HRH4 (histamine receptor H4)

Gene

• Entrez ID: 59340
• Gene name: Histamine receptor H4
• Gene symbol: HRH4
• Synonyms (NCBI Gene): AXOR35, BG26, GPCR105, GPRv53, H4, H4R, HH4R
• Chromosome: 18
• Chromosome location: 18q11.2
• Summary: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This ge

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017500	hsa-miR-335-5p	Microarray	18185580
MIRT019358	hsa-miR-148b-3p	Microarray	17612493
MIRT626872	hsa-miR-4282	HITS-CLIP	19536157
MIRT724571	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT681995	hsa-miR-4695-5p	HITS-CLIP	23706177
MIRT681994	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT681993	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT681992	hsa-miR-1245a	HITS-CLIP	23706177
MIRT681991	hsa-miR-8079	HITS-CLIP	23706177
MIRT681990	hsa-miR-4257	HITS-CLIP	23706177
MIRT681989	hsa-miR-4459	HITS-CLIP	23706177
MIRT681988	hsa-miR-665	HITS-CLIP	23706177
MIRT681987	hsa-miR-6840-3p	HITS-CLIP	23706177
MIRT681986	hsa-miR-345-3p	HITS-CLIP	23706177
MIRT681985	hsa-miR-4732-3p	HITS-CLIP	23706177
MIRT681984	hsa-miR-125a-5p	HITS-CLIP	23706177
MIRT681983	hsa-miR-125b-5p	HITS-CLIP	23706177
MIRT681982	hsa-miR-4319	HITS-CLIP	23706177
MIRT681981	hsa-miR-1827	HITS-CLIP	23706177
MIRT681980	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT681979	hsa-miR-6086	HITS-CLIP	23706177
MIRT681978	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT681977	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681976	hsa-miR-3612	HITS-CLIP	23706177
MIRT681975	hsa-miR-650	HITS-CLIP	23706177
MIRT681974	hsa-miR-670-5p	HITS-CLIP	23706177
MIRT681973	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681972	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT681971	hsa-miR-1273e	HITS-CLIP	23706177
MIRT678818	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678817	hsa-miR-2392	HITS-CLIP	23824327
MIRT678816	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678815	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678814	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678813	hsa-miR-1976	HITS-CLIP	23824327
MIRT678812	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678811	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678810	hsa-miR-4454	HITS-CLIP	23824327
MIRT678809	hsa-miR-1193	HITS-CLIP	23824327
MIRT678808	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678807	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678806	hsa-miR-433-3p	HITS-CLIP	23824327
MIRT678805	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678804	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT678803	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT678802	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT626872	hsa-miR-4282	HITS-CLIP	23824327
MIRT626871	hsa-miR-7702	HITS-CLIP	23824327
MIRT626872	hsa-miR-4282	HITS-CLIP	19536157
MIRT724571	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT681995	hsa-miR-4695-5p	HITS-CLIP	23706177
MIRT681994	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT681993	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT681992	hsa-miR-1245a	HITS-CLIP	23706177
MIRT681991	hsa-miR-8079	HITS-CLIP	23706177
MIRT681990	hsa-miR-4257	HITS-CLIP	23706177
MIRT681989	hsa-miR-4459	HITS-CLIP	23706177
MIRT681988	hsa-miR-665	HITS-CLIP	23706177
MIRT681987	hsa-miR-6840-3p	HITS-CLIP	23706177
MIRT681986	hsa-miR-345-3p	HITS-CLIP	23706177
MIRT681985	hsa-miR-4732-3p	HITS-CLIP	23706177
MIRT681984	hsa-miR-125a-5p	HITS-CLIP	23706177
MIRT681983	hsa-miR-125b-5p	HITS-CLIP	23706177
MIRT681982	hsa-miR-4319	HITS-CLIP	23706177
MIRT681981	hsa-miR-1827	HITS-CLIP	23706177
MIRT681980	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT681979	hsa-miR-6086	HITS-CLIP	23706177
MIRT681978	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT681977	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681976	hsa-miR-3612	HITS-CLIP	23706177
MIRT681975	hsa-miR-650	HITS-CLIP	23706177
MIRT681974	hsa-miR-670-5p	HITS-CLIP	23706177
MIRT681973	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681972	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT681971	hsa-miR-1273e	HITS-CLIP	23706177
MIRT678818	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678817	hsa-miR-2392	HITS-CLIP	23824327
MIRT678816	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678815	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678814	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678813	hsa-miR-1976	HITS-CLIP	23824327
MIRT678812	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678811	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678810	hsa-miR-4454	HITS-CLIP	23824327
MIRT678809	hsa-miR-1193	HITS-CLIP	23824327
MIRT678808	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678807	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678806	hsa-miR-433-3p	HITS-CLIP	23824327
MIRT678805	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678804	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT678803	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT678802	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT626872	hsa-miR-4282	HITS-CLIP	23824327
MIRT626871	hsa-miR-7702	HITS-CLIP	23824327
MIRT756050	hsa-miR-3915	Microarray, qRT-PCR	35899934
MIRT756051	hsa-miR-583	Microarray, qRT-PCR	35899934
MIRT1054706	hsa-miR-1245	CLIP-seq
MIRT1054707	hsa-miR-125b	CLIP-seq
MIRT1054708	hsa-miR-1262	CLIP-seq
MIRT1054709	hsa-miR-1302	CLIP-seq
MIRT1054710	hsa-miR-1305	CLIP-seq
MIRT1054711	hsa-miR-217	CLIP-seq
MIRT1054712	hsa-miR-3192	CLIP-seq
MIRT1054713	hsa-miR-3913-3p	CLIP-seq
MIRT1054714	hsa-miR-3925-5p	CLIP-seq
MIRT1054715	hsa-miR-3960	CLIP-seq
MIRT1054716	hsa-miR-4298	CLIP-seq
MIRT1054717	hsa-miR-4311	CLIP-seq
MIRT1054718	hsa-miR-4418	CLIP-seq
MIRT1054719	hsa-miR-4438	CLIP-seq
MIRT1054720	hsa-miR-451b	CLIP-seq
MIRT1054721	hsa-miR-4645-5p	CLIP-seq
MIRT1054722	hsa-miR-4673	CLIP-seq
MIRT1054723	hsa-miR-4701-3p	CLIP-seq
MIRT1054724	hsa-miR-4773	CLIP-seq
MIRT1054725	hsa-miR-4793-3p	CLIP-seq
MIRT1054726	hsa-miR-489	CLIP-seq
MIRT1054727	hsa-miR-508-5p	CLIP-seq
MIRT1054728	hsa-miR-509-3-5p	CLIP-seq
MIRT1054729	hsa-miR-5095	CLIP-seq
MIRT1054730	hsa-miR-509-5p	CLIP-seq
MIRT1054731	hsa-miR-542-3p	CLIP-seq
MIRT1054732	hsa-miR-548c-3p	CLIP-seq
MIRT1054733	hsa-miR-610	CLIP-seq
MIRT1054734	hsa-miR-626	CLIP-seq
MIRT1054735	hsa-miR-661	CLIP-seq
MIRT1054736	hsa-miR-670	CLIP-seq
MIRT1054737	hsa-miR-766	CLIP-seq
MIRT1054738	hsa-miR-944	CLIP-seq
MIRT2012441	hsa-miR-1236	CLIP-seq
MIRT2012442	hsa-miR-197	CLIP-seq
MIRT2012443	hsa-miR-3614-3p	CLIP-seq
MIRT2012444	hsa-miR-3918	CLIP-seq
MIRT2012445	hsa-miR-412	CLIP-seq
MIRT2012446	hsa-miR-4685-5p	CLIP-seq
MIRT2012441	hsa-miR-1236	CLIP-seq
MIRT2244736	hsa-miR-1237	CLIP-seq
MIRT1054708	hsa-miR-1262	CLIP-seq
MIRT1054709	hsa-miR-1302	CLIP-seq
MIRT1054710	hsa-miR-1305	CLIP-seq
MIRT2244737	hsa-miR-139-5p	CLIP-seq
MIRT2244738	hsa-miR-188-5p	CLIP-seq
MIRT2012442	hsa-miR-197	CLIP-seq
MIRT1054711	hsa-miR-217	CLIP-seq
MIRT1054712	hsa-miR-3192	CLIP-seq
MIRT2244739	hsa-miR-33a	CLIP-seq
MIRT2244740	hsa-miR-33b	CLIP-seq
MIRT2012443	hsa-miR-3614-3p	CLIP-seq
MIRT2244741	hsa-miR-3672	CLIP-seq
MIRT1054714	hsa-miR-3925-5p	CLIP-seq
MIRT2012445	hsa-miR-412	CLIP-seq
MIRT2244742	hsa-miR-4297	CLIP-seq
MIRT1054716	hsa-miR-4298	CLIP-seq
MIRT2244743	hsa-miR-431	CLIP-seq
MIRT1054717	hsa-miR-4311	CLIP-seq
MIRT1054718	hsa-miR-4418	CLIP-seq
MIRT1054720	hsa-miR-451b	CLIP-seq
MIRT1054721	hsa-miR-4645-5p	CLIP-seq
MIRT1054722	hsa-miR-4673	CLIP-seq
MIRT2244744	hsa-miR-4684-5p	CLIP-seq
MIRT1054723	hsa-miR-4701-3p	CLIP-seq
MIRT2244745	hsa-miR-4711-3p	CLIP-seq
MIRT1054724	hsa-miR-4773	CLIP-seq
MIRT2244746	hsa-miR-4780	CLIP-seq
MIRT1054725	hsa-miR-4793-3p	CLIP-seq
MIRT1054727	hsa-miR-508-5p	CLIP-seq
MIRT1054728	hsa-miR-509-3-5p	CLIP-seq
MIRT1054730	hsa-miR-509-5p	CLIP-seq
MIRT1054731	hsa-miR-542-3p	CLIP-seq
MIRT2244747	hsa-miR-550a	CLIP-seq
MIRT2244748	hsa-miR-581	CLIP-seq
MIRT1054733	hsa-miR-610	CLIP-seq
MIRT2244749	hsa-miR-623	CLIP-seq
MIRT1054734	hsa-miR-626	CLIP-seq
MIRT1054735	hsa-miR-661	CLIP-seq
MIRT1054737	hsa-miR-766	CLIP-seq
MIRT1054710	hsa-miR-1305	CLIP-seq
MIRT2389175	hsa-miR-2909	CLIP-seq
MIRT2389176	hsa-miR-3122	CLIP-seq
MIRT2389177	hsa-miR-3162-5p	CLIP-seq
MIRT2389178	hsa-miR-3689a-3p	CLIP-seq
MIRT2389179	hsa-miR-3689c	CLIP-seq
MIRT2389180	hsa-miR-3913-5p	CLIP-seq
MIRT2389181	hsa-miR-4445	CLIP-seq
MIRT2389182	hsa-miR-4728-5p	CLIP-seq
MIRT2389183	hsa-miR-607	CLIP-seq
MIRT1054706	hsa-miR-1245	CLIP-seq
MIRT1054707	hsa-miR-125b	CLIP-seq
MIRT1054708	hsa-miR-1262	CLIP-seq
MIRT2451387	hsa-miR-134	CLIP-seq
MIRT1054711	hsa-miR-217	CLIP-seq
MIRT2451388	hsa-miR-3118	CLIP-seq
MIRT2451389	hsa-miR-3146	CLIP-seq
MIRT1054713	hsa-miR-3913-3p	CLIP-seq
MIRT2451390	hsa-miR-3973	CLIP-seq
MIRT2451391	hsa-miR-4276	CLIP-seq
MIRT1054718	hsa-miR-4418	CLIP-seq
MIRT1054723	hsa-miR-4701-3p	CLIP-seq
MIRT1054725	hsa-miR-4793-3p	CLIP-seq
MIRT1054726	hsa-miR-489	CLIP-seq
MIRT1054727	hsa-miR-508-5p	CLIP-seq
MIRT1054728	hsa-miR-509-3-5p	CLIP-seq
MIRT1054730	hsa-miR-509-5p	CLIP-seq
MIRT1054731	hsa-miR-542-3p	CLIP-seq
MIRT1054732	hsa-miR-548c-3p	CLIP-seq
MIRT2451392	hsa-miR-548l	CLIP-seq
MIRT1054735	hsa-miR-661	CLIP-seq
MIRT1054736	hsa-miR-670	CLIP-seq
MIRT1054737	hsa-miR-766	CLIP-seq
MIRT2451393	hsa-miR-943	CLIP-seq
MIRT1054738	hsa-miR-944	CLIP-seq
MIRT2465450	hsa-miR-1281	CLIP-seq
MIRT2465451	hsa-miR-331-3p	CLIP-seq
MIRT2465452	hsa-miR-4470	CLIP-seq
MIRT2465453	hsa-miR-4532	CLIP-seq
MIRT2465454	hsa-miR-498	CLIP-seq
MIRT2389176	hsa-miR-3122	CLIP-seq
MIRT2547696	hsa-miR-3622a-5p	CLIP-seq
MIRT2389178	hsa-miR-3689a-3p	CLIP-seq
MIRT2389179	hsa-miR-3689c	CLIP-seq
MIRT2389180	hsa-miR-3913-5p	CLIP-seq
MIRT2547697	hsa-miR-4423-3p	CLIP-seq
MIRT2389182	hsa-miR-4728-5p	CLIP-seq
MIRT2244747	hsa-miR-550a	CLIP-seq
MIRT2389176	hsa-miR-3122	CLIP-seq
MIRT2389178	hsa-miR-3689a-3p	CLIP-seq
MIRT2389179	hsa-miR-3689c	CLIP-seq
MIRT2389180	hsa-miR-3913-5p	CLIP-seq
MIRT2389182	hsa-miR-4728-5p	CLIP-seq
MIRT2244747	hsa-miR-550a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004969	Function	Histamine receptor activity	IBA
GO:0004969	Function	Histamine receptor activity	IEA
GO:0004969	Function	Histamine receptor activity	NAS	10973974, 11118334
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006954	Process	Inflammatory response	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
GO:0007197	Process	Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0016020	Component	Membrane	IEA
GO:0030425	Component	Dendrite	IBA
GO:0030594	Function	Neurotransmitter receptor activity	IBA
GO:0043408	Process	Regulation of MAPK cascade	IEA
GO:0045202	Component	Synapse	IBA

Other IDs

• MIM: 606792
• HGNC: 17383
• e!Ensembl: ENSG00000134489

Protein

• UniProt ID: Q9H3N8
• Protein name: Histamine H4 receptor (H4R) (HH4R) (AXOR35) (G-protein coupled receptor 105) (GPRv53) (Pfi-013) (SP9144)
• Protein function: The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
• PDB: 7YFC, 7YFD, 8HN8, 8HOC, 8JXT, 8JXV, 8JXW, 8JXX, 8YN9, 8YNA
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	32 → 358	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of perip
• Sequence:

  MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
  DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
  SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
  LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
  STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
  LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
  CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS

• Sequence length: 390

Pathways

KEGG:

Neuroactive ligand-receptor interaction

Reactome:

Histamine receptors
G alpha (i) signalling events