Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6051
Gene name Gene Name - the full gene name approved by the HGNC.	Arginyl aminopeptidase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RNPEP
Synonyms (NCBI Gene) Gene synonyms aliases	AP-B, APB
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q32.1

Show/Hide all(118)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045299	hsa-miR-186-5p	CLASH	23622248
MIRT1314340	hsa-miR-1184	CLIP-seq
MIRT1314341	hsa-miR-1254	CLIP-seq
MIRT1314342	hsa-miR-153	CLIP-seq
MIRT1314343	hsa-miR-185	CLIP-seq
MIRT1314344	hsa-miR-1910	CLIP-seq
MIRT1314345	hsa-miR-3116	CLIP-seq
MIRT1314346	hsa-miR-3137	CLIP-seq
MIRT1314347	hsa-miR-3163	CLIP-seq
MIRT1314348	hsa-miR-3175	CLIP-seq
MIRT1314349	hsa-miR-3183	CLIP-seq
MIRT1314350	hsa-miR-3909	CLIP-seq
MIRT1314351	hsa-miR-4254	CLIP-seq
MIRT1314352	hsa-miR-4306	CLIP-seq
MIRT1314353	hsa-miR-4311	CLIP-seq
MIRT1314354	hsa-miR-4436b-5p	CLIP-seq
MIRT1314355	hsa-miR-448	CLIP-seq
MIRT1314356	hsa-miR-451b	CLIP-seq
MIRT1314357	hsa-miR-455-3p	CLIP-seq
MIRT1314358	hsa-miR-4644	CLIP-seq
MIRT1314359	hsa-miR-4668-3p	CLIP-seq
MIRT1314360	hsa-miR-4706	CLIP-seq
MIRT1314361	hsa-miR-4711-5p	CLIP-seq
MIRT1314362	hsa-miR-4723-3p	CLIP-seq
MIRT1314363	hsa-miR-4749-5p	CLIP-seq
MIRT1314364	hsa-miR-4766-5p	CLIP-seq
MIRT1314365	hsa-miR-4778-3p	CLIP-seq
MIRT1314366	hsa-miR-4778-5p	CLIP-seq
MIRT1314367	hsa-miR-4781-5p	CLIP-seq
MIRT1314368	hsa-miR-545	CLIP-seq
MIRT1314369	hsa-miR-944	CLIP-seq
MIRT2093513	hsa-miR-2117	CLIP-seq
MIRT2093514	hsa-miR-24	CLIP-seq
MIRT2093515	hsa-miR-3120-5p	CLIP-seq
MIRT1314346	hsa-miR-3137	CLIP-seq
MIRT1314348	hsa-miR-3175	CLIP-seq
MIRT2093516	hsa-miR-3976	CLIP-seq
MIRT2093517	hsa-miR-4265	CLIP-seq
MIRT2093518	hsa-miR-4283	CLIP-seq
MIRT2093519	hsa-miR-4296	CLIP-seq
MIRT2093520	hsa-miR-4322	CLIP-seq
MIRT2093521	hsa-miR-4417	CLIP-seq
MIRT2093522	hsa-miR-4437	CLIP-seq
MIRT2093523	hsa-miR-4508	CLIP-seq
MIRT1314360	hsa-miR-4706	CLIP-seq
MIRT2093524	hsa-miR-4736	CLIP-seq
MIRT1314363	hsa-miR-4749-5p	CLIP-seq
MIRT1314367	hsa-miR-4781-5p	CLIP-seq
MIRT2093525	hsa-miR-657	CLIP-seq
MIRT2318061	hsa-miR-1202	CLIP-seq
MIRT2318062	hsa-miR-129-3p	CLIP-seq
MIRT1314342	hsa-miR-153	CLIP-seq
MIRT2318063	hsa-miR-3121-5p	CLIP-seq
MIRT1314347	hsa-miR-3163	CLIP-seq
MIRT2318064	hsa-miR-3184	CLIP-seq
MIRT2318065	hsa-miR-3194-5p	CLIP-seq
MIRT2318066	hsa-miR-383	CLIP-seq
MIRT2318067	hsa-miR-3972	CLIP-seq
MIRT2318068	hsa-miR-423-5p	CLIP-seq
MIRT2318069	hsa-miR-4270	CLIP-seq
MIRT2318070	hsa-miR-4441	CLIP-seq
MIRT1314355	hsa-miR-448	CLIP-seq
MIRT1314359	hsa-miR-4668-3p	CLIP-seq
MIRT1314361	hsa-miR-4711-5p	CLIP-seq
MIRT2318071	hsa-miR-4772-5p	CLIP-seq
MIRT2318072	hsa-miR-508-5p	CLIP-seq
MIRT2318073	hsa-miR-665	CLIP-seq
MIRT2613793	hsa-miR-1200	CLIP-seq
MIRT1314341	hsa-miR-1254	CLIP-seq
MIRT2613794	hsa-miR-1292	CLIP-seq
MIRT1314345	hsa-miR-3116	CLIP-seq
MIRT2613795	hsa-miR-3122	CLIP-seq
MIRT2613796	hsa-miR-3123	CLIP-seq
MIRT2318064	hsa-miR-3184	CLIP-seq
MIRT2318066	hsa-miR-383	CLIP-seq
MIRT2613797	hsa-miR-3913-5p	CLIP-seq
MIRT2613798	hsa-miR-3925-5p	CLIP-seq
MIRT2318068	hsa-miR-423-5p	CLIP-seq
MIRT1314351	hsa-miR-4254	CLIP-seq
MIRT2318069	hsa-miR-4270	CLIP-seq
MIRT2613799	hsa-miR-4324	CLIP-seq
MIRT2318070	hsa-miR-4441	CLIP-seq
MIRT2613800	hsa-miR-4471	CLIP-seq
MIRT1314364	hsa-miR-4766-5p	CLIP-seq
MIRT2318071	hsa-miR-4772-5p	CLIP-seq
MIRT1314366	hsa-miR-4778-5p	CLIP-seq
MIRT2613801	hsa-miR-495	CLIP-seq
MIRT2318072	hsa-miR-508-5p	CLIP-seq
MIRT2613802	hsa-miR-544b	CLIP-seq
MIRT2318073	hsa-miR-665	CLIP-seq
MIRT1314369	hsa-miR-944	CLIP-seq
MIRT2613793	hsa-miR-1200	CLIP-seq
MIRT1314341	hsa-miR-1254	CLIP-seq
MIRT2613794	hsa-miR-1292	CLIP-seq
MIRT1314343	hsa-miR-185	CLIP-seq
MIRT1314345	hsa-miR-3116	CLIP-seq
MIRT2613795	hsa-miR-3122	CLIP-seq
MIRT2613796	hsa-miR-3123	CLIP-seq
MIRT2318064	hsa-miR-3184	CLIP-seq
MIRT2318066	hsa-miR-383	CLIP-seq
MIRT2613797	hsa-miR-3913-5p	CLIP-seq
MIRT2613798	hsa-miR-3925-5p	CLIP-seq
MIRT2318068	hsa-miR-423-5p	CLIP-seq
MIRT1314351	hsa-miR-4254	CLIP-seq
MIRT2318069	hsa-miR-4270	CLIP-seq
MIRT1314352	hsa-miR-4306	CLIP-seq
MIRT2613799	hsa-miR-4324	CLIP-seq
MIRT2318070	hsa-miR-4441	CLIP-seq
MIRT2613800	hsa-miR-4471	CLIP-seq
MIRT1314358	hsa-miR-4644	CLIP-seq
MIRT1314364	hsa-miR-4766-5p	CLIP-seq
MIRT2318071	hsa-miR-4772-5p	CLIP-seq
MIRT1314366	hsa-miR-4778-5p	CLIP-seq
MIRT2613801	hsa-miR-495	CLIP-seq
MIRT2318072	hsa-miR-508-5p	CLIP-seq
MIRT2613802	hsa-miR-544b	CLIP-seq
MIRT2318073	hsa-miR-665	CLIP-seq
MIRT1314369	hsa-miR-944	CLIP-seq

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004177	Function	Aminopeptidase activity	IEA
GO:0004177	Function	Aminopeptidase activity	ISS	9405297
GO:0004177	Function	Aminopeptidase activity	NAS	12119107
GO:0004301	Function	Epoxide hydrolase activity	NAS	12119107
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	ISS	9405297
GO:0005576	Component	Extracellular region	TAS	10467730
GO:0005615	Component	Extracellular space	IBA
GO:0005886	Component	Plasma membrane	ISS	9405297
GO:0005886	Component	Plasma membrane	TAS	10467730
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IC	12119107
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008235	Function	Metalloexopeptidase activity	NAS	12119107
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008270	Function	Zinc ion binding	NAS	12119107
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070006	Function	Metalloaminopeptidase activity	IBA
GO:0070006	Function	Metalloaminopeptidase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145

MIM	HGNC	e!Ensembl
602675	10078	ENSG00000176393

Protein

UniProt ID

Q9H4A4

Protein name

Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase)

Protein function

Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17900	Peptidase_M1_N	37 → 230		Domain
PF01433	Peptidase_M1	261 → 482	Peptidase family M1 domain	Domain
PF09127	Leuk-A4-hydro_C	530 → 645	Leukotriene A4 hydrolase, C-terminal	Family

Sequence

MASGEHSPGSGAARRPLHSAQAVDVASASNFRAFELLHLHLDLRAEFGPPGPGAGSRGLS
GTAVLDLRCLEPEGAAELRLDSHPCLEVTAAALRRERPGSEEPPAEPVSFYTQPFSHYGQ
ALCVSFPQPCRAAERLQVLLTYRVGEGPGVCWLAPEQTAGKKKPFVYTQGQAVLNRAFFP
CFDTPAVKYKYSALIEVPDGFTAVMSASTWEKRGPNKFFFQMCQPIPSYLIALAIGDLVS
AEVGPRSRVWAEPCLIDAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGM
ENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRIST
ILFGAAYTCLEAATGRALLRQHMDITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCF
VSYLAHLVGDQDQFDSFLKAYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFD
RWLNTPGWPPYLPDLSPGDSLMKPAEELAQLWAAEELDMKAIEAVAISPWKTYQLVYFLD
KILQKSPLPPGNVKKLGDTYPSISNARNAELRLRWGQIVLKNDHQEDFWKVKEFLHNQGK
QKYTLPLYHAMMGGSEVAQTLAKETFASTASQLHSNVVNYVQQIVAPKGS

Sequence length

650

Interactions

View interactions

RNPEP (arginyl aminopeptidase)