RENBP (renin binding protein)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5973
Gene name Gene Name - the full gene name approved by the HGNC.
Renin binding protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RENBP
Synonyms (NCBI Gene) Gene synonyms aliases
RBP, RNBP
Chromosome Chromosome number
X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xq28
Summary Summary of gene provided in NCBI Entrez Gene.
The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(20)
GO ID Ontology Definition Evidence Reference
GO:0004866 Function Endopeptidase inhibitor activity TAS 9285790
GO:0005515 Function Protein binding IPI 32296183
GO:0005829 Component Cytosol TAS
GO:0005975 Process Carbohydrate metabolic process IEA
GO:0006040 Process Amino sugar metabolic process IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
312420 9959 ENSG00000102032
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P51606
Protein name N-acylglucosamine 2-epimerase (AGE) (EC 5.1.3.8) (GlcNAc 2-epimerase) (N-acetyl-D-glucosamine 2-epimerase) (Renin-binding protein) (RnBP)
Protein function Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine (PubMed:10502668, PubMed:12499362, PubMed:9990133). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze format
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07221 GlcNAc_2-epim 47 → 396 Domain
Sequence
Sequence length 427
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Amino sugar and nucleotide sugar metabolism
Metabolic pathways 		  Synthesis of UDP-N-acetyl-glucosamine
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Schizophrenia Schizophrenia N/A N/A GWAS
Show/Hide Text Mining Associations (85)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 34824300
Arthritis Rheumatoid Associate 40190499
Atherosclerosis Associate 16573830, 17088950, 21844128, 2247477, 39273671
Atrial Fibrillation Associate 35697725
Blood Coagulation Disorders Associate 24624928
Blood Platelet Disorders Associate 20604957
Bone Diseases Associate 16344492
Calcinosis Stimulate 34162041
Carcinoma Non Small Cell Lung Associate 35256890
Carcinoma Renal Cell Associate 39273671