Gene Gene information from NCBI Gene database.
Entrez ID 5985
Gene name Replication factor C subunit 5
Gene symbol RFC5
Synonyms (NCBI Gene)
RFC36
Chromosome 12
Chromosome location 12q24.23
Summary This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell
miRNA miRNA information provided by mirtarbase database.
259
miRTarBase ID miRNA Experiments Reference
MIRT016278 hsa-miR-193b-3p Microarray 20304954
MIRT023584 hsa-miR-1-3p Proteomics 18668040
MIRT042743 hsa-miR-339-5p CLASH 23622248
MIRT573327 hsa-miR-6856-3p PAR-CLIP 20371350
MIRT573326 hsa-miR-4323 PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003677 Function DNA binding IEA
GO:0003689 Function DNA clamp loader activity IBA
GO:0003689 Function DNA clamp loader activity IDA 12930902
GO:0005515 Function Protein binding IPI 9488738, 16189514, 25416956, 28514442, 29892012, 30021884, 31515488, 32296183, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600407 9973 ENSG00000111445
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P40937
Protein name Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)
Protein function Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA.
PDB 6VVO , 7Z6H , 8UI7 , 8UI8 , 8UI9 , 8UII , 8UMT , 8UMU , 8UMV , 8UMW , 8UMY , 8UN0 , 8UNJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00004 AAA 56 177 ATPase family associated with various cellular activities (AAA) Domain
PF08542 Rep_fac_C 242 328 Replication factor C C-terminal domain Domain
Sequence
Sequence length 340
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  DNA replication
Base excision repair
Nucleotide excision repair
Mismatch repair
  Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Polymerase switching on the C-strand of the telomere
Activation of ATR in response to replication stress
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Activity through Phosphorylation
Polymerase switching
G2/M DNA damage checkpoint
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
DYSLEXIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OBESITY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Acute erythroleukemia Associate 35544695
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Hereditary Nonpolyposis Associate 31297992
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 2 Associate 31797865
★☆☆☆☆
Found in Text Mining only
DNA Virus Infections Associate 23112151
★☆☆☆☆
Found in Text Mining only
Esophageal Squamous Cell Carcinoma Associate 31845510
★☆☆☆☆
Found in Text Mining only
Fanconi Anemia Associate 34404366
★☆☆☆☆
Found in Text Mining only
Leukemia Myeloid Acute Associate 35544695
★☆☆☆☆
Found in Text Mining only
Neoplasm Metastasis Associate 37302025
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 37302025
★☆☆☆☆
Found in Text Mining only
Sarcoma Stimulate 35483337
★☆☆☆☆
Found in Text Mining only