RENBP (renin binding protein)

Gene Gene information from NCBI Gene database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 5973
Gene name Renin binding protein
Gene symbol RENBP
Synonyms (NCBI Gene)
RBPRNBP
Chromosome X
Chromosome location Xq28
Summary The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (20)
GO ID Ontology Definition Evidence Reference
GO:0004866 Function Endopeptidase inhibitor activity TAS 9285790
GO:0005515 Function Protein binding IPI 32296183
GO:0005829 Component Cytosol TAS
GO:0005975 Process Carbohydrate metabolic process IEA
GO:0006040 Process Amino sugar metabolic process IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
312420 9959 ENSG00000102032
Protein Protein information from UniProt database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P51606
Protein name N-acylglucosamine 2-epimerase (AGE) (EC 5.1.3.8) (GlcNAc 2-epimerase) (N-acetyl-D-glucosamine 2-epimerase) (Renin-binding protein) (RnBP)
Protein function Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine (PubMed:10502668, PubMed:12499362, PubMed:9990133). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze format
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07221 GlcNAc_2-epim 47 → 396 Domain
Sequence
Sequence length 427
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Amino sugar and nucleotide sugar metabolism
Metabolic pathways 		  Synthesis of UDP-N-acetyl-glucosamine
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Gastric cancer Benign rs142718878 RCV005908348
Lung cancer Benign rs142718878 RCV005908350
Ovarian serous cystadenocarcinoma Benign rs142718878 RCV005908349
Show/Hide Text Mining Associations (85)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 34824300
Arthritis Rheumatoid Associate 40190499
Atherosclerosis Associate 16573830, 17088950, 21844128, 2247477, 39273671
Atrial Fibrillation Associate 35697725
Blood Coagulation Disorders Associate 24624928
Blood Platelet Disorders Associate 20604957
Bone Diseases Associate 16344492
Calcinosis Stimulate 34162041
Carcinoma Non Small Cell Lung Associate 35256890
Carcinoma Renal Cell Associate 39273671