CYB5RL (cytochrome b5 reductase like)

Gene

• Entrez ID: 606495
• Gene name: Cytochrome b5 reductase like
• Gene symbol: CYB5RL
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1p32.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT919694	hsa-miR-1236	CLIP-seq
MIRT919695	hsa-miR-1245b-3p	CLIP-seq
MIRT919696	hsa-miR-1253	CLIP-seq
MIRT919697	hsa-miR-1271	CLIP-seq
MIRT919698	hsa-miR-1299	CLIP-seq
MIRT919699	hsa-miR-1301	CLIP-seq
MIRT919700	hsa-miR-190	CLIP-seq
MIRT919701	hsa-miR-190b	CLIP-seq
MIRT919702	hsa-miR-298	CLIP-seq
MIRT919703	hsa-miR-3184	CLIP-seq
MIRT919704	hsa-miR-3185	CLIP-seq
MIRT919705	hsa-miR-3194-3p	CLIP-seq
MIRT919706	hsa-miR-331-3p	CLIP-seq
MIRT919707	hsa-miR-34a	CLIP-seq
MIRT919708	hsa-miR-34c-5p	CLIP-seq
MIRT919709	hsa-miR-361-3p	CLIP-seq
MIRT919710	hsa-miR-3650	CLIP-seq
MIRT919711	hsa-miR-3677-5p	CLIP-seq
MIRT919712	hsa-miR-377	CLIP-seq
MIRT919713	hsa-miR-3974	CLIP-seq
MIRT919714	hsa-miR-423-5p	CLIP-seq
MIRT919715	hsa-miR-4268	CLIP-seq
MIRT919716	hsa-miR-4303	CLIP-seq
MIRT919717	hsa-miR-4431	CLIP-seq
MIRT919718	hsa-miR-4468	CLIP-seq
MIRT919719	hsa-miR-4496	CLIP-seq
MIRT919720	hsa-miR-449a	CLIP-seq
MIRT919721	hsa-miR-449b	CLIP-seq
MIRT919722	hsa-miR-4640-5p	CLIP-seq
MIRT919723	hsa-miR-4660	CLIP-seq
MIRT919724	hsa-miR-4668-3p	CLIP-seq
MIRT919725	hsa-miR-4709-3p	CLIP-seq
MIRT919726	hsa-miR-4726-5p	CLIP-seq
MIRT919727	hsa-miR-4782-5p	CLIP-seq
MIRT919728	hsa-miR-493	CLIP-seq
MIRT919729	hsa-miR-500a	CLIP-seq
MIRT919730	hsa-miR-501-5p	CLIP-seq
MIRT919731	hsa-miR-5047	CLIP-seq
MIRT919732	hsa-miR-516b	CLIP-seq
MIRT919733	hsa-miR-548c-3p	CLIP-seq
MIRT919734	hsa-miR-592	CLIP-seq
MIRT919735	hsa-miR-597	CLIP-seq
MIRT919736	hsa-miR-7	CLIP-seq
MIRT919737	hsa-miR-875-3p	CLIP-seq
MIRT919738	hsa-miR-944	CLIP-seq
MIRT919739	hsa-miR-96	CLIP-seq
MIRT1547720	hsa-miR-219-2-3p	CLIP-seq
MIRT1547721	hsa-miR-2964a-3p	CLIP-seq
MIRT1547722	hsa-miR-302f	CLIP-seq
MIRT1547723	hsa-miR-3667-3p	CLIP-seq
MIRT1547724	hsa-miR-4297	CLIP-seq
MIRT1547725	hsa-miR-4452	CLIP-seq
MIRT1547726	hsa-miR-502-5p	CLIP-seq
MIRT1547727	hsa-miR-645	CLIP-seq
MIRT1972629	hsa-miR-127-5p	CLIP-seq
MIRT1972630	hsa-miR-1285	CLIP-seq
MIRT1972631	hsa-miR-1288	CLIP-seq
MIRT1547720	hsa-miR-219-2-3p	CLIP-seq
MIRT1547721	hsa-miR-2964a-3p	CLIP-seq
MIRT1547722	hsa-miR-302f	CLIP-seq
MIRT1972632	hsa-miR-3187-5p	CLIP-seq
MIRT919705	hsa-miR-3194-3p	CLIP-seq
MIRT1972633	hsa-miR-3199	CLIP-seq
MIRT1547723	hsa-miR-3667-3p	CLIP-seq
MIRT1972634	hsa-miR-3907	CLIP-seq
MIRT1972635	hsa-miR-3929	CLIP-seq
MIRT1547724	hsa-miR-4297	CLIP-seq
MIRT1972636	hsa-miR-4419b	CLIP-seq
MIRT1547725	hsa-miR-4452	CLIP-seq
MIRT1972637	hsa-miR-4459	CLIP-seq
MIRT1972638	hsa-miR-4478	CLIP-seq
MIRT1972639	hsa-miR-4649-3p	CLIP-seq
MIRT1972640	hsa-miR-4659a-5p	CLIP-seq
MIRT1972641	hsa-miR-4659b-5p	CLIP-seq
MIRT1972642	hsa-miR-4663	CLIP-seq
MIRT1972643	hsa-miR-4669	CLIP-seq
MIRT1972644	hsa-miR-4717-5p	CLIP-seq
MIRT1972645	hsa-miR-4740-5p	CLIP-seq
MIRT1547726	hsa-miR-502-5p	CLIP-seq
MIRT1972646	hsa-miR-612	CLIP-seq
MIRT1972647	hsa-miR-642b	CLIP-seq
MIRT1547727	hsa-miR-645	CLIP-seq
MIRT1972648	hsa-miR-889	CLIP-seq
MIRT919697	hsa-miR-1271	CLIP-seq
MIRT1972629	hsa-miR-127-5p	CLIP-seq
MIRT2208211	hsa-miR-1343	CLIP-seq
MIRT2208212	hsa-miR-145	CLIP-seq
MIRT2208213	hsa-miR-151-3p	CLIP-seq
MIRT2208214	hsa-miR-187	CLIP-seq
MIRT1547720	hsa-miR-219-2-3p	CLIP-seq
MIRT1547721	hsa-miR-2964a-3p	CLIP-seq
MIRT2208215	hsa-miR-297	CLIP-seq
MIRT919702	hsa-miR-298	CLIP-seq
MIRT1547722	hsa-miR-302f	CLIP-seq
MIRT2208216	hsa-miR-3128	CLIP-seq
MIRT2208217	hsa-miR-3182	CLIP-seq
MIRT2208218	hsa-miR-3188	CLIP-seq
MIRT2208219	hsa-miR-342-5p	CLIP-seq
MIRT2208220	hsa-miR-34b	CLIP-seq
MIRT2208221	hsa-miR-3605-3p	CLIP-seq
MIRT2208222	hsa-miR-3622a-3p	CLIP-seq
MIRT2208223	hsa-miR-3622b-3p	CLIP-seq
MIRT2208224	hsa-miR-3920	CLIP-seq
MIRT2208225	hsa-miR-4266	CLIP-seq
MIRT2208226	hsa-miR-4307	CLIP-seq
MIRT2208227	hsa-miR-4420	CLIP-seq
MIRT1547725	hsa-miR-4452	CLIP-seq
MIRT2208228	hsa-miR-4470	CLIP-seq
MIRT2208229	hsa-miR-4664-5p	CLIP-seq
MIRT2208230	hsa-miR-4695-5p	CLIP-seq
MIRT2208231	hsa-miR-4711-3p	CLIP-seq
MIRT2208232	hsa-miR-4755-3p	CLIP-seq
MIRT2208233	hsa-miR-4762-3p	CLIP-seq
MIRT2208234	hsa-miR-4779	CLIP-seq
MIRT2208235	hsa-miR-5095	CLIP-seq
MIRT2208236	hsa-miR-552	CLIP-seq
MIRT2208237	hsa-miR-567	CLIP-seq
MIRT2208238	hsa-miR-600	CLIP-seq
MIRT2208239	hsa-miR-622	CLIP-seq
MIRT919739	hsa-miR-96	CLIP-seq
MIRT2208212	hsa-miR-145	CLIP-seq
MIRT2208214	hsa-miR-187	CLIP-seq
MIRT2208217	hsa-miR-3182	CLIP-seq
MIRT2386626	hsa-miR-3192	CLIP-seq
MIRT1547723	hsa-miR-3667-3p	CLIP-seq
MIRT2208224	hsa-miR-3920	CLIP-seq
MIRT2208231	hsa-miR-4711-3p	CLIP-seq
MIRT2208233	hsa-miR-4762-3p	CLIP-seq
MIRT2208239	hsa-miR-622	CLIP-seq
MIRT2511892	hsa-miR-1178	CLIP-seq
MIRT2511893	hsa-miR-1266	CLIP-seq
MIRT1972629	hsa-miR-127-5p	CLIP-seq
MIRT2208213	hsa-miR-151-3p	CLIP-seq
MIRT1547720	hsa-miR-219-2-3p	CLIP-seq
MIRT2511894	hsa-miR-27a	CLIP-seq
MIRT2511895	hsa-miR-27b	CLIP-seq
MIRT1547721	hsa-miR-2964a-3p	CLIP-seq
MIRT2511896	hsa-miR-296-5p	CLIP-seq
MIRT2511897	hsa-miR-300	CLIP-seq
MIRT1547722	hsa-miR-302f	CLIP-seq
MIRT2511898	hsa-miR-3120-3p	CLIP-seq
MIRT2511899	hsa-miR-3127-5p	CLIP-seq
MIRT2511900	hsa-miR-323b-3p	CLIP-seq
MIRT1547723	hsa-miR-3667-3p	CLIP-seq
MIRT2511901	hsa-miR-381	CLIP-seq
MIRT2511902	hsa-miR-3918	CLIP-seq
MIRT2511903	hsa-miR-4260	CLIP-seq
MIRT1547724	hsa-miR-4297	CLIP-seq
MIRT1547725	hsa-miR-4452	CLIP-seq
MIRT2511904	hsa-miR-4518	CLIP-seq
MIRT2511905	hsa-miR-451b	CLIP-seq
MIRT1547726	hsa-miR-502-5p	CLIP-seq
MIRT2208235	hsa-miR-5095	CLIP-seq
MIRT2511906	hsa-miR-513a-5p	CLIP-seq
MIRT2208236	hsa-miR-552	CLIP-seq
MIRT2511907	hsa-miR-580	CLIP-seq
MIRT2208238	hsa-miR-600	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004128	Function	Cytochrome-b5 reductase activity, acting on NAD(P)H	IEA
GO:0004128	Function	Cytochrome-b5 reductase activity, acting on NAD(P)H	TAS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0015701	Process	Bicarbonate transport	TAS
GO:0016491	Function	Oxidoreductase activity	IBA
GO:0016491	Function	Oxidoreductase activity	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q6IPT4
• Protein name: NADH-cytochrome b5 reductase-like (EC 1.6.2.2)
• Protein function: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09791	Oxidored-like	14 → 57	Oxidoreductase-like protein, N-terminal	Family
  PF00970	FAD_binding_6	79 → 176	Oxidoreductase FAD-binding domain	Domain
  PF00175	NAD_binding_1	186 → 300	Oxidoreductase NAD-binding domain	Domain

• Sequence:

  MMAEREEDDDTEEAWMQLRPTEPLPSQCCGSGCSPCVFDLYHRDLARWEAAQASKDRSLL
  RGPESQSCPSKLNPETFVAFCIIAMDRLTKDTYRVRFALPGNSQLGLRPGQHLILRGIVD
  DLEIQRAYTPISPANAEGYFEVLIKCYQMGLMSRYVESWRVGDTAFWRGPFGDFFYKPNQ
  YGELLLLAAGTGLAPMVPILQSITDNENDETFVTLVGCFKTFESIYLKTFLQEQARFWNV
  RTFFVLSQESSSEQLPWSYQEKTHFGHLGQDLIKELVSCCRRKPFALVCGSAEFTKDIAR
  CLLCAGLTEDSYFLF

• Sequence length: 315

Pathways

KEGG:

Biosynthesis of various nucleotide sugars

Reactome:

Erythrocytes take up carbon dioxide and release oxygen

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations