Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5998
Gene name Gene Name - the full gene name approved by the HGNC.
Regulator of G protein signaling 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RGS3
Synonyms (NCBI Gene) Gene synonyms aliases
C2PA, RGP3
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q32
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multipl
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000966 hsa-miR-126-3p Luciferase reporter assay 18834857
MIRT000966 hsa-miR-126-3p Reporter assay 21249429
MIRT021713 hsa-miR-133a-3p Reporter assay 21249429
MIRT029621 hsa-miR-26b-5p Microarray 19088304
MIRT000966 hsa-miR-126-3p Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 27754994
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000188 Process Inactivation of MAPK activity TAS 8602223
GO:0003924 Function GTPase activity TAS
GO:0005096 Function GTPase activator activity TAS 9858594
GO:0005515 Function Protein binding IPI 21044950, 25416956
GO:0005634 Component Nucleus IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602189 9999 ENSG00000138835
Protein
UniProt ID P49796
Protein name Regulator of G-protein signaling 3 (RGP3) (RGS3)
Protein function Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activa
PDB 2F5Y , 2OJ4 , 3FBK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00168 C2 150 258 C2 domain Domain
PF00595 PDZ 299 373 PDZ domain Domain
PF00615 RGS 1073 1188 Regulator of G protein signaling domain Domain
Sequence
MPVIPALWEVEMGRSQGQEIETILANRSHSDSTPLPNFLSGSHRPECCTCRLLTASGAQD
SLPFGRRLYSGPWRSCEEVCHVSVLSVLSTSCGLSLSLPIFPGWMEWLSPDIALPRRDEW
TQTSPARKRITHAKVQGAGQLRLSIDAQDRVLLLHIIEGKGLISKQPGTCDPYVKISLIP
EDSRLRHQKTQTVPDCRDPAFHEHFFFPVQEEDDQKRLLVTVWNRASQSRQSGLIGCMSF
GVKSLLTPDKEISGWYYL
LGEHLGRTKHLKVARRRLRPLRDPLLRMPGGGDTENGKKLKI
TIPRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHE
IRSCPSEIILLVW
RMVPQVKPGPDGGVLRRASCKSTHDLQSPPNKREKNCTHGVQARPEQ
RHSCHLVCDSSDGLLLGGWERYTEVAKRGGQHTLPALSRATAPTDPNYIILAPLNPGSQL
LRPVYQEDTIPEESGSPSKGKSYTGLGKKSRLMKTVQTMKGHGNYQNCPVVRPHATHSSY
GTYVTLAPKVLVFPVFVQPLDLCNPARTLLLSEELLLYEGRNKAAEVTLFAYSDLLLFTK
EDEPGRCDVLRNPLYLQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKRVCWC
LSENIAKQQQLAASPPDSKMFETEADEKREMALEEGKGPGAEDSPPSKEPSPGQELPPGQ
DLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQ
DLPAGQEPLPHQDPLLTKDLPAIQESPTRDLPPCQDLPPSQVSLPAKALTEDTMSSGDLL
AATGDPPAAPRPAFVIPEVRLDSTYSQKAGAEQGCSGDEEDAEEAEEVEEGEEGEEDEDE
DTSDDNYGERSEAKRSSMIETGQGAEGGLSLRVQNSLRRRTHSEGSLLQEPRGPCFASDT
TLHCSDGEGAASTWGMPSPSTLKKELGRNGGSMHHLSLFFTGHRKMSGADTVGDDDEASR
KRKSKNLAKDMKNKLGIFRRRNESPGAPPAGKADKMMKSFKPTSEEALKWGESLEKLLVH
KYGLAVFQAFLRTEFSEENLEFWLACEDFKKVKSQSKMASKAKKIFAEYIAIQACKEVNL
DSYTREHTKDNLQSVTRGCFDLAQKRIFGLMEKDSYPRFLRSDLYLDL
INQKKMSPPL
Sequence length 1198
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Axon guidance   G alpha (q) signalling events
G alpha (i) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Hypertrophic cardiomyopathy Hypertrophic Cardiomyopathy rs63750743, rs104894655, rs121908987, rs587776643, rs28938173, rs121908989, rs121908991, rs267606977, rs267606978, rs193922384, rs121909374, rs886041030, rs886041031, rs121909375, rs121909377
View all (752 more)
23255317
Unknown
Disease term Disease name Evidence References Source
Strabismus Strabismus GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 36936167
Carcinoma Hepatocellular Associate 36214767
Genetic Diseases Inborn Associate 36318984
Heart Diseases Associate 30971721
Heart Failure Associate 30971721
Mental Retardation X Linked Nonsyndromic Associate 36318984
Myopathies Structural Congenital Associate 30971721
Neoplasms Associate 16948864
Ovarian Neoplasms Associate 33845140
Sarcoma Associate 16948864