Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5901
Gene name Gene Name - the full gene name approved by the HGNC.
RAN, member RAS oncogene family
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RAN
Synonyms (NCBI Gene) Gene synonyms aliases
ARA24, Gsp1, TC4
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q24.33
Summary Summary of gene provided in NCBI Entrez Gene.
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis an
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001196 hsa-miR-29a-3p flow, qRT-PCR, GFP reporter assay 19818597
MIRT021084 hsa-miR-186-5p Sequencing 20371350
MIRT051173 hsa-miR-16-5p CLASH 23622248
MIRT045558 hsa-miR-149-5p CLASH 23622248
MIRT045558 hsa-miR-149-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000054 Process Ribosomal subunit export from nucleus IBA 21873635
GO:0000055 Process Ribosomal large subunit export from nucleus IMP 12773398
GO:0000056 Process Ribosomal small subunit export from nucleus IMP 12773398
GO:0000070 Process Mitotic sister chromatid segregation IMP 29040603
GO:0000278 Process Mitotic cell cycle TAS 8421051
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601179 9846 ENSG00000132341
Protein
UniProt ID P62826
Protein name GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Protein function GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:17209048, PubMed:26272610, PubMed:27306458, PubMed:8276887, PubMed:8636225, PubMed:869
PDB 1I2M , 1IBR , 1K5D , 1K5G , 1QBK , 1RRP , 2MMC , 2MMG , 2N1B , 3CH5 , 3EA5 , 3GJ0 , 3GJ3 , 3GJ4 , 3GJ5 , 3GJ6 , 3GJ7 , 3GJ8 , 3GJX , 3NBY , 3NBZ , 3NC0 , 3NC1 , 3ZJY , 4C0Q , 4GMX , 4GPT , 4HAT , 4HAU , 4HAV , 4HAW , 4HAX , 4HAY , 4HAZ , 4HB0 , 4HB2 , 4HB3 , 4HB4 , 4OL0 , 4WVF , 5CIQ , 5CIT , 5CIW , 5CJ2 , 5CLL , 5CLQ , 5DH9 , 5DHA , 5DHF , 5DI9 , 5DIF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 12 170 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in a variety of tissues. {ECO:0000269|PubMed:2108320}.
Sequence
Sequence length 216
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ribosome biogenesis in eukaryotes
Nucleocytoplasmic transport
Viral life cycle - HIV-1
Human T-cell leukemia virus 1 infection
  Rev-mediated nuclear export of HIV RNA
Regulation of cholesterol biosynthesis by SREBP (SREBF)
NEP/NS2 Interacts with the Cellular Export Machinery
Nuclear import of Rev protein
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
tRNA processing in the nucleus
Postmitotic nuclear pore complex (NPC) reformation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Arthritis Degenerative polyarthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 18784066
Carcinoma Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 16316942, 12376462
Unknown
Disease term Disease name Evidence References Source
Panic Disorder Panic Disorder GWAS
Pemphigus Foliaceus Pemphigus Foliaceus GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenoma Associate 38509667
Alzheimer Disease Inhibit 23308199
Breast Neoplasms Associate 22090358, 23468463, 27716616, 28163220, 29750309, 30560466, 32600395
Bulbo Spinal Atrophy X Linked Associate 10400640
Carcinogenesis Associate 26481147, 29706609
Carcinoma Hepatocellular Associate 27611467, 33411682, 39457014
Carcinoma Non Small Cell Lung Associate 34299277
Carcinoma Ovarian Epithelial Associate 24625450
Carcinoma Squamous Cell Associate 20705629
Colorectal Neoplasms Associate 23311631, 26147304