TRMT11 (tRNA methyltransferase 11)

Gene

• Entrez ID: 60487
• Gene name: TRNA methyltransferase 11
• Gene symbol: TRMT11
• Synonyms (NCBI Gene): C6orf75, MDS024, TRM11, TRMT11-1
• Chromosome: 6
• Chromosome location: 6q22.32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029017	hsa-miR-26b-5p	Microarray	19088304
MIRT2136868	hsa-miR-23a	CLIP-seq
MIRT2136869	hsa-miR-23b	CLIP-seq
MIRT2136870	hsa-miR-23c	CLIP-seq
MIRT2357652	hsa-miR-3674	CLIP-seq
MIRT2357653	hsa-miR-410	CLIP-seq
MIRT2357654	hsa-miR-4699-3p	CLIP-seq
MIRT2651326	hsa-miR-153	CLIP-seq
MIRT2651327	hsa-miR-302f	CLIP-seq
MIRT2651328	hsa-miR-3065-5p	CLIP-seq
MIRT2651329	hsa-miR-338-3p	CLIP-seq
MIRT2651330	hsa-miR-3646	CLIP-seq
MIRT2651331	hsa-miR-369-3p	CLIP-seq
MIRT2651332	hsa-miR-374a	CLIP-seq
MIRT2651333	hsa-miR-374b	CLIP-seq
MIRT2651334	hsa-miR-4307	CLIP-seq
MIRT2651335	hsa-miR-448	CLIP-seq
MIRT2651336	hsa-miR-4530	CLIP-seq
MIRT2651337	hsa-miR-505	CLIP-seq
MIRT2651338	hsa-miR-548aa	CLIP-seq
MIRT2651339	hsa-miR-548ac	CLIP-seq
MIRT2651340	hsa-miR-548d-3p	CLIP-seq
MIRT2651341	hsa-miR-548n	CLIP-seq
MIRT2651342	hsa-miR-548t	CLIP-seq
MIRT2651343	hsa-miR-548z	CLIP-seq
MIRT2651344	hsa-miR-549	CLIP-seq
MIRT2651345	hsa-miR-606	CLIP-seq
MIRT2651346	hsa-miR-922	CLIP-seq
MIRT2651326	hsa-miR-153	CLIP-seq
MIRT2651327	hsa-miR-302f	CLIP-seq
MIRT2651329	hsa-miR-338-3p	CLIP-seq
MIRT2651330	hsa-miR-3646	CLIP-seq
MIRT2651331	hsa-miR-369-3p	CLIP-seq
MIRT2651332	hsa-miR-374a	CLIP-seq
MIRT2651333	hsa-miR-374b	CLIP-seq
MIRT2651335	hsa-miR-448	CLIP-seq
MIRT2651336	hsa-miR-4530	CLIP-seq
MIRT2651338	hsa-miR-548aa	CLIP-seq
MIRT2651339	hsa-miR-548ac	CLIP-seq
MIRT2651340	hsa-miR-548d-3p	CLIP-seq
MIRT2651343	hsa-miR-548z	CLIP-seq
MIRT2651344	hsa-miR-549	CLIP-seq
MIRT2651345	hsa-miR-606	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 33961781, 34948388
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	34948388
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0006396	Process	RNA processing	IEA
GO:0008033	Process	TRNA processing	IEA
GO:0008168	Function	Methyltransferase activity	IBA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032259	Process	Methylation	IEA
GO:0043528	Component	TRNA (m2G10) methyltransferase complex	IDA	37283053
GO:0160102	Function	TRNA (guanine(10)-N2)-methyltransferase activity	IDA	37283053
GO:0160102	Function	TRNA (guanine(10)-N2)-methyltransferase activity	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q7Z4G4
• Protein name: tRNA (guanine(10)-N(2))-methyltransferase TRMT11 (EC 2.1.1.214) (tRNA methyltransferase 11 homolog)
• Protein function: Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs (PubMed:37283053). This is one of the maj
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01170	UPF0020	189 → 326	Putative RNA methylase family UPF0020	Domain

• Sequence:

  MALSCTLNRYLLLMAQEHLEFRLPEIKSLLLLFGGQFASSQETYGKSPFWILSIPSEDIA
  RNLMKRTVCAKSIFELWGHGQSPEELYSSLKNYPVEKMVPFLHSDSTYKIKIHTFNKTLT
  QEEKIKRIDALEFLPFEGKVNLKKPQHVFSVLEDYGLDPNCIPENPHNIYFGRWIADGQR
  ELIESYSVKKRHFIGNTSMDAGLSFIMANHGKVKENDIVFDPFVGTGGLLIACAHFGAYV
  YGTDIDYNTVHGLGKATRKNQKWRGPDENIRANLRQYGLEKYYLDVLVSDASKPSWRKGT
  YFDAIITDPPYGIRESTRRTGSQKEIPKGIEKWEKCPESHVPVSLSYHLSDMFLDLLNFA
  AETLVLGGRLVYWLPVYTPEYTEEMVPWHPCLELVSNCEQKLSSHTSRRLITMEKVKKFE
  NRDQYSHLLSDHFLPYQGHNSFREKYFSGVTKRIAKEEKSTQE

• Sequence length: 463