Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5921
Gene name Gene Name - the full gene name approved by the HGNC.	RAS p21 protein activator 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RASA1
Synonyms (NCBI Gene) Gene synonyms aliases	CM-AVM, CMAVM, CMAVM1, GAP, PKWS, RASA, RASGAP, p120, p120GAP, p120RASGAP
Disease Acronyms (UniProt) Disease acronyms from UniProt database	CMAVM1
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q14.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS f

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SNP ID	Visualize variation	Clinical significance	Consequence
rs797044451	CT>-	Pathogenic	Upstream transcript variant, genic upstream transcript variant, coding sequence variant, frameshift variant, 5 prime UTR variant
rs1057518367	G>A	Likely-pathogenic	5 prime UTR variant, intron variant
rs1384480619	AG>-	Pathogenic	Genic upstream transcript variant, frameshift variant, coding sequence variant, upstream transcript variant
rs1554038827	T>-	Pathogenic	Coding sequence variant, frameshift variant, upstream transcript variant, genic upstream transcript variant
rs1580179449	CCCCTTTG>-	Pathogenic	Frameshift variant, upstream transcript variant, coding sequence variant, genic upstream transcript variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT003988	hsa-miR-21-5p	Luciferase reporter assay, Western blot	18372920
MIRT003230	hsa-miR-335-5p	Luciferase reporter assay	20065103
MIRT007010	hsa-miR-132-3p	Immunoblot, Western blot	21868695
MIRT007292	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	23322774
MIRT024963	hsa-miR-214-3p	Microarray;Other	19859982
MIRT050067	hsa-miR-26a-5p	CLASH	23622248
MIRT049006	hsa-miR-92a-3p	CLASH	23622248
MIRT047898	hsa-miR-30c-5p	CLASH	23622248
MIRT053397	hsa-miR-96-5p	Microarray	23807165
MIRT003230	hsa-miR-335-5p	qRT-PCR, Western blot	25520857
MIRT003230	hsa-miR-335-5p	qRT-PCR, Western blot	25520857
MIRT097556	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT097557	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT007292	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	26747707
MIRT007292	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	26747707
MIRT003230	hsa-miR-335-5p	Luciferase reporter assay, qRT-PCR, Western blot	26708214
MIRT003230	hsa-miR-335-5p	Luciferase reporter assay, qRT-PCR, Western blot	26708214
MIRT003988	hsa-miR-21-5p	Luciferase reporter assay, qRT-PCR, Western blot	25663768
MIRT003988	hsa-miR-21-5p	Luciferase reporter assay, Western blot	27876571
MIRT003988	hsa-miR-21-5p	Luciferase reporter assay, Western blot	27876571
MIRT007292	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	26657862
MIRT007292	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	26657862
MIRT007292	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	26657862
MIRT003230	hsa-miR-335-5p	Luciferase reporter assay, qRT-PCR, RNA-seq, Western blotting	33767913
MIRT735662	hsa-miR-582-3p	Immunohistochemistry (IHC)	33510968
MIRT756157	hsa-miR-376a-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunoprecipitaion (IP)	36747515
MIRT1291737	hsa-miR-101	CLIP-seq
MIRT1291738	hsa-miR-103b	CLIP-seq
MIRT1291739	hsa-miR-105	CLIP-seq
MIRT1291740	hsa-miR-1179	CLIP-seq
MIRT1291741	hsa-miR-1231	CLIP-seq
MIRT1291742	hsa-miR-1244	CLIP-seq
MIRT1291743	hsa-miR-1257	CLIP-seq
MIRT1291744	hsa-miR-1261	CLIP-seq
MIRT1291745	hsa-miR-1279	CLIP-seq
MIRT1291746	hsa-miR-1290	CLIP-seq
MIRT1291747	hsa-miR-130a	CLIP-seq
MIRT1291748	hsa-miR-130b	CLIP-seq
MIRT1291749	hsa-miR-132	CLIP-seq
MIRT1291750	hsa-miR-144	CLIP-seq
MIRT1291751	hsa-miR-153	CLIP-seq
MIRT1291752	hsa-miR-188-5p	CLIP-seq
MIRT1291753	hsa-miR-19a	CLIP-seq
MIRT1291754	hsa-miR-19b	CLIP-seq
MIRT1291755	hsa-miR-2053	CLIP-seq
MIRT1291756	hsa-miR-21	CLIP-seq
MIRT1291757	hsa-miR-2113	CLIP-seq
MIRT1291758	hsa-miR-212	CLIP-seq
MIRT1291759	hsa-miR-2276	CLIP-seq
MIRT1291760	hsa-miR-24	CLIP-seq
MIRT1291761	hsa-miR-2682	CLIP-seq
MIRT1291762	hsa-miR-301a	CLIP-seq
MIRT1291763	hsa-miR-301b	CLIP-seq
MIRT1291764	hsa-miR-30a	CLIP-seq
MIRT1291765	hsa-miR-30b	CLIP-seq
MIRT1291766	hsa-miR-30c	CLIP-seq
MIRT1291767	hsa-miR-30d	CLIP-seq
MIRT1291768	hsa-miR-30e	CLIP-seq
MIRT1291769	hsa-miR-3134	CLIP-seq
MIRT1291770	hsa-miR-3167	CLIP-seq
MIRT1291771	hsa-miR-3190	CLIP-seq
MIRT1291772	hsa-miR-320a	CLIP-seq
MIRT1291773	hsa-miR-320b	CLIP-seq
MIRT1291774	hsa-miR-320c	CLIP-seq
MIRT1291775	hsa-miR-320d	CLIP-seq
MIRT1291776	hsa-miR-323-5p	CLIP-seq
MIRT1291777	hsa-miR-323b-5p	CLIP-seq
MIRT1291778	hsa-miR-330-3p	CLIP-seq
MIRT1291779	hsa-miR-342-3p	CLIP-seq
MIRT1291780	hsa-miR-346	CLIP-seq
MIRT1291781	hsa-miR-3611	CLIP-seq
MIRT1291782	hsa-miR-3647-3p	CLIP-seq
MIRT1291783	hsa-miR-3666	CLIP-seq
MIRT1291784	hsa-miR-377	CLIP-seq
MIRT1291785	hsa-miR-3936	CLIP-seq
MIRT1291786	hsa-miR-3942-5p	CLIP-seq
MIRT1291787	hsa-miR-4257	CLIP-seq
MIRT1291788	hsa-miR-4288	CLIP-seq
MIRT1291789	hsa-miR-4295	CLIP-seq
MIRT1291790	hsa-miR-4307	CLIP-seq
MIRT1291791	hsa-miR-4422	CLIP-seq
MIRT1291792	hsa-miR-4423-3p	CLIP-seq
MIRT1291793	hsa-miR-4426	CLIP-seq
MIRT1291794	hsa-miR-4429	CLIP-seq
MIRT1291795	hsa-miR-4452	CLIP-seq
MIRT1291796	hsa-miR-448	CLIP-seq
MIRT1291797	hsa-miR-4491	CLIP-seq
MIRT1291798	hsa-miR-449c	CLIP-seq
MIRT1291799	hsa-miR-4502	CLIP-seq
MIRT1291800	hsa-miR-4511	CLIP-seq
MIRT1291801	hsa-miR-451b	CLIP-seq
MIRT1291802	hsa-miR-4527	CLIP-seq
MIRT1291803	hsa-miR-454	CLIP-seq
MIRT1291804	hsa-miR-4647	CLIP-seq
MIRT1291805	hsa-miR-4657	CLIP-seq
MIRT1291806	hsa-miR-4662b	CLIP-seq
MIRT1291807	hsa-miR-4671-3p	CLIP-seq
MIRT1291808	hsa-miR-4699-3p	CLIP-seq
MIRT1291809	hsa-miR-4703-5p	CLIP-seq
MIRT1291810	hsa-miR-4716-5p	CLIP-seq
MIRT1291811	hsa-miR-4719	CLIP-seq
MIRT1291812	hsa-miR-4720-5p	CLIP-seq
MIRT1291813	hsa-miR-4724-5p	CLIP-seq
MIRT1291814	hsa-miR-4772-3p	CLIP-seq
MIRT1291815	hsa-miR-4773	CLIP-seq
MIRT1291816	hsa-miR-4780	CLIP-seq
MIRT1291817	hsa-miR-4799-3p	CLIP-seq
MIRT1291818	hsa-miR-488	CLIP-seq
MIRT1291819	hsa-miR-495	CLIP-seq
MIRT1291820	hsa-miR-496	CLIP-seq
MIRT1291821	hsa-miR-499-3p	CLIP-seq
MIRT1291822	hsa-miR-499a-3p	CLIP-seq
MIRT1291823	hsa-miR-522	CLIP-seq
MIRT1291824	hsa-miR-539	CLIP-seq
MIRT1291825	hsa-miR-548b-3p	CLIP-seq
MIRT1291826	hsa-miR-567	CLIP-seq
MIRT1291827	hsa-miR-582-5p	CLIP-seq
MIRT1291828	hsa-miR-590-5p	CLIP-seq
MIRT1291829	hsa-miR-622	CLIP-seq
MIRT1291830	hsa-miR-623	CLIP-seq
MIRT1291831	hsa-miR-624	CLIP-seq
MIRT1291832	hsa-miR-632	CLIP-seq
MIRT1291833	hsa-miR-758	CLIP-seq
MIRT1291834	hsa-miR-873	CLIP-seq
MIRT1291835	hsa-miR-876-5p	CLIP-seq
MIRT1291836	hsa-miR-940	CLIP-seq
MIRT1291737	hsa-miR-101	CLIP-seq
MIRT1291739	hsa-miR-105	CLIP-seq
MIRT1291740	hsa-miR-1179	CLIP-seq
MIRT1291837	hsa-miR-1226	CLIP-seq
MIRT1291742	hsa-miR-1244	CLIP-seq
MIRT1291745	hsa-miR-1279	CLIP-seq
MIRT1291838	hsa-miR-1284	CLIP-seq
MIRT1291746	hsa-miR-1290	CLIP-seq
MIRT1291749	hsa-miR-132	CLIP-seq
MIRT1291750	hsa-miR-144	CLIP-seq
MIRT1291839	hsa-miR-197	CLIP-seq
MIRT1291755	hsa-miR-2053	CLIP-seq
MIRT1291756	hsa-miR-21	CLIP-seq
MIRT1291757	hsa-miR-2113	CLIP-seq
MIRT1291758	hsa-miR-212	CLIP-seq
MIRT1291840	hsa-miR-223	CLIP-seq
MIRT1291759	hsa-miR-2276	CLIP-seq
MIRT1291760	hsa-miR-24	CLIP-seq
MIRT1291770	hsa-miR-3167	CLIP-seq
MIRT1291776	hsa-miR-323-5p	CLIP-seq
MIRT1291841	hsa-miR-3545-3p	CLIP-seq
MIRT1291781	hsa-miR-3611	CLIP-seq
MIRT1291842	hsa-miR-3655	CLIP-seq
MIRT1291843	hsa-miR-376a	CLIP-seq
MIRT1291844	hsa-miR-376b	CLIP-seq
MIRT1291787	hsa-miR-4257	CLIP-seq
MIRT1291845	hsa-miR-432	CLIP-seq
MIRT1291800	hsa-miR-4511	CLIP-seq
MIRT1291846	hsa-miR-4520a-3p	CLIP-seq
MIRT1291847	hsa-miR-4520b-3p	CLIP-seq
MIRT1291802	hsa-miR-4527	CLIP-seq
MIRT1291848	hsa-miR-4530	CLIP-seq
MIRT1291849	hsa-miR-4697-3p	CLIP-seq
MIRT1291810	hsa-miR-4716-5p	CLIP-seq
MIRT1291812	hsa-miR-4720-5p	CLIP-seq
MIRT1291850	hsa-miR-4728-3p	CLIP-seq
MIRT1291851	hsa-miR-4731-3p	CLIP-seq
MIRT1291852	hsa-miR-4733-3p	CLIP-seq
MIRT1291814	hsa-miR-4772-3p	CLIP-seq
MIRT1291815	hsa-miR-4773	CLIP-seq
MIRT1291853	hsa-miR-4781-3p	CLIP-seq
MIRT1291854	hsa-miR-4789-5p	CLIP-seq
MIRT1291817	hsa-miR-4799-3p	CLIP-seq
MIRT1291855	hsa-miR-4801	CLIP-seq
MIRT1291818	hsa-miR-488	CLIP-seq
MIRT1291823	hsa-miR-522	CLIP-seq
MIRT1291825	hsa-miR-548b-3p	CLIP-seq
MIRT1291856	hsa-miR-578	CLIP-seq
MIRT1291827	hsa-miR-582-5p	CLIP-seq
MIRT1291828	hsa-miR-590-5p	CLIP-seq
MIRT1291829	hsa-miR-622	CLIP-seq
MIRT1291831	hsa-miR-624	CLIP-seq
MIRT1291857	hsa-miR-634	CLIP-seq
MIRT1291833	hsa-miR-758	CLIP-seq
MIRT1291834	hsa-miR-873	CLIP-seq
MIRT1291835	hsa-miR-876-5p	CLIP-seq
MIRT1291858	hsa-miR-922	CLIP-seq
MIRT1291808	hsa-miR-4699-3p	CLIP-seq
MIRT1291738	hsa-miR-103b	CLIP-seq
MIRT1291740	hsa-miR-1179	CLIP-seq
MIRT2086812	hsa-miR-1271	CLIP-seq
MIRT1291746	hsa-miR-1290	CLIP-seq
MIRT1291747	hsa-miR-130a	CLIP-seq
MIRT1291748	hsa-miR-130b	CLIP-seq
MIRT1291749	hsa-miR-132	CLIP-seq
MIRT1291753	hsa-miR-19a	CLIP-seq
MIRT1291754	hsa-miR-19b	CLIP-seq
MIRT1291755	hsa-miR-2053	CLIP-seq
MIRT1291757	hsa-miR-2113	CLIP-seq
MIRT1291758	hsa-miR-212	CLIP-seq
MIRT1291760	hsa-miR-24	CLIP-seq
MIRT1291762	hsa-miR-301a	CLIP-seq
MIRT1291763	hsa-miR-301b	CLIP-seq
MIRT1291770	hsa-miR-3167	CLIP-seq
MIRT1291771	hsa-miR-3190	CLIP-seq
MIRT1291776	hsa-miR-323-5p	CLIP-seq
MIRT2086813	hsa-miR-338-3p	CLIP-seq
MIRT1291781	hsa-miR-3611	CLIP-seq
MIRT1291783	hsa-miR-3666	CLIP-seq
MIRT1291787	hsa-miR-4257	CLIP-seq
MIRT1291789	hsa-miR-4295	CLIP-seq
MIRT1291845	hsa-miR-432	CLIP-seq
MIRT1291797	hsa-miR-4491	CLIP-seq
MIRT1291801	hsa-miR-451b	CLIP-seq
MIRT1291802	hsa-miR-4527	CLIP-seq
MIRT1291848	hsa-miR-4530	CLIP-seq
MIRT1291803	hsa-miR-454	CLIP-seq
MIRT1291805	hsa-miR-4657	CLIP-seq
MIRT1291807	hsa-miR-4671-3p	CLIP-seq
MIRT1291810	hsa-miR-4716-5p	CLIP-seq
MIRT1291818	hsa-miR-488	CLIP-seq
MIRT1291820	hsa-miR-496	CLIP-seq
MIRT1291824	hsa-miR-539	CLIP-seq
MIRT2086814	hsa-miR-548g	CLIP-seq
MIRT1291833	hsa-miR-758	CLIP-seq
MIRT1291835	hsa-miR-876-5p	CLIP-seq
MIRT1291858	hsa-miR-922	CLIP-seq
MIRT2086815	hsa-miR-96	CLIP-seq
MIRT1291808	hsa-miR-4699-3p	CLIP-seq
MIRT1291739	hsa-miR-105	CLIP-seq
MIRT1291740	hsa-miR-1179	CLIP-seq
MIRT2086812	hsa-miR-1271	CLIP-seq
MIRT1291745	hsa-miR-1279	CLIP-seq
MIRT2311697	hsa-miR-1305	CLIP-seq
MIRT1291749	hsa-miR-132	CLIP-seq
MIRT2311698	hsa-miR-182	CLIP-seq
MIRT1291755	hsa-miR-2053	CLIP-seq
MIRT1291758	hsa-miR-212	CLIP-seq
MIRT1291760	hsa-miR-24	CLIP-seq
MIRT2311699	hsa-miR-3065-5p	CLIP-seq
MIRT1291771	hsa-miR-3190	CLIP-seq
MIRT1291776	hsa-miR-323-5p	CLIP-seq
MIRT2086813	hsa-miR-338-3p	CLIP-seq
MIRT1291781	hsa-miR-3611	CLIP-seq
MIRT2311700	hsa-miR-374a	CLIP-seq
MIRT2311701	hsa-miR-374b	CLIP-seq
MIRT2311702	hsa-miR-421	CLIP-seq
MIRT1291787	hsa-miR-4257	CLIP-seq
MIRT1291790	hsa-miR-4307	CLIP-seq
MIRT1291795	hsa-miR-4452	CLIP-seq
MIRT1291797	hsa-miR-4491	CLIP-seq
MIRT1291801	hsa-miR-451b	CLIP-seq
MIRT1291802	hsa-miR-4527	CLIP-seq
MIRT1291848	hsa-miR-4530	CLIP-seq
MIRT1291805	hsa-miR-4657	CLIP-seq
MIRT2311703	hsa-miR-4680-3p	CLIP-seq
MIRT1291808	hsa-miR-4699-3p	CLIP-seq
MIRT2311704	hsa-miR-4709-5p	CLIP-seq
MIRT1291813	hsa-miR-4724-5p	CLIP-seq
MIRT1291818	hsa-miR-488	CLIP-seq
MIRT2311705	hsa-miR-514	CLIP-seq
MIRT2311706	hsa-miR-514b-3p	CLIP-seq
MIRT1291823	hsa-miR-522	CLIP-seq
MIRT1291826	hsa-miR-567	CLIP-seq
MIRT1291833	hsa-miR-758	CLIP-seq
MIRT2086815	hsa-miR-96	CLIP-seq
MIRT1291738	hsa-miR-103b	CLIP-seq
MIRT1291740	hsa-miR-1179	CLIP-seq
MIRT1291747	hsa-miR-130a	CLIP-seq
MIRT1291748	hsa-miR-130b	CLIP-seq
MIRT1291749	hsa-miR-132	CLIP-seq
MIRT1291753	hsa-miR-19a	CLIP-seq
MIRT1291754	hsa-miR-19b	CLIP-seq
MIRT1291758	hsa-miR-212	CLIP-seq
MIRT1291840	hsa-miR-223	CLIP-seq
MIRT1291762	hsa-miR-301a	CLIP-seq
MIRT1291763	hsa-miR-301b	CLIP-seq
MIRT1291771	hsa-miR-3190	CLIP-seq
MIRT1291842	hsa-miR-3655	CLIP-seq
MIRT1291783	hsa-miR-3666	CLIP-seq
MIRT1291789	hsa-miR-4295	CLIP-seq
MIRT1291797	hsa-miR-4491	CLIP-seq
MIRT1291848	hsa-miR-4530	CLIP-seq
MIRT1291803	hsa-miR-454	CLIP-seq
MIRT1291805	hsa-miR-4657	CLIP-seq
MIRT1291807	hsa-miR-4671-3p	CLIP-seq
MIRT1291849	hsa-miR-4697-3p	CLIP-seq
MIRT1291810	hsa-miR-4716-5p	CLIP-seq
MIRT1291856	hsa-miR-578	CLIP-seq
MIRT2457760	hsa-miR-1	CLIP-seq
MIRT2086812	hsa-miR-1271	CLIP-seq
MIRT2457761	hsa-miR-129-5p	CLIP-seq
MIRT2311698	hsa-miR-182	CLIP-seq
MIRT2457762	hsa-miR-206	CLIP-seq
MIRT2457763	hsa-miR-31	CLIP-seq
MIRT2457764	hsa-miR-3148	CLIP-seq
MIRT1291771	hsa-miR-3190	CLIP-seq
MIRT2457765	hsa-miR-335	CLIP-seq
MIRT2457766	hsa-miR-3673	CLIP-seq
MIRT1291784	hsa-miR-377	CLIP-seq
MIRT2457767	hsa-miR-4428	CLIP-seq
MIRT1291797	hsa-miR-4491	CLIP-seq
MIRT1291805	hsa-miR-4657	CLIP-seq
MIRT1291821	hsa-miR-499-3p	CLIP-seq
MIRT1291822	hsa-miR-499a-3p	CLIP-seq
MIRT2457768	hsa-miR-548t	CLIP-seq
MIRT2457769	hsa-miR-595	CLIP-seq
MIRT2457770	hsa-miR-613	CLIP-seq
MIRT2457771	hsa-miR-648	CLIP-seq
MIRT2086815	hsa-miR-96	CLIP-seq
MIRT2457760	hsa-miR-1	CLIP-seq
MIRT1291737	hsa-miR-101	CLIP-seq
MIRT1291739	hsa-miR-105	CLIP-seq
MIRT1291742	hsa-miR-1244	CLIP-seq
MIRT2086812	hsa-miR-1271	CLIP-seq
MIRT1291745	hsa-miR-1279	CLIP-seq
MIRT2457761	hsa-miR-129-5p	CLIP-seq
MIRT2608154	hsa-miR-1299	CLIP-seq
MIRT2311697	hsa-miR-1305	CLIP-seq
MIRT1291749	hsa-miR-132	CLIP-seq
MIRT1291750	hsa-miR-144	CLIP-seq
MIRT2311698	hsa-miR-182	CLIP-seq
MIRT2457762	hsa-miR-206	CLIP-seq
MIRT1291758	hsa-miR-212	CLIP-seq
MIRT2311699	hsa-miR-3065-5p	CLIP-seq
MIRT2457763	hsa-miR-31	CLIP-seq
MIRT2457764	hsa-miR-3148	CLIP-seq
MIRT1291771	hsa-miR-3190	CLIP-seq
MIRT1291772	hsa-miR-320a	CLIP-seq
MIRT1291773	hsa-miR-320b	CLIP-seq
MIRT1291774	hsa-miR-320c	CLIP-seq
MIRT1291775	hsa-miR-320d	CLIP-seq
MIRT2457765	hsa-miR-335	CLIP-seq
MIRT2086813	hsa-miR-338-3p	CLIP-seq
MIRT2608155	hsa-miR-3607-3p	CLIP-seq
MIRT2457766	hsa-miR-3673	CLIP-seq
MIRT1291784	hsa-miR-377	CLIP-seq
MIRT1291786	hsa-miR-3942-5p	CLIP-seq
MIRT2311702	hsa-miR-421	CLIP-seq
MIRT2608156	hsa-miR-4261	CLIP-seq
MIRT1291790	hsa-miR-4307	CLIP-seq
MIRT2457767	hsa-miR-4428	CLIP-seq
MIRT1291794	hsa-miR-4429	CLIP-seq
MIRT1291797	hsa-miR-4491	CLIP-seq
MIRT1291799	hsa-miR-4502	CLIP-seq
MIRT1291801	hsa-miR-451b	CLIP-seq
MIRT1291848	hsa-miR-4530	CLIP-seq
MIRT1291805	hsa-miR-4657	CLIP-seq
MIRT1291809	hsa-miR-4703-5p	CLIP-seq
MIRT2311704	hsa-miR-4709-5p	CLIP-seq
MIRT2608157	hsa-miR-4738-3p	CLIP-seq
MIRT1291821	hsa-miR-499-3p	CLIP-seq
MIRT1291822	hsa-miR-499a-3p	CLIP-seq
MIRT1291823	hsa-miR-522	CLIP-seq
MIRT1291824	hsa-miR-539	CLIP-seq
MIRT2086814	hsa-miR-548g	CLIP-seq
MIRT2457768	hsa-miR-548t	CLIP-seq
MIRT1291826	hsa-miR-567	CLIP-seq
MIRT1291827	hsa-miR-582-5p	CLIP-seq
MIRT2457769	hsa-miR-595	CLIP-seq
MIRT2457770	hsa-miR-613	CLIP-seq
MIRT2457771	hsa-miR-648	CLIP-seq
MIRT1291834	hsa-miR-873	CLIP-seq
MIRT2608158	hsa-miR-875-3p	CLIP-seq
MIRT2086815	hsa-miR-96	CLIP-seq
MIRT2457760	hsa-miR-1	CLIP-seq
MIRT1291739	hsa-miR-105	CLIP-seq
MIRT2086812	hsa-miR-1271	CLIP-seq
MIRT2457761	hsa-miR-129-5p	CLIP-seq
MIRT2311697	hsa-miR-1305	CLIP-seq
MIRT1291749	hsa-miR-132	CLIP-seq
MIRT2311698	hsa-miR-182	CLIP-seq
MIRT2457762	hsa-miR-206	CLIP-seq
MIRT1291758	hsa-miR-212	CLIP-seq
MIRT2311699	hsa-miR-3065-5p	CLIP-seq
MIRT2457763	hsa-miR-31	CLIP-seq
MIRT2457764	hsa-miR-3148	CLIP-seq
MIRT1291771	hsa-miR-3190	CLIP-seq
MIRT1291772	hsa-miR-320a	CLIP-seq
MIRT1291773	hsa-miR-320b	CLIP-seq
MIRT1291774	hsa-miR-320c	CLIP-seq
MIRT1291775	hsa-miR-320d	CLIP-seq
MIRT2457765	hsa-miR-335	CLIP-seq
MIRT2457766	hsa-miR-3673	CLIP-seq
MIRT1291784	hsa-miR-377	CLIP-seq
MIRT2311702	hsa-miR-421	CLIP-seq
MIRT1291790	hsa-miR-4307	CLIP-seq
MIRT2457767	hsa-miR-4428	CLIP-seq
MIRT1291794	hsa-miR-4429	CLIP-seq
MIRT1291797	hsa-miR-4491	CLIP-seq
MIRT1291805	hsa-miR-4657	CLIP-seq
MIRT1291821	hsa-miR-499-3p	CLIP-seq
MIRT1291822	hsa-miR-499a-3p	CLIP-seq
MIRT1291823	hsa-miR-522	CLIP-seq
MIRT2457768	hsa-miR-548t	CLIP-seq
MIRT1291826	hsa-miR-567	CLIP-seq
MIRT2457769	hsa-miR-595	CLIP-seq
MIRT2457770	hsa-miR-613	CLIP-seq
MIRT2457771	hsa-miR-648	CLIP-seq
MIRT2086815	hsa-miR-96	CLIP-seq
MIRT1291801	hsa-miR-451b	CLIP-seq

Show/Hide all(27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS
GO:0000281	Process	Mitotic cytokinesis	ISS
GO:0001570	Process	Vasculogenesis	ISS
GO:0001726	Component	Ruffle	IEA
GO:0001784	Function	Phosphotyrosine residue binding	IPI	20624904
GO:0001953	Process	Negative regulation of cell-matrix adhesion	IDA	8344248
GO:0003924	Function	GTPase activity	TAS
GO:0005096	Function	GTPase activator activity	EXP	7478585
GO:0005102	Function	Signaling receptor binding	IPI	2157284, 2176151
GO:0005515	Function	Protein binding	IPI	1314164, 1375321, 1689011, 8382774, 8618896, 8649363, 9219684, 15077193, 15504032, 15574420, 16273093, 18761085, 19151751, 20598684, 20808760, 21664272, 24412244, 24728074, 28086240, 30578106, 32296183, 32814053
GO:0005737	Component	Cytoplasm	NAS	2821624
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0007162	Process	Negative regulation of cell adhesion	IDA	8344248
GO:0007165	Process	Signal transduction	IDA	1756860
GO:0008360	Process	Regulation of cell shape	NAS	9113414
GO:0019870	Function	Potassium channel inhibitor activity	NAS	1553544
GO:0030833	Process	Regulation of actin filament polymerization	IDA	8344248
GO:0035556	Process	Intracellular signal transduction	NAS	1581965
GO:0043066	Process	Negative regulation of apoptotic process	IDA	15542850
GO:0043524	Process	Negative regulation of neuron apoptotic process	ISS
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0046580	Process	Negative regulation of Ras protein signal transduction	IEA
GO:0048013	Process	Ephrin receptor signaling pathway	TAS
GO:0048514	Process	Blood vessel morphogenesis	IMP	23687085
GO:0051020	Function	GTPase binding	IPI	2122974
GO:0051252	Process	Regulation of RNA metabolic process	NAS	9113414

MIM	HGNC	e!Ensembl
139150	9871	ENSG00000145715

Protein

UniProt ID

P20936

Protein name

Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP)

Protein function

Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1.

PDB

1WER , 1WQ1 , 2GQI , 2GSB , 2J05 , 2J06 , 2M51 , 4FSS , 6PXB , 6PXC , 6WAX , 6WAY , 8BOS , 8DGQ , 9BZ4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00017	SH2	181 → 256	SH2 domain	Domain
PF00018	SH3_1	285 → 333	SH3 domain	Domain
PF00017	SH2	351 → 426	SH2 domain	Domain
PF00169	PH	475 → 577	PH domain	Domain
PF00168	C2	594 → 692	C2 domain	Domain
PF00616	RasGAP	836 → 942	GTPase-activator protein for Ras-like GTPase	Family

Tissue specificity

TISSUE SPECIFICITY: In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level). {ECO:0000269|PubMed:8360177}.

Sequence

MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT
LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP
TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY
IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS
FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE
AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG
DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY
LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC
FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI
EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN
KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE
EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM
EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED
VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV
FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI
KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ
HVLKKLLAITELLQQKQNQYTKTNDVR

Sequence length

1047

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway Ras signaling pathway Axon guidance		Downstream signal transduction EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

Show/Hide Causal Diseases (11)

Disease term	Disease name	dbSNP ID	References
Causal
Capillary malformation-arteriovenous malformation	CAPILLARY MALFORMATION-ARTERIOVENOUS MALFORMATION (disorder), CAPILLARY MALFORMATION-ARTERIOVENOUS MALFORMATION 1, Capillary malformation-arteriovenous malformation	rs797044451, rs137853217, rs137853218, rs1348578241, rs1580386963, rs878854569, rs1060503441, rs1060503439, rs1554049394, rs1554050230, rs1554050584, rs1384480619, rs1554045819, rs983011713, rs1204340475 View all (14 more)	29120072, 26499346, 23164092, 30635911, 24038909, 14639529, 18446851, 27081547, 22342634
Carcinoma	Carcinoma, Basal cell carcinoma, Squamous cell carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma, Carcinoma, Basal Cell	rs121912654, rs555607708, rs786202962, rs1564055259	12606953, 27158780
Carcinoma, somatic	BASAL CELL CARCINOMA, SOMATIC	rs587776628, rs121918347, rs121918348, rs587776689, rs137853214, rs137853215, rs137853216
Cardiofaciocutaneous syndrome	Cardio-facio-cutaneous syndrome	rs121434497, rs121434498, rs121434499, rs267607230, rs121913530, rs104894359, rs104894360, rs104894366, rs104894361, rs104894362, rs121908594, rs121908595, rs121908596, rs121913348, rs180177034 View all (61 more)
Costello syndrome	Costello syndrome (disorder)	rs104894230, rs104894229, rs104894226, rs104894227, rs104894228, rs104894231, rs121917756, rs121917757, rs121917758, rs121917759, rs398122808, rs398122809, rs727503093, rs730880460, rs587777239 View all (4 more)
Glaucoma	Glaucoma	rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328 View all (29 more)
Leopard syndrome	LEOPARD Syndrome	rs28933386, rs121918455, rs121918456, rs121918461, rs121918457, rs121918462, rs121918463, rs121918468, rs121918469, rs121918470, rs267606990, rs80338796, rs80338797, rs180177035, rs387906661 View all (19 more)
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370 View all (5 more)	27158780
Noonan syndrome	Noonan Syndrome	rs121434312, rs267607048, rs121434499, rs113954997, rs104894359, rs104894360, rs104894364, rs104894365, rs104894366, rs104894367, rs193929331, rs28933406, rs104894230, rs104894226, rs104894228 View all (240 more)	26969842
Noonan-like syndrome with loose anagen hair	Noonan-Like Syndrome With Loose Anagen Hair, Noonan syndrome-like disorder with loose anagen hair	rs267607048, rs730881020, rs886037952, rs886037954, rs886037955, rs1114167429, rs1553311527
Prostate cancer	Prostate carcinoma	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	25939597

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Source
Unknown
Congestive heart failure	Congestive heart failure	ClinVar
Capillary Malformation-Arteriovenous Malformation	capillary malformation-arteriovenous malformation syndrome	GenCC
Noonan Syndrome	Noonan syndrome	GenCC
Diabetes	Diabetes	GWAS

Show/Hide Text Mining Associations (59)

Disease Name	Relationship Type	References
Associations from Text Mining
Arteriovenous Fistula	Associate	29891884
Arteriovenous Malformations	Associate	29891884
Atrioventricular Block	Associate	24139535
Breast Neoplasms	Associate	24347041, 32635943
Calcinosis Cutis	Associate	24347041
Capillary Malformation Arteriovenous Malformation	Associate	14639529, 18446851, 20007727, 23933248, 29024832, 29110021, 29891884, 30026675, 32635776, 32635943, 36980822, 40526942
Carcinoma Hepatocellular	Inhibit	24443565
Carcinoma Hepatocellular	Associate	26126858
Carcinoma Non Small Cell Lung	Associate	29127119, 29343556, 37390335
Carcinoma Squamous Cell	Associate	25303977, 27158780, 32434476
Colorectal Neoplasms	Associate	24465899
Diabetic Nephropathies	Associate	36585417
Dystonic Disorders	Associate	36002837
Familial cerebral cavernous malformation	Associate	34491620
Fistula	Associate	24139535
Gastro enteropancreatic neuroendocrine tumor	Associate	26684240
Genetic Diseases Inborn	Associate	40526942
Headache	Associate	24139535
Heart Defects Congenital	Associate	36002837
Heart Failure	Associate	36002837
Hemangioma Cavernous	Associate	24139535
Hydrops Fetalis	Associate	35397126
Hypoxia	Associate	26126858
Inflammation	Associate	32434476
Intracranial Arteriovenous Malformations	Associate	14639529, 18446851, 20007727, 28687708
Intracranial Hemorrhages	Associate	34491620
Leukemia	Associate	15284113, 8245773
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	8195713, 8245773
Lung Diseases	Associate	27158780
Lung Neoplasms	Associate	29343556
Lymphatic Metastasis	Associate	27101583
Lymphedema and Cerebral Arteriovenous Anomaly	Associate	20007727
Melanoma	Associate	26502337
Mitochondrial Diseases	Stimulate	17510315
Mouth Diseases	Associate	29024832
Multifocal Choroiditis	Associate	20007727
Myelodysplastic Syndromes	Inhibit	26521017
Nausea	Associate	24139535
Neoplasms	Associate	17510315, 19151751, 24347041, 25008324, 25303977, 26392535, 27137215, 29127119, 30927944, 37995182, 38275291
Neoplasms	Inhibit	19372580, 24443565, 25486365, 26008146, 26502337
Neoplastic Syndromes Hereditary	Associate	29891884
Neurofibromatosis 1	Associate	23082153
No Reflow Phenomenon	Associate	18446851
Pancreatic Neoplasms	Associate	26747707, 27137215
Pentalogy of Cantrell	Associate	36980822
Philadelphia Chromosome	Associate	8195713
Prostate Cancer Hereditary 7	Associate	25939597
Prostatic Neoplasms	Associate	25189356, 25939597
Squamous Cell Carcinoma of Head and Neck	Associate	28435450
Sturge Weber Syndrome	Associate	14639529, 18446851, 22402795, 29891884, 32843429
Telangiectasia Hereditary Hemorrhagic	Associate	28687708
Thyroid Neoplasms	Associate	26008146, 38275291
Triple Negative Breast Neoplasms	Associate	25202123, 34168046
Trophoblastic Neoplasms	Inhibit	7747802
Uterine Cervical Neoplasms	Associate	27101583
Vascular Diseases	Associate	18446851, 25939597, 32843429
Vascular Malformations	Associate	24139535
Vein of Galen aneurysm	Associate	18446851
Vomiting	Associate	24139535

RASA1 (RAS p21 protein activator 1)