Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	60490
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphopantothenoylcysteine decarboxylase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PPCDC
Synonyms (NCBI Gene) Gene synonyms aliases	MDS018, PPC-DC, coaC
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q24.2
Summary Summary of gene provided in NCBI Entrez Gene.	Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopante

Show/Hide all(121)

miRTarBase ID	miRNA	Experiments
MIRT1252246	hsa-miR-1256	CLIP-seq
MIRT1252247	hsa-miR-1976	CLIP-seq
MIRT1252248	hsa-miR-224	CLIP-seq
MIRT1252249	hsa-miR-2682	CLIP-seq
MIRT1252250	hsa-miR-3120-5p	CLIP-seq
MIRT1252251	hsa-miR-3128	CLIP-seq
MIRT1252252	hsa-miR-3132	CLIP-seq
MIRT1252253	hsa-miR-3146	CLIP-seq
MIRT1252254	hsa-miR-320a	CLIP-seq
MIRT1252255	hsa-miR-320b	CLIP-seq
MIRT1252256	hsa-miR-320c	CLIP-seq
MIRT1252257	hsa-miR-320d	CLIP-seq
MIRT1252258	hsa-miR-320e	CLIP-seq
MIRT1252259	hsa-miR-326	CLIP-seq
MIRT1252260	hsa-miR-330-5p	CLIP-seq
MIRT1252261	hsa-miR-4252	CLIP-seq
MIRT1252262	hsa-miR-4429	CLIP-seq
MIRT1252263	hsa-miR-4487	CLIP-seq
MIRT1252264	hsa-miR-4496	CLIP-seq
MIRT1252265	hsa-miR-449c	CLIP-seq
MIRT1252266	hsa-miR-4675	CLIP-seq
MIRT1252267	hsa-miR-4688	CLIP-seq
MIRT1252268	hsa-miR-4720-5p	CLIP-seq
MIRT1252269	hsa-miR-4741	CLIP-seq
MIRT1252270	hsa-miR-4757-5p	CLIP-seq
MIRT1252271	hsa-miR-4761-3p	CLIP-seq
MIRT1252272	hsa-miR-4799-3p	CLIP-seq
MIRT1252273	hsa-miR-563	CLIP-seq
MIRT1252274	hsa-miR-626	CLIP-seq
MIRT1252275	hsa-miR-628-3p	CLIP-seq
MIRT1252276	hsa-miR-885-3p	CLIP-seq
MIRT1252277	hsa-miR-940	CLIP-seq
MIRT2074305	hsa-miR-3622b-5p	CLIP-seq
MIRT2301281	hsa-miR-1184	CLIP-seq
MIRT2301282	hsa-miR-1285	CLIP-seq
MIRT2301283	hsa-miR-153	CLIP-seq
MIRT2301284	hsa-miR-3187-5p	CLIP-seq
MIRT2301285	hsa-miR-3614-5p	CLIP-seq
MIRT2301286	hsa-miR-448	CLIP-seq
MIRT2301287	hsa-miR-4662a-3p	CLIP-seq
MIRT2301288	hsa-miR-4691-3p	CLIP-seq
MIRT2301289	hsa-miR-4764-5p	CLIP-seq
MIRT2301290	hsa-miR-505	CLIP-seq
MIRT2301291	hsa-miR-592	CLIP-seq
MIRT2301292	hsa-miR-597	CLIP-seq
MIRT2301293	hsa-miR-612	CLIP-seq
MIRT2301294	hsa-miR-668	CLIP-seq
MIRT2301282	hsa-miR-1285	CLIP-seq
MIRT2597980	hsa-miR-145	CLIP-seq
MIRT2597981	hsa-miR-150	CLIP-seq
MIRT2597982	hsa-miR-2278	CLIP-seq
MIRT2597983	hsa-miR-24	CLIP-seq
MIRT2597984	hsa-miR-2861	CLIP-seq
MIRT2597985	hsa-miR-3155	CLIP-seq
MIRT2597986	hsa-miR-3155b	CLIP-seq
MIRT2597987	hsa-miR-3157-5p	CLIP-seq
MIRT2301284	hsa-miR-3187-5p	CLIP-seq
MIRT2597988	hsa-miR-331-3p	CLIP-seq
MIRT2597989	hsa-miR-361-3p	CLIP-seq
MIRT2597990	hsa-miR-3661	CLIP-seq
MIRT2597991	hsa-miR-3925-3p	CLIP-seq
MIRT2597992	hsa-miR-4254	CLIP-seq
MIRT2597993	hsa-miR-4267	CLIP-seq
MIRT2597994	hsa-miR-4291	CLIP-seq
MIRT2597995	hsa-miR-4292	CLIP-seq
MIRT2597996	hsa-miR-4297	CLIP-seq
MIRT2597997	hsa-miR-4650-5p	CLIP-seq
MIRT2597998	hsa-miR-4690-5p	CLIP-seq
MIRT2301288	hsa-miR-4691-3p	CLIP-seq
MIRT2597999	hsa-miR-4694-5p	CLIP-seq
MIRT2598000	hsa-miR-4738-3p	CLIP-seq
MIRT2598001	hsa-miR-4786-5p	CLIP-seq
MIRT2598002	hsa-miR-484	CLIP-seq
MIRT2598003	hsa-miR-490-3p	CLIP-seq
MIRT2598004	hsa-miR-545	CLIP-seq
MIRT2301293	hsa-miR-612	CLIP-seq
MIRT2598005	hsa-miR-619	CLIP-seq
MIRT2598006	hsa-miR-631	CLIP-seq
MIRT2598007	hsa-miR-649	CLIP-seq
MIRT2598008	hsa-miR-766	CLIP-seq
MIRT2598009	hsa-miR-769-5p	CLIP-seq
MIRT2688417	hsa-miR-1228	CLIP-seq
MIRT2301282	hsa-miR-1285	CLIP-seq
MIRT2597980	hsa-miR-145	CLIP-seq
MIRT2688418	hsa-miR-148a	CLIP-seq
MIRT2688419	hsa-miR-148b	CLIP-seq
MIRT2597981	hsa-miR-150	CLIP-seq
MIRT2688420	hsa-miR-152	CLIP-seq
MIRT2597982	hsa-miR-2278	CLIP-seq
MIRT2688421	hsa-miR-2355-5p	CLIP-seq
MIRT2597983	hsa-miR-24	CLIP-seq
MIRT2597984	hsa-miR-2861	CLIP-seq
MIRT2597985	hsa-miR-3155	CLIP-seq
MIRT2597986	hsa-miR-3155b	CLIP-seq
MIRT2597987	hsa-miR-3157-5p	CLIP-seq
MIRT2301284	hsa-miR-3187-5p	CLIP-seq
MIRT2597988	hsa-miR-331-3p	CLIP-seq
MIRT2597989	hsa-miR-361-3p	CLIP-seq
MIRT2597990	hsa-miR-3661	CLIP-seq
MIRT2597991	hsa-miR-3925-3p	CLIP-seq
MIRT2597992	hsa-miR-4254	CLIP-seq
MIRT2597993	hsa-miR-4267	CLIP-seq
MIRT2597994	hsa-miR-4291	CLIP-seq
MIRT2597995	hsa-miR-4292	CLIP-seq
MIRT2597996	hsa-miR-4297	CLIP-seq
MIRT2688422	hsa-miR-4330	CLIP-seq
MIRT2597997	hsa-miR-4650-5p	CLIP-seq
MIRT2597998	hsa-miR-4690-5p	CLIP-seq
MIRT2301288	hsa-miR-4691-3p	CLIP-seq
MIRT2688423	hsa-miR-4717-3p	CLIP-seq
MIRT2598000	hsa-miR-4738-3p	CLIP-seq
MIRT2598001	hsa-miR-4786-5p	CLIP-seq
MIRT2598002	hsa-miR-484	CLIP-seq
MIRT2598003	hsa-miR-490-3p	CLIP-seq
MIRT2598004	hsa-miR-545	CLIP-seq
MIRT2301293	hsa-miR-612	CLIP-seq
MIRT2598005	hsa-miR-619	CLIP-seq
MIRT2598006	hsa-miR-631	CLIP-seq
MIRT2598007	hsa-miR-649	CLIP-seq
MIRT2598008	hsa-miR-766	CLIP-seq
MIRT2598009	hsa-miR-769-5p	CLIP-seq

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004633	Function	Phosphopantothenoylcysteine decarboxylase activity	EXP	15581364
GO:0004633	Function	Phosphopantothenoylcysteine decarboxylase activity	IBA
GO:0004633	Function	Phosphopantothenoylcysteine decarboxylase activity	IDA	11923312, 15581364
GO:0004633	Function	Phosphopantothenoylcysteine decarboxylase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0010181	Function	FMN binding	IBA
GO:0010181	Function	FMN binding	IDA	14501115
GO:0015937	Process	Coenzyme A biosynthetic process	IBA
GO:0015937	Process	Coenzyme A biosynthetic process	IDA	11923312
GO:0015937	Process	Coenzyme A biosynthetic process	IEA
GO:0015937	Process	Coenzyme A biosynthetic process	TAS
GO:0016829	Function	Lyase activity	IEA
GO:0016831	Function	Carboxy-lyase activity	IEA
GO:0042802	Function	Identical protein binding	IDA	14501115
GO:0042802	Function	Identical protein binding	IPI	25416956, 26514574, 32296183
GO:0071513	Component	Phosphopantothenoylcysteine decarboxylase complex	IBA

MIM	HGNC	e!Ensembl
609854	28107	ENSG00000138621

Protein

UniProt ID

Q96CD2

Protein name

Phosphopantothenoylcysteine decarboxylase (PPC-DC) (EC 4.1.1.36) (CoaC)

Protein function

Catalyzes the decarboxylation of the cysteine moiety of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine and this reaction forms part of the biosynthesis of coenzyme A.

PDB

1QZU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02441	Flavoprotein	18 → 195	Flavoprotein	Family

Sequence

MEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGLEVAVVTTERAKHFY
SPQDIPVTLYSDADEWEIWKSRSDPVLHIDLRRWADLLLVAPLDANTLGKVASGICDNLL
TCVMRAWDRSKPLLFCPAMNTAMWEHPITAQQVDQLKAFGYVEIPCVAKKLVCGDEGLGA
MAEVGTIVDKVKEVLFQHSGFQQS

Sequence length

204

Interactions

View interactions

	KEGG		Reactome
	Pantothenate and CoA biosynthesis Metabolic pathways Biosynthesis of cofactors		Coenzyme A biosynthesis

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Eczema	Eczema	N/A	N/A	GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Amenorrhea	Associate	31371054
Arthritis Rheumatoid	Associate	29482039

PPCDC (phosphopantothenoylcysteine decarboxylase)