Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5980
Gene name	REV3 like, DNA directed polymerase zeta catalytic subunit
Gene symbol	REV3L
Synonyms (NCBI Gene)	POLZREV3
Chromosome	6
Chromosome location	6q21
Summary	The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause o

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1057519367	T>A	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant

350

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019556	hsa-miR-340-5p	Sequencing	20371350
MIRT025031	hsa-miR-183-5p	Sequencing	20371350
MIRT028057	hsa-miR-93-5p	Sequencing	20371350
MIRT030718	hsa-miR-21-5p	Microarray	18591254
MIRT054928	hsa-miR-25-3p	Luciferase reporter assay	22349819
MIRT054929	hsa-miR-32-5p	Luciferase reporter assay	22349819
MIRT566049	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT054928	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT054929	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT566048	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT566047	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT566046	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT098316	hsa-miR-4282	PAR-CLIP	20371350
MIRT566045	hsa-miR-548av-5p	PAR-CLIP	20371350
MIRT566044	hsa-miR-548k	PAR-CLIP	20371350
MIRT566042	hsa-miR-8054	PAR-CLIP	20371350
MIRT566043	hsa-miR-548l	PAR-CLIP	20371350
MIRT566040	hsa-miR-4694-3p	PAR-CLIP	20371350
MIRT566041	hsa-miR-3163	PAR-CLIP	20371350
MIRT566039	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT566038	hsa-miR-4470	PAR-CLIP	20371350
MIRT566037	hsa-miR-124-5p	PAR-CLIP	20371350
MIRT566036	hsa-miR-2113	PAR-CLIP	20371350
MIRT566035	hsa-miR-5010-3p	PAR-CLIP	20371350
MIRT439783	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439783	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT726769	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT726768	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT726767	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT726766	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT726765	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT566046	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT566049	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT054929	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT566049	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT054928	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT054929	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT566048	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT566047	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT566046	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT098316	hsa-miR-4282	PAR-CLIP	20371350
MIRT566045	hsa-miR-548av-5p	PAR-CLIP	20371350
MIRT566044	hsa-miR-548k	PAR-CLIP	20371350
MIRT566042	hsa-miR-8054	PAR-CLIP	20371350
MIRT566043	hsa-miR-548l	PAR-CLIP	20371350
MIRT566040	hsa-miR-4694-3p	PAR-CLIP	20371350
MIRT566041	hsa-miR-3163	PAR-CLIP	20371350
MIRT566039	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT566038	hsa-miR-4470	PAR-CLIP	20371350
MIRT566037	hsa-miR-124-5p	PAR-CLIP	20371350
MIRT566036	hsa-miR-2113	PAR-CLIP	20371350
MIRT566035	hsa-miR-5010-3p	PAR-CLIP	20371350
MIRT1301135	hsa-miR-105	CLIP-seq
MIRT1301136	hsa-miR-106a	CLIP-seq
MIRT1301137	hsa-miR-106b	CLIP-seq
MIRT1301138	hsa-miR-1243	CLIP-seq
MIRT1301139	hsa-miR-1257	CLIP-seq
MIRT1301140	hsa-miR-1264	CLIP-seq
MIRT1301141	hsa-miR-1284	CLIP-seq
MIRT1301142	hsa-miR-1324	CLIP-seq
MIRT1301143	hsa-miR-142-5p	CLIP-seq
MIRT1301144	hsa-miR-145	CLIP-seq
MIRT1301145	hsa-miR-148a	CLIP-seq
MIRT1301146	hsa-miR-148b	CLIP-seq
MIRT1301147	hsa-miR-152	CLIP-seq
MIRT1301148	hsa-miR-17	CLIP-seq
MIRT1301149	hsa-miR-194	CLIP-seq
MIRT1301150	hsa-miR-20a	CLIP-seq
MIRT1301151	hsa-miR-20b	CLIP-seq
MIRT1301152	hsa-miR-25	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT1301156	hsa-miR-300	CLIP-seq
MIRT1301157	hsa-miR-30a	CLIP-seq
MIRT1301158	hsa-miR-30b	CLIP-seq
MIRT1301159	hsa-miR-30c	CLIP-seq
MIRT1301160	hsa-miR-30d	CLIP-seq
MIRT1301161	hsa-miR-30e	CLIP-seq
MIRT1301162	hsa-miR-3125	CLIP-seq
MIRT1301163	hsa-miR-3140-3p	CLIP-seq
MIRT1301164	hsa-miR-3180-5p	CLIP-seq
MIRT1301165	hsa-miR-3189-5p	CLIP-seq
MIRT1301166	hsa-miR-32	CLIP-seq
MIRT1301167	hsa-miR-3201	CLIP-seq
MIRT1301168	hsa-miR-340	CLIP-seq
MIRT1301169	hsa-miR-3609	CLIP-seq
MIRT1301170	hsa-miR-362-5p	CLIP-seq
MIRT1301171	hsa-miR-363	CLIP-seq
MIRT1301172	hsa-miR-3646	CLIP-seq
MIRT1301173	hsa-miR-3647-3p	CLIP-seq
MIRT1301174	hsa-miR-365	CLIP-seq
MIRT1301175	hsa-miR-3654	CLIP-seq
MIRT1301176	hsa-miR-3658	CLIP-seq
MIRT1301177	hsa-miR-3662	CLIP-seq
MIRT1301178	hsa-miR-3667-3p	CLIP-seq
MIRT1301179	hsa-miR-367	CLIP-seq
MIRT1301180	hsa-miR-376a	CLIP-seq
MIRT1301181	hsa-miR-376b	CLIP-seq
MIRT1301182	hsa-miR-381	CLIP-seq
MIRT1301183	hsa-miR-3916	CLIP-seq
MIRT1301184	hsa-miR-3942-3p	CLIP-seq
MIRT1301185	hsa-miR-4268	CLIP-seq
MIRT1301186	hsa-miR-4276	CLIP-seq
MIRT1301187	hsa-miR-4326	CLIP-seq
MIRT1301188	hsa-miR-4422	CLIP-seq
MIRT1301189	hsa-miR-4426	CLIP-seq
MIRT1301190	hsa-miR-4436b-5p	CLIP-seq
MIRT1301191	hsa-miR-4448	CLIP-seq
MIRT1301192	hsa-miR-4464	CLIP-seq
MIRT1301193	hsa-miR-450b-5p	CLIP-seq
MIRT1301194	hsa-miR-4528	CLIP-seq
MIRT1301195	hsa-miR-4646-5p	CLIP-seq
MIRT1301196	hsa-miR-4647	CLIP-seq
MIRT1301197	hsa-miR-4662b	CLIP-seq
MIRT1301198	hsa-miR-4666-3p	CLIP-seq
MIRT1301199	hsa-miR-4698	CLIP-seq
MIRT1301200	hsa-miR-4699-3p	CLIP-seq
MIRT1301201	hsa-miR-4719	CLIP-seq
MIRT1301202	hsa-miR-4747-5p	CLIP-seq
MIRT1301203	hsa-miR-4748	CLIP-seq
MIRT1301204	hsa-miR-4758-3p	CLIP-seq
MIRT1301205	hsa-miR-4790-3p	CLIP-seq
MIRT1301206	hsa-miR-4791	CLIP-seq
MIRT1301207	hsa-miR-4796-3p	CLIP-seq
MIRT1301208	hsa-miR-4796-5p	CLIP-seq
MIRT1301209	hsa-miR-495	CLIP-seq
MIRT1301210	hsa-miR-500b	CLIP-seq
MIRT1301211	hsa-miR-507	CLIP-seq
MIRT1301212	hsa-miR-511	CLIP-seq
MIRT1301213	hsa-miR-519d	CLIP-seq
MIRT1301214	hsa-miR-520d-5p	CLIP-seq
MIRT1301215	hsa-miR-524-5p	CLIP-seq
MIRT1301216	hsa-miR-548a-5p	CLIP-seq
MIRT1301217	hsa-miR-548ab	CLIP-seq
MIRT1301218	hsa-miR-548ah	CLIP-seq
MIRT1301219	hsa-miR-548ak	CLIP-seq
MIRT1301220	hsa-miR-548b-5p	CLIP-seq
MIRT1301221	hsa-miR-548c-5p	CLIP-seq
MIRT1301222	hsa-miR-548d-5p	CLIP-seq
MIRT1301223	hsa-miR-548h	CLIP-seq
MIRT1301224	hsa-miR-548i	CLIP-seq
MIRT1301225	hsa-miR-548j	CLIP-seq
MIRT1301226	hsa-miR-548w	CLIP-seq
MIRT1301227	hsa-miR-548y	CLIP-seq
MIRT1301228	hsa-miR-557	CLIP-seq
MIRT1301229	hsa-miR-559	CLIP-seq
MIRT1301230	hsa-miR-570	CLIP-seq
MIRT1301231	hsa-miR-579	CLIP-seq
MIRT1301232	hsa-miR-633	CLIP-seq
MIRT1301233	hsa-miR-767-5p	CLIP-seq
MIRT1301234	hsa-miR-802	CLIP-seq
MIRT1301235	hsa-miR-877	CLIP-seq
MIRT1301236	hsa-miR-888	CLIP-seq
MIRT1301237	hsa-miR-92a	CLIP-seq
MIRT1301238	hsa-miR-92b	CLIP-seq
MIRT1301239	hsa-miR-93	CLIP-seq
MIRT2089445	hsa-miR-101	CLIP-seq
MIRT1301136	hsa-miR-106a	CLIP-seq
MIRT1301137	hsa-miR-106b	CLIP-seq
MIRT1301139	hsa-miR-1257	CLIP-seq
MIRT1301143	hsa-miR-142-5p	CLIP-seq
MIRT2089446	hsa-miR-144	CLIP-seq
MIRT1301144	hsa-miR-145	CLIP-seq
MIRT1301148	hsa-miR-17	CLIP-seq
MIRT1301150	hsa-miR-20a	CLIP-seq
MIRT1301151	hsa-miR-20b	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT1301162	hsa-miR-3125	CLIP-seq
MIRT1301164	hsa-miR-3180-5p	CLIP-seq
MIRT1301167	hsa-miR-3201	CLIP-seq
MIRT1301168	hsa-miR-340	CLIP-seq
MIRT1301169	hsa-miR-3609	CLIP-seq
MIRT1301183	hsa-miR-3916	CLIP-seq
MIRT1301193	hsa-miR-450b-5p	CLIP-seq
MIRT1301199	hsa-miR-4698	CLIP-seq
MIRT1301205	hsa-miR-4790-3p	CLIP-seq
MIRT1301206	hsa-miR-4791	CLIP-seq
MIRT1301207	hsa-miR-4796-3p	CLIP-seq
MIRT1301211	hsa-miR-507	CLIP-seq
MIRT1301213	hsa-miR-519d	CLIP-seq
MIRT1301218	hsa-miR-548ah	CLIP-seq
MIRT2089447	hsa-miR-548p	CLIP-seq
MIRT1301228	hsa-miR-557	CLIP-seq
MIRT1301235	hsa-miR-877	CLIP-seq
MIRT1301239	hsa-miR-93	CLIP-seq
MIRT2089445	hsa-miR-101	CLIP-seq
MIRT1301135	hsa-miR-105	CLIP-seq
MIRT1301136	hsa-miR-106a	CLIP-seq
MIRT1301137	hsa-miR-106b	CLIP-seq
MIRT1301139	hsa-miR-1257	CLIP-seq
MIRT1301140	hsa-miR-1264	CLIP-seq
MIRT1301142	hsa-miR-1324	CLIP-seq
MIRT2314353	hsa-miR-140-5p	CLIP-seq
MIRT1301143	hsa-miR-142-5p	CLIP-seq
MIRT2089446	hsa-miR-144	CLIP-seq
MIRT1301148	hsa-miR-17	CLIP-seq
MIRT2314354	hsa-miR-200b	CLIP-seq
MIRT2314355	hsa-miR-200c	CLIP-seq
MIRT2314356	hsa-miR-2054	CLIP-seq
MIRT1301150	hsa-miR-20a	CLIP-seq
MIRT1301151	hsa-miR-20b	CLIP-seq
MIRT1301152	hsa-miR-25	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT1301157	hsa-miR-30a	CLIP-seq
MIRT1301158	hsa-miR-30b	CLIP-seq
MIRT1301159	hsa-miR-30c	CLIP-seq
MIRT1301160	hsa-miR-30d	CLIP-seq
MIRT1301161	hsa-miR-30e	CLIP-seq
MIRT1301162	hsa-miR-3125	CLIP-seq
MIRT2314357	hsa-miR-3145-3p	CLIP-seq
MIRT1301165	hsa-miR-3189-5p	CLIP-seq
MIRT1301166	hsa-miR-32	CLIP-seq
MIRT1301167	hsa-miR-3201	CLIP-seq
MIRT1301168	hsa-miR-340	CLIP-seq
MIRT2314358	hsa-miR-3545-5p	CLIP-seq
MIRT2314359	hsa-miR-3591-5p	CLIP-seq
MIRT1301169	hsa-miR-3609	CLIP-seq
MIRT1301170	hsa-miR-362-5p	CLIP-seq
MIRT1301171	hsa-miR-363	CLIP-seq
MIRT1301174	hsa-miR-365	CLIP-seq
MIRT1301178	hsa-miR-3667-3p	CLIP-seq
MIRT1301179	hsa-miR-367	CLIP-seq
MIRT2314360	hsa-miR-3689a-5p	CLIP-seq
MIRT2314361	hsa-miR-3689b	CLIP-seq
MIRT2314362	hsa-miR-3689e	CLIP-seq
MIRT2314363	hsa-miR-3689f	CLIP-seq
MIRT1301180	hsa-miR-376a	CLIP-seq
MIRT1301181	hsa-miR-376b	CLIP-seq
MIRT1301183	hsa-miR-3916	CLIP-seq
MIRT1301184	hsa-miR-3942-3p	CLIP-seq
MIRT1301185	hsa-miR-4268	CLIP-seq
MIRT2314364	hsa-miR-429	CLIP-seq
MIRT2314365	hsa-miR-4310	CLIP-seq
MIRT2314366	hsa-miR-4318	CLIP-seq
MIRT1301187	hsa-miR-4326	CLIP-seq
MIRT1301188	hsa-miR-4422	CLIP-seq
MIRT1301190	hsa-miR-4436b-5p	CLIP-seq
MIRT1301191	hsa-miR-4448	CLIP-seq
MIRT2314367	hsa-miR-4460	CLIP-seq
MIRT1301193	hsa-miR-450b-5p	CLIP-seq
MIRT2314368	hsa-miR-4517	CLIP-seq
MIRT2314369	hsa-miR-451b	CLIP-seq
MIRT1301194	hsa-miR-4528	CLIP-seq
MIRT1301195	hsa-miR-4646-5p	CLIP-seq
MIRT2314370	hsa-miR-466	CLIP-seq
MIRT2314371	hsa-miR-4679	CLIP-seq
MIRT2314372	hsa-miR-4693-5p	CLIP-seq
MIRT2314373	hsa-miR-4696	CLIP-seq
MIRT1301199	hsa-miR-4698	CLIP-seq
MIRT2314374	hsa-miR-4709-5p	CLIP-seq
MIRT2314375	hsa-miR-4727-3p	CLIP-seq
MIRT1301202	hsa-miR-4747-5p	CLIP-seq
MIRT1301204	hsa-miR-4758-3p	CLIP-seq
MIRT1301205	hsa-miR-4790-3p	CLIP-seq
MIRT1301206	hsa-miR-4791	CLIP-seq
MIRT1301207	hsa-miR-4796-3p	CLIP-seq
MIRT1301210	hsa-miR-500b	CLIP-seq
MIRT1301211	hsa-miR-507	CLIP-seq
MIRT1301213	hsa-miR-519d	CLIP-seq
MIRT1301216	hsa-miR-548a-5p	CLIP-seq
MIRT1301217	hsa-miR-548ab	CLIP-seq
MIRT1301218	hsa-miR-548ah	CLIP-seq
MIRT1301219	hsa-miR-548ak	CLIP-seq
MIRT1301220	hsa-miR-548b-5p	CLIP-seq
MIRT1301221	hsa-miR-548c-5p	CLIP-seq
MIRT1301222	hsa-miR-548d-5p	CLIP-seq
MIRT1301223	hsa-miR-548h	CLIP-seq
MIRT1301224	hsa-miR-548i	CLIP-seq
MIRT1301225	hsa-miR-548j	CLIP-seq
MIRT2089447	hsa-miR-548p	CLIP-seq
MIRT1301226	hsa-miR-548w	CLIP-seq
MIRT1301227	hsa-miR-548y	CLIP-seq
MIRT1301228	hsa-miR-557	CLIP-seq
MIRT1301229	hsa-miR-559	CLIP-seq
MIRT2314376	hsa-miR-584	CLIP-seq
MIRT2314377	hsa-miR-590-3p	CLIP-seq
MIRT2314378	hsa-miR-627	CLIP-seq
MIRT1301232	hsa-miR-633	CLIP-seq
MIRT1301233	hsa-miR-767-5p	CLIP-seq
MIRT1301234	hsa-miR-802	CLIP-seq
MIRT1301235	hsa-miR-877	CLIP-seq
MIRT2314379	hsa-miR-889	CLIP-seq
MIRT2314380	hsa-miR-892a	CLIP-seq
MIRT1301237	hsa-miR-92a	CLIP-seq
MIRT1301238	hsa-miR-92b	CLIP-seq
MIRT1301239	hsa-miR-93	CLIP-seq
MIRT1301142	hsa-miR-1324	CLIP-seq
MIRT1301174	hsa-miR-365	CLIP-seq
MIRT1301187	hsa-miR-4326	CLIP-seq
MIRT2089445	hsa-miR-101	CLIP-seq
MIRT2089446	hsa-miR-144	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT1301156	hsa-miR-300	CLIP-seq
MIRT1301182	hsa-miR-381	CLIP-seq
MIRT2432677	hsa-miR-3941	CLIP-seq
MIRT2432678	hsa-miR-452	CLIP-seq
MIRT2314370	hsa-miR-466	CLIP-seq
MIRT1301198	hsa-miR-4666-3p	CLIP-seq
MIRT2432679	hsa-miR-4672	CLIP-seq
MIRT2432680	hsa-miR-4676-3p	CLIP-seq
MIRT1301199	hsa-miR-4698	CLIP-seq
MIRT2432681	hsa-miR-4789-5p	CLIP-seq
MIRT1301211	hsa-miR-507	CLIP-seq
MIRT1301228	hsa-miR-557	CLIP-seq
MIRT2314353	hsa-miR-140-5p	CLIP-seq
MIRT2314354	hsa-miR-200b	CLIP-seq
MIRT2314355	hsa-miR-200c	CLIP-seq
MIRT2314356	hsa-miR-2054	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT2314357	hsa-miR-3145-3p	CLIP-seq
MIRT2314358	hsa-miR-3545-5p	CLIP-seq
MIRT2314359	hsa-miR-3591-5p	CLIP-seq
MIRT2314360	hsa-miR-3689a-5p	CLIP-seq
MIRT2314361	hsa-miR-3689b	CLIP-seq
MIRT2314362	hsa-miR-3689e	CLIP-seq
MIRT2314363	hsa-miR-3689f	CLIP-seq
MIRT2314364	hsa-miR-429	CLIP-seq
MIRT2314366	hsa-miR-4318	CLIP-seq
MIRT2314367	hsa-miR-4460	CLIP-seq
MIRT2314371	hsa-miR-4679	CLIP-seq
MIRT2314372	hsa-miR-4693-5p	CLIP-seq
MIRT2314374	hsa-miR-4709-5p	CLIP-seq
MIRT2314375	hsa-miR-4727-3p	CLIP-seq
MIRT1301233	hsa-miR-767-5p	CLIP-seq
MIRT2314380	hsa-miR-892a	CLIP-seq
MIRT2314354	hsa-miR-200b	CLIP-seq
MIRT2314355	hsa-miR-200c	CLIP-seq
MIRT2314356	hsa-miR-2054	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT2314359	hsa-miR-3591-5p	CLIP-seq
MIRT2314364	hsa-miR-429	CLIP-seq
MIRT2314366	hsa-miR-4318	CLIP-seq
MIRT2314367	hsa-miR-4460	CLIP-seq
MIRT2314371	hsa-miR-4679	CLIP-seq
MIRT2314372	hsa-miR-4693-5p	CLIP-seq
MIRT2314374	hsa-miR-4709-5p	CLIP-seq
MIRT2314375	hsa-miR-4727-3p	CLIP-seq
MIRT1301233	hsa-miR-767-5p	CLIP-seq
MIRT2314380	hsa-miR-892a	CLIP-seq

Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000724	Process	Double-strand break repair via homologous recombination	IBA
GO:0000731	Process	DNA synthesis involved in DNA repair	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003887	Function	DNA-directed DNA polymerase activity	IBA
GO:0003887	Function	DNA-directed DNA polymerase activity	IEA
GO:0003887	Function	DNA-directed DNA polymerase activity	TAS	9618506
GO:0005515	Function	Protein binding	IPI	22828282
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IEA
GO:0006260	Process	DNA replication	IEA
GO:0006261	Process	DNA-templated DNA replication	IEA
GO:0006261	Process	DNA-templated DNA replication	TAS	9618506
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016035	Component	Zeta DNA polymerase complex	IBA
GO:0016035	Component	Zeta DNA polymerase complex	IDA	20164194, 22465957
GO:0016035	Component	Zeta DNA polymerase complex	IEA
GO:0016035	Component	Zeta DNA polymerase complex	IPI	24449906
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0019985	Process	Translesion synthesis	IEA
GO:0031981	Component	Nuclear lumen	IEA
GO:0034061	Function	DNA polymerase activity	IEA
GO:0042276	Process	Error-prone translesion synthesis	IBA
GO:0042276	Process	Error-prone translesion synthesis	IDA	24449906
GO:0046872	Function	Metal ion binding	IEA
GO:0051536	Function	Iron-sulfur cluster binding	IEA
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IEA

MIM	HGNC	e!Ensembl
602776	9968	ENSG00000009413

O60673

Protein name

DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3)

Protein function

Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.

PDB

3ABD , 3ABE , 3VU7 , 4EXT , 4GK0 , 4GK5 , 5O8K , 6BC8 , 6BCD , 6BI7 , 6EKM , 6KEA , 6WS0 , 6WS5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03104	DNA_pol_B_exo1	43 → 203	DNA polymerase family B, exonuclease domain	Family
PF15735	DUF4683	746 → 1133	Domain of unknown function (DUF4683)	Family
PF03104	DNA_pol_B_exo1	2221 → 2484	DNA polymerase family B, exonuclease domain	Family
PF00136	DNA_pol_B	2549 → 3001	DNA polymerase family B	Family
PF14260	zf-C4pol	3042 → 3110	C4-type zinc-finger of DNA polymerase delta	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed.

Sequence

MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPY
LYVPYDGYGQQPESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKER
HFMKIYLYNPTMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAV
KFRKARRKSNTLHATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDA
VAADILNRLDIEAQIGGNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKK
FQKRLQEILKQNDFSVTLSGSVDYSDGSQEFSAELTLHSEVLSPEMLQCTPANMVEVHKD
KESSKGHTRHKVEEALINEEAILNLMENSQTFQPLTQRLSESPVFMDSSPDEALVHLLAG
LESDGYRGERNRMPSPCRSFGNNKYPQNSDDEENEPQIEKEEMELSLVMSQRWDSNIEEH
CAKKRSLCRNTHRSSTEDDDSSSGEEMEWSDNSLLLASLSIPQLDGTADENSDNPLNNEN
SRTHSSVIATSKLSVKPSIFHKDAATLEPSSSAKITFQCKHTSALSSHVLNKEDLIEDLS
QTNKNTEKGLDNSVTSFTNESTYSMKYPGSLSSTVHSENSHKENSKKEILPVSSCESSIF
DYEEDIPSVTRQVPSRKYTNIRKIEKDSPFIHMHRHPNENTLGKNSFNFSDLNHSKNKVS
SEGNEKGNSTALSSLFPSSFTENCELLSCSGENRTMVHSLNSTADESGLNKLKIRYEEFQ
EHKTEKPSLSQQAAHYMFFPSVVLSNCLTRPQKLSPVTYKLQPGNKPSRLKLNKRKLAGH
QETSTKSSETGSTKDNFIQNNPCNSNPEKDNALASDLTKTTRGAFENKTPTDGFIDCHFG
DGTLETEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTHNSKISLPHPMEIGESLDGTLK
SRKRRKMSKKLPPVIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKKLAPL
KDFWPKVPDSPATKYPIYPLTPKKSHRRKSKHKSAKKKTGKQQRTNNENIKRTLSFRKKR
SHAILSPPSPSYNAETEDCDLNYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEEIM
AAAEKEAMLFKGPNVYKKTVNSRIGKTSRARAQIKKSKAKLANPSIVTKKRNKRNQTNKL
VDDGKKKPRAKQKTNEKGTSRKHTTLKDEKIKSQSGAEVKFVLKHQNVSEFASSSGGSQL
LFKQKDMPLMGSAVDHPLSASLPTGINAQQKLSGCFSSFLESKKSVDLQTFPSSRDDLHP
SVVCNSIGPGVSKINVQRPHNQSAMFTLKESTLIQKNIFDLSNHLSQVAQNTQISSGMSS
KIEDNANNIQRNYLSSIGKLSEYRNSLESKLDQAYTPNFLHCKDSQQQIVCIAEQSKHSE
TCSPGNTASEESQMPNNCFVTSLRSPIKQIAWEQKQRGFILDMSNFKPERVKPRSLSEAI
SQTKALSQCKNRNVSTPSAFGEGQSGLAVLKELLQKRQQKAQNANTTQDPLSNKHQPNKN
ISGSLEHNKANKRTRSVTSPRKPRTPRSTKQKEKIPKLLKVDSLNLQNSSQLDNSVSDDS
PIFFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSFYSGSQFVPADQNLPQKFLSD
AVQDLFPGQAIEKNEFLSHDNQKCDEDKHHTTDSASWIRSGTLSPEIFEKSTIDSNENRR
HNQWKNSFHPLTTRSNSIMDSFCVQQAEDCLSEKSRLNRSSVSKEVFLSLPQPNNSDWIQ
GHTRKEMGQSLDSANTSFTAILSSPDGELVDVACEDLELYVSRNNDMLTPTPDSSPRSTS
SPSQSKNGSFTPRTANILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPR
EIGGRLLMVETRLANDLAEFEGDFSLEGLRLWKTAFSAMTQNPRPGSPLRSGQGVVNKGS
SNSPKMVEDKKIVIMPCKCAPSRQLVQVWLQAKEEYERSKKLPKTKPTGVVKSAENFSSS
VNPDDKPVVPPKMDVSPCILPTTAHTKEDVDNSQIALQAPTTGCSQTASESQMLPPVASA
SDPEKDEDDDDNYYISYSSPDSPVIPPWQQPISPDSKALNGDDRPSSPVEELPSLAFENF
LKPIKDGIQKSPCSEPQEPLVISPINTRARTGKCESLCFHSTPIIQRKLLERLPEAPGLS
PLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGFKV
SIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTEKT
ELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDPDI
LLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINIVG
RITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHY
VSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVT
PSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVENL
GKYDEFKFGCTSLRVPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMV
KQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETL
ERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKF
EKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFET
RDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRR
SEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFSL
IGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCDDLTQHGICSKCRSQ
PQHVAVILNQEIRELERQQEQLVKICKNCTGCFDRHIPCVSLNCPVLFKLSRVNRELSKA
PYLRQLLDQF

Sequence length

3130

Interactions

View interactions

	KEGG		Reactome
	Platinum drug resistance Fanconi anemia pathway		Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Carcinoma of colon	Likely pathogenic	rs1057519367	RCV000416681

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs2534914851	RCV004557915
Gastric cancer	Benign	rs3218595	RCV005910102
Ovarian serous cystadenocarcinoma	Benign	rs3218595	RCV005910103
REV3L-related disorder	Benign; Likely benign	rs3204954, rs3204953, rs3218606, rs461646, rs458486, rs3218587, rs777224158, rs369318693, rs455732, rs3218600, rs201233180, rs3218590, rs17539651, rs458017, rs56365810 View all (30 more)	RCV003980849 RCV003975920 RCV003929797 RCV003974413 RCV003974698 RCV003974123 RCV003981403 RCV003964560 RCV003984649 RCV003916765 RCV003967295 RCV003981207 RCV003917121 RCV003919452 RCV003941429 RCV003941493 RCV003924584 RCV003956969 RCV003957123 RCV003921951 RCV003924266 RCV003932208 RCV003974777 RCV003981957 RCV003971438 RCV003972272 RCV003935796 RCV003935918 RCV003913246 RCV003925887 RCV003906085 RCV003940370 RCV003910514 RCV003920534 RCV003967986 RCV003948374 RCV003932870 RCV004758086 RCV003958109 RCV003913130 RCV003923277 RCV003978076 RCV003928514 RCV003916071 RCV003906094
Thymoma	Benign	rs458017, rs3218595	RCV005938571 RCV005910104
Thyroid cancer, nonmedullary, 1	Benign	rs3218595	RCV005910105
Uterine carcinosarcoma	Benign	rs458017	RCV005938570
Uveal melanoma	Benign	rs458017	RCV005938569

Show/Hide Text Mining Associations (26)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Anemia Hemolytic	Associate	31915374
Arthritis Rheumatoid	Associate	25014791
Colorectal Neoplasms	Associate	27165003, 30591675
Death	Associate	23303771
Diabetes Mellitus	Associate	28729637
Diabetes Mellitus Type 2	Associate	28729637
Drug Related Side Effects and Adverse Reactions	Associate	19289490
Embryo Loss	Inhibit	23303771
Fanconi Anemia	Associate	27165003
Fragile X Syndrome	Associate	23303771
Glioma	Associate	19289490
Hereditary Breast and Ovarian Cancer Syndrome	Associate	22028621
Lung Diseases	Associate	22028621
Lung Neoplasms	Associate	25113059, 29307819
Mobius Syndrome	Associate	27884122, 31033088
Neoplasms	Associate	19289490, 22028621, 24167294, 25113059, 29307819, 32838755
Osteosarcoma	Associate	25748439
Pectoralis Muscle Absence of	Associate	27884122
Poland Syndrome	Associate	27884122
Squamous Cell Carcinoma of Head and Neck	Associate	26790612
Stomach Diseases	Associate	32838755
Stomach Neoplasms	Associate	12717825, 32838755
Tuberculosis	Associate	36476775
Urinary Bladder Neoplasms	Associate	39237917
Uterine Cervical Neoplasms	Associate	25781640
Xeroderma Pigmentosum	Associate	35328096

REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit)