Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	59340
Gene name Gene Name - the full gene name approved by the HGNC.	Histamine receptor H4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HRH4
Synonyms (NCBI Gene) Gene synonyms aliases	AXOR35, BG26, GPCR105, GPRv53, H4, H4R, HH4R
Chromosome Chromosome number	18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	18q11.2
Summary Summary of gene provided in NCBI Entrez Gene.	Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This ge

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017500	hsa-miR-335-5p	Microarray	18185580
MIRT019358	hsa-miR-148b-3p	Microarray	17612493
MIRT626872	hsa-miR-4282	HITS-CLIP	19536157
MIRT724571	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT681995	hsa-miR-4695-5p	HITS-CLIP	23706177
MIRT681994	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT681993	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT681992	hsa-miR-1245a	HITS-CLIP	23706177
MIRT681991	hsa-miR-8079	HITS-CLIP	23706177
MIRT681990	hsa-miR-4257	HITS-CLIP	23706177
MIRT681989	hsa-miR-4459	HITS-CLIP	23706177
MIRT681988	hsa-miR-665	HITS-CLIP	23706177
MIRT681987	hsa-miR-6840-3p	HITS-CLIP	23706177
MIRT681986	hsa-miR-345-3p	HITS-CLIP	23706177
MIRT681985	hsa-miR-4732-3p	HITS-CLIP	23706177
MIRT681984	hsa-miR-125a-5p	HITS-CLIP	23706177
MIRT681983	hsa-miR-125b-5p	HITS-CLIP	23706177
MIRT681982	hsa-miR-4319	HITS-CLIP	23706177
MIRT681981	hsa-miR-1827	HITS-CLIP	23706177
MIRT681980	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT681979	hsa-miR-6086	HITS-CLIP	23706177
MIRT681978	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT681977	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681976	hsa-miR-3612	HITS-CLIP	23706177
MIRT681975	hsa-miR-650	HITS-CLIP	23706177
MIRT681974	hsa-miR-670-5p	HITS-CLIP	23706177
MIRT681973	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681972	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT681971	hsa-miR-1273e	HITS-CLIP	23706177
MIRT678818	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678817	hsa-miR-2392	HITS-CLIP	23824327
MIRT678816	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678815	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678814	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678813	hsa-miR-1976	HITS-CLIP	23824327
MIRT678812	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678811	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678810	hsa-miR-4454	HITS-CLIP	23824327
MIRT678809	hsa-miR-1193	HITS-CLIP	23824327
MIRT678808	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678807	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678806	hsa-miR-433-3p	HITS-CLIP	23824327
MIRT678805	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678804	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT678803	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT678802	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT626872	hsa-miR-4282	HITS-CLIP	23824327
MIRT626871	hsa-miR-7702	HITS-CLIP	23824327
MIRT626872	hsa-miR-4282	HITS-CLIP	19536157
MIRT724571	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT681995	hsa-miR-4695-5p	HITS-CLIP	23706177
MIRT681994	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT681993	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT681992	hsa-miR-1245a	HITS-CLIP	23706177
MIRT681991	hsa-miR-8079	HITS-CLIP	23706177
MIRT681990	hsa-miR-4257	HITS-CLIP	23706177
MIRT681989	hsa-miR-4459	HITS-CLIP	23706177
MIRT681988	hsa-miR-665	HITS-CLIP	23706177
MIRT681987	hsa-miR-6840-3p	HITS-CLIP	23706177
MIRT681986	hsa-miR-345-3p	HITS-CLIP	23706177
MIRT681985	hsa-miR-4732-3p	HITS-CLIP	23706177
MIRT681984	hsa-miR-125a-5p	HITS-CLIP	23706177
MIRT681983	hsa-miR-125b-5p	HITS-CLIP	23706177
MIRT681982	hsa-miR-4319	HITS-CLIP	23706177
MIRT681981	hsa-miR-1827	HITS-CLIP	23706177
MIRT681980	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT681979	hsa-miR-6086	HITS-CLIP	23706177
MIRT681978	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT681977	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681976	hsa-miR-3612	HITS-CLIP	23706177
MIRT681975	hsa-miR-650	HITS-CLIP	23706177
MIRT681974	hsa-miR-670-5p	HITS-CLIP	23706177
MIRT681973	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681972	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT681971	hsa-miR-1273e	HITS-CLIP	23706177
MIRT678818	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678817	hsa-miR-2392	HITS-CLIP	23824327
MIRT678816	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678815	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678814	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678813	hsa-miR-1976	HITS-CLIP	23824327
MIRT678812	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678811	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678810	hsa-miR-4454	HITS-CLIP	23824327
MIRT678809	hsa-miR-1193	HITS-CLIP	23824327
MIRT678808	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678807	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678806	hsa-miR-433-3p	HITS-CLIP	23824327
MIRT678805	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678804	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT678803	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT678802	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT626872	hsa-miR-4282	HITS-CLIP	23824327
MIRT626871	hsa-miR-7702	HITS-CLIP	23824327
MIRT756050	hsa-miR-3915	Microarray, qRT-PCR	35899934
MIRT756051	hsa-miR-583	Microarray, qRT-PCR	35899934
MIRT1054706	hsa-miR-1245	CLIP-seq
MIRT1054707	hsa-miR-125b	CLIP-seq
MIRT1054708	hsa-miR-1262	CLIP-seq
MIRT1054709	hsa-miR-1302	CLIP-seq
MIRT1054710	hsa-miR-1305	CLIP-seq
MIRT1054711	hsa-miR-217	CLIP-seq
MIRT1054712	hsa-miR-3192	CLIP-seq
MIRT1054713	hsa-miR-3913-3p	CLIP-seq
MIRT1054714	hsa-miR-3925-5p	CLIP-seq
MIRT1054715	hsa-miR-3960	CLIP-seq
MIRT1054716	hsa-miR-4298	CLIP-seq
MIRT1054717	hsa-miR-4311	CLIP-seq
MIRT1054718	hsa-miR-4418	CLIP-seq
MIRT1054719	hsa-miR-4438	CLIP-seq
MIRT1054720	hsa-miR-451b	CLIP-seq
MIRT1054721	hsa-miR-4645-5p	CLIP-seq
MIRT1054722	hsa-miR-4673	CLIP-seq
MIRT1054723	hsa-miR-4701-3p	CLIP-seq
MIRT1054724	hsa-miR-4773	CLIP-seq
MIRT1054725	hsa-miR-4793-3p	CLIP-seq
MIRT1054726	hsa-miR-489	CLIP-seq
MIRT1054727	hsa-miR-508-5p	CLIP-seq
MIRT1054728	hsa-miR-509-3-5p	CLIP-seq
MIRT1054729	hsa-miR-5095	CLIP-seq
MIRT1054730	hsa-miR-509-5p	CLIP-seq
MIRT1054731	hsa-miR-542-3p	CLIP-seq
MIRT1054732	hsa-miR-548c-3p	CLIP-seq
MIRT1054733	hsa-miR-610	CLIP-seq
MIRT1054734	hsa-miR-626	CLIP-seq
MIRT1054735	hsa-miR-661	CLIP-seq
MIRT1054736	hsa-miR-670	CLIP-seq
MIRT1054737	hsa-miR-766	CLIP-seq
MIRT1054738	hsa-miR-944	CLIP-seq
MIRT2012441	hsa-miR-1236	CLIP-seq
MIRT2012442	hsa-miR-197	CLIP-seq
MIRT2012443	hsa-miR-3614-3p	CLIP-seq
MIRT2012444	hsa-miR-3918	CLIP-seq
MIRT2012445	hsa-miR-412	CLIP-seq
MIRT2012446	hsa-miR-4685-5p	CLIP-seq
MIRT2012441	hsa-miR-1236	CLIP-seq
MIRT2244736	hsa-miR-1237	CLIP-seq
MIRT1054708	hsa-miR-1262	CLIP-seq
MIRT1054709	hsa-miR-1302	CLIP-seq
MIRT1054710	hsa-miR-1305	CLIP-seq
MIRT2244737	hsa-miR-139-5p	CLIP-seq
MIRT2244738	hsa-miR-188-5p	CLIP-seq
MIRT2012442	hsa-miR-197	CLIP-seq
MIRT1054711	hsa-miR-217	CLIP-seq
MIRT1054712	hsa-miR-3192	CLIP-seq
MIRT2244739	hsa-miR-33a	CLIP-seq
MIRT2244740	hsa-miR-33b	CLIP-seq
MIRT2012443	hsa-miR-3614-3p	CLIP-seq
MIRT2244741	hsa-miR-3672	CLIP-seq
MIRT1054714	hsa-miR-3925-5p	CLIP-seq
MIRT2012445	hsa-miR-412	CLIP-seq
MIRT2244742	hsa-miR-4297	CLIP-seq
MIRT1054716	hsa-miR-4298	CLIP-seq
MIRT2244743	hsa-miR-431	CLIP-seq
MIRT1054717	hsa-miR-4311	CLIP-seq
MIRT1054718	hsa-miR-4418	CLIP-seq
MIRT1054720	hsa-miR-451b	CLIP-seq
MIRT1054721	hsa-miR-4645-5p	CLIP-seq
MIRT1054722	hsa-miR-4673	CLIP-seq
MIRT2244744	hsa-miR-4684-5p	CLIP-seq
MIRT1054723	hsa-miR-4701-3p	CLIP-seq
MIRT2244745	hsa-miR-4711-3p	CLIP-seq
MIRT1054724	hsa-miR-4773	CLIP-seq
MIRT2244746	hsa-miR-4780	CLIP-seq
MIRT1054725	hsa-miR-4793-3p	CLIP-seq
MIRT1054727	hsa-miR-508-5p	CLIP-seq
MIRT1054728	hsa-miR-509-3-5p	CLIP-seq
MIRT1054730	hsa-miR-509-5p	CLIP-seq
MIRT1054731	hsa-miR-542-3p	CLIP-seq
MIRT2244747	hsa-miR-550a	CLIP-seq
MIRT2244748	hsa-miR-581	CLIP-seq
MIRT1054733	hsa-miR-610	CLIP-seq
MIRT2244749	hsa-miR-623	CLIP-seq
MIRT1054734	hsa-miR-626	CLIP-seq
MIRT1054735	hsa-miR-661	CLIP-seq
MIRT1054737	hsa-miR-766	CLIP-seq
MIRT1054710	hsa-miR-1305	CLIP-seq
MIRT2389175	hsa-miR-2909	CLIP-seq
MIRT2389176	hsa-miR-3122	CLIP-seq
MIRT2389177	hsa-miR-3162-5p	CLIP-seq
MIRT2389178	hsa-miR-3689a-3p	CLIP-seq
MIRT2389179	hsa-miR-3689c	CLIP-seq
MIRT2389180	hsa-miR-3913-5p	CLIP-seq
MIRT2389181	hsa-miR-4445	CLIP-seq
MIRT2389182	hsa-miR-4728-5p	CLIP-seq
MIRT2389183	hsa-miR-607	CLIP-seq
MIRT1054706	hsa-miR-1245	CLIP-seq
MIRT1054707	hsa-miR-125b	CLIP-seq
MIRT1054708	hsa-miR-1262	CLIP-seq
MIRT2451387	hsa-miR-134	CLIP-seq
MIRT1054711	hsa-miR-217	CLIP-seq
MIRT2451388	hsa-miR-3118	CLIP-seq
MIRT2451389	hsa-miR-3146	CLIP-seq
MIRT1054713	hsa-miR-3913-3p	CLIP-seq
MIRT2451390	hsa-miR-3973	CLIP-seq
MIRT2451391	hsa-miR-4276	CLIP-seq
MIRT1054718	hsa-miR-4418	CLIP-seq
MIRT1054723	hsa-miR-4701-3p	CLIP-seq
MIRT1054725	hsa-miR-4793-3p	CLIP-seq
MIRT1054726	hsa-miR-489	CLIP-seq
MIRT1054727	hsa-miR-508-5p	CLIP-seq
MIRT1054728	hsa-miR-509-3-5p	CLIP-seq
MIRT1054730	hsa-miR-509-5p	CLIP-seq
MIRT1054731	hsa-miR-542-3p	CLIP-seq
MIRT1054732	hsa-miR-548c-3p	CLIP-seq
MIRT2451392	hsa-miR-548l	CLIP-seq
MIRT1054735	hsa-miR-661	CLIP-seq
MIRT1054736	hsa-miR-670	CLIP-seq
MIRT1054737	hsa-miR-766	CLIP-seq
MIRT2451393	hsa-miR-943	CLIP-seq
MIRT1054738	hsa-miR-944	CLIP-seq
MIRT2465450	hsa-miR-1281	CLIP-seq
MIRT2465451	hsa-miR-331-3p	CLIP-seq
MIRT2465452	hsa-miR-4470	CLIP-seq
MIRT2465453	hsa-miR-4532	CLIP-seq
MIRT2465454	hsa-miR-498	CLIP-seq
MIRT2389176	hsa-miR-3122	CLIP-seq
MIRT2547696	hsa-miR-3622a-5p	CLIP-seq
MIRT2389178	hsa-miR-3689a-3p	CLIP-seq
MIRT2389179	hsa-miR-3689c	CLIP-seq
MIRT2389180	hsa-miR-3913-5p	CLIP-seq
MIRT2547697	hsa-miR-4423-3p	CLIP-seq
MIRT2389182	hsa-miR-4728-5p	CLIP-seq
MIRT2244747	hsa-miR-550a	CLIP-seq
MIRT2389176	hsa-miR-3122	CLIP-seq
MIRT2389178	hsa-miR-3689a-3p	CLIP-seq
MIRT2389179	hsa-miR-3689c	CLIP-seq
MIRT2389180	hsa-miR-3913-5p	CLIP-seq
MIRT2389182	hsa-miR-4728-5p	CLIP-seq
MIRT2244747	hsa-miR-550a	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004969	Function	Histamine receptor activity	NAS	10973974, 11118334
GO:0004993	Function	G protein-coupled serotonin receptor activity	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA	21873635
GO:0007197	Process	Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA	21873635
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0007268	Process	Chemical synaptic transmission	IBA	21873635
GO:0008150	Process	Biological_process	ND
GO:0016907	Function	G protein-coupled acetylcholine receptor activity	IBA	21873635
GO:0030425	Component	Dendrite	IBA	21873635
GO:0030594	Function	Neurotransmitter receptor activity	IBA	21873635
GO:0043408	Process	Regulation of MAPK cascade	IEA
GO:0045202	Component	Synapse	IBA	21873635
GO:0098664	Process	G protein-coupled serotonin receptor signaling pathway	IEA

MIM	HGNC	e!Ensembl
606792	17383	ENSG00000134489

Protein

UniProt ID

Q9H3N8

Protein name

Histamine H4 receptor (H4R) (HH4R) (AXOR35) (G-protein coupled receptor 105) (GPRv53) (Pfi-013) (SP9144)

Protein function

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).

PDB

7YFC , 7YFD , 8HN8 , 8HOC , 8JXT , 8JXV , 8JXW , 8JXX , 8YN9 , 8YNA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	32 → 358	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of perip

Sequence

MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS

Sequence length

390

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction		Histamine receptors G alpha (i) signalling events

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Adenocarcinoma	Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular	rs121913530, rs886039394, rs121913474	22363581
Carcinoma	Carcinoma, Cribriform, Carcinoma, Granular Cell	rs121912654, rs555607708, rs786202962, rs1564055259	22363581
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802 View all (244 more)	22363581

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Schizophrenia	Schizophrenia			GWAS

Show/Hide Text Mining Associations (31)

Disease Name	Relationship Type	References
Associations from Text Mining
Arthritis Psoriatic	Associate	17978505
Arthritis Rheumatoid	Associate	16204969, 28446753
Asthma	Associate	32277847
Bone Diseases	Associate	28446753
Breast Neoplasms	Associate	21622113, 35227109, 40425926
Carcinoma Basal Cell	Inhibit	35227109
Colorectal Neoplasms	Inhibit	21609450, 22363581
Conjunctival Diseases	Associate	28391980
Cystitis Interstitial	Stimulate	31718622
Dermatitis	Associate	32277847
Dermatitis Atopic	Associate	18239617, 36142206
Drug Hypersensitivity	Associate	17978505
Drug Hypersensitivity	Inhibit	30742585
Eosinophilic Esophagitis	Stimulate	25723478
Gastrointestinal Diseases	Associate	16299042
Head and Neck Neoplasms	Associate	26747525
Hyperglycemia	Associate	33328159
Inflammation	Associate	17978505, 18239617, 24799603, 25723478, 28391980
Inflammation	Inhibit	20722760
Leishmaniasis Visceral	Associate	32361248
Lichen Planus Oral	Associate	30974892
Lymphoma T Cell	Associate	35163302
Meniere Disease	Associate	31133025
Neoplasms	Associate	17932461, 21609450, 22363581, 35227109
Psoriasis	Associate	21614010
Rhinitis	Associate	32277847
Spondylitis Ankylosing	Associate	26823878
Stomach Neoplasms	Associate	22363581
Tertiary Lymphoid Structures	Inhibit	35227109
Triple Negative Breast Neoplasms	Inhibit	35227109
Vertigo	Associate	31133025

HRH4 (histamine receptor H4)