Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5962
Gene name Gene Name - the full gene name approved by the HGNC.
Radixin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RDX
Synonyms (NCBI Gene) Gene synonyms aliases
DFNB24
Disease Acronyms (UniProt) Disease acronyms from UniProt database
DFNB24
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q22.3
Summary Summary of gene provided in NCBI Entrez Gene.
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated ver
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs121918379 C>T Pathogenic Coding sequence variant, missense variant
rs121918380 G>A Pathogenic Coding sequence variant, stop gained, intron variant
rs727504709 C>- Pathogenic Coding sequence variant, intron variant, frameshift variant
rs1057520174 C>T Likely-pathogenic Intron variant, splice donor variant
rs1191259480 C>T Pathogenic Splice donor variant, intron variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004979 hsa-miR-31-5p Luciferase reporter assay, qRT-PCR, Western blot 19524507
MIRT004979 hsa-miR-31-5p Luciferase reporter assay, qRT-PCR, Western blot 19524507
MIRT006807 hsa-miR-409-3p Luciferase reporter assay, qRT-PCR, Western blot 22179828
MIRT032442 hsa-let-7b-5p Proteomics 18668040
MIRT051447 hsa-let-7e-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
CREB5 Repression 21132541
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0003779 Function Actin binding IDA 17825285
GO:0005515 Function Protein binding IPI 10806479, 17321526, 21148287, 23414517, 26496610, 29568061
GO:0005615 Component Extracellular space HDA 16502470
GO:0005886 Component Plasma membrane IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
179410 9944 ENSG00000137710
Protein
UniProt ID P35241
Protein name Radixin
Protein function Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09379 FERM_N 9 71 FERM N-terminal domain Domain
PF00373 FERM_M 88 206 FERM central domain Domain
PF09380 FERM_C 210 299 FERM C-terminal PH-like domain Domain
PF00769 ERM 338 583 Ezrin/radixin/moesin family Coiled-coil
Sequence
Sequence length 583
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Tight junction
Regulation of actin cytoskeleton
Proteoglycans in cancer
MicroRNAs in cancer
  Recycling pathway of L1
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Cholestasis Cholestasis rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039 17681005
Deafness DEAFNESS, AUTOSOMAL RECESSIVE, 24 rs267607135, rs387906219, rs387906220, rs387906221, rs387906222, rs606231120, rs267606855, rs121918370, rs137853185, rs137853186, rs137853187, rs137853188, rs587776522, rs587776523, rs200781822
View all (1019 more)
8486357, 17226784
Nonsyndromic deafness Nonsyndromic Deafness rs606231410, rs794729665, rs730880338, rs1566538321 24285636, 19215054, 15314067, 22567349, 23334578, 26226137, 14983055, 17226784
Psoriasis Psoriasis rs281875215, rs587777763, rs281875213, rs281875212 23143594, 26974007
Unknown
Disease term Disease name Evidence References Source
Crohn disease Crohn Disease 26974007 ClinVar
Psoriasis vulgaris Psoriasis vulgaris GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Bronchiolo Alveolar Inhibit 11092524
Adenocarcinoma of Lung Inhibit 11092524
Alzheimer Disease Associate 31989994
Arthritis Rheumatoid Associate 24854655
Atherosclerosis Associate 32469254
Bartter Syndrome Type 4A Associate 29986705
Breast Neoplasms Associate 23339187, 26938523, 32028690, 37455906
Colorectal Neoplasms Associate 20406101
Colorectal Neoplasms Stimulate 25136657
Hearing Loss Associate 31250571