Gene Gene information from NCBI Gene database.
Entrez ID 59339
Gene name Pleckstrin homology domain containing A2
Gene symbol PLEKHA2
Synonyms (NCBI Gene)
TAPP2
Chromosome 8
Chromosome location 8p11.22
miRNA miRNA information provided by mirtarbase database.
1176
miRTarBase ID miRNA Experiments Reference
MIRT634412 hsa-miR-329-3p HITS-CLIP 22927820
MIRT634411 hsa-miR-362-3p HITS-CLIP 22927820
MIRT609820 hsa-miR-6856-3p HITS-CLIP 22927820
MIRT609819 hsa-miR-4690-3p HITS-CLIP 22927820
MIRT609818 hsa-miR-5685 HITS-CLIP 22927820
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0001954 Process Positive regulation of cell-matrix adhesion IMP 19786618
GO:0001968 Function Fibronectin binding IMP 19786618
GO:0005515 Function Protein binding IPI 19786618, 32296183
GO:0005543 Function Phospholipid binding IBA
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607773 14336 ENSG00000169499
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9HB19
Protein name Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2)
Protein function Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00169 PH 8 113 PH domain Domain
PF00169 PH 199 298 PH domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in heart, kidney, spleen and peripheral blood leukocytes. Detected at lower levels in brain, skeletal muscle, colon, thymus, liver, small intestine, placenta and lung.
Sequence
MPYVDRQNRICGFLDIEEHENSGKFLRRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQ
LTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDMKDWVEALNQASK
ITVPKGG
GLPMTTEVLKSLAAPPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILR
RSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLR
TIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQ
AL
KCHPRETSFSRSISLTRPGSSSLSSGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPV
PQAGEKLLPPGDTSEDSLFTPRPGEGAPPGVLPSSRIRHRSEPQHPKEKPFMFNLDDENI
RTSDV
Sequence length 425
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Synthesis of PIPs at the plasma membrane
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
NEUROTIC DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Leukemia Associate 19786618
★☆☆☆☆
Found in Text Mining only
Leukemia B Cell Associate 19786618
★☆☆☆☆
Found in Text Mining only
Leukemia Lymphocytic Chronic B Cell Associate 19786618
★☆☆☆☆
Found in Text Mining only
Leukemia Prolymphocytic T Cell Associate 19278963
★☆☆☆☆
Found in Text Mining only
Osteoporosis Associate 32496000
★☆☆☆☆
Found in Text Mining only