Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5898
Gene name Gene Name - the full gene name approved by the HGNC.
RAS like proto-oncogene A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RALA
Synonyms (NCBI Gene) Gene synonyms aliases
HINCONS, RAL
Disease Acronyms (UniProt) Disease acronyms from UniProt database
HINCONS
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p14.1
Summary Summary of gene provided in NCBI Entrez Gene.
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-lik
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1554297905 G>A Pathogenic, likely-pathogenic Genic downstream transcript variant, coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006194 hsa-miR-181a-5p Flow, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 22442671
MIRT006194 hsa-miR-181a-5p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 22442671
MIRT006194 hsa-miR-181a-5p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 22442671
MIRT006194 hsa-miR-181a-5p Flow, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 22442671
MIRT006194 hsa-miR-181a-5p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 22442671
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001843 Process Neural tube closure IEA
GO:0003924 Function GTPase activity IBA 21873635
GO:0005515 Function Protein binding IPI 7673236, 10051605, 12839989, 16291724, 17540176, 19306925, 21241894, 24056301, 25241761, 28851898, 31980649
GO:0005525 Function GTP binding IBA 21873635
GO:0005525 Function GTP binding IDA 24056301
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
179550 9839 ENSG00000006451
Protein
UniProt ID P11233
Protein name Ras-related protein Ral-A (EC 3.6.5.2)
Protein function Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct
PDB 1UAD , 1ZC3 , 1ZC4 , 2A78 , 2A9K , 2BOV , 6P0I , 6P0J , 6P0K , 6P0L , 6P0M , 6P0N , 6P0O , 7NQC , 8FJH , 8FJI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 16 177 Ras family Domain
Sequence
Sequence length 206
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ras signaling pathway
Rap1 signaling pathway
Phospholipase D signaling pathway
Salmonella infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
  Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Autism Autistic behavior rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699
View all (8 more)
30500825
Developmental delay Global developmental delay rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291
View all (32 more)
30500825
Mental retardation Moderate intellectual disability, Intellectual Disability rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315
View all (1024 more)
30500825
Unknown
Disease term Disease name Evidence References Source
Neurodevelopmental Disorders complex neurodevelopmental disorder GenCC
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 32614981
Breast Neoplasms Associate 19609003, 36229838
Carcinogenesis Associate 26152517, 33122623
Carcinoma Hepatocellular Associate 17717605, 19683863, 19822090, 34767674, 36466919
Carcinoma Non Small Cell Lung Associate 22247021
Carcinoma Pancreatic Ductal Associate 20801877, 22331470, 24222664
Carcinoma Renal Cell Associate 22580611
Carcinoma Squamous Cell Associate 21159665
Carcinoma Squamous Cell Inhibit 22586063
Carcinosarcoma Associate 34745385