MOK (MOK protein kinase)

Gene
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5891
Gene name Gene Name - the full gene name approved by the HGNC.
MOK protein kinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MOK
Synonyms (NCBI Gene) Gene synonyms aliases
RAGE, RAGE-1, RAGE1, STK30
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q32.31
Summary Summary of gene provided in NCBI Entrez Gene.
This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all(27)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0004672 Function Protein kinase activity IEA
GO:0004672 Function Protein kinase activity TAS 10421840
GO:0004674 Function Protein serine/threonine kinase activity IBA
GO:0004674 Function Protein serine/threonine kinase activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
605762 9833 ENSG00000080823
Protein
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID Q9UQ07
Protein name MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1)
Protein function Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 4 → 285 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.
Sequence
Sequence length 419
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Mucopolysaccharidosis Mucopolysaccharidosis, MPS-III-D N/A N/A ClinVar
Oligodendroglioma Oligodendroglioma N/A N/A GWAS
Show/Hide Text Mining Associations (28)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
AA amyloidosis Associate 38067191
Albuminuria Associate 23593165
Alzheimer Disease Associate 34824300, 38067191
Atrial Fibrillation Associate 35697725
Brain Ischemia Stimulate 38067191
Carcinoma Hepatocellular Associate 28403886
Cholestasis Associate 35196362
Cognitive Dysfunction Associate 23593165
Coronary Artery Disease Associate 30961613, 35801781
Dementia Associate 38067191