Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5908
Gene name Gene Name - the full gene name approved by the HGNC.
RAP1B, member of RAS oncogene family
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RAP1B
Synonyms (NCBI Gene) Gene synonyms aliases
K-REV, RAL1B, THC11
Disease Acronyms (UniProt) Disease acronyms from UniProt database
THC11
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q15
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006853 hsa-miR-518b Luciferase reporter assay 22958893
MIRT006853 hsa-miR-518b Luciferase reporter assay 22958893
MIRT020552 hsa-miR-155-5p Proteomics 18668040
MIRT023540 hsa-miR-1-3p Proteomics 18668040
MIRT028850 hsa-miR-26b-5p Microarray 19088304
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003924 Function GTPase activity IBA 21873635
GO:0003924 Function GTPase activity IDA 18309292
GO:0005515 Function Protein binding IPI 16452984, 18309292, 18660803, 21988832, 22705156, 25416956, 26780829, 32296183, 32814053
GO:0005525 Function GTP binding IBA 21873635
GO:0005525 Function GTP binding IDA 18309292
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
179530 9857 ENSG00000127314
Protein
UniProt ID P61224
Protein name Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B)
Protein function GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of
PDB 3BRW , 3CF6 , 4DXA , 4HDO , 4HDQ , 4M8N , 4MGI , 4MGK , 4MGY , 4MGZ , 4MH0 , 5KHO , 6AXF , 6BA6 , 6KYK , 6OQ3 , 6OQ4 , 6UZK , 7C7I , 7C7J , 8SU8 , 8T09 , 8T7V
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 5 167 Ras family Domain
Sequence
Sequence length 184
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Focal adhesion
Adherens junction
Platelet activation
Leukocyte transendothelial migration
Long-term potentiation
Neurotrophin signaling pathway
Cushing syndrome
Pancreatic secretion
Renal cell carcinoma
Lipid and atherosclerosis
  Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Rap1 signalling
MAP2K and MAPK activation
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates RAP1 and RAC1
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Signaling downstream of RAS mutants
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Congenital diaphragmatic hernia Congenital diaphragmatic hernia rs121908602, rs121908604, rs864309713, rs775394591
Congenital ocular coloboma Congenital ocular coloboma (disorder) rs587778875, rs587777249, rs767611891, rs2091986259, rs2091987023, rs2091988799
Cryptorchidism Cryptorchidism rs121912555, rs104894697, rs104894698, rs398122886
Hearing loss Conductive hearing loss, Sensorineural Hearing Loss (disorder) rs267607135, rs267606855, rs779841884, rs267606854, rs28942097, rs121908073, rs121908076, rs74315289, rs121908144, rs111033313, rs74315437, rs121908348, rs121908349, rs121908350, rs397515359
View all (184 more)
Unknown
Disease term Disease name Evidence References Source
Ptosis Blepharoptosis, Ptosis ClinVar
Glioblastoma Glioblastoma CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 32432747
Breast Neoplasms Associate 26209110
Carcinoma Non Small Cell Lung Associate 17951244
Carcinoma Renal Cell Associate 33759378
Chromosome 12 12p trisomy Stimulate 24829201
Clear cell metastatic renal cell carcinoma Associate 33759378
Colorectal Neoplasms Associate 24942287
Epilepsy rolandic with paroxysmal exercise induced dystonia and writer's cramp Associate 40646440
Esophageal Squamous Cell Carcinoma Associate 22958893
Gilbert Disease Associate 39225097