Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5998
Gene name	Regulator of G protein signaling 3
Gene symbol	RGS3
Synonyms (NCBI Gene)	C2PARGP3
Chromosome	9
Chromosome location	9q32
Summary	This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multipl

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miRTarBase ID	miRNA	Experiments	Reference
MIRT000966	hsa-miR-126-3p	Luciferase reporter assay	18834857
MIRT000966	hsa-miR-126-3p	Reporter assay	21249429
MIRT021713	hsa-miR-133a-3p	Reporter assay	21249429
MIRT029621	hsa-miR-26b-5p	Microarray	19088304
MIRT000966	hsa-miR-126-3p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	27754994
MIRT000966	hsa-miR-126-3p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	27754994
MIRT1304351	hsa-miR-1237	CLIP-seq
MIRT1304352	hsa-miR-1248	CLIP-seq
MIRT1304353	hsa-miR-1256	CLIP-seq
MIRT1304354	hsa-miR-1267	CLIP-seq
MIRT1304355	hsa-miR-1294	CLIP-seq
MIRT1304356	hsa-miR-1302	CLIP-seq
MIRT1304357	hsa-miR-145	CLIP-seq
MIRT1304358	hsa-miR-15a	CLIP-seq
MIRT1304359	hsa-miR-15b	CLIP-seq
MIRT1304360	hsa-miR-16	CLIP-seq
MIRT1304361	hsa-miR-195	CLIP-seq
MIRT1304362	hsa-miR-2116	CLIP-seq
MIRT1304363	hsa-miR-2681	CLIP-seq
MIRT1304364	hsa-miR-2964a-5p	CLIP-seq
MIRT1304365	hsa-miR-3122	CLIP-seq
MIRT1304366	hsa-miR-3128	CLIP-seq
MIRT1304367	hsa-miR-3177-5p	CLIP-seq
MIRT1304368	hsa-miR-3182	CLIP-seq
MIRT1304369	hsa-miR-3183	CLIP-seq
MIRT1304370	hsa-miR-3199	CLIP-seq
MIRT1304371	hsa-miR-3909	CLIP-seq
MIRT1304372	hsa-miR-3913-3p	CLIP-seq
MIRT1304373	hsa-miR-3913-5p	CLIP-seq
MIRT1304374	hsa-miR-424	CLIP-seq
MIRT1304375	hsa-miR-4273	CLIP-seq
MIRT1304376	hsa-miR-4279	CLIP-seq
MIRT1304377	hsa-miR-4289	CLIP-seq
MIRT1304378	hsa-miR-4298	CLIP-seq
MIRT1304379	hsa-miR-4318	CLIP-seq
MIRT1304380	hsa-miR-4652-3p	CLIP-seq
MIRT1304381	hsa-miR-4677-5p	CLIP-seq
MIRT1304382	hsa-miR-4693-5p	CLIP-seq
MIRT1304383	hsa-miR-4710	CLIP-seq
MIRT1304384	hsa-miR-4720-5p	CLIP-seq
MIRT1304385	hsa-miR-4723-3p	CLIP-seq
MIRT1304386	hsa-miR-4799-3p	CLIP-seq
MIRT1304387	hsa-miR-489	CLIP-seq
MIRT1304388	hsa-miR-497	CLIP-seq
MIRT1304389	hsa-miR-544	CLIP-seq
MIRT1304390	hsa-miR-552	CLIP-seq
MIRT1304391	hsa-miR-635	CLIP-seq
MIRT1304392	hsa-miR-885-3p	CLIP-seq
MIRT1304393	hsa-miR-892a	CLIP-seq
MIRT1304394	hsa-miR-922	CLIP-seq
MIRT1304395	hsa-miR-1207-5p	CLIP-seq
MIRT1304396	hsa-miR-1827	CLIP-seq
MIRT1304397	hsa-miR-1909	CLIP-seq
MIRT1304398	hsa-miR-3144-5p	CLIP-seq
MIRT1304399	hsa-miR-3612	CLIP-seq
MIRT1304400	hsa-miR-3665	CLIP-seq
MIRT1304401	hsa-miR-4736	CLIP-seq
MIRT1304402	hsa-miR-4763-3p	CLIP-seq
MIRT1304403	hsa-miR-541	CLIP-seq
MIRT1304404	hsa-miR-650	CLIP-seq
MIRT1304405	hsa-miR-654-5p	CLIP-seq
MIRT1304406	hsa-miR-711	CLIP-seq
MIRT1304407	hsa-miR-940	CLIP-seq
MIRT2090200	hsa-miR-1913	CLIP-seq
MIRT2090201	hsa-miR-1976	CLIP-seq
MIRT2090202	hsa-miR-324-3p	CLIP-seq
MIRT2090203	hsa-miR-370	CLIP-seq
MIRT2090204	hsa-miR-4313	CLIP-seq
MIRT2090205	hsa-miR-501-3p	CLIP-seq
MIRT2090206	hsa-miR-502-3p	CLIP-seq
MIRT1304395	hsa-miR-1207-5p	CLIP-seq
MIRT2314928	hsa-miR-1321	CLIP-seq
MIRT1304396	hsa-miR-1827	CLIP-seq
MIRT1304399	hsa-miR-3612	CLIP-seq
MIRT1304400	hsa-miR-3665	CLIP-seq
MIRT2314929	hsa-miR-4270	CLIP-seq
MIRT2314930	hsa-miR-4441	CLIP-seq
MIRT1304401	hsa-miR-4736	CLIP-seq
MIRT2314931	hsa-miR-4739	CLIP-seq
MIRT2314932	hsa-miR-4756-5p	CLIP-seq
MIRT1304402	hsa-miR-4763-3p	CLIP-seq
MIRT1304403	hsa-miR-541	CLIP-seq
MIRT1304404	hsa-miR-650	CLIP-seq
MIRT1304405	hsa-miR-654-5p	CLIP-seq
MIRT1304407	hsa-miR-940	CLIP-seq
MIRT1304353	hsa-miR-1256	CLIP-seq
MIRT2611237	hsa-miR-127-5p	CLIP-seq
MIRT2611238	hsa-miR-150	CLIP-seq
MIRT2611239	hsa-miR-25	CLIP-seq
MIRT2611240	hsa-miR-3121-5p	CLIP-seq
MIRT2611241	hsa-miR-3135b	CLIP-seq
MIRT2611242	hsa-miR-32	CLIP-seq
MIRT2611243	hsa-miR-320e	CLIP-seq
MIRT2611244	hsa-miR-331-3p	CLIP-seq
MIRT2611245	hsa-miR-363	CLIP-seq
MIRT2611246	hsa-miR-367	CLIP-seq
MIRT2611247	hsa-miR-3910	CLIP-seq
MIRT2611248	hsa-miR-4325	CLIP-seq
MIRT2611249	hsa-miR-4434	CLIP-seq
MIRT2611250	hsa-miR-4516	CLIP-seq
MIRT2611251	hsa-miR-4531	CLIP-seq
MIRT2611252	hsa-miR-4713-5p	CLIP-seq
MIRT2611253	hsa-miR-4715-3p	CLIP-seq
MIRT2611254	hsa-miR-4790-3p	CLIP-seq
MIRT2611255	hsa-miR-532-3p	CLIP-seq
MIRT1304392	hsa-miR-885-3p	CLIP-seq
MIRT2611256	hsa-miR-92a	CLIP-seq
MIRT2611257	hsa-miR-92b	CLIP-seq
MIRT2611253	hsa-miR-4715-3p	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	TAS
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS	9858594
GO:0005515	Function	Protein binding	IPI	21044950, 25416956, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS	9858594
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	TAS	9858594
GO:0009968	Process	Negative regulation of signal transduction	IEA
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
602189	9999	ENSG00000138835

P49796

Protein name

Regulator of G-protein signaling 3 (RGP3) (RGS3)

Protein function

Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activa

PDB

2F5Y , 2OJ4 , 3FBK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00168	C2	150 → 258	C2 domain	Domain
PF00595	PDZ	299 → 373	PDZ domain	Domain
PF00615	RGS	1073 → 1188	Regulator of G protein signaling domain	Domain

Sequence

MPVIPALWEVEMGRSQGQEIETILANRSHSDSTPLPNFLSGSHRPECCTCRLLTASGAQD
SLPFGRRLYSGPWRSCEEVCHVSVLSVLSTSCGLSLSLPIFPGWMEWLSPDIALPRRDEW
TQTSPARKRITHAKVQGAGQLRLSIDAQDRVLLLHIIEGKGLISKQPGTCDPYVKISLIP
EDSRLRHQKTQTVPDCRDPAFHEHFFFPVQEEDDQKRLLVTVWNRASQSRQSGLIGCMSF
GVKSLLTPDKEISGWYYLLGEHLGRTKHLKVARRRLRPLRDPLLRMPGGGDTENGKKLKI
TIPRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHE
IRSCPSEIILLVWRMVPQVKPGPDGGVLRRASCKSTHDLQSPPNKREKNCTHGVQARPEQ
RHSCHLVCDSSDGLLLGGWERYTEVAKRGGQHTLPALSRATAPTDPNYIILAPLNPGSQL
LRPVYQEDTIPEESGSPSKGKSYTGLGKKSRLMKTVQTMKGHGNYQNCPVVRPHATHSSY
GTYVTLAPKVLVFPVFVQPLDLCNPARTLLLSEELLLYEGRNKAAEVTLFAYSDLLLFTK
EDEPGRCDVLRNPLYLQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKRVCWC
LSENIAKQQQLAASPPDSKMFETEADEKREMALEEGKGPGAEDSPPSKEPSPGQELPPGQ
DLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQ
DLPAGQEPLPHQDPLLTKDLPAIQESPTRDLPPCQDLPPSQVSLPAKALTEDTMSSGDLL
AATGDPPAAPRPAFVIPEVRLDSTYSQKAGAEQGCSGDEEDAEEAEEVEEGEEGEEDEDE
DTSDDNYGERSEAKRSSMIETGQGAEGGLSLRVQNSLRRRTHSEGSLLQEPRGPCFASDT
TLHCSDGEGAASTWGMPSPSTLKKELGRNGGSMHHLSLFFTGHRKMSGADTVGDDDEASR
KRKSKNLAKDMKNKLGIFRRRNESPGAPPAGKADKMMKSFKPTSEEALKWGESLEKLLVH
KYGLAVFQAFLRTEFSEENLEFWLACEDFKKVKSQSKMASKAKKIFAEYIAIQACKEVNL
DSYTREHTKDNLQSVTRGCFDLAQKRIFGLMEKDSYPRFLRSDLYLDLINQKKMSPPL

Sequence length

1198

Interactions

View interactions

	KEGG		Reactome
	Axon guidance		G alpha (q) signalling events G alpha (i) signalling events

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Uncertain significance	rs150045948	RCV005939169
Familial cancer of breast	Uncertain significance	rs147458690	RCV005926935

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	36936167
Carcinoma Hepatocellular	Associate	36214767
Genetic Diseases Inborn	Associate	36318984
Heart Diseases	Associate	30971721
Heart Failure	Associate	30971721
Mental Retardation X Linked Nonsyndromic	Associate	36318984
Myopathies Structural Congenital	Associate	30971721
Neoplasms	Associate	16948864
Ovarian Neoplasms	Associate	33845140
Sarcoma	Associate	16948864
Schizophrenia	Associate	36318984
Ventricular Remodeling	Associate	30971721

RGS3 (regulator of G protein signaling 3)