Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5892
Gene name Gene Name - the full gene name approved by the HGNC.	RAD51 paralog D
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RAD51D
Synonyms (NCBI Gene) Gene synonyms aliases	BROVCA4, R51H3, RAD51L3, TRAD
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q12
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This

Show/Hide all(126)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029789	hsa-miR-26b-5p	Microarray	19088304
MIRT043149	hsa-miR-324-5p	CLASH	23622248
MIRT040122	hsa-miR-615-3p	CLASH	23622248
MIRT483766	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT483765	hsa-miR-520f-3p	PAR-CLIP	23592263
MIRT483764	hsa-miR-509-3p	PAR-CLIP	23592263
MIRT483763	hsa-miR-636	PAR-CLIP	23592263
MIRT483762	hsa-miR-5587-5p	PAR-CLIP	23592263
MIRT483761	hsa-miR-550b-2-5p	PAR-CLIP	23592263
MIRT483766	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT483765	hsa-miR-520f-3p	PAR-CLIP	23592263
MIRT483764	hsa-miR-509-3p	PAR-CLIP	23592263
MIRT483763	hsa-miR-636	PAR-CLIP	23592263
MIRT483762	hsa-miR-5587-5p	PAR-CLIP	23592263
MIRT483761	hsa-miR-550b-2-5p	PAR-CLIP	23592263
MIRT1288157	hsa-miR-1207-3p	CLIP-seq
MIRT1288158	hsa-miR-1207-5p	CLIP-seq
MIRT1288159	hsa-miR-1226	CLIP-seq
MIRT1288160	hsa-miR-1825	CLIP-seq
MIRT1288161	hsa-miR-2115	CLIP-seq
MIRT1288162	hsa-miR-214	CLIP-seq
MIRT1288163	hsa-miR-25	CLIP-seq
MIRT1288164	hsa-miR-28-3p	CLIP-seq
MIRT1288165	hsa-miR-30a	CLIP-seq
MIRT1288166	hsa-miR-30b	CLIP-seq
MIRT1288167	hsa-miR-30c	CLIP-seq
MIRT1288168	hsa-miR-30d	CLIP-seq
MIRT1288169	hsa-miR-30e	CLIP-seq
MIRT1288170	hsa-miR-3188	CLIP-seq
MIRT1288171	hsa-miR-32	CLIP-seq
MIRT1288172	hsa-miR-339-5p	CLIP-seq
MIRT1288173	hsa-miR-34a	CLIP-seq
MIRT1288174	hsa-miR-34c-5p	CLIP-seq
MIRT1288175	hsa-miR-3619-5p	CLIP-seq
MIRT1288176	hsa-miR-363	CLIP-seq
MIRT1288177	hsa-miR-3658	CLIP-seq
MIRT1288178	hsa-miR-367	CLIP-seq
MIRT1288179	hsa-miR-3689a-3p	CLIP-seq
MIRT1288180	hsa-miR-3689c	CLIP-seq
MIRT1288181	hsa-miR-3908	CLIP-seq
MIRT1288182	hsa-miR-3914	CLIP-seq
MIRT1288183	hsa-miR-4259	CLIP-seq
MIRT1288184	hsa-miR-4316	CLIP-seq
MIRT1288185	hsa-miR-432	CLIP-seq
MIRT1288186	hsa-miR-4425	CLIP-seq
MIRT1288187	hsa-miR-4436b-3p	CLIP-seq
MIRT1288188	hsa-miR-449a	CLIP-seq
MIRT1288189	hsa-miR-449b	CLIP-seq
MIRT1288190	hsa-miR-4536	CLIP-seq
MIRT1288191	hsa-miR-4646-5p	CLIP-seq
MIRT1288192	hsa-miR-4659a-5p	CLIP-seq
MIRT1288193	hsa-miR-4659b-5p	CLIP-seq
MIRT1288194	hsa-miR-4661-5p	CLIP-seq
MIRT1288195	hsa-miR-4690-5p	CLIP-seq
MIRT1288196	hsa-miR-4693-3p	CLIP-seq
MIRT1288197	hsa-miR-4728-5p	CLIP-seq
MIRT1288198	hsa-miR-4733-3p	CLIP-seq
MIRT1288199	hsa-miR-4736	CLIP-seq
MIRT1288200	hsa-miR-4747-5p	CLIP-seq
MIRT1288201	hsa-miR-4755-3p	CLIP-seq
MIRT1288202	hsa-miR-4759	CLIP-seq
MIRT1288203	hsa-miR-4761-3p	CLIP-seq
MIRT1288204	hsa-miR-4763-3p	CLIP-seq
MIRT1288205	hsa-miR-4776-3p	CLIP-seq
MIRT1288206	hsa-miR-4795-3p	CLIP-seq
MIRT1288207	hsa-miR-516a-3p	CLIP-seq
MIRT1288208	hsa-miR-544	CLIP-seq
MIRT1288209	hsa-miR-548p	CLIP-seq
MIRT1288210	hsa-miR-615-5p	CLIP-seq
MIRT1288211	hsa-miR-634	CLIP-seq
MIRT1288212	hsa-miR-670	CLIP-seq
MIRT1288213	hsa-miR-761	CLIP-seq
MIRT1288214	hsa-miR-877	CLIP-seq
MIRT1288215	hsa-miR-92a	CLIP-seq
MIRT1288216	hsa-miR-92b	CLIP-seq
MIRT1288217	hsa-miR-944	CLIP-seq
MIRT1288157	hsa-miR-1207-3p	CLIP-seq
MIRT2085311	hsa-miR-149	CLIP-seq
MIRT1288164	hsa-miR-28-3p	CLIP-seq
MIRT2085312	hsa-miR-4318	CLIP-seq
MIRT2085313	hsa-miR-4446-5p	CLIP-seq
MIRT2085314	hsa-miR-4693-5p	CLIP-seq
MIRT2085315	hsa-miR-4699-3p	CLIP-seq
MIRT1288202	hsa-miR-4759	CLIP-seq
MIRT1288208	hsa-miR-544	CLIP-seq
MIRT2085316	hsa-miR-545	CLIP-seq
MIRT2085317	hsa-miR-760	CLIP-seq
MIRT2085318	hsa-miR-892a	CLIP-seq
MIRT2310751	hsa-miR-1252	CLIP-seq
MIRT1288162	hsa-miR-214	CLIP-seq
MIRT1288165	hsa-miR-30a	CLIP-seq
MIRT1288166	hsa-miR-30b	CLIP-seq
MIRT1288167	hsa-miR-30c	CLIP-seq
MIRT1288168	hsa-miR-30d	CLIP-seq
MIRT1288169	hsa-miR-30e	CLIP-seq
MIRT2310752	hsa-miR-3115	CLIP-seq
MIRT2310753	hsa-miR-3120-5p	CLIP-seq
MIRT1288173	hsa-miR-34a	CLIP-seq
MIRT1288174	hsa-miR-34c-5p	CLIP-seq
MIRT1288175	hsa-miR-3619-5p	CLIP-seq
MIRT2310754	hsa-miR-3692	CLIP-seq
MIRT2310755	hsa-miR-3714	CLIP-seq
MIRT2310756	hsa-miR-3936	CLIP-seq
MIRT2310757	hsa-miR-4279	CLIP-seq
MIRT2310758	hsa-miR-4496	CLIP-seq
MIRT1288188	hsa-miR-449a	CLIP-seq
MIRT1288189	hsa-miR-449b	CLIP-seq
MIRT1288195	hsa-miR-4690-5p	CLIP-seq
MIRT2310759	hsa-miR-548an	CLIP-seq
MIRT2085317	hsa-miR-760	CLIP-seq
MIRT1288213	hsa-miR-761	CLIP-seq
MIRT2457694	hsa-miR-4481	CLIP-seq
MIRT2457695	hsa-miR-4521	CLIP-seq
MIRT2457696	hsa-miR-4745-5p	CLIP-seq
MIRT2457697	hsa-miR-610	CLIP-seq
MIRT2457694	hsa-miR-4481	CLIP-seq
MIRT2457695	hsa-miR-4521	CLIP-seq
MIRT2457696	hsa-miR-4745-5p	CLIP-seq
MIRT2457697	hsa-miR-610	CLIP-seq
MIRT2607137	hsa-miR-3919	CLIP-seq
MIRT2607138	hsa-miR-4708-5p	CLIP-seq
MIRT2607139	hsa-miR-4756-3p	CLIP-seq
MIRT2689280	hsa-miR-3125	CLIP-seq
MIRT2689281	hsa-miR-3173-3p	CLIP-seq
MIRT2689282	hsa-miR-3916	CLIP-seq
MIRT2689283	hsa-miR-548g	CLIP-seq

Show/Hide all(47)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000400	Function	Four-way junction DNA binding	IBA
GO:0000400	Function	Four-way junction DNA binding	IDA	20207730
GO:0000722	Process	Telomere maintenance via recombination	IMP	15109494
GO:0000723	Process	Telomere maintenance	IBA
GO:0000723	Process	Telomere maintenance	IEA
GO:0000723	Process	Telomere maintenance	IMP	15109494
GO:0000724	Process	Double-strand break repair via homologous recombination	IBA
GO:0000724	Process	Double-strand break repair via homologous recombination	IMP	23149936
GO:0000781	Component	Chromosome, telomeric region	IDA	15109494
GO:0000781	Component	Chromosome, telomeric region	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	TAS	9570954
GO:0003697	Function	Single-stranded DNA binding	IBA
GO:0003697	Function	Single-stranded DNA binding	IDA	10871607
GO:0005515	Function	Protein binding	IPI	10749867, 10871607, 11751635, 11842113, 12975363, 16710300, 21516116, 21965664, 24141787, 25416956, 25910212, 28864920, 31515488, 32296183, 33961781, 34591612
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9570954
GO:0005654	Component	Nucleoplasm	TAS
GO:0005657	Component	Replication fork	IBA
GO:0005657	Component	Replication fork	IDA	20207730
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	21276791
GO:0005813	Component	Centrosome	IEA
GO:0005815	Component	Microtubule organizing center	IBA
GO:0005856	Component	Cytoskeleton	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	TAS	9570954
GO:0006310	Process	DNA recombination	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0007131	Process	Reciprocal meiotic recombination	IBA
GO:0007131	Process	Reciprocal meiotic recombination	TAS	9570954
GO:0008094	Function	ATP-dependent activity, acting on DNA	IBA
GO:0008094	Function	ATP-dependent activity, acting on DNA	IDA	10871607
GO:0033063	Component	Rad51B-Rad51C-Rad51D-XRCC2 complex	IBA
GO:0033063	Component	Rad51B-Rad51C-Rad51D-XRCC2 complex	IDA	11751635
GO:0036297	Process	Interstrand cross-link repair	IEA
GO:0042148	Process	DNA strand invasion	IBA
GO:0042148	Process	DNA strand invasion	IDA	11834724
GO:0043015	Function	Gamma-tubulin binding	IDA	21276791
GO:0051276	Process	Chromosome organization	IEA
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0140664	Function	ATP-dependent DNA damage sensor activity	IEA
GO:0140664	Function	ATP-dependent DNA damage sensor activity	IMP	16717288

MIM	HGNC	e!Ensembl
602954	9823	ENSG00000185379

Protein

UniProt ID

O75771

Protein name

DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD)

Protein function

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the

PDB

2KZ3 , 8FAZ , 8GBJ , 8OUY , 8OUZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08423	Rad51	36 → 315	Rad51	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in colon, prostate, spleen, testis, ovary, thymus and small intestine. Weakly expressed in leukocytes.

Sequence

MGVLRVGLCPGLTEEMIQLLRSHRIKTVVDLVSADLEEVAQKCGLSYKALVALRRVLLAQ
FSAFPVNGADLYEELKTSTAILSTGIGSLDKLLDAGLYTGEVTEIVGGPGSGKTQVCLCM
AANVAHGLQQNVLYVDSNGGLTASRLLQLLQAKTQDEEEQAEALRRIQVVHAFDIFQMLD
VLQELRGTVAQQVTGSSGTVKVVVVDSVTAVVSPLLGGQQREGLALMMQLARELKTLARD
LGMAVVVTNHITRDRDSGRLKPALGRSWSFVPSTRILLDTIEGAGASGGRRMACLAKSSR
QPTGFQEMVDIGTWGTSEQSATLQGDQT

Sequence length

328

Interactions

View interactions

	KEGG		Reactome
	Homologous recombination		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes

Show/Hide Causal Diseases (5)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Breast Cancer	Malignant tumor of breast	rs387906843, rs370228071, rs750621215, rs1555567202	N/A
Breast Carcinoma	breast carcinoma	rs137886232	N/A
gastric cancer	Gastric cancer	rs587780104, rs750621215, rs753862052, rs1403784434	N/A
Ovarian Carcinoma	ovarian carcinoma	rs137886232	N/A
colorectal cancer	Colorectal cancer	rs587780104	N/A

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
hereditary cancer	Hereditary cancer	N/A	N/A	ClinVar
Lynch syndrome	Lynch syndrome 1	N/A	N/A	ClinVar

Show/Hide Text Mining Associations (35)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenomatous Polyposis Coli	Associate	39519399
Bloom Syndrome	Associate	12975363
Breast Diseases	Associate	36315097
Breast Neoplasms	Associate	23372765, 25452441, 26534844, 28424414, 30099541, 30165555, 30257646, 31206626, 31575519, 32068069, 32091585, 32107557, 32318955, 32866190, 33471974 View all (19 more)
Carcinogenesis	Associate	38255960
Carcinoma Hepatocellular	Associate	30883040
Carcinoma Ovarian Epithelial	Associate	26261251, 29020732, 30640700
Carcinoma Pancreatic Ductal	Associate	35171259, 37024097
Carcinoma Renal Cell	Associate	33062672
Colorectal Neoplasms	Associate	35567913
Colorectal Neoplasms Hereditary Nonpolyposis	Associate	40282418
Death	Associate	36544182
Drug Related Side Effects and Adverse Reactions	Associate	24485306
Endometrial Neoplasms	Associate	36744932
Fallopian Tube Diseases	Associate	38255960
Fallopian Tube Neoplasms	Associate	33452952
Fanconi Anemia	Associate	22986143, 31584931, 35904444
Graft vs Host Disease	Associate	30640700
Hereditary Breast and Ovarian Cancer Syndrome	Associate	22415235, 22652533, 23300655, 23372765, 26976419, 29255180, 29988077, 30128536, 30306255, 30623411, 32107557, 34299313, 36307613, 36544182, 37237042, 37563628, 40428378 View all (2 more)
Neoplasms	Associate	29020732, 29053726, 29360550, 30165555, 30836272, 31584931, 31682005, 32068069, 32091585, 32107557, 32318955, 33452952, 35904444, 36011273, 36162851 View all (10 more)
Neoplasms	Inhibit	32669601
Neoplasms Cystic Mucinous and Serous	Associate	36544182, 40428378
Neoplastic Syndromes Hereditary	Associate	30099541, 40282418
Ovarian Neoplasms	Associate	22415235, 22652533, 22986143, 23372765, 24240112, 26057125, 26261251, 26718727, 28591191, 28888541, 29255180, 29988077, 31682005, 32107557, 33452952 View all (12 more)
Pancreatic Neoplasms	Associate	37024097
Peritoneal Neoplasms	Associate	36544182
Polycythemia Vera	Associate	33926482, 34793666, 37024097, 40282418
Prostatic Neoplasms	Associate	35666082, 37733366
Recombinant chromosome 8 syndrome	Associate	35643464, 37193789
Small Cell Lung Carcinoma	Associate	33504652
Stomach Neoplasms	Associate	37239438, 39206620, 40282418
T Lymphocytopenia Idiopathic CD4 Positive	Associate	37344587
Triple Negative Breast Neoplasms	Associate	25452441, 33471974, 35084436
Urinary Bladder Neoplasms	Stimulate	40282418
Uterine Cervical Neoplasms	Associate	24485306, 36380687

RAD51D (RAD51 paralog D)