IL21 (interleukin 21)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
59067
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 21
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL21
Synonyms (NCBI Gene) Gene synonyms aliases
CVID11, IL-21, Za11
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q27
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multi
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT1064517 hsa-miR-3190 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
NFKB1 Unknown 19617351
STAT3 Activation 18209077
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(48)
GO ID Ontology Definition Evidence Reference
GO:0001779 Process Natural killer cell differentiation IEA
GO:0001819 Process Positive regulation of cytokine production IBA
GO:0001819 Process Positive regulation of cytokine production IDA 19322899
GO:0001819 Process Positive regulation of cytokine production IEA
GO:0002314 Process Germinal center B cell differentiation IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
605384 6005 ENSG00000138684
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9HBE4
Protein name Interleukin-21 (IL-21) (Za11)
Protein function Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper
PDB 2OQP , 3TGX , 8ENT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02372 IL15 11 → 149 Interleukin 15 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. {ECO:0000269|PubMed:11081504}.
Sequence
Sequence length 162
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
JAK-STAT signaling pathway
Th17 cell differentiation
Inflammatory bowel disease 		  Interleukin-21 signaling
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Inflammatory Bowel Disease il21-related infantile inflammatory bowel disease rs587777338 N/A
Show/Hide Unknown Diseases (17)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alopecia Areata Alopecia areata N/A N/A GWAS
Asthma Asthma (time to event), Asthma, Asthma (childhood onset), Atopic asthma N/A N/A GWAS
Biliary Cholangitis Primary biliary cholangitis N/A N/A GWAS
Bipolar Disorder Bipolar disorder, Bipolar I disorder N/A N/A GWAS
Show/Hide Text Mining Associations (178)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Habitual Associate 21768062
Abortion Spontaneous Associate 21768062
Abortion Spontaneous Stimulate 36096448
Acrodermatitis Associate 27884624
Adenocarcinoma Associate 35800186
Agammaglobulinemia Associate 33228556
Anti Neutrophil Cytoplasmic Antibody Associated Vasculitis Associate 23799890, 31164680
Antiphospholipid Syndrome Associate 30872365
Aortic Aneurysm Thoracic Associate 30810667
Aortic Valve Calcification of Associate 33173427