Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6122
Gene name Gene Name - the full gene name approved by the HGNC.	Ribosomal protein L3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RPL3
Synonyms (NCBI Gene) Gene synonyms aliases	ASC-1, L3, TARBP-B, uL3
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q13.1
Summary Summary of gene provided in NCBI Entrez Gene.	Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal prot

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miRTarBase ID	miRNA	Experiments	Reference
MIRT031945	hsa-miR-16-5p	Proteomics	18668040
MIRT049123	hsa-miR-92a-3p	qRT-PCR	23622248
MIRT051787	hsa-let-7c-5p	CLASH	23622248
MIRT049123	hsa-miR-92a-3p	CLASH	23622248
MIRT049123	hsa-miR-92a-3p	CLASH	23622248
MIRT047026	hsa-miR-204-5p	CLASH	23622248
MIRT046052	hsa-miR-125b-5p	CLASH	23622248
MIRT042530	hsa-miR-423-3p	CLASH	23622248
MIRT040684	hsa-miR-92b-3p	CLASH	23622248
MIRT039771	hsa-miR-615-3p	CLASH	23622248
MIRT039771	hsa-miR-615-3p	CLASH	23622248
MIRT039771	hsa-miR-615-3p	CLASH	23622248
MIRT039282	hsa-miR-671-5p	CLASH	23622248
MIRT037436	hsa-miR-744-5p	CLASH	23622248
MIRT036275	hsa-miR-1229-3p	CLASH	23622248
MIRT036120	hsa-miR-1296-5p	CLASH	23622248
MIRT035991	hsa-miR-1301-3p	CLASH	23622248
MIRT035792	hsa-miR-1914-5p	CLASH	23622248
MIRT052681	hsa-miR-1260b	CLASH	23622248
MIRT052681	hsa-miR-1260b	CLASH	23622248
MIRT439739	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439738	hsa-miR-493-3p	HITS-CLIP	24374217
MIRT439739	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439738	hsa-miR-493-3p	HITS-CLIP	24374217
MIRT1316736	hsa-miR-3672	CLIP-seq
MIRT1316737	hsa-miR-4461	CLIP-seq
MIRT1316738	hsa-miR-4786-5p	CLIP-seq
MIRT1316739	hsa-miR-769-5p	CLIP-seq
MIRT2094094	hsa-miR-1343	CLIP-seq
MIRT1316736	hsa-miR-3672	CLIP-seq
MIRT2094095	hsa-miR-4326	CLIP-seq
MIRT1316737	hsa-miR-4461	CLIP-seq
MIRT1316738	hsa-miR-4786-5p	CLIP-seq
MIRT1316739	hsa-miR-769-5p	CLIP-seq
MIRT1316736	hsa-miR-3672	CLIP-seq
MIRT1316737	hsa-miR-4461	CLIP-seq
MIRT1316738	hsa-miR-4786-5p	CLIP-seq
MIRT1316739	hsa-miR-769-5p	CLIP-seq
MIRT2094094	hsa-miR-1343	CLIP-seq
MIRT2094095	hsa-miR-4326	CLIP-seq
MIRT1316738	hsa-miR-4786-5p	CLIP-seq
MIRT1316739	hsa-miR-769-5p	CLIP-seq
MIRT2094094	hsa-miR-1343	CLIP-seq
MIRT2094095	hsa-miR-4326	CLIP-seq
MIRT1316738	hsa-miR-4786-5p	CLIP-seq
MIRT1316739	hsa-miR-769-5p	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
KHSRP	Unknown	21705779
NPM1	Unknown	21705779

Show/Hide all(37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	TAS
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS
GO:0005515	Function	Protein binding	IPI	23349634, 24965446, 25854864, 26100019, 32814053
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	HDA	16791210
GO:0005730	Component	Nucleolus	IDA	16963496
GO:0005730	Component	Nucleolus	IEA
GO:0005730	Component	Nucleolus	TAS
GO:0005737	Component	Cytoplasm	HDA	16791210
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IBA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS
GO:0022626	Component	Cytosolic ribosome	IDA	32669547
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0032991	Component	Protein-containing complex	IDA	23349634
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0071353	Process	Cellular response to interleukin-4	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
604163	10332	ENSG00000100316

Protein

UniProt ID

P39023

Protein name

Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (HIV-1 TAR RNA-binding protein B) (TARBP-B)

Protein function

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547, PubMed:35674491). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ , 8FL0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00297	Ribosomal_L3	1 → 375	Ribosomal protein L3	Family

Sequence

MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREV
DRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYK
NWHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHL
MEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKL
PRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIK
NNASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRAL
EKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA

Sequence length

403

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Unknown Diseases (7)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Biliary Cholangitis	Primary biliary cholangitis	N/A	N/A	GWAS
Colorectal Cancer	Colorectal cancer	N/A	N/A	GWAS
Crohn Disease	Crohn's disease	N/A	N/A	GWAS
Hypothyroidism	Hypothyroidism	N/A	N/A	GWAS
Inflammatory Bowel Disease	Inflammatory bowel disease (MTAG), Inflammatory bowel disease	N/A	N/A	GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus	N/A	N/A	GWAS
Ulcerative colitis	Ulcerative colitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Aspergillosis Allergic Bronchopulmonary	Associate	12974759
Autoimmune Diseases	Associate	12974759
Breast Neoplasms	Associate	27926932, 36308067
Carcinogenesis	Associate	32987560
Carcinoma Hepatocellular	Associate	36378050
Colorectal Neoplasms	Associate	27385096, 27835895, 35127345
Glioblastoma	Associate	29687002
Glioma	Associate	32987560
Intervertebral disc disease	Associate	33761671
Liver Cirrhosis Biliary	Associate	28425483
Lung Neoplasms	Associate	26636733, 27924828
Multiple Organ Failure	Associate	37533854
Multiple Sclerosis	Associate	23077530
Multiple Sclerosis Relapsing Remitting	Associate	23077530
Neoplasms	Associate	12177805, 26636733, 27385096
Thyroid Neoplasms	Associate	37745716

RPL3 (ribosomal protein L3)