RNASE3 (ribonuclease A family member 3)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6037
Gene name Gene Name - the full gene name approved by the HGNC.
Ribonuclease A family member 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RNASE3
Synonyms (NCBI Gene) Gene synonyms aliases
ECP, RAF1, RNS3
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q11.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT2091582 hsa-miR-1909 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(21)
GO ID Ontology Definition Evidence Reference
GO:0001530 Function Lipopolysaccharide binding IDA 23992292
GO:0002227 Process Innate immune response in mucosa IBA 21873635
GO:0002227 Process Innate immune response in mucosa IDA 12860195
GO:0003676 Function Nucleic acid binding IEA
GO:0004519 Function Endonuclease activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
131398 10046 ENSG00000169397
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P12724
Protein name Eosinophil cationic protein (ECP) (EC 3.1.27.-) (Ribonuclease 3) (RNase 3)
Protein function Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also G
PDB 1DYT , 1H1H , 1QMT , 2KB5 , 2LVZ , 4A2O , 4A2Y , 4OWZ , 4OXB , 4OXF , 4X08
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00074 RnaseA 33 → 157 Pancreatic ribonuclease Domain
Sequence
Sequence length 160
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Asthma   Neutrophil degranulation
Antimicrobial peptides
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 12153692, 8874658, 12587966 ClinVar
Renal Carcinoma Renal Carcinoma GWAS
Show/Hide Text Mining Associations (53)
Associations from Text Mining
Disease Name Relationship Type References
Asthma Associate 10770817, 20534163, 29281699, 39871194
Asthma Stimulate 26600485, 33566255
Berylliosis Associate 34399367
Blister Stimulate 9602632
Bronchitis Stimulate 12814157
Carcinoma Renal Cell Associate 33456353
Churg Strauss Syndrome Associate 10456969, 17437420
Cognition Disorders Associate 20534163
Colitis Ulcerative Associate 23197886
Colitis Ulcerative Stimulate 32815414