RBP1 (retinol binding protein 1)

Gene

• Entrez ID: 5947
• Gene name: Retinol binding protein 1
• Gene symbol: RBP1
• Synonyms (NCBI Gene): CRABP-I, CRBP, CRBP1, CRBPI, RBPC, hCRBP1
• Chromosome: 3
• Chromosome location: 3q23
• Summary: This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues,

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018800	hsa-miR-335-5p	Microarray	18185580
MIRT1297332	hsa-miR-1273e	CLIP-seq
MIRT1297333	hsa-miR-1287	CLIP-seq
MIRT1297334	hsa-miR-134	CLIP-seq
MIRT1297335	hsa-miR-142-3p	CLIP-seq
MIRT1297336	hsa-miR-155	CLIP-seq
MIRT1297337	hsa-miR-1827	CLIP-seq
MIRT1297338	hsa-miR-2054	CLIP-seq
MIRT1297339	hsa-miR-24	CLIP-seq
MIRT1297340	hsa-miR-2964a-3p	CLIP-seq
MIRT1297341	hsa-miR-302f	CLIP-seq
MIRT1297342	hsa-miR-3118	CLIP-seq
MIRT1297343	hsa-miR-3135b	CLIP-seq
MIRT1297344	hsa-miR-338-3p	CLIP-seq
MIRT1297345	hsa-miR-342-3p	CLIP-seq
MIRT1297346	hsa-miR-3677-5p	CLIP-seq
MIRT1297347	hsa-miR-3689a-3p	CLIP-seq
MIRT1297348	hsa-miR-3689c	CLIP-seq
MIRT1297349	hsa-miR-3929	CLIP-seq
MIRT1297350	hsa-miR-4270	CLIP-seq
MIRT1297351	hsa-miR-4284	CLIP-seq
MIRT1297352	hsa-miR-4292	CLIP-seq
MIRT1297353	hsa-miR-4308	CLIP-seq
MIRT1297354	hsa-miR-4310	CLIP-seq
MIRT1297355	hsa-miR-4419b	CLIP-seq
MIRT1297356	hsa-miR-4441	CLIP-seq
MIRT1297357	hsa-miR-4456	CLIP-seq
MIRT1297358	hsa-miR-4478	CLIP-seq
MIRT1297359	hsa-miR-4649-3p	CLIP-seq
MIRT1297360	hsa-miR-4722-5p	CLIP-seq
MIRT1297361	hsa-miR-4728-5p	CLIP-seq
MIRT1297362	hsa-miR-4747-5p	CLIP-seq
MIRT1297363	hsa-miR-4768-3p	CLIP-seq
MIRT1297364	hsa-miR-485-5p	CLIP-seq
MIRT1297365	hsa-miR-541	CLIP-seq
MIRT1297366	hsa-miR-654-5p	CLIP-seq
MIRT1297367	hsa-miR-890	CLIP-seq
MIRT1297368	hsa-miR-940	CLIP-seq
MIRT1297369	hsa-miR-943	CLIP-seq
MIRT1297333	hsa-miR-1287	CLIP-seq
MIRT1297336	hsa-miR-155	CLIP-seq
MIRT1297343	hsa-miR-3135b	CLIP-seq
MIRT1297332	hsa-miR-1273e	CLIP-seq
MIRT1297333	hsa-miR-1287	CLIP-seq
MIRT1297334	hsa-miR-134	CLIP-seq
MIRT1297337	hsa-miR-1827	CLIP-seq
MIRT1297340	hsa-miR-2964a-3p	CLIP-seq
MIRT1297341	hsa-miR-302f	CLIP-seq
MIRT1297342	hsa-miR-3118	CLIP-seq
MIRT2088379	hsa-miR-3122	CLIP-seq
MIRT1297343	hsa-miR-3135b	CLIP-seq
MIRT2088380	hsa-miR-3164	CLIP-seq
MIRT2088381	hsa-miR-3606	CLIP-seq
MIRT2088382	hsa-miR-3672	CLIP-seq
MIRT1297347	hsa-miR-3689a-3p	CLIP-seq
MIRT1297348	hsa-miR-3689c	CLIP-seq
MIRT2088383	hsa-miR-3913-5p	CLIP-seq
MIRT1297349	hsa-miR-3929	CLIP-seq
MIRT1297350	hsa-miR-4270	CLIP-seq
MIRT1297352	hsa-miR-4292	CLIP-seq
MIRT2088384	hsa-miR-4293	CLIP-seq
MIRT1297353	hsa-miR-4308	CLIP-seq
MIRT1297355	hsa-miR-4419b	CLIP-seq
MIRT1297356	hsa-miR-4441	CLIP-seq
MIRT1297357	hsa-miR-4456	CLIP-seq
MIRT1297358	hsa-miR-4478	CLIP-seq
MIRT1297359	hsa-miR-4649-3p	CLIP-seq
MIRT1297360	hsa-miR-4722-5p	CLIP-seq
MIRT1297361	hsa-miR-4728-5p	CLIP-seq
MIRT1297362	hsa-miR-4747-5p	CLIP-seq
MIRT1297363	hsa-miR-4768-3p	CLIP-seq
MIRT2088385	hsa-miR-4786-5p	CLIP-seq
MIRT1297364	hsa-miR-485-5p	CLIP-seq
MIRT1297365	hsa-miR-541	CLIP-seq
MIRT1297366	hsa-miR-654-5p	CLIP-seq
MIRT2088386	hsa-miR-769-5p	CLIP-seq
MIRT1297367	hsa-miR-890	CLIP-seq
MIRT1297368	hsa-miR-940	CLIP-seq
MIRT1297369	hsa-miR-943	CLIP-seq
MIRT1297332	hsa-miR-1273e	CLIP-seq
MIRT1297335	hsa-miR-142-3p	CLIP-seq
MIRT1297337	hsa-miR-1827	CLIP-seq
MIRT1297338	hsa-miR-2054	CLIP-seq
MIRT1297339	hsa-miR-24	CLIP-seq
MIRT2313308	hsa-miR-2467-3p	CLIP-seq
MIRT1297340	hsa-miR-2964a-3p	CLIP-seq
MIRT1297341	hsa-miR-302f	CLIP-seq
MIRT2088379	hsa-miR-3122	CLIP-seq
MIRT2313309	hsa-miR-3134	CLIP-seq
MIRT1297344	hsa-miR-338-3p	CLIP-seq
MIRT1297345	hsa-miR-342-3p	CLIP-seq
MIRT2313310	hsa-miR-3612	CLIP-seq
MIRT1297346	hsa-miR-3677-5p	CLIP-seq
MIRT1297347	hsa-miR-3689a-3p	CLIP-seq
MIRT1297348	hsa-miR-3689c	CLIP-seq
MIRT2088383	hsa-miR-3913-5p	CLIP-seq
MIRT1297349	hsa-miR-3929	CLIP-seq
MIRT1297350	hsa-miR-4270	CLIP-seq
MIRT1297351	hsa-miR-4284	CLIP-seq
MIRT1297352	hsa-miR-4292	CLIP-seq
MIRT1297353	hsa-miR-4308	CLIP-seq
MIRT1297354	hsa-miR-4310	CLIP-seq
MIRT1297355	hsa-miR-4419b	CLIP-seq
MIRT1297356	hsa-miR-4441	CLIP-seq
MIRT1297357	hsa-miR-4456	CLIP-seq
MIRT1297358	hsa-miR-4478	CLIP-seq
MIRT1297359	hsa-miR-4649-3p	CLIP-seq
MIRT1297360	hsa-miR-4722-5p	CLIP-seq
MIRT1297361	hsa-miR-4728-5p	CLIP-seq
MIRT1297362	hsa-miR-4747-5p	CLIP-seq
MIRT1297363	hsa-miR-4768-3p	CLIP-seq
MIRT1297364	hsa-miR-485-5p	CLIP-seq
MIRT1297365	hsa-miR-541	CLIP-seq
MIRT2313311	hsa-miR-650	CLIP-seq
MIRT1297366	hsa-miR-654-5p	CLIP-seq
MIRT1297367	hsa-miR-890	CLIP-seq
MIRT1297368	hsa-miR-940	CLIP-seq
MIRT1297333	hsa-miR-1287	CLIP-seq
MIRT1297338	hsa-miR-2054	CLIP-seq
MIRT2088379	hsa-miR-3122	CLIP-seq
MIRT1297343	hsa-miR-3135b	CLIP-seq
MIRT1297344	hsa-miR-338-3p	CLIP-seq
MIRT1297347	hsa-miR-3689a-3p	CLIP-seq
MIRT1297348	hsa-miR-3689c	CLIP-seq
MIRT2088383	hsa-miR-3913-5p	CLIP-seq
MIRT1297354	hsa-miR-4310	CLIP-seq
MIRT1297361	hsa-miR-4728-5p	CLIP-seq
MIRT2432480	hsa-miR-3123	CLIP-seq
MIRT1297344	hsa-miR-338-3p	CLIP-seq
MIRT2432481	hsa-miR-3919	CLIP-seq
MIRT2432482	hsa-miR-4530	CLIP-seq
MIRT2432483	hsa-miR-4790-3p	CLIP-seq
MIRT2432484	hsa-miR-922	CLIP-seq
MIRT2432480	hsa-miR-3123	CLIP-seq
MIRT1297344	hsa-miR-338-3p	CLIP-seq
MIRT2432481	hsa-miR-3919	CLIP-seq
MIRT2432482	hsa-miR-4530	CLIP-seq
MIRT2432483	hsa-miR-4790-3p	CLIP-seq
MIRT2432484	hsa-miR-922	CLIP-seq
MIRT1297338	hsa-miR-2054	CLIP-seq
MIRT2088379	hsa-miR-3122	CLIP-seq
MIRT1297344	hsa-miR-338-3p	CLIP-seq
MIRT1297347	hsa-miR-3689a-3p	CLIP-seq
MIRT1297348	hsa-miR-3689c	CLIP-seq
MIRT2088383	hsa-miR-3913-5p	CLIP-seq
MIRT1297349	hsa-miR-3929	CLIP-seq
MIRT1297354	hsa-miR-4310	CLIP-seq
MIRT1297355	hsa-miR-4419b	CLIP-seq
MIRT1297358	hsa-miR-4478	CLIP-seq
MIRT1297361	hsa-miR-4728-5p	CLIP-seq
MIRT1297364	hsa-miR-485-5p	CLIP-seq
MIRT2609570	hsa-miR-10a	CLIP-seq
MIRT2609571	hsa-miR-10b	CLIP-seq
MIRT1297332	hsa-miR-1273e	CLIP-seq
MIRT1297334	hsa-miR-134	CLIP-seq
MIRT1297337	hsa-miR-1827	CLIP-seq
MIRT1297338	hsa-miR-2054	CLIP-seq
MIRT1297340	hsa-miR-2964a-3p	CLIP-seq
MIRT1297341	hsa-miR-302f	CLIP-seq
MIRT1297342	hsa-miR-3118	CLIP-seq
MIRT2088379	hsa-miR-3122	CLIP-seq
MIRT2088380	hsa-miR-3164	CLIP-seq
MIRT1297344	hsa-miR-338-3p	CLIP-seq
MIRT2609572	hsa-miR-339-5p	CLIP-seq
MIRT1297347	hsa-miR-3689a-3p	CLIP-seq
MIRT1297348	hsa-miR-3689c	CLIP-seq
MIRT2088383	hsa-miR-3913-5p	CLIP-seq
MIRT1297349	hsa-miR-3929	CLIP-seq
MIRT1297354	hsa-miR-4310	CLIP-seq
MIRT1297355	hsa-miR-4419b	CLIP-seq
MIRT2609573	hsa-miR-4421	CLIP-seq
MIRT1297358	hsa-miR-4478	CLIP-seq
MIRT1297359	hsa-miR-4649-3p	CLIP-seq
MIRT2609574	hsa-miR-4684-5p	CLIP-seq
MIRT1297360	hsa-miR-4722-5p	CLIP-seq
MIRT1297361	hsa-miR-4728-5p	CLIP-seq
MIRT1297363	hsa-miR-4768-3p	CLIP-seq
MIRT1297364	hsa-miR-485-5p	CLIP-seq
MIRT2609575	hsa-miR-593	CLIP-seq
MIRT1297367	hsa-miR-890	CLIP-seq
MIRT1297368	hsa-miR-940	CLIP-seq
MIRT1297369	hsa-miR-943	CLIP-seq
MIRT2609570	hsa-miR-10a	CLIP-seq
MIRT2609571	hsa-miR-10b	CLIP-seq
MIRT1297332	hsa-miR-1273e	CLIP-seq
MIRT1297334	hsa-miR-134	CLIP-seq
MIRT1297337	hsa-miR-1827	CLIP-seq
MIRT1297338	hsa-miR-2054	CLIP-seq
MIRT1297340	hsa-miR-2964a-3p	CLIP-seq
MIRT1297341	hsa-miR-302f	CLIP-seq
MIRT1297342	hsa-miR-3118	CLIP-seq
MIRT2088380	hsa-miR-3164	CLIP-seq
MIRT1297344	hsa-miR-338-3p	CLIP-seq
MIRT2609572	hsa-miR-339-5p	CLIP-seq
MIRT1297347	hsa-miR-3689a-3p	CLIP-seq
MIRT1297348	hsa-miR-3689c	CLIP-seq
MIRT1297349	hsa-miR-3929	CLIP-seq
MIRT1297354	hsa-miR-4310	CLIP-seq
MIRT1297355	hsa-miR-4419b	CLIP-seq
MIRT2609573	hsa-miR-4421	CLIP-seq
MIRT1297358	hsa-miR-4478	CLIP-seq
MIRT1297359	hsa-miR-4649-3p	CLIP-seq
MIRT2609574	hsa-miR-4684-5p	CLIP-seq
MIRT1297360	hsa-miR-4722-5p	CLIP-seq
MIRT1297361	hsa-miR-4728-5p	CLIP-seq
MIRT1297363	hsa-miR-4768-3p	CLIP-seq
MIRT1297364	hsa-miR-485-5p	CLIP-seq
MIRT2609575	hsa-miR-593	CLIP-seq
MIRT1297367	hsa-miR-890	CLIP-seq
MIRT1297368	hsa-miR-940	CLIP-seq
MIRT1297369	hsa-miR-943	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	TAS
GO:0002138	Process	Retinoic acid biosynthetic process	IEA
GO:0005501	Function	Retinoid binding	TAS	3472205
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005811	Component	Lipid droplet	IDA	15632377
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006776	Process	Vitamin A metabolic process	IMP	15632377
GO:0016918	Function	Retinal binding	IEA
GO:0055088	Process	Lipid homeostasis	IMP	15632377
GO:1904768	Function	All-trans-retinol binding	IDA	28057518

Other IDs

• MIM: 180260
• HGNC: 9919
• e!Ensembl: ENSG00000114115

Protein

• UniProt ID: P09455
• Protein name: Retinol-binding protein 1 (Cellular retinol-binding protein) (CRBP) (Cellular retinol-binding protein I) (CRBP-I)
• Protein function: Cytoplasmic retinol-binding protein (PubMed:22665496, PubMed:26900151, PubMed:28057518). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (PubMed:15632377, PubMed:22665
• PDB: 5H8T, 5H9A, 5HA1, 5HBS, 5LJB, 5LJC, 5LJD, 5LJE, 5LJG, 5LJH, 5LJK, 6E5L, 6E5T, 6E6M, 8GD2, 8GDM, 8GEM, 8GEU, 8GEV, 8GEY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00061	Lipocalin	6 → 134	Lipocalin / cytosolic fatty-acid binding protein family	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in nearly all the tissues with higher expression in adult ovary, pancreas, pituitary gland and adrenal gland, and fetal liver. {ECO:0000269|PubMed:11274389}.
• Sequence:

  MPVDFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRN
  YIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDELHLEM
  RVEGVVCKQVFKKVQ

• Sequence length: 135

Pathways

Reactome:

Retinoid cycle disease events
The canonical retinoid cycle in rods (twilight vision)
Retinoid metabolism and transport

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Carcinoma	Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	12376462
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	16367923, 16134180
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	18332876

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma	Associate	16598760, 18831746
Arthritis Psoriatic	Stimulate	1335015
Barrett Esophagus	Associate	18831746
Breast Neoplasms	Associate	20716965, 25287138
Breast Neoplasms	Stimulate	29720147
Breast Neoplasms	Inhibit	35269414
Carcinoma Non Small Cell Lung	Associate	16598760, 32909215
Carcinoma Squamous Cell	Associate	1335015
Cholangiocarcinoma	Associate	17550320
Colonic Neoplasms	Associate	36518255
Death	Associate	22945948, 29720147
Endometrial Hyperplasia	Associate	16575402
Esophageal Squamous Cell Carcinoma	Inhibit	16128742
Fetal Growth Retardation	Stimulate	28157488
Gastrointestinal Neoplasms	Associate	32883271
Glioblastoma	Associate	22945948, 40348204
Glioma	Associate	22945948
Glioma	Stimulate	34866280
Liver Cirrhosis	Associate	35168183
Lung Neoplasms	Associate	32909215
Lymphoma Large B Cell Diffuse	Associate	18288132
Mammary Neoplasms Animal	Inhibit	35269414
Multiple Myeloma	Associate	23699600
Neoplasms	Inhibit	16128742, 20716965, 24040446, 37392167
Neoplasms	Associate	16575402, 18831746, 18843024, 21514413, 22945948, 23699600, 29720147, 34866280
Ovarian Diseases	Associate	19110304
Ovarian Neoplasms	Associate	19110304, 20132413, 29720147
Polycystic Ovary Syndrome	Associate	27846214
Prostatic Neoplasms	Associate	15280411, 29720147
Prostatitis	Associate	15280411
Rectal Neoplasms	Associate	28291773
Squamous Cell Carcinoma of Head and Neck	Associate	29720147, 33466212, 35426219
Stomach Neoplasms	Associate	16134180
Urinary Bladder Neoplasms	Associate	18843024, 36030212
Uterine Cervical Neoplasms	Associate	18217980, 24040446