RIC8A (RIC8 guanine nucleotide exchange factor A)

Gene

• Entrez ID: 60626
• Gene name: RIC8 guanine nucleotide exchange factor A
• Gene symbol: RIC8A
• Synonyms (NCBI Gene): RIC8
• Chromosome: 11
• Chromosome location: 11p15.5

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049571	hsa-miR-92a-3p	CLASH	23622248
MIRT526127	hsa-miR-603	PAR-CLIP	22012620
MIRT526125	hsa-miR-6757-3p	PAR-CLIP	22012620
MIRT526126	hsa-miR-892b	PAR-CLIP	22012620
MIRT526124	hsa-miR-648	PAR-CLIP	22012620
MIRT526122	hsa-miR-4302	PAR-CLIP	22012620
MIRT526123	hsa-miR-199a-5p	PAR-CLIP	22012620
MIRT526121	hsa-miR-199b-5p	PAR-CLIP	22012620
MIRT526120	hsa-miR-6793-3p	PAR-CLIP	22012620
MIRT526119	hsa-miR-4769-3p	PAR-CLIP	22012620
MIRT526118	hsa-miR-6817-5p	PAR-CLIP	22012620
MIRT526117	hsa-miR-149-5p	PAR-CLIP	22012620
MIRT526115	hsa-miR-3194-3p	PAR-CLIP	22012620
MIRT526116	hsa-miR-6822-3p	PAR-CLIP	22012620
MIRT526114	hsa-miR-760	PAR-CLIP	22012620
MIRT526113	hsa-miR-1227-3p	PAR-CLIP	22012620
MIRT526112	hsa-miR-4727-5p	PAR-CLIP	22012620
MIRT526111	hsa-miR-192-3p	PAR-CLIP	22012620
MIRT526110	hsa-miR-8057	PAR-CLIP	22012620
MIRT526127	hsa-miR-603	PAR-CLIP	22012620
MIRT526125	hsa-miR-6757-3p	PAR-CLIP	22012620
MIRT526126	hsa-miR-892b	PAR-CLIP	22012620
MIRT526124	hsa-miR-648	PAR-CLIP	22012620
MIRT526122	hsa-miR-4302	PAR-CLIP	22012620
MIRT526123	hsa-miR-199a-5p	PAR-CLIP	22012620
MIRT526121	hsa-miR-199b-5p	PAR-CLIP	22012620
MIRT526120	hsa-miR-6793-3p	PAR-CLIP	22012620
MIRT526119	hsa-miR-4769-3p	PAR-CLIP	22012620
MIRT526118	hsa-miR-6817-5p	PAR-CLIP	22012620
MIRT526117	hsa-miR-149-5p	PAR-CLIP	22012620
MIRT526115	hsa-miR-3194-3p	PAR-CLIP	22012620
MIRT526116	hsa-miR-6822-3p	PAR-CLIP	22012620
MIRT526114	hsa-miR-760	PAR-CLIP	22012620
MIRT526113	hsa-miR-1227-3p	PAR-CLIP	22012620
MIRT526112	hsa-miR-4727-5p	PAR-CLIP	22012620
MIRT526111	hsa-miR-192-3p	PAR-CLIP	22012620
MIRT526110	hsa-miR-8057	PAR-CLIP	22012620
MIRT1306444	hsa-miR-103a	CLIP-seq
MIRT1306445	hsa-miR-107	CLIP-seq
MIRT1306446	hsa-miR-1299	CLIP-seq
MIRT1306447	hsa-miR-15a	CLIP-seq
MIRT1306448	hsa-miR-15b	CLIP-seq
MIRT1306449	hsa-miR-16	CLIP-seq
MIRT1306450	hsa-miR-1910	CLIP-seq
MIRT1306451	hsa-miR-195	CLIP-seq
MIRT1306452	hsa-miR-29a	CLIP-seq
MIRT1306453	hsa-miR-29b	CLIP-seq
MIRT1306454	hsa-miR-29c	CLIP-seq
MIRT1306455	hsa-miR-3065-3p	CLIP-seq
MIRT1306456	hsa-miR-3184	CLIP-seq
MIRT1306457	hsa-miR-326	CLIP-seq
MIRT1306458	hsa-miR-330-5p	CLIP-seq
MIRT1306459	hsa-miR-3613-5p	CLIP-seq
MIRT1306460	hsa-miR-3944-5p	CLIP-seq
MIRT1306461	hsa-miR-423-5p	CLIP-seq
MIRT1306462	hsa-miR-424	CLIP-seq
MIRT1306463	hsa-miR-4280	CLIP-seq
MIRT1306464	hsa-miR-4287	CLIP-seq
MIRT1306465	hsa-miR-4292	CLIP-seq
MIRT1306466	hsa-miR-4308	CLIP-seq
MIRT1306467	hsa-miR-4469	CLIP-seq
MIRT1306468	hsa-miR-4646-5p	CLIP-seq
MIRT1306469	hsa-miR-4685-3p	CLIP-seq
MIRT1306470	hsa-miR-4688	CLIP-seq
MIRT1306471	hsa-miR-4713-5p	CLIP-seq
MIRT1306472	hsa-miR-4747-5p	CLIP-seq
MIRT1306473	hsa-miR-497	CLIP-seq
MIRT1306474	hsa-miR-502-5p	CLIP-seq
MIRT1306475	hsa-miR-519a	CLIP-seq
MIRT1306476	hsa-miR-519b-3p	CLIP-seq
MIRT1306477	hsa-miR-519c-3p	CLIP-seq
MIRT1306478	hsa-miR-593	CLIP-seq
MIRT1306479	hsa-miR-595	CLIP-seq
MIRT1306480	hsa-miR-671-5p	CLIP-seq
MIRT1306481	hsa-miR-875-3p	CLIP-seq
MIRT2090769	hsa-miR-1323	CLIP-seq
MIRT2090770	hsa-miR-147	CLIP-seq
MIRT2090771	hsa-miR-299-3p	CLIP-seq
MIRT2090772	hsa-miR-3200-3p	CLIP-seq
MIRT2090773	hsa-miR-3202	CLIP-seq
MIRT2090774	hsa-miR-3650	CLIP-seq
MIRT2090775	hsa-miR-3691-5p	CLIP-seq
MIRT2090776	hsa-miR-3911	CLIP-seq
MIRT2090777	hsa-miR-3929	CLIP-seq
MIRT2090778	hsa-miR-4293	CLIP-seq
MIRT2090779	hsa-miR-4419b	CLIP-seq
MIRT2090780	hsa-miR-4436a	CLIP-seq
MIRT2090781	hsa-miR-4455	CLIP-seq
MIRT2090782	hsa-miR-4474-3p	CLIP-seq
MIRT2090783	hsa-miR-4478	CLIP-seq
MIRT2090784	hsa-miR-4491	CLIP-seq
MIRT2090785	hsa-miR-4533	CLIP-seq
MIRT2090786	hsa-miR-4536	CLIP-seq
MIRT2090787	hsa-miR-4652-3p	CLIP-seq
MIRT2090788	hsa-miR-4657	CLIP-seq
MIRT2090789	hsa-miR-4663	CLIP-seq
MIRT2090790	hsa-miR-4682	CLIP-seq
MIRT2090791	hsa-miR-4700-3p	CLIP-seq
MIRT2090792	hsa-miR-4752	CLIP-seq
MIRT2090793	hsa-miR-4762-3p	CLIP-seq
MIRT2090794	hsa-miR-4778-3p	CLIP-seq
MIRT2090795	hsa-miR-485-5p	CLIP-seq
MIRT2090796	hsa-miR-498	CLIP-seq
MIRT1306475	hsa-miR-519a	CLIP-seq
MIRT1306476	hsa-miR-519b-3p	CLIP-seq
MIRT1306477	hsa-miR-519c-3p	CLIP-seq
MIRT2090797	hsa-miR-548o	CLIP-seq
MIRT2090798	hsa-miR-644	CLIP-seq
MIRT2090799	hsa-miR-873	CLIP-seq
MIRT2315453	hsa-miR-146a	CLIP-seq
MIRT2315454	hsa-miR-146b-5p	CLIP-seq
MIRT2090770	hsa-miR-147	CLIP-seq
MIRT2315455	hsa-miR-1539	CLIP-seq
MIRT2090771	hsa-miR-299-3p	CLIP-seq
MIRT2315456	hsa-miR-3173-5p	CLIP-seq
MIRT1306456	hsa-miR-3184	CLIP-seq
MIRT2090775	hsa-miR-3691-5p	CLIP-seq
MIRT2090776	hsa-miR-3911	CLIP-seq
MIRT1306461	hsa-miR-423-5p	CLIP-seq
MIRT2315457	hsa-miR-4276	CLIP-seq
MIRT2315458	hsa-miR-4318	CLIP-seq
MIRT2090782	hsa-miR-4474-3p	CLIP-seq
MIRT2090784	hsa-miR-4491	CLIP-seq
MIRT2090786	hsa-miR-4536	CLIP-seq
MIRT2090787	hsa-miR-4652-3p	CLIP-seq
MIRT2090788	hsa-miR-4657	CLIP-seq
MIRT1306470	hsa-miR-4688	CLIP-seq
MIRT2090792	hsa-miR-4752	CLIP-seq
MIRT2315459	hsa-miR-548aa	CLIP-seq
MIRT2090798	hsa-miR-644	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001701	Process	In utero embryonic development	IEA
GO:0001944	Process	Vasculature development	IEA
GO:0001965	Function	G-protein alpha-subunit binding	IBA
GO:0001965	Function	G-protein alpha-subunit binding	IEA
GO:0001965	Function	G-protein alpha-subunit binding	ISS
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005515	Function	Protein binding	IPI	16189514, 16713569, 21516116, 21988832, 25074811, 25416956, 28119500, 29892012, 29966094, 32296183, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005938	Component	Cell cortex	IEA
GO:0006457	Process	Protein folding	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	ISS
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA
GO:0007369	Process	Gastrulation	IEA
GO:0008542	Process	Visual learning	IEA
GO:0009416	Process	Response to light stimulus	IEA
GO:0016020	Component	Membrane	IEA
GO:0042074	Process	Cell migration involved in gastrulation	IEA
GO:0044183	Function	Protein folding chaperone	IEA
GO:0044183	Function	Protein folding chaperone	ISS
GO:0070586	Process	Cell-cell adhesion involved in gastrulation	IEA
GO:0071711	Process	Basement membrane organization	IEA

Other IDs

• MIM: 609146
• HGNC: 29550
• e!Ensembl: ENSG00000177963

Protein

• UniProt ID: Q9NPQ8
• Protein name: Chaperone Ric-8A (Synembryn-A)
• Protein function: Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (By similarity). Does not fold G(s) G-alpha proteins GNAS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10165	Ric8	66 → 506	Guanine nucleotide exchange factor synembryn	Family

• Sequence:

  MEPRAVAEAVETGEEDVIMEALRSYNQEHSQSFTFDDAQQEDRKRLAELLVSVLEQGLPP
  SHRVIWLQSVRILSRDRNCLDPFTSRQSLQALACYADISVSEGSVPESADMDVVLESLKC
  LCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQ
  QLFQELKGVRLLTDTLELTLGVTPEGNPPPTLLPSQETERAMEILKVLFNITLDSIKGEV
  DEEDAALYRHLGTLLRHCVMIATAGDRTEEFHGHAVNLLGNLPLKCLDVLLTLEPHGDST
  EFMGVNMDVIRALLIFLEKRLHKTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPL
  RDVRTRPEVGEMLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLL
  AARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEA
  MKLVTMFDKLSRNRVIQPMGMSPRGHLTSLQDAMCETMEQQLSSDPDSDPD

• Sequence length: 531