Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6002
Gene name Gene Name - the full gene name approved by the HGNC.	Regulator of G protein signaling 12
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RGS12
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4p16.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the `regulator of G protein signaling` (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumo

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miRTarBase ID	miRNA	Experiments	Reference
MIRT045830	hsa-miR-138-5p	CLASH	23622248
MIRT045473	hsa-miR-149-5p	CLASH	23622248
MIRT716003	hsa-miR-4459	HITS-CLIP	19536157
MIRT716002	hsa-miR-665	HITS-CLIP	19536157
MIRT716001	hsa-miR-6840-3p	HITS-CLIP	19536157
MIRT716000	hsa-miR-1915-3p	HITS-CLIP	19536157
MIRT715999	hsa-miR-6764-5p	HITS-CLIP	19536157
MIRT715998	hsa-miR-4726-3p	HITS-CLIP	19536157
MIRT715997	hsa-miR-4532	HITS-CLIP	19536157
MIRT715996	hsa-miR-7704	HITS-CLIP	19536157
MIRT716003	hsa-miR-4459	HITS-CLIP	19536157
MIRT716002	hsa-miR-665	HITS-CLIP	19536157
MIRT716001	hsa-miR-6840-3p	HITS-CLIP	19536157
MIRT716000	hsa-miR-1915-3p	HITS-CLIP	19536157
MIRT715999	hsa-miR-6764-5p	HITS-CLIP	19536157
MIRT715998	hsa-miR-4726-3p	HITS-CLIP	19536157
MIRT715997	hsa-miR-4532	HITS-CLIP	19536157
MIRT715996	hsa-miR-7704	HITS-CLIP	19536157
MIRT1304102	hsa-miR-1197	CLIP-seq
MIRT1304103	hsa-miR-1266	CLIP-seq
MIRT1304104	hsa-miR-2467-3p	CLIP-seq
MIRT1304105	hsa-miR-3158-5p	CLIP-seq
MIRT1304106	hsa-miR-335	CLIP-seq
MIRT1304107	hsa-miR-3612	CLIP-seq
MIRT1304108	hsa-miR-365	CLIP-seq
MIRT1304109	hsa-miR-3664-3p	CLIP-seq
MIRT1304110	hsa-miR-3678-3p	CLIP-seq
MIRT1304111	hsa-miR-3680	CLIP-seq
MIRT1304112	hsa-miR-377	CLIP-seq
MIRT1304113	hsa-miR-4420	CLIP-seq
MIRT1304114	hsa-miR-4436a	CLIP-seq
MIRT1304115	hsa-miR-4443	CLIP-seq
MIRT1304116	hsa-miR-4518	CLIP-seq
MIRT1304117	hsa-miR-4651	CLIP-seq
MIRT1304118	hsa-miR-4696	CLIP-seq
MIRT1304119	hsa-miR-4733-3p	CLIP-seq
MIRT1304120	hsa-miR-4793-5p	CLIP-seq
MIRT1304121	hsa-miR-485-5p	CLIP-seq
MIRT1304122	hsa-miR-539	CLIP-seq
MIRT1304123	hsa-miR-580	CLIP-seq
MIRT1304124	hsa-miR-608	CLIP-seq
MIRT1304125	hsa-miR-650	CLIP-seq
MIRT1304126	hsa-miR-759	CLIP-seq
MIRT2314892	hsa-miR-3690	CLIP-seq
MIRT2314893	hsa-miR-4254	CLIP-seq
MIRT2314894	hsa-miR-4310	CLIP-seq
MIRT1304120	hsa-miR-4793-5p	CLIP-seq
MIRT2314895	hsa-miR-626	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000794	Component	Condensed nuclear chromosome	TAS	10869340
GO:0003924	Function	GTPase activity	TAS
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	TAS	9651375
GO:0009968	Process	Negative regulation of signal transduction	IEA
GO:0016363	Component	Nuclear matrix	IEA
GO:0030425	Component	Dendrite	ISS
GO:0030695	Function	GTPase regulator activity	IDA	9651375
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0045202	Component	Synapse	ISS

MIM	HGNC	e!Ensembl
602512	9994	ENSG00000159788

Protein

UniProt ID

O14924

Protein name

Regulator of G-protein signaling 12 (RGS12)

Protein function

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. ; FUNCTI

PDB

2EBZ , 2KV8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00595	PDZ	22 → 96	PDZ domain	Domain
PF00615	RGS	715 → 831	Regulator of G protein signaling domain	Domain
PF16613	RGS12_us1	836 → 953		Disordered
PF02196	RBD	963 → 1030	Raf-like Ras-binding domain	Domain
PF02196	RBD	1034 → 1102	Raf-like Ras-binding domain	Domain
PF16611	RGS12_us2	1106 → 1180		Disordered
PF02188	GoLoco	1188 → 1209	GoLoco motif	Motif
PF16612	RGS12_usC	1239 → 1376		Disordered

Tissue specificity

TISSUE SPECIFICITY: Isoform 3 is brain specific.

Sequence

MFRAGEASKRPLPGPSPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRA
GDQILAVNEINVKKASHEDVVKLIGKCSGVLHMVIAEGVGRFESCSSDEEGGLYEGKGWL
KPKLDSKALGINRAERVVEEMQSGGIFNMIFENPSLCASNSEPLKLKQRSLSESAATRFD
VGHESINNPNPNMLSKEEISKVIHDDSVFSIGLESHDDFALDASILNVAMIVGYLGSIEL
PSTSSNLESDSLQAIRGCMRRLRAEQKIHSLVTMKIMHDCVQLSTDKAGVVAEYPAEKLA
FSAVCPDDRRFFGLVTMQTNDDGSLAQEEEGALRTSCHVFMVDPDLFNHKIHQGIARRFG
FECTADPDTNGCLEFPASSLPVLQFISVLYRDMGELIEGMRARAFLDGDADAHQNNSTSS
NSDSGIGNFHQEEKSNRVLVVDLGGSSSRHGPGGSAWDGVGGRGAQPWGAPWTGPFCPDP
EGSPPFEAAHQTDRFWDLNKHLGPASPVEVPPASLRSSVPPSKRGTVGAGCGFNQRWLPV
HVLREWQCGHTSDQDSYTDSTDGWSSINCGTLPPPMSKIPADRYRVEGSFAQPPLNAPKR
EWSRKAFGMQSIFGPHRNVRKTKEDKKGSKFGRGTGLTQPSQRTSARRSFGRSKRFSITR
SLDDLESATVSDGELTGADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLL
QDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATT
PVNIDSQAQLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRA
LPDSQQVPSSPASKHSLGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSW
SRTRSTGRSQKKREHGDHADDALHANGGLCRRESQGSVSSAGSLDLSEACRTLAPEKDKA
TKHCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSS
ILESRDLRLEKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSG
EKEPLDLGAPISSLDGQRVVLEEKDPSRGKASADKQKGVPVKQNTAVNSSSRNHSATGEE
RTLGKSNSIKIKGENGKNARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSN
RADDQRGLLRKEDLVLPEFLRLPPGSTELTLPTPAAVAKGFSKRSATGNGRESASQPGEQ
WEPVQESSDSPSTSPGSASSPPGPPGTTPPGQKSPSGPFCTPQSPVSLAQEGTAQIWKRQ
SQEVEAGGIQTVEDEHVAELTLMGEGDISSPNSTLLPPPSTPQEVPGPSRPGSGTHGSRD
LPVNRIIDVDLVTGSAPGRDGGIAGAQAGPGRSQASGGPPTSDLPGLGPVPGEPAKPKTS
AHHATFV

Sequence length

1447

Interactions

View interactions

	Reactome
			G alpha (i) signalling events

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	21822266

Show/Hide Unknown Diseases (5)

Disease term	Disease name	References	Source
Unknown
Huntington disease	Huntington Disease	22387017	ClinVar
Myocardial infarction	Myocardial Infarction	21211798	ClinVar
Metabolic Syndrome	Metabolic Syndrome		GWAS
Dementia	Dementia		GWAS
Myocardial Infarction	Myocardial Infarction		GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining
Arthritis Rheumatoid	Associate	25848939
Bipolar Disorder	Associate	32066727, 39518985
Breast Neoplasms	Associate	28798985
Carcinoma Hepatocellular	Stimulate	35068348
Carcinoma Non Small Cell Lung	Associate	21698121
Colorectal Neoplasms	Associate	21209843
Fibrocystic Breast Disease	Associate	28798985
Heart Diseases	Associate	35748249
Schizophrenia	Associate	25420024
Stomach Neoplasms	Associate	34034702

RGS12 (regulator of G protein signaling 12)