Gene Gene information from NCBI Gene database.
Entrez ID 5890
Gene name RAD51 paralog B
Gene symbol RAD51B
Synonyms (NCBI Gene)
R51H2RAD51L1REC2
Chromosome 14
Chromosome location 14q24.1
Summary The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the fa
SNPs SNP information provided by dbSNP.
2
SNP ID Visualize variation Clinical significance Consequence
rs28908468 C>G Drug-response Intron variant, genic downstream transcript variant, coding sequence variant, missense variant
rs764896402 G>A Likely-pathogenic 5 prime UTR variant, synonymous variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
167
miRTarBase ID miRNA Experiments Reference
MIRT041780 hsa-miR-484 CLASH 23622248
MIRT449236 hsa-miR-4506 PAR-CLIP 22100165
MIRT449234 hsa-miR-4496 PAR-CLIP 22100165
MIRT449233 hsa-miR-6871-5p PAR-CLIP 22100165
MIRT449232 hsa-miR-766-5p PAR-CLIP 22100165
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
GTF3A Unknown 9878257
TP53 Unknown 9878257
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
35
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000400 Function Four-way junction DNA binding IBA
GO:0000400 Function Four-way junction DNA binding IDA 20207730
GO:0000724 Process Double-strand break repair via homologous recombination IBA
GO:0000724 Process Double-strand break repair via homologous recombination IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602948 9822 ENSG00000182185
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O15315
Protein name DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1)
Protein function Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-str
PDB 8FAZ , 8GBJ , 8OUY , 8OUZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08423 Rad51 42 344 Rad51 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in a wide range of tissues.
Sequence
Sequence length 384
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Homologous recombination   HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange
Factors involved in megakaryocyte development and platelet production
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
134
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign; Likely benign; Conflicting classifications of pathogenicity rs34594234, rs148518198 RCV005929918
RCV005901753
Adrenocortical carcinoma, hereditary Benign; Likely benign rs34594234 RCV005929921
Cervical cancer Benign; Likely benign rs34594234, rs34436700 RCV005929922
RCV005893829
Clear cell carcinoma of kidney Benign; Likely benign rs34594234 RCV005929923
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Aneuploidy Stimulate 27651161
Arthritis Rheumatoid Associate 24532676, 28361912, 36835215
Asthma Associate 31095684
Brain Neoplasms Associate 37878192
Breast Neoplasms Associate 19330030, 21593217, 21791674, 21844186, 21852249, 21959381, 22232737, 22313133, 22454379, 23190577, 23593120, 23635555, 24139550, 24325915, 24729084
View all (12 more)
Breast Neoplasms Male Associate 23001122, 27149063
Carcinogenesis Inhibit 12441335
Carcinoma Ovarian Epithelial Associate 24190013, 26261251
Carcinoma Pancreatic Ductal Associate 35737913
Carcinoma Squamous Cell Associate 32098697