MOK (MOK protein kinase)

Gene Gene information from NCBI Gene database.
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID 5891
Gene name MOK protein kinase
Gene symbol MOK
Synonyms (NCBI Gene)
RAGERAGE-1RAGE1STK30
Chromosome 14
Chromosome location 14q32.31
Summary This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all (27)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0004672 Function Protein kinase activity IEA
GO:0004672 Function Protein kinase activity TAS 10421840
GO:0004674 Function Protein serine/threonine kinase activity IBA
GO:0004674 Function Protein serine/threonine kinase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
605762 9833 ENSG00000080823
Protein Protein information from UniProt database.
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UQ07
Protein name MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1)
Protein function Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 4 → 285 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.
Sequence
Sequence length 419
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
6
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (6)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs149850506 RCV005907526
Clear cell carcinoma of kidney Benign rs149850506 RCV005907527
Familial cancer of breast Benign rs149850506 RCV005907525
Lung cancer Benign rs149850506 RCV005907529
Show/Hide Text Mining Associations (28)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
AA amyloidosis Associate 38067191
Albuminuria Associate 23593165
Alzheimer Disease Associate 34824300, 38067191
Atrial Fibrillation Associate 35697725
Brain Ischemia Stimulate 38067191
Carcinoma Hepatocellular Associate 28403886
Cholestasis Associate 35196362
Cognitive Dysfunction Associate 23593165
Coronary Artery Disease Associate 30961613, 35801781
Dementia Associate 38067191