Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5926
Gene name	AT-rich interaction domain 4A
Gene symbol	ARID4A
Synonyms (NCBI Gene)	RBBP-1RBBP1RBP-1RBP1
Chromosome	14
Chromosome location	14q23.1
Summary	The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein

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SNP ID	Visualize variation	Clinical significance	Consequence
rs62621193	G>A,C	Conflicting-interpretations-of-pathogenicity	Splice donor variant, genic downstream transcript variant, coding sequence variant, missense variant
rs1594966387	G>T	Likely-pathogenic	Genic downstream transcript variant, stop gained, coding sequence variant

283

Show/Hide all (283)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018511	hsa-miR-335-5p	Microarray	18185580
MIRT030996	hsa-miR-21-5p	Microarray	18591254
MIRT624668	hsa-miR-548ac	HITS-CLIP	23824327
MIRT624667	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT624666	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT624665	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT624664	hsa-miR-548z	HITS-CLIP	23824327
MIRT624663	hsa-miR-548as-3p	HITS-CLIP	23824327
MIRT660532	hsa-miR-6771-3p	HITS-CLIP	23824327
MIRT624668	hsa-miR-548ac	HITS-CLIP	23824327
MIRT624667	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT624666	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT624665	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT624664	hsa-miR-548z	HITS-CLIP	23824327
MIRT624663	hsa-miR-548as-3p	HITS-CLIP	23824327
MIRT624668	hsa-miR-548ac	HITS-CLIP	23824327
MIRT624667	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT624666	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT624665	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT624664	hsa-miR-548z	HITS-CLIP	23824327
MIRT624663	hsa-miR-548as-3p	HITS-CLIP	23824327
MIRT660532	hsa-miR-6771-3p	HITS-CLIP	23824327
MIRT624668	hsa-miR-548ac	HITS-CLIP	23824327
MIRT624667	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT624666	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT624665	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT624664	hsa-miR-548z	HITS-CLIP	23824327
MIRT624663	hsa-miR-548as-3p	HITS-CLIP	23824327
MIRT796674	hsa-miR-103a	CLIP-seq
MIRT796675	hsa-miR-106a	CLIP-seq
MIRT796676	hsa-miR-106b	CLIP-seq
MIRT796677	hsa-miR-107	CLIP-seq
MIRT796678	hsa-miR-1207-5p	CLIP-seq
MIRT796679	hsa-miR-1254	CLIP-seq
MIRT796680	hsa-miR-1273g	CLIP-seq
MIRT796681	hsa-miR-153	CLIP-seq
MIRT796682	hsa-miR-17	CLIP-seq
MIRT796683	hsa-miR-183	CLIP-seq
MIRT796684	hsa-miR-2054	CLIP-seq
MIRT796685	hsa-miR-20a	CLIP-seq
MIRT796686	hsa-miR-20b	CLIP-seq
MIRT796687	hsa-miR-2110	CLIP-seq
MIRT796688	hsa-miR-2113	CLIP-seq
MIRT796689	hsa-miR-218	CLIP-seq
MIRT796690	hsa-miR-27a	CLIP-seq
MIRT796691	hsa-miR-27b	CLIP-seq
MIRT796692	hsa-miR-30a	CLIP-seq
MIRT796693	hsa-miR-30b	CLIP-seq
MIRT796694	hsa-miR-30c	CLIP-seq
MIRT796695	hsa-miR-30d	CLIP-seq
MIRT796696	hsa-miR-30e	CLIP-seq
MIRT796697	hsa-miR-3116	CLIP-seq
MIRT796698	hsa-miR-3127-5p	CLIP-seq
MIRT796699	hsa-miR-3148	CLIP-seq
MIRT796700	hsa-miR-3150a-3p	CLIP-seq
MIRT796701	hsa-miR-3160-5p	CLIP-seq
MIRT796702	hsa-miR-323b-5p	CLIP-seq
MIRT796703	hsa-miR-330-3p	CLIP-seq
MIRT796704	hsa-miR-3606	CLIP-seq
MIRT796705	hsa-miR-3607-3p	CLIP-seq
MIRT796706	hsa-miR-3613-3p	CLIP-seq
MIRT796707	hsa-miR-3671	CLIP-seq
MIRT796708	hsa-miR-3680	CLIP-seq
MIRT796709	hsa-miR-3682-5p	CLIP-seq
MIRT796710	hsa-miR-371b-5p	CLIP-seq
MIRT796711	hsa-miR-376c	CLIP-seq
MIRT796712	hsa-miR-3908	CLIP-seq
MIRT796713	hsa-miR-3942-5p	CLIP-seq
MIRT796714	hsa-miR-3944-5p	CLIP-seq
MIRT796715	hsa-miR-425	CLIP-seq
MIRT796716	hsa-miR-4255	CLIP-seq
MIRT796717	hsa-miR-4260	CLIP-seq
MIRT796718	hsa-miR-4422	CLIP-seq
MIRT796719	hsa-miR-4436b-5p	CLIP-seq
MIRT796720	hsa-miR-4450	CLIP-seq
MIRT796721	hsa-miR-4461	CLIP-seq
MIRT796722	hsa-miR-4477a	CLIP-seq
MIRT796723	hsa-miR-448	CLIP-seq
MIRT796724	hsa-miR-450b-5p	CLIP-seq
MIRT796725	hsa-miR-4640-3p	CLIP-seq
MIRT796726	hsa-miR-4652-3p	CLIP-seq
MIRT796727	hsa-miR-4658	CLIP-seq
MIRT796728	hsa-miR-4666-3p	CLIP-seq
MIRT796729	hsa-miR-4668-3p	CLIP-seq
MIRT796730	hsa-miR-4703-5p	CLIP-seq
MIRT796731	hsa-miR-4720-3p	CLIP-seq
MIRT796732	hsa-miR-4736	CLIP-seq
MIRT796733	hsa-miR-4758-5p	CLIP-seq
MIRT796734	hsa-miR-4760-3p	CLIP-seq
MIRT796735	hsa-miR-4763-3p	CLIP-seq
MIRT796736	hsa-miR-4766-3p	CLIP-seq
MIRT796737	hsa-miR-4775	CLIP-seq
MIRT796738	hsa-miR-4798-3p	CLIP-seq
MIRT796739	hsa-miR-4804-3p	CLIP-seq
MIRT796740	hsa-miR-513a-5p	CLIP-seq
MIRT796741	hsa-miR-513b	CLIP-seq
MIRT796742	hsa-miR-518a-5p	CLIP-seq
MIRT796743	hsa-miR-519a	CLIP-seq
MIRT796744	hsa-miR-519b-3p	CLIP-seq
MIRT796745	hsa-miR-519c-3p	CLIP-seq
MIRT796746	hsa-miR-519d	CLIP-seq
MIRT796747	hsa-miR-520f	CLIP-seq
MIRT796748	hsa-miR-527	CLIP-seq
MIRT796749	hsa-miR-548c-3p	CLIP-seq
MIRT796750	hsa-miR-548t	CLIP-seq
MIRT796751	hsa-miR-570	CLIP-seq
MIRT796752	hsa-miR-590-3p	CLIP-seq
MIRT796753	hsa-miR-607	CLIP-seq
MIRT796754	hsa-miR-875-3p	CLIP-seq
MIRT796755	hsa-miR-921	CLIP-seq
MIRT796756	hsa-miR-93	CLIP-seq
MIRT796675	hsa-miR-106a	CLIP-seq
MIRT796676	hsa-miR-106b	CLIP-seq
MIRT796757	hsa-miR-1284	CLIP-seq
MIRT796758	hsa-miR-139-5p	CLIP-seq
MIRT796682	hsa-miR-17	CLIP-seq
MIRT796685	hsa-miR-20a	CLIP-seq
MIRT796686	hsa-miR-20b	CLIP-seq
MIRT796687	hsa-miR-2110	CLIP-seq
MIRT796759	hsa-miR-3120-3p	CLIP-seq
MIRT796700	hsa-miR-3150a-3p	CLIP-seq
MIRT796760	hsa-miR-3168	CLIP-seq
MIRT796761	hsa-miR-3173-3p	CLIP-seq
MIRT796705	hsa-miR-3607-3p	CLIP-seq
MIRT796720	hsa-miR-4450	CLIP-seq
MIRT796762	hsa-miR-452	CLIP-seq
MIRT796763	hsa-miR-4641	CLIP-seq
MIRT796764	hsa-miR-4676-3p	CLIP-seq
MIRT796765	hsa-miR-4729	CLIP-seq
MIRT796766	hsa-miR-486-5p	CLIP-seq
MIRT796743	hsa-miR-519a	CLIP-seq
MIRT796744	hsa-miR-519b-3p	CLIP-seq
MIRT796745	hsa-miR-519c-3p	CLIP-seq
MIRT796746	hsa-miR-519d	CLIP-seq
MIRT796767	hsa-miR-545	CLIP-seq
MIRT796750	hsa-miR-548t	CLIP-seq
MIRT796768	hsa-miR-640	CLIP-seq
MIRT796769	hsa-miR-7	CLIP-seq
MIRT796770	hsa-miR-885-3p	CLIP-seq
MIRT796756	hsa-miR-93	CLIP-seq
MIRT796771	hsa-miR-944	CLIP-seq
MIRT796674	hsa-miR-103a	CLIP-seq
MIRT796677	hsa-miR-107	CLIP-seq
MIRT1935282	hsa-miR-1207-3p	CLIP-seq
MIRT796714	hsa-miR-3944-5p	CLIP-seq
MIRT1935283	hsa-miR-555	CLIP-seq
MIRT1935284	hsa-miR-1288	CLIP-seq
MIRT1935285	hsa-miR-194	CLIP-seq
MIRT1935286	hsa-miR-4799-5p	CLIP-seq
MIRT1935287	hsa-miR-495	CLIP-seq
MIRT796679	hsa-miR-1254	CLIP-seq
MIRT2175252	hsa-miR-1271	CLIP-seq
MIRT796680	hsa-miR-1273g	CLIP-seq
MIRT2175253	hsa-miR-1285	CLIP-seq
MIRT2175254	hsa-miR-1343	CLIP-seq
MIRT2175255	hsa-miR-154	CLIP-seq
MIRT2175256	hsa-miR-182	CLIP-seq
MIRT796684	hsa-miR-2054	CLIP-seq
MIRT796687	hsa-miR-2110	CLIP-seq
MIRT2175257	hsa-miR-2278	CLIP-seq
MIRT796690	hsa-miR-27a	CLIP-seq
MIRT796691	hsa-miR-27b	CLIP-seq
MIRT796692	hsa-miR-30a	CLIP-seq
MIRT796693	hsa-miR-30b	CLIP-seq
MIRT796694	hsa-miR-30c	CLIP-seq
MIRT796695	hsa-miR-30d	CLIP-seq
MIRT796696	hsa-miR-30e	CLIP-seq
MIRT796697	hsa-miR-3116	CLIP-seq
MIRT2175258	hsa-miR-3121-3p	CLIP-seq
MIRT796698	hsa-miR-3127-5p	CLIP-seq
MIRT796699	hsa-miR-3148	CLIP-seq
MIRT796700	hsa-miR-3150a-3p	CLIP-seq
MIRT796701	hsa-miR-3160-5p	CLIP-seq
MIRT796760	hsa-miR-3168	CLIP-seq
MIRT2175259	hsa-miR-3187-5p	CLIP-seq
MIRT796702	hsa-miR-323b-5p	CLIP-seq
MIRT796703	hsa-miR-330-3p	CLIP-seq
MIRT2175260	hsa-miR-34a	CLIP-seq
MIRT2175261	hsa-miR-34c-5p	CLIP-seq
MIRT796705	hsa-miR-3607-3p	CLIP-seq
MIRT796708	hsa-miR-3680	CLIP-seq
MIRT796711	hsa-miR-376c	CLIP-seq
MIRT796717	hsa-miR-4260	CLIP-seq
MIRT2175262	hsa-miR-4277	CLIP-seq
MIRT796718	hsa-miR-4422	CLIP-seq
MIRT796719	hsa-miR-4436b-5p	CLIP-seq
MIRT796720	hsa-miR-4450	CLIP-seq
MIRT2175263	hsa-miR-449a	CLIP-seq
MIRT2175264	hsa-miR-449b	CLIP-seq
MIRT796726	hsa-miR-4652-3p	CLIP-seq
MIRT796727	hsa-miR-4658	CLIP-seq
MIRT2175265	hsa-miR-4662a-3p	CLIP-seq
MIRT796733	hsa-miR-4758-5p	CLIP-seq
MIRT796734	hsa-miR-4760-3p	CLIP-seq
MIRT2175266	hsa-miR-4795-3p	CLIP-seq
MIRT796738	hsa-miR-4798-3p	CLIP-seq
MIRT1935286	hsa-miR-4799-5p	CLIP-seq
MIRT796740	hsa-miR-513a-5p	CLIP-seq
MIRT2175267	hsa-miR-518d-5p	CLIP-seq
MIRT2175268	hsa-miR-519b-5p	CLIP-seq
MIRT2175269	hsa-miR-519c-5p	CLIP-seq
MIRT2175270	hsa-miR-520c-5p	CLIP-seq
MIRT796747	hsa-miR-520f	CLIP-seq
MIRT2175271	hsa-miR-526a	CLIP-seq
MIRT796767	hsa-miR-545	CLIP-seq
MIRT2175272	hsa-miR-548l	CLIP-seq
MIRT2175273	hsa-miR-548n	CLIP-seq
MIRT2175274	hsa-miR-612	CLIP-seq
MIRT796754	hsa-miR-875-3p	CLIP-seq
MIRT796770	hsa-miR-885-3p	CLIP-seq
MIRT2175275	hsa-miR-96	CLIP-seq
MIRT2478571	hsa-miR-1205	CLIP-seq
MIRT796678	hsa-miR-1207-5p	CLIP-seq
MIRT2478572	hsa-miR-1286	CLIP-seq
MIRT2478573	hsa-miR-129-5p	CLIP-seq
MIRT796681	hsa-miR-153	CLIP-seq
MIRT796683	hsa-miR-183	CLIP-seq
MIRT2478574	hsa-miR-204	CLIP-seq
MIRT2478575	hsa-miR-21	CLIP-seq
MIRT2478576	hsa-miR-211	CLIP-seq
MIRT796688	hsa-miR-2113	CLIP-seq
MIRT796689	hsa-miR-218	CLIP-seq
MIRT796692	hsa-miR-30a	CLIP-seq
MIRT796693	hsa-miR-30b	CLIP-seq
MIRT796694	hsa-miR-30c	CLIP-seq
MIRT796695	hsa-miR-30d	CLIP-seq
MIRT796696	hsa-miR-30e	CLIP-seq
MIRT2478577	hsa-miR-3163	CLIP-seq
MIRT2478578	hsa-miR-3190	CLIP-seq
MIRT2478579	hsa-miR-337-3p	CLIP-seq
MIRT796705	hsa-miR-3607-3p	CLIP-seq
MIRT796706	hsa-miR-3613-3p	CLIP-seq
MIRT796710	hsa-miR-371b-5p	CLIP-seq
MIRT2478580	hsa-miR-4287	CLIP-seq
MIRT796719	hsa-miR-4436b-5p	CLIP-seq
MIRT796722	hsa-miR-4477a	CLIP-seq
MIRT796723	hsa-miR-448	CLIP-seq
MIRT796724	hsa-miR-450b-5p	CLIP-seq
MIRT796729	hsa-miR-4668-3p	CLIP-seq
MIRT2478581	hsa-miR-4685-3p	CLIP-seq
MIRT2478582	hsa-miR-4708-3p	CLIP-seq
MIRT796731	hsa-miR-4720-3p	CLIP-seq
MIRT2478583	hsa-miR-4722-5p	CLIP-seq
MIRT796732	hsa-miR-4736	CLIP-seq
MIRT2478584	hsa-miR-4742-5p	CLIP-seq
MIRT796735	hsa-miR-4763-3p	CLIP-seq
MIRT796737	hsa-miR-4775	CLIP-seq
MIRT2478585	hsa-miR-4796-3p	CLIP-seq
MIRT796739	hsa-miR-4804-3p	CLIP-seq
MIRT796766	hsa-miR-486-5p	CLIP-seq
MIRT2478586	hsa-miR-507	CLIP-seq
MIRT796741	hsa-miR-513b	CLIP-seq
MIRT796749	hsa-miR-548c-3p	CLIP-seq
MIRT796750	hsa-miR-548t	CLIP-seq
MIRT2478587	hsa-miR-557	CLIP-seq
MIRT796751	hsa-miR-570	CLIP-seq
MIRT796752	hsa-miR-590-3p	CLIP-seq
MIRT2478588	hsa-miR-590-5p	CLIP-seq
MIRT796769	hsa-miR-7	CLIP-seq
MIRT2478571	hsa-miR-1205	CLIP-seq
MIRT796678	hsa-miR-1207-5p	CLIP-seq
MIRT2478572	hsa-miR-1286	CLIP-seq
MIRT2478573	hsa-miR-129-5p	CLIP-seq
MIRT796683	hsa-miR-183	CLIP-seq
MIRT2478574	hsa-miR-204	CLIP-seq
MIRT2478575	hsa-miR-21	CLIP-seq
MIRT2478576	hsa-miR-211	CLIP-seq
MIRT796705	hsa-miR-3607-3p	CLIP-seq
MIRT2478580	hsa-miR-4287	CLIP-seq
MIRT796722	hsa-miR-4477a	CLIP-seq
MIRT796724	hsa-miR-450b-5p	CLIP-seq
MIRT2478581	hsa-miR-4685-3p	CLIP-seq
MIRT2478582	hsa-miR-4708-3p	CLIP-seq
MIRT796731	hsa-miR-4720-3p	CLIP-seq
MIRT2478583	hsa-miR-4722-5p	CLIP-seq
MIRT796732	hsa-miR-4736	CLIP-seq
MIRT2478584	hsa-miR-4742-5p	CLIP-seq
MIRT796735	hsa-miR-4763-3p	CLIP-seq
MIRT796739	hsa-miR-4804-3p	CLIP-seq
MIRT796766	hsa-miR-486-5p	CLIP-seq
MIRT2478586	hsa-miR-507	CLIP-seq
MIRT2478587	hsa-miR-557	CLIP-seq
MIRT2478588	hsa-miR-590-5p	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	NAS	9651585, 22865885
GO:0000976	Function	Transcription cis-regulatory region binding	IBA
GO:0003677	Function	DNA binding	IDA	15640446
GO:0003677	Function	DNA binding	IEA
GO:0003690	Function	Double-stranded DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	11283269
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	28554894
GO:0005634	Component	Nucleus	TAS	8414517
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0006325	Process	Chromatin organization	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0017053	Component	Transcription repressor complex	IDA	11283269
GO:0030154	Process	Cell differentiation	IEA
GO:0030336	Process	Negative regulation of cell migration	NAS	22984288
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	NAS	22984288
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	12724404
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048821	Process	Erythrocyte development	IEA
GO:0070822	Component	Sin3-type complex	NAS	28554894
GO:0071514	Process	Genomic imprinting	IEA
GO:0097368	Process	Establishment of Sertoli cell barrier	IEA
GO:1902455	Process	Negative regulation of stem cell population maintenance	NAS	28554894
GO:1902459	Process	Positive regulation of stem cell population maintenance	NAS	28554894

MIM	HGNC	e!Ensembl
180201	9885	ENSG00000032219

P29374

Protein name

AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1)

Protein function

DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Ha

PDB

2LCC , 2MAM , 2YRV , 6BPH , 6L87 , 7SMC , 7V8N

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08169	RBB1NT	170 → 262	RBB1NT (NUC162) domain	Domain
PF01388	ARID	311 → 397	ARID/BRIGHT DNA binding domain	Domain
PF11717	Tudor-knot	574 → 630	RNA binding activity-knot of a chromodomain	Family

Sequence

MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL
RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL
DQLPLTNPEHFGTPVIAKKTNRGRRSSLPVTEDEKEEESSEEEDEDKRRLNDELLGKVVS
VVSATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILNLPES
ELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEE
EVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNID
SGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVKEE
KKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSI
KKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDK
DSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTE
IDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEE
RQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEELSLKDE
LEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTE
EVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS
ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF
EQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCH
EVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVK
SESDITIEVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNS
GLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARS
PARISPHIKDGEKDKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYY
MSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR

Sequence length

1257

Interactions

View interactions

	Reactome
			HDACs deacetylate histones

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Multiple myeloma	Likely pathogenic	rs1594966387	RCV000984133

Show/Hide Unknown Diseases (20)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Conflicting classifications of pathogenicity	rs62621193	RCV005895501
Cervical cancer	Conflicting classifications of pathogenicity	rs62621193	RCV005895505
Clear cell carcinoma of kidney	Conflicting classifications of pathogenicity	rs62621193	RCV005895506
Colon adenocarcinoma	Uncertain significance; Conflicting classifications of pathogenicity	rs141577860, rs62621193	RCV005928919 RCV005895500
Colorectal cancer	Conflicting classifications of pathogenicity	rs62621193	RCV005895508
Familial cancer of breast	Conflicting classifications of pathogenicity	rs62621193	RCV005895499
Gastric cancer	Conflicting classifications of pathogenicity	rs62621193	RCV005895510
Hepatocellular carcinoma	Conflicting classifications of pathogenicity	rs62621193	RCV005895502
Lung cancer	Conflicting classifications of pathogenicity	rs62621193	RCV005895517
Lymphoma	Conflicting classifications of pathogenicity	rs62621193	RCV005895511
Malignant tumor of esophagus	Conflicting classifications of pathogenicity	rs62621193	RCV005895503
Melanoma	Conflicting classifications of pathogenicity	rs62621193	RCV005895516
Nonpapillary renal cell carcinoma	Conflicting classifications of pathogenicity	rs62621193	RCV005895504
Ovarian serous cystadenocarcinoma	Conflicting classifications of pathogenicity	rs62621193	RCV005895512
Sarcoma	Conflicting classifications of pathogenicity	rs62621193	RCV005895509
Thymoma	Conflicting classifications of pathogenicity	rs62621193	RCV005895514
Thyroid cancer, nonmedullary, 1	Conflicting classifications of pathogenicity	rs62621193	RCV005895515
Uterine carcinosarcoma	Conflicting classifications of pathogenicity	rs62621193	RCV005895513
Uterine corpus endometrial carcinoma	Conflicting classifications of pathogenicity	rs62621193	RCV005895518
Uveal melanoma	Conflicting classifications of pathogenicity	rs62621193	RCV005895507

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	10496363, 33592583
Calcinosis Cutis	Associate	31668133
Death	Associate	12824904
Leukemia	Associate	22247551
Neoplasms	Associate	20441585, 22247551, 28486502
Prader Willi Syndrome	Associate	22247551
Pre Eclampsia	Associate	35296332
Stomach Neoplasms	Associate	28486502
Venous Thromboembolism	Associate	31420334

ARID4A (AT-rich interaction domain 4A)