RELB (RELB proto-oncogene, NF-kB subunit)

Gene
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5971
Gene name Gene Name - the full gene name approved by the HGNC.
RELB proto-oncogene, NF-kB subunit
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RELB
Synonyms (NCBI Gene) Gene synonyms aliases
I-REL, IMD53, IREL, REL-B
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.32
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
SNP ID Visualize variation Clinical significance Consequence
rs745463649 C>A,T Pathogenic Synonymous variant, stop gained, coding sequence variant, intron variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(8)
miRTarBase ID miRNA Experiments Reference
MIRT029940 hsa-miR-26b-5p Microarray 19088304
MIRT1300073 hsa-miR-3662 CLIP-seq
MIRT1300074 hsa-miR-4437 CLIP-seq
MIRT1300075 hsa-miR-4674 CLIP-seq
MIRT2314012 hsa-miR-1913 CLIP-seq
Transcription factors
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
ARNT Unknown 17900530
JUN Unknown 15596805
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(53)
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin IDA 23729669
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 23729669
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604758 9956 ENSG00000104856
Protein
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q01201
Protein name Transcription factor RelB (I-Rel)
Protein function NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a ho
PDB 8G8R
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16180 RelB_leu_zip 18 → 104 RelB leucine zipper Domain
PF00554 RHD_DNA_bind 127 → 295 Rel homology DNA-binding domain Domain
PF16179 RHD_dimer 304 → 401 Rel homology dimerisation domain Domain
PF16181 RelB_transactiv 403 → 579 RelB transactivation domain Domain
Sequence
Sequence length 579
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  MAPK signaling pathway
NF-kappa B signaling pathway
Osteoclast differentiation
C-type lectin receptor signaling pathway
Human T-cell leukemia virus 1 infection
Epstein-Barr virus infection 		  Dectin-1 mediated noncanonical NF-kB signaling
CD209 (DC-SIGN) signaling
NIK-->noncanonical NF-kB signaling
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Immunodeficiency immunodeficiency 53 rs745463649 N/A
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease, Alzheimer's disease or gastroesophageal reflux disease N/A N/A GWAS
Hyperlipidemia Familial combined hyperlipidemia defined by Brunzell criteria N/A N/A GWAS
Show/Hide Text Mining Associations (68)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
AA amyloidosis Associate 28589856
Achalasia Addisonianism Alacrimia syndrome Associate 27764181
Adenocarcinoma Associate 19502791
Alzheimer Disease Associate 37386009
Anodontia Inhibit 38139378
Arthritis Rheumatoid Associate 10765923, 15743469
Atherosclerosis Associate 31362988
Autoimmune Diseases Associate 36402602
Breast Neoplasms Associate 19433448, 19687301, 21640702, 27764181, 36936167, 9681829
Burkitt Lymphoma Associate 11027342