PROK2 (prokineticin 2)

Gene
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
60675
Gene name Gene Name - the full gene name approved by the HGNC.
Prokineticin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PROK2
Synonyms (NCBI Gene) Gene synonyms aliases
BV8, HH4, KAL4, MIT1, PK2
Disease Acronyms (UniProt) Disease acronyms from UniProt database
HH4
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p13
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precurso
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(4)
SNP ID Visualize variation Clinical significance Consequence
rs121434272 G>A,C Pathogenic Missense variant, coding sequence variant
rs554675432 T>- Pathogenic Stop gained, coding sequence variant
rs587777864 C>T Pathogenic Missense variant, coding sequence variant
rs768413190 A>-,AA Likely-pathogenic Coding sequence variant, frameshift variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(23)
miRTarBase ID miRNA Experiments Reference
MIRT027934 hsa-miR-96-5p Sequencing 20371350
MIRT640996 hsa-miR-548c-3p HITS-CLIP 23824327
MIRT640995 hsa-miR-4729 HITS-CLIP 23824327
MIRT640994 hsa-miR-520d-5p HITS-CLIP 23824327
MIRT640993 hsa-miR-524-5p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(22)
GO ID Ontology Definition Evidence Reference
GO:0000187 Process Activation of MAPK activity IBA 21873635
GO:0000187 Process Activation of MAPK activity TAS 12728244
GO:0001525 Process Angiogenesis IDA 12604792
GO:0001664 Function G protein-coupled receptor binding IBA 21873635
GO:0001664 Function G protein-coupled receptor binding TAS 12728244
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
607002 18455 ENSG00000163421
Protein
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9HC23
Protein name Prokineticin-2 (PK2) (Protein Bv8 homolog)
Protein function May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06607 Prokineticin 1 → 126 Prokineticin Family
Tissue specificity TISSUE SPECIFICITY: Expressed in the testis and, at low levels, in the small intestine.
Sequence
Sequence length 129
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Peptide ligand-binding receptors
G alpha (q) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (12)
Causal
Disease term Disease name dbSNP ID References
Cryptorchidism Cryptorchidism rs121912555, rs104894697, rs104894698, rs398122886
Hearing loss Sensorineural Hearing Loss (disorder) rs267607135, rs267606855, rs779841884, rs267606854, rs28942097, rs121908073, rs121908076, rs74315289, rs121908144, rs111033313, rs74315437, rs121908348, rs121908349, rs121908350, rs397515359
View all (184 more)
Hypogonadotropic hypogonadism Hypogonadotropic hypogonadism rs104894702, rs104893836, rs104893837, rs104893842, rs121909628, rs138249161, rs1601946139
Hypogonadotropic hypogonadism with or without anosmia HYPOGONADOTROPIC HYPOGONADISM 4 WITH OR WITHOUT ANOSMIA rs387906271, rs587777834, rs74315419, rs554675432, rs28939719, rs104894701, rs104894702, rs104894703, rs137852659, rs137852661, rs137852662, rs137852663, rs137852512, rs137852513, rs137852514
View all (110 more)		 30712880, 23643382, 25077900, 18559922, 17054399
Show/Hide Unknown Diseases (4)
Unknown
Disease term Disease name Evidence References Source
Mental depression Depressive disorder, Unipolar Depression, Major Depressive Disorder 20471630, 19544013 ClinVar
Ptosis Blepharoptosis, Ptosis ClinVar
Hypogonadotropic Hypogonadism With Or Without Anosmia hypogonadotropic hypogonadism 4 with or without anosmia GenCC
Restless Legs Syndrome Restless Legs Syndrome GWAS
Show/Hide Text Mining Associations (48)
Associations from Text Mining
Disease Name Relationship Type References
3 methylcrotonyl CoA carboxylase 1 deficiency Associate 24496457
Acute Coronary Syndrome Associate 34753383
Alzheimer Disease Associate 32348224
Anemia Hemolytic Associate 5666119
Aneurysm Ruptured Associate 19111481
Blepharophimosis Associate 19332160
Carcinoma Hepatocellular Inhibit 18300343
Carcinoma Merkel Cell Associate 24496457
Cartilage Diseases Associate 38057865
Chronobiology Disorders Associate 24423319