Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6123
Gene name Gene Name - the full gene name approved by the HGNC.	Ribosomal protein L3 like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RPL3L
Synonyms (NCBI Gene) Gene synonyms aliases	CMD2D
Disease Acronyms (UniProt) Disease acronyms from UniProt database	CMD2D
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that shares sequence similarity with ribosomal protein L3. The protein belongs to the L3P family of ribosomal proteins. Unlike the ubiquitous expression of ribosomal protein genes, this gene has a tissue-specific pattern of exp

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miRTarBase ID	miRNA	Experiments	Reference
MIRT621012	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT611851	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT611850	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT611849	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT611856	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611855	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611854	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611853	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611852	hsa-miR-548z	HITS-CLIP	23824327
MIRT621012	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT621011	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT621010	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT621009	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT621008	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT621007	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT611851	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT611850	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT611849	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT611856	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611855	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611854	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611853	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611852	hsa-miR-548z	HITS-CLIP	23824327
MIRT611851	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT611850	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT611849	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT621012	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT611851	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT611850	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT611849	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT611856	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611855	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611854	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611853	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611852	hsa-miR-548z	HITS-CLIP	23824327
MIRT621012	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT621011	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT621010	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT621009	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT621008	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT621007	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT611851	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT611850	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT611849	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT611856	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611855	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611854	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611853	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611852	hsa-miR-548z	HITS-CLIP	23824327
MIRT611851	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT611850	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT611849	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT2094119	hsa-miR-1324	CLIP-seq
MIRT2094120	hsa-miR-3166	CLIP-seq
MIRT2094121	hsa-miR-4260	CLIP-seq
MIRT2094122	hsa-miR-4267	CLIP-seq
MIRT2094123	hsa-miR-486-3p	CLIP-seq
MIRT2094119	hsa-miR-1324	CLIP-seq
MIRT2318722	hsa-miR-25	CLIP-seq
MIRT2094120	hsa-miR-3166	CLIP-seq
MIRT2318723	hsa-miR-32	CLIP-seq
MIRT2318724	hsa-miR-363	CLIP-seq
MIRT2318725	hsa-miR-367	CLIP-seq
MIRT2094121	hsa-miR-4260	CLIP-seq
MIRT2318726	hsa-miR-4684-5p	CLIP-seq
MIRT2318727	hsa-miR-4768-5p	CLIP-seq
MIRT2094123	hsa-miR-486-3p	CLIP-seq
MIRT2318728	hsa-miR-92a	CLIP-seq
MIRT2318729	hsa-miR-92b	CLIP-seq
MIRT2094119	hsa-miR-1324	CLIP-seq
MIRT2094120	hsa-miR-3166	CLIP-seq
MIRT2094121	hsa-miR-4260	CLIP-seq
MIRT2094123	hsa-miR-486-3p	CLIP-seq
MIRT2094119	hsa-miR-1324	CLIP-seq
MIRT2094120	hsa-miR-3166	CLIP-seq
MIRT2094121	hsa-miR-4260	CLIP-seq
MIRT2094123	hsa-miR-486-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000027	Process	Ribosomal large subunit assembly	IBA	21873635
GO:0003723	Function	RNA binding	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005840	Component	Ribosome	TAS	8921388
GO:0006412	Process	Translation	NAS	12962325
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA	21873635

MIM	HGNC	e!Ensembl
617416	10351	ENSG00000140986

Protein

UniProt ID

Q92901

Protein name

Ribosomal protein uL3-like (60S ribosomal protein L3-like) (Large ribosomal subunit protein uL3-like)

Protein function

Heart- and skeletal muscle-specific component of the ribosome, which regulates muscle function. Component of the large ribosomal subunit in striated muscle cells: replaces the RPL3 paralog in the ribosome in these cells. The ribosome is a large

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00297	Ribosomal_L3	1 → 375	Ribosomal protein L3	Family

Sequence

MSHRKFSAPRHGHLGFLPHKRSHRHRGKVKTWPRDDPSQPVHLTAFLGYKAGMTHTLREV
HRPGLKISKREEVEAVTIVETPPLVVVGVVGYVATPRGLRSFKTIFAEHLSDECRRRFYK
DWHKSKKKAFTKACKRWRDTDGKKQLQKDFAAMKKYCKVIRVIVHTQMKLLPFRQKKAHI
MEIQLNGGTVAEKVAWAQARLEKQVPVHSVFSQSEVIDVIAVTKGRGVKGVTSRWHTKKL
PRKTHKGLRKVACIGAWHPARVGCSIARAGQKGYHHRTELNKKIFRIGRGPHMEDGKLVK
NNASTSYDVTAKSITPLGGFPHYGEVNNDFVMLKGCIAGTKKRVITLRKSLLVHHSRQAV
ENIELKFIDTTSKFGHGRFQTAQEKRAFMGPQKKHLEKETPETSGDL

Sequence length

407

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557 View all (6 more)	29892015, 30061737

Show/Hide Unknown Diseases (4)

Disease term	Disease name	References	Source
Unknown
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	30061737	ClinVar
Myopathy	dilated cardiomyopathy		GenCC
Cardiomyopathy	cardiomyopathy, dilated, 2D		GenCC
Atrial Fibrillation	Atrial Fibrillation		GWAS

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining
Azoospermia	Inhibit	36589848
Cardiomyopathy Dilated	Associate	32514796
Colonic Neoplasms	Associate	35712285
Hearing Loss	Associate	33078831
Oligospermia	Associate	36589848
Syndrome	Associate	36589848

RPL3L (ribosomal protein L3 like)