NPS (neuropeptide S)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
594857
Gene name Gene Name - the full gene name approved by the HGNC.
Neuropeptide S
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NPS
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q26.2
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(8)
GO ID Ontology Definition Evidence Reference
GO:0005576 Component Extracellular region TAS
GO:0007186 Process G protein-coupled receptor signaling pathway TAS
GO:0007218 Process Neuropeptide signaling pathway IEA
GO:0008542 Process Visual learning IEA
GO:0010841 Process Positive regulation of circadian sleep/wake cycle, wakefulness IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
609513 33940 ENSG00000214285
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P0C0P6
Protein name Neuropeptide S
Protein function Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440). {ECO:0000250, ECO:00
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14993 Neuropeptide_S 24 → 88 Neuropeptide S precursor protein Family
Sequence
Sequence length 89
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Neuroactive ligand-receptor interaction   Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)		 22078257
Show/Hide Unknown Diseases (3)
Unknown
Disease term Disease name Evidence References Source
Mental depression Mental Depression, Depressive disorder 20171785 ClinVar
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis GWAS
Insomnia Insomnia GWAS
Show/Hide Text Mining Associations (17)
Associations from Text Mining
Disease Name Relationship Type References
Anxiety Associate 22216302, 24331455, 24386135, 33332443
Anxiety Disorders Associate 21525857, 25971599
Asthma Associate 16790440, 24386135, 28463995
Endometriosis Associate 38287231
Gastrointestinal Diseases Associate 19732772
Hyperkinesis Associate 24386135
Inflammation Associate 22216302
Inflammation Inhibit 30174554
Inflammatory Bowel Diseases Associate 24386135
Irritable Bowel Syndrome Associate 22158028