RCV003134434 RCV002466790 RCV000006556 RCV000006559 RCV000006561 RCV003486402 RCV005631229 RCV002249419 RCV000006558 RCV000853337 RCV001265621 RCV001267892
Glioma susceptibility 1	Likely pathogenic	rs1394064043	RCV005930266
RPL5-related disorder	Likely pathogenic	rs2524448298	RCV003400213
See cases	Likely pathogenic	rs2100676956	RCV002252835

Show/Hide Unknown Diseases (19)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
-	no classification for the single variant	rs558220259, rs576892621, rs182018447, rs559377519	-
Acute myeloid leukemia	Benign; Likely benign; Conflicting classifications of pathogenicity	rs200628272, rs145058455	RCV005895548 RCV005891743
Cervical cancer	Benign; Likely benign	rs200628272	RCV005895551
Cholangiocarcinoma	Benign; Likely benign	rs200628272	RCV005895561
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign; Likely benign	rs200628272	RCV005895563
Colorectal cancer	Benign; Likely benign	rs200628272	RCV005895554
Familial cancer of breast	Benign; Likely benign; Conflicting classifications of pathogenicity	rs200628272, rs145058455	RCV005895547 RCV005891742
Gastric cancer	Benign; Likely benign	rs200628272	RCV005895556
Lung cancer	Benign; Likely benign; Conflicting classifications of pathogenicity	rs200628272, rs145058455	RCV005895562 RCV005891746
Lymphoma	Benign; Likely benign	rs200628272	RCV005895557
Malignant tumor of esophagus	Benign; Likely benign	rs200628272	RCV005895549
Melanoma	Benign; Likely benign	rs200628272	RCV005895560
Nonpapillary renal cell carcinoma	Benign; Likely benign	rs200628272	RCV005895550
Ovarian cancer	Benign; Likely benign	rs200628272	RCV005895552
Sarcoma	Benign; Likely benign; Conflicting classifications of pathogenicity	rs200628272, rs145058455	RCV005895555 RCV005891744
Thymoma	Benign; Likely benign; Conflicting classifications of pathogenicity	rs200628272, rs145058455	RCV005895559 RCV005891745
Uterine carcinosarcoma	Benign; Likely benign	rs200628272	RCV005895558
Uterine corpus endometrial carcinoma	Benign; Conflicting classifications of pathogenicity	rs112571271, rs145058455	RCV005918721 RCV005891747
Uveal melanoma	Benign; Likely benign	rs200628272	RCV005895553

Show/Hide Text Mining Associations (29)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Amyotrophic Lateral Sclerosis	Associate	39252332
Anemia Diamond Blackfan	Associate	19061985, 19765279, 19773262, 20116044, 20378560, 20960466, 22262766, 22431104, 22689679, 23744582, 24675553, 25946618, 26258650, 27258031, 28376382, 30700418 View all (1 more)
Anhedonia	Associate	19061985, 20378560
Appendicitis	Associate	39252332
Breast Neoplasms	Associate	27926932
Budd Chiari Syndrome	Associate	34470834
Capillary Malformation Arteriovenous Malformation	Associate	19773262, 20960466
Carcinoma Hepatocellular	Associate	32316188, 35318110
Chromosome Deletion	Inhibit	27909306
Cleft Lip	Associate	34032749
Cleft Palate	Associate	19061985, 20378560
Colorectal Neoplasms	Associate	36384455
Congenital Hereditary and Neonatal Diseases and Abnormalities	Associate	29146883
Craniofacial Abnormalities	Associate	19773262
Demyelinating Diseases	Associate	20368992
Ectrodactyly	Associate	19773262
Growth Disorders	Associate	22262766
HIV Infections	Associate	23933117
Manouvrier syndrome	Associate	19061985
Multiple Myeloma	Associate	27909306
Multiple Sclerosis	Associate	20087403, 34483448
Neoplasm Invasiveness	Associate	30651076
Neoplasms	Inhibit	20221446, 24061479
Neoplasms	Associate	31240215, 36384455
Thrombosis	Associate	34483448
Thumb deformity	Associate	19061985
Thumb deformity alopecia pigmentation anomaly	Associate	20378560
Uveal melanoma	Associate	32415113
Venous Thromboembolism	Associate	29620629

RPL5 (ribosomal protein L5)