TSKS (testis specific serine kinase substrate)

Gene
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
60385
Gene name Gene Name - the full gene name approved by the HGNC.
Testis specific serine kinase substrate
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TSKS
Synonyms (NCBI Gene) Gene synonyms aliases
PPP1R161, STK22S1, TSKS1, TSSKS
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.33
Summary Summary of gene provided in NCBI Entrez Gene.
This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3 among the related RAS vi
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all(9)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 15044604, 32296183
GO:0005737 Component Cytoplasm IEA
GO:0005814 Component Centriole IBA
GO:0005814 Component Centriole IDA 18495105
GO:0005814 Component Centriole IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
608253 30719 ENSG00000126467
Protein
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID Q9UJT2
Protein name Testis-specific serine kinase substrate (Testis-specific kinase substrate) (STK22 substrate 1)
Protein function May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15358 TSKS 26 → 592 Testis-specific serine kinase substrate Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in testis. Expressed at low levels in prostate, female breast, placenta, ovary and thymus. {ECO:0000269|PubMed:11444856, ECO:0000269|PubMed:15044604}.
Sequence
Sequence length 592
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Gout Gout N/A N/A GWAS
Panic Disorder Panic disorder N/A N/A GWAS