RAB5C (RAB5C, member RAS oncogene family)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 5878
Gene name RAB5C, member RAS oncogene family
Gene symbol RAB5C
Synonyms (NCBI Gene)
L1880RAB5CLRAB5LRABL
Chromosome 17
Chromosome location 17q21.2
Summary Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMI
miRNA miRNA information provided by mirtarbase database.
784
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (784)
miRTarBase ID miRNA Experiments Reference
MIRT001510 hsa-miR-155-5p pSILAC 18668040
MIRT016288 hsa-miR-193b-3p Proteomics 21512034
MIRT001510 hsa-miR-155-5p Proteomics;Other 18668040
MIRT048550 hsa-miR-100-5p CLASH 23622248
MIRT046868 hsa-miR-221-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
38
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (38)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IDA 17562788
GO:0003924 Function GTPase activity IEA
GO:0003924 Function GTPase activity TAS 8646882
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604037 9785 ENSG00000108774
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P51148
Protein name Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r
PDB 4KYI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 23 → 184 Ras family Domain
Sequence
Sequence length 216
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Ras signaling pathway
Mitophagy - animal
Endocytosis
Phagosome
Efferocytosis
Vasopressin-regulated water reabsorption
Salmonella infection
Amoebiasis
Tuberculosis 		  Golgi Associated Vesicle Biogenesis
Neutrophil degranulation
TBC/RABGAPs
Clathrin-mediated endocytosis
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
RAB5C-related disorder Uncertain significance rs2144062523 RCV001837736
Show/Hide Text Mining Associations (7)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 40545963
Heart Failure Associate 32602534
Ovarian Neoplasms Associate 25096996
Precursor B Cell Lymphoblastic Leukemia Lymphoma Associate 25368993
Precursor Cell Lymphoblastic Leukemia Lymphoma Associate 25368993
Thyroid Cancer Papillary Associate 32788878
Triple Negative Breast Neoplasms Associate 40545963