Gene Gene information from NCBI Gene database.
Entrez ID 60559
Gene name Signal peptidase complex subunit 3
Gene symbol SPCS3
Synonyms (NCBI Gene)
PRO3567SPC22SPC22/23SPC23SPC3YLR066W
Chromosome 4
Chromosome location 4q34.2
miRNA miRNA information provided by mirtarbase database.
991
miRTarBase ID miRNA Experiments Reference
MIRT001589 hsa-let-7b-5p pSILAC 18668040
MIRT024756 hsa-miR-215-5p Microarray 19074876
MIRT026732 hsa-miR-192-5p Microarray 19074876
MIRT028607 hsa-miR-30a-5p Proteomics 18668040
MIRT031839 hsa-miR-16-5p Proteomics 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25959826, 28514442, 32814053, 33961781, 34388369
GO:0005783 Component Endoplasmic reticulum IDA
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005787 Component Signal peptidase complex IBA
GO:0005787 Component Signal peptidase complex IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618854 26212 ENSG00000129128
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61009
Protein name Signal peptidase complex subunit 3 (Microsomal signal peptidase 22/23 kDa subunit) (SPC22/23) (SPase 22/23 kDa subunit)
Protein function Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:27499293, PubMed:34388369).
PDB 7P2P , 7P2Q
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04573 SPC22 4 173 Signal peptidase subunit Family
Sequence
Sequence length 180
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Protein export   Synthesis, secretion, and deacylation of Ghrelin