Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5878
Gene name Gene Name - the full gene name approved by the HGNC.
RAB5C, member RAS oncogene family
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RAB5C
Synonyms (NCBI Gene) Gene synonyms aliases
L1880, RAB5CL, RAB5L, RABL
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.2
Summary Summary of gene provided in NCBI Entrez Gene.
Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMI
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001510 hsa-miR-155-5p pSILAC 18668040
MIRT016288 hsa-miR-193b-3p Proteomics 21512034
MIRT001510 hsa-miR-155-5p Proteomics;Other 18668040
MIRT048550 hsa-miR-100-5p CLASH 23622248
MIRT046868 hsa-miR-221-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003924 Function GTPase activity IBA 21873635
GO:0003924 Function GTPase activity IDA 17562788
GO:0005515 Function Protein binding IPI 17562788, 21750715, 25416956, 31515488, 32296183
GO:0005525 Function GTP binding IEA
GO:0005765 Component Lysosomal membrane HDA 17897319
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604037 9785 ENSG00000108774
Protein
UniProt ID P51148
Protein name Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r
PDB 4KYI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 23 184 Ras family Domain
Sequence
Sequence length 216
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ras signaling pathway
Mitophagy - animal
Endocytosis
Phagosome
Efferocytosis
Vasopressin-regulated water reabsorption
Salmonella infection
Amoebiasis
Tuberculosis
  Golgi Associated Vesicle Biogenesis
Neutrophil degranulation
TBC/RABGAPs
Clathrin-mediated endocytosis
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Autoimmune diseases Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2 rs869025224 30595370
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Hypothyroidism Hypothyroidism rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912
View all (22 more)
30595370
Unknown
Disease term Disease name Evidence References Source
Vitiligo Vitiligo GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 40545963
Heart Failure Associate 32602534
Ovarian Neoplasms Associate 25096996
Precursor B Cell Lymphoblastic Leukemia Lymphoma Associate 25368993
Precursor Cell Lymphoblastic Leukemia Lymphoma Associate 25368993
Thyroid Cancer Papillary Associate 32788878
Triple Negative Breast Neoplasms Associate 40545963