Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
60559
Gene name Gene Name - the full gene name approved by the HGNC.
Signal peptidase complex subunit 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SPCS3
Synonyms (NCBI Gene) Gene synonyms aliases
PRO3567, SPC22, SPC22/23, SPC23, SPC3, YLR066W
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q34.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001589 hsa-let-7b-5p pSILAC 18668040
MIRT024756 hsa-miR-215-5p Microarray 19074876
MIRT026732 hsa-miR-192-5p Microarray 19074876
MIRT028607 hsa-miR-30a-5p Proteomics 18668040
MIRT031839 hsa-miR-16-5p Proteomics 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25959826, 28514442, 32814053, 33961781, 34388369
GO:0005783 Component Endoplasmic reticulum IDA
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005787 Component Signal peptidase complex IBA
GO:0005787 Component Signal peptidase complex IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
618854 26212 ENSG00000129128
Protein
UniProt ID P61009
Protein name Signal peptidase complex subunit 3 (Microsomal signal peptidase 22/23 kDa subunit) (SPC22/23) (SPase 22/23 kDa subunit)
Protein function Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:27499293, PubMed:34388369).
PDB 7P2P , 7P2Q
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04573 SPC22 4 173 Signal peptidase subunit Family
Sequence
Sequence length 180
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Protein export   Synthesis, secretion, and deacylation of Ghrelin
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Astrocytoma Pilocytic astrocytoma N/A N/A GWAS
Intracranial Aneurysm Intracranial aneurysm N/A N/A GWAS
Tremor Essential tremor N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Bipolar Disorder Associate 31695175
Cardiomyopathy Restrictive Associate 24480542
Dwarfism Pituitary Associate 24480542
Schizophrenia Associate 31695175