Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6046
Gene name	Bromodomain containing 2
Gene symbol	BRD2
Synonyms (NCBI Gene)	BRD2-IT1D6S113EFSHFSHRG1FSRG1NATO27.1.1RING3RNF3
Chromosome	6
Chromosome location	6p21.32
Summary	This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds

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miRTarBase ID	miRNA	Experiments	Reference
MIRT052027	hsa-let-7b-5p	CLASH	23622248
MIRT051807	hsa-let-7c-5p	CLASH	23622248
MIRT049226	hsa-miR-92a-3p	CLASH	23622248
MIRT049226	hsa-miR-92a-3p	CLASH	23622248
MIRT047023	hsa-miR-204-5p	CLASH	23622248
MIRT042162	hsa-miR-484	CLASH	23622248
MIRT041086	hsa-miR-504-5p	CLASH	23622248
MIRT039679	hsa-miR-615-3p	CLASH	23622248
MIRT039679	hsa-miR-615-3p	CLASH	23622248
MIRT039079	hsa-miR-769-3p	CLASH	23622248
MIRT038361	hsa-miR-296-3p	CLASH	23622248
MIRT038361	hsa-miR-296-3p	CLASH	23622248
MIRT038361	hsa-miR-296-3p	CLASH	23622248
MIRT037955	hsa-miR-505-5p	CLASH	23622248
MIRT037308	hsa-miR-877-5p	CLASH	23622248
MIRT036599	hsa-miR-940	CLASH	23622248
MIRT036359	hsa-miR-1229-3p	CLASH	23622248
MIRT755309	hsa-miR-143-3p	PAR-CLIP	26701625
MIRT755309	hsa-miR-143-3p	PAR-CLIP	26701625
MIRT755309	hsa-miR-143-3p	PAR-CLIP	26701625
MIRT755309	hsa-miR-143-3p	PAR-CLIP	26701625
MIRT755309	hsa-miR-143-3p	Western blottingqRT-PCR	38463605
MIRT824185	hsa-miR-1224-3p	CLIP-seq
MIRT824186	hsa-miR-1260	CLIP-seq
MIRT824187	hsa-miR-1260b	CLIP-seq
MIRT824188	hsa-miR-1280	CLIP-seq
MIRT824189	hsa-miR-143	CLIP-seq
MIRT824190	hsa-miR-1539	CLIP-seq
MIRT824191	hsa-miR-1913	CLIP-seq
MIRT824192	hsa-miR-3074-5p	CLIP-seq
MIRT824193	hsa-miR-3126-3p	CLIP-seq
MIRT824194	hsa-miR-3127-5p	CLIP-seq
MIRT824195	hsa-miR-3158-3p	CLIP-seq
MIRT824196	hsa-miR-3176	CLIP-seq
MIRT824197	hsa-miR-3189-5p	CLIP-seq
MIRT824198	hsa-miR-3193	CLIP-seq
MIRT824199	hsa-miR-323-5p	CLIP-seq
MIRT824200	hsa-miR-324-3p	CLIP-seq
MIRT824201	hsa-miR-361-3p	CLIP-seq
MIRT824202	hsa-miR-3614-3p	CLIP-seq
MIRT824203	hsa-miR-3667-3p	CLIP-seq
MIRT824204	hsa-miR-3918	CLIP-seq
MIRT824205	hsa-miR-3922-3p	CLIP-seq
MIRT824206	hsa-miR-4297	CLIP-seq
MIRT824207	hsa-miR-4699-3p	CLIP-seq
MIRT824208	hsa-miR-4722-3p	CLIP-seq
MIRT824209	hsa-miR-4757-5p	CLIP-seq
MIRT824210	hsa-miR-4758-3p	CLIP-seq
MIRT824211	hsa-miR-4764-3p	CLIP-seq
MIRT824212	hsa-miR-4772-5p	CLIP-seq
MIRT824213	hsa-miR-507	CLIP-seq
MIRT824214	hsa-miR-508-5p	CLIP-seq
MIRT824215	hsa-miR-532-3p	CLIP-seq
MIRT824216	hsa-miR-557	CLIP-seq
MIRT824217	hsa-miR-601	CLIP-seq
MIRT824218	hsa-miR-615-5p	CLIP-seq
MIRT824219	hsa-miR-658	CLIP-seq
MIRT824220	hsa-miR-663b	CLIP-seq
MIRT824221	hsa-miR-939	CLIP-seq
MIRT824222	hsa-miR-1248	CLIP-seq
MIRT824223	hsa-miR-1276	CLIP-seq
MIRT824189	hsa-miR-143	CLIP-seq
MIRT824224	hsa-miR-1470	CLIP-seq
MIRT824225	hsa-miR-3127-3p	CLIP-seq
MIRT824226	hsa-miR-3184	CLIP-seq
MIRT824227	hsa-miR-3612	CLIP-seq
MIRT824201	hsa-miR-361-3p	CLIP-seq
MIRT824228	hsa-miR-3929	CLIP-seq
MIRT824229	hsa-miR-423-5p	CLIP-seq
MIRT824230	hsa-miR-4419b	CLIP-seq
MIRT824231	hsa-miR-4443	CLIP-seq
MIRT824232	hsa-miR-4478	CLIP-seq
MIRT824233	hsa-miR-4667-3p	CLIP-seq
MIRT824210	hsa-miR-4758-3p	CLIP-seq
MIRT824234	hsa-miR-4778-3p	CLIP-seq
MIRT824235	hsa-miR-4802-5p	CLIP-seq
MIRT824236	hsa-miR-485-5p	CLIP-seq
MIRT824237	hsa-miR-642a	CLIP-seq
MIRT824238	hsa-miR-650	CLIP-seq
MIRT824221	hsa-miR-939	CLIP-seq
MIRT824239	hsa-miR-1323	CLIP-seq
MIRT824189	hsa-miR-143	CLIP-seq
MIRT824240	hsa-miR-216a	CLIP-seq
MIRT824201	hsa-miR-361-3p	CLIP-seq
MIRT824241	hsa-miR-3657	CLIP-seq
MIRT824242	hsa-miR-3675-5p	CLIP-seq
MIRT824243	hsa-miR-371-5p	CLIP-seq
MIRT824244	hsa-miR-371b-5p	CLIP-seq
MIRT824204	hsa-miR-3918	CLIP-seq
MIRT824245	hsa-miR-409-3p	CLIP-seq
MIRT824246	hsa-miR-4283	CLIP-seq
MIRT824247	hsa-miR-4489	CLIP-seq
MIRT824248	hsa-miR-4492	CLIP-seq
MIRT824249	hsa-miR-4498	CLIP-seq
MIRT824250	hsa-miR-4505	CLIP-seq
MIRT824251	hsa-miR-4646-5p	CLIP-seq
MIRT824252	hsa-miR-4669	CLIP-seq
MIRT824209	hsa-miR-4757-5p	CLIP-seq
MIRT824211	hsa-miR-4764-3p	CLIP-seq
MIRT824253	hsa-miR-483-3p	CLIP-seq
MIRT824214	hsa-miR-508-5p	CLIP-seq
MIRT824254	hsa-miR-548o	CLIP-seq
MIRT824220	hsa-miR-663b	CLIP-seq
MIRT824255	hsa-miR-762	CLIP-seq
MIRT824256	hsa-miR-938	CLIP-seq
MIRT824221	hsa-miR-939	CLIP-seq
MIRT824209	hsa-miR-4757-5p	CLIP-seq
MIRT824220	hsa-miR-663b	CLIP-seq
MIRT1556039	hsa-miR-486-3p	CLIP-seq
MIRT824224	hsa-miR-1470	CLIP-seq
MIRT824191	hsa-miR-1913	CLIP-seq
MIRT824197	hsa-miR-3189-5p	CLIP-seq
MIRT824200	hsa-miR-324-3p	CLIP-seq
MIRT824204	hsa-miR-3918	CLIP-seq
MIRT1943652	hsa-miR-4286	CLIP-seq
MIRT1943653	hsa-miR-4418	CLIP-seq
MIRT824210	hsa-miR-4758-3p	CLIP-seq
MIRT1556039	hsa-miR-486-3p	CLIP-seq
MIRT1943654	hsa-miR-509-3-5p	CLIP-seq
MIRT1943655	hsa-miR-509-5p	CLIP-seq
MIRT824217	hsa-miR-601	CLIP-seq
MIRT824204	hsa-miR-3918	CLIP-seq
MIRT2182308	hsa-miR-1207-5p	CLIP-seq
MIRT2182309	hsa-miR-1273f	CLIP-seq
MIRT824239	hsa-miR-1323	CLIP-seq
MIRT824189	hsa-miR-143	CLIP-seq
MIRT824224	hsa-miR-1470	CLIP-seq
MIRT824190	hsa-miR-1539	CLIP-seq
MIRT2182310	hsa-miR-1908	CLIP-seq
MIRT824191	hsa-miR-1913	CLIP-seq
MIRT2182311	hsa-miR-1915	CLIP-seq
MIRT824240	hsa-miR-216a	CLIP-seq
MIRT2182312	hsa-miR-296-5p	CLIP-seq
MIRT824192	hsa-miR-3074-5p	CLIP-seq
MIRT2182313	hsa-miR-3120-3p	CLIP-seq
MIRT824193	hsa-miR-3126-3p	CLIP-seq
MIRT824194	hsa-miR-3127-5p	CLIP-seq
MIRT2182314	hsa-miR-3151	CLIP-seq
MIRT824195	hsa-miR-3158-3p	CLIP-seq
MIRT824196	hsa-miR-3176	CLIP-seq
MIRT2182315	hsa-miR-3179	CLIP-seq
MIRT2182316	hsa-miR-3180	CLIP-seq
MIRT2182317	hsa-miR-3180-3p	CLIP-seq
MIRT2182318	hsa-miR-3185	CLIP-seq
MIRT824197	hsa-miR-3189-5p	CLIP-seq
MIRT824198	hsa-miR-3193	CLIP-seq
MIRT2182319	hsa-miR-3196	CLIP-seq
MIRT2182320	hsa-miR-3202	CLIP-seq
MIRT824200	hsa-miR-324-3p	CLIP-seq
MIRT2182321	hsa-miR-324-5p	CLIP-seq
MIRT824201	hsa-miR-361-3p	CLIP-seq
MIRT824202	hsa-miR-3614-3p	CLIP-seq
MIRT2182322	hsa-miR-3665	CLIP-seq
MIRT824203	hsa-miR-3667-3p	CLIP-seq
MIRT824242	hsa-miR-3675-5p	CLIP-seq
MIRT824243	hsa-miR-371-5p	CLIP-seq
MIRT824244	hsa-miR-371b-5p	CLIP-seq
MIRT824204	hsa-miR-3918	CLIP-seq
MIRT824205	hsa-miR-3922-3p	CLIP-seq
MIRT824245	hsa-miR-409-3p	CLIP-seq
MIRT2182323	hsa-miR-4267	CLIP-seq
MIRT2182324	hsa-miR-4271	CLIP-seq
MIRT824246	hsa-miR-4283	CLIP-seq
MIRT1943652	hsa-miR-4286	CLIP-seq
MIRT824206	hsa-miR-4297	CLIP-seq
MIRT1943653	hsa-miR-4418	CLIP-seq
MIRT2182325	hsa-miR-4436b-3p	CLIP-seq
MIRT2182326	hsa-miR-4488	CLIP-seq
MIRT824247	hsa-miR-4489	CLIP-seq
MIRT824248	hsa-miR-4492	CLIP-seq
MIRT824249	hsa-miR-4498	CLIP-seq
MIRT824250	hsa-miR-4505	CLIP-seq
MIRT824251	hsa-miR-4646-5p	CLIP-seq
MIRT824233	hsa-miR-4667-3p	CLIP-seq
MIRT2182327	hsa-miR-4688	CLIP-seq
MIRT2182328	hsa-miR-4694-3p	CLIP-seq
MIRT2182329	hsa-miR-4697-5p	CLIP-seq
MIRT824207	hsa-miR-4699-3p	CLIP-seq
MIRT2182330	hsa-miR-4708-5p	CLIP-seq
MIRT2182331	hsa-miR-4716-3p	CLIP-seq
MIRT2182332	hsa-miR-4716-5p	CLIP-seq
MIRT824208	hsa-miR-4722-3p	CLIP-seq
MIRT2182333	hsa-miR-4725-3p	CLIP-seq
MIRT2182334	hsa-miR-4736	CLIP-seq
MIRT2182335	hsa-miR-4747-5p	CLIP-seq
MIRT824209	hsa-miR-4757-5p	CLIP-seq
MIRT824210	hsa-miR-4758-3p	CLIP-seq
MIRT2182336	hsa-miR-4761-3p	CLIP-seq
MIRT2182337	hsa-miR-4763-3p	CLIP-seq
MIRT824211	hsa-miR-4764-3p	CLIP-seq
MIRT824212	hsa-miR-4772-5p	CLIP-seq
MIRT824253	hsa-miR-483-3p	CLIP-seq
MIRT1556039	hsa-miR-486-3p	CLIP-seq
MIRT824213	hsa-miR-507	CLIP-seq
MIRT824214	hsa-miR-508-5p	CLIP-seq
MIRT1943654	hsa-miR-509-3-5p	CLIP-seq
MIRT1943655	hsa-miR-509-5p	CLIP-seq
MIRT2182338	hsa-miR-545	CLIP-seq
MIRT824254	hsa-miR-548o	CLIP-seq
MIRT824216	hsa-miR-557	CLIP-seq
MIRT2182339	hsa-miR-597	CLIP-seq
MIRT2182340	hsa-miR-625	CLIP-seq
MIRT824219	hsa-miR-658	CLIP-seq
MIRT2182341	hsa-miR-663	CLIP-seq
MIRT824220	hsa-miR-663b	CLIP-seq
MIRT824255	hsa-miR-762	CLIP-seq
MIRT824256	hsa-miR-938	CLIP-seq
MIRT824221	hsa-miR-939	CLIP-seq
MIRT824224	hsa-miR-1470	CLIP-seq
MIRT2384872	hsa-miR-2052	CLIP-seq
MIRT2384873	hsa-miR-2355-3p	CLIP-seq
MIRT824245	hsa-miR-409-3p	CLIP-seq
MIRT2384874	hsa-miR-4646-3p	CLIP-seq
MIRT2182332	hsa-miR-4716-5p	CLIP-seq
MIRT1556039	hsa-miR-486-3p	CLIP-seq
MIRT824207	hsa-miR-4699-3p	CLIP-seq
MIRT824224	hsa-miR-1470	CLIP-seq
MIRT2384872	hsa-miR-2052	CLIP-seq
MIRT2384873	hsa-miR-2355-3p	CLIP-seq
MIRT2384874	hsa-miR-4646-3p	CLIP-seq
MIRT824233	hsa-miR-4667-3p	CLIP-seq
MIRT2182332	hsa-miR-4716-5p	CLIP-seq
MIRT2486011	hsa-miR-1252	CLIP-seq
MIRT824223	hsa-miR-1276	CLIP-seq
MIRT824224	hsa-miR-1470	CLIP-seq
MIRT2182311	hsa-miR-1915	CLIP-seq
MIRT2486012	hsa-miR-205	CLIP-seq
MIRT2384872	hsa-miR-2052	CLIP-seq
MIRT2384873	hsa-miR-2355-3p	CLIP-seq
MIRT2182312	hsa-miR-296-5p	CLIP-seq
MIRT2486013	hsa-miR-3148	CLIP-seq
MIRT824201	hsa-miR-361-3p	CLIP-seq
MIRT824241	hsa-miR-3657	CLIP-seq
MIRT824204	hsa-miR-3918	CLIP-seq
MIRT824246	hsa-miR-4283	CLIP-seq
MIRT2182326	hsa-miR-4488	CLIP-seq
MIRT2486014	hsa-miR-4533	CLIP-seq
MIRT2384874	hsa-miR-4646-3p	CLIP-seq
MIRT824233	hsa-miR-4667-3p	CLIP-seq
MIRT2486015	hsa-miR-4668-5p	CLIP-seq
MIRT824252	hsa-miR-4669	CLIP-seq
MIRT2182328	hsa-miR-4694-3p	CLIP-seq
MIRT2182329	hsa-miR-4697-5p	CLIP-seq
MIRT2182332	hsa-miR-4716-5p	CLIP-seq
MIRT2486016	hsa-miR-4790-3p	CLIP-seq
MIRT2486017	hsa-miR-4797-5p	CLIP-seq
MIRT2486018	hsa-miR-548c-3p	CLIP-seq
MIRT2486019	hsa-miR-570	CLIP-seq
MIRT2486020	hsa-miR-760	CLIP-seq
MIRT2486011	hsa-miR-1252	CLIP-seq
MIRT824223	hsa-miR-1276	CLIP-seq
MIRT824224	hsa-miR-1470	CLIP-seq
MIRT2182311	hsa-miR-1915	CLIP-seq
MIRT2486012	hsa-miR-205	CLIP-seq
MIRT2384872	hsa-miR-2052	CLIP-seq
MIRT2384873	hsa-miR-2355-3p	CLIP-seq
MIRT2182312	hsa-miR-296-5p	CLIP-seq
MIRT2486013	hsa-miR-3148	CLIP-seq
MIRT824201	hsa-miR-361-3p	CLIP-seq
MIRT824241	hsa-miR-3657	CLIP-seq
MIRT824204	hsa-miR-3918	CLIP-seq
MIRT824246	hsa-miR-4283	CLIP-seq
MIRT2182326	hsa-miR-4488	CLIP-seq
MIRT2486014	hsa-miR-4533	CLIP-seq
MIRT2384874	hsa-miR-4646-3p	CLIP-seq
MIRT824233	hsa-miR-4667-3p	CLIP-seq
MIRT2486015	hsa-miR-4668-5p	CLIP-seq
MIRT824252	hsa-miR-4669	CLIP-seq
MIRT2182328	hsa-miR-4694-3p	CLIP-seq
MIRT2182329	hsa-miR-4697-5p	CLIP-seq
MIRT2182332	hsa-miR-4716-5p	CLIP-seq
MIRT2486016	hsa-miR-4790-3p	CLIP-seq
MIRT2486017	hsa-miR-4797-5p	CLIP-seq
MIRT2486018	hsa-miR-548c-3p	CLIP-seq
MIRT2486019	hsa-miR-570	CLIP-seq
MIRT2486020	hsa-miR-760	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
BRD7	Activation	12600283

Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IBA
GO:0000785	Component	Chromatin	IDA	17848202, 20048151, 20709061
GO:0001843	Process	Neural tube closure	IEA
GO:0003682	Function	Chromatin binding	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	8595877
GO:0005515	Function	Protein binding	IPI	20709061, 24229708
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	8595877, 25593309
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006334	Process	Nucleosome assembly	IMP	18406326
GO:0006338	Process	Chromatin remodeling	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	18406326, 28262505
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0007259	Process	Cell surface receptor signaling pathway via JAK-STAT	IDA	8272873
GO:0007283	Process	Spermatogenesis	TAS	9693039
GO:0010468	Process	Regulation of gene expression	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0030674	Function	Protein-macromolecule adaptor activity	IEA
GO:0042393	Function	Histone binding	IBA
GO:0042393	Function	Histone binding	IEA
GO:0071168	Process	Protein localization to chromatin	IDA	28262505
GO:0071168	Process	Protein localization to chromatin	IEA
GO:0072540	Process	T-helper 17 cell lineage commitment	TAS	27893700
GO:0140011	Function	Histone H4K12ac reader activity	IDA	17848202, 18406326, 20048151, 20709061
GO:0140011	Function	Histone H4K12ac reader activity	IEA
GO:0140012	Function	Histone H4K5ac reader activity	IDA	18406326, 20709061
GO:0140015	Function	Histone H3K14ac reader activity	IDA	18406326
GO:0140033	Function	Acetylation-dependent protein binding	IDA	28262505
GO:0140033	Function	Acetylation-dependent protein binding	IEA
GO:0140588	Process	Chromatin looping	IDA	35410381
GO:0140588	Process	Chromatin looping	IEA
GO:2000330	Process	Positive regulation of T-helper 17 cell lineage commitment	IDA	28262505
GO:2000330	Process	Positive regulation of T-helper 17 cell lineage commitment	IEA

MIM	HGNC	e!Ensembl
601540	1103	ENSG00000204256

P25440

Protein name

Bromodomain-containing protein 2 (O27.1.1)

Protein function

Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17

PDB

1X0J , 2DVQ , 2DVR , 2DVS , 2DVV , 2E3K , 2G4A , 2YDW , 2YEK , 3AQA , 3ONI , 4A9E , 4A9F , 4A9H , 4A9I , 4A9J , 4A9M , 4A9N , 4A9O , 4AKN , 4ALG , 4ALH , 4J1P , 4MR5 , 4MR6 , 4QEU , 4QEV , 4QEW , 4UYF , 4UYG , 4UYH , 5BT5 , 5DFB , 5DFC , 5DFD , 5DW1 , 5EK9 , 5HEL , 5HEM , 5HEN , 5HFQ , 5IBN , 5IG6 , 5N2L , 5O38 , 5O39 , 5O3A , 5O3B , 5O3C , 5O3D , 5O3E

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00439	Bromodomain	83 → 168	Bromodomain	Domain
PF00439	Bromodomain	353 → 441	Bromodomain	Domain
PF17035	BET	641 → 705	Bromodomain extra-terminal - transcription regulation	Domain

Sequence

MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
SDSSSSSSSSSSSDTSDSDSG

Sequence length

801

Interactions

View interactions

	Reactome
			RUNX3 regulates p14-ARF

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs147965395	RCV005905340
Adrenocortical carcinoma, hereditary	Benign	rs147965395	RCV005905341
BRD2-related disorder	Benign; Uncertain significance; Likely benign	rs3097644, rs3918142, rs206781, rs516535, rs1063379, rs635688, rs571205164, rs375312758, rs3918143, rs115120098, rs144861747, rs186277039, rs176250, rs34530779, rs3752528, rs375791386, rs55778408, rs147965395 View all (3 more)	RCV003982879 RCV003974974 RCV003974536 RCV003967357 RCV003984676 RCV003982331 RCV003941928 RCV003944411 RCV003976577 RCV003915801 RCV003926092 RCV003905957 RCV003916243 RCV003930701 RCV003910736 RCV003920836 RCV003925796 RCV003933287
Cervical cancer	Benign	rs147965395	RCV005905342
Colon adenocarcinoma	Benign	rs147965395	RCV005905339
Gastric cancer	Benign	rs147965395	RCV005905343
Lung cancer	Benign	rs147965395	RCV005905347
Melanoma	Benign	rs147965395	RCV005905346
Ovarian serous cystadenocarcinoma	Benign	rs147965395	RCV005905344
Thymoma	Benign	rs147965395	RCV005905345
Uterine corpus endometrial carcinoma	Benign	rs147965395	RCV005905348

Show/Hide Text Mining Associations (48)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Abnormalities Drug Induced	Associate	21608014
Adrenocortical Carcinoma	Associate	36793283
Aphasia Broca	Associate	36818472
Arthritis Rheumatoid	Associate	27898717, 33717143
Azoospermia	Associate	32860660
Bipolar Disorder	Associate	33168801
Breast Neoplasms	Associate	15743503, 25001387, 30952871, 33099470
Carcinoma Ovarian Epithelial	Associate	31043489
Carcinoma Pancreatic Ductal	Associate	28096419
Colitis Ulcerative	Associate	28008999
Colorectal Neoplasms	Associate	15015580, 18990750
COVID 19	Associate	34176789, 35027731, 36818472
Diabetes Mellitus Type 2	Associate	26409796
Epilepsy	Associate	21608014
Epilepsy Idiopathic Generalized	Associate	12830434
Hematologic Neoplasms	Associate	24435449
HIV Infections	Associate	23255218
Infertility Male	Associate	32860660
Inflammation	Associate	31300040, 33717143
Inflammatory Bowel Diseases	Associate	28008999
Leiomyosarcoma	Stimulate	39273015
Leukemia	Associate	15796204, 25989842
Lymphoma Non Hodgkin	Associate	15725081
Lymphoma T Cell	Associate	32459053
Melanoma	Associate	26051178, 29149598
Multiple Sclerosis	Associate	36755464
Myoclonic Epilepsy Juvenile	Associate	12830434, 17437413, 29608786
Nasopharyngeal Carcinoma	Stimulate	31270100
Nasopharyngeal Carcinoma	Associate	31289279
Nasopharyngeal Neoplasms	Associate	31270100
Neoplasm Metastasis	Inhibit	34813359
Neoplasms	Stimulate	16158187
Neoplasms	Associate	25001387, 25804798, 26035625, 26080064, 28096419, 30952871, 36793283
Osteosarcoma	Associate	15015580
Ovarian Hyperstimulation Syndrome	Associate	29869218
Ovarian Neoplasms	Associate	33509905
Parkinson Disease	Associate	36813848
Precancerous Conditions	Associate	26617241, 26840026, 8396914
Primary Myelofibrosis	Associate	23872309
Prostatic Neoplasms	Associate	35361883
Pulmonary Arterial Hypertension	Associate	37516840
Sarcoidosis	Associate	37399103
Seizures	Associate	21608014
Seminoma	Associate	16158187
Squamous Cell Carcinoma of Head and Neck	Associate	34346116
Triple Negative Breast Neoplasms	Associate	38073442
Tyrosine Kinase 2 Deficiency	Associate	24435449
Urinary Bladder Neoplasms	Associate	10507782, 8396914

BRD2 (bromodomain containing 2)