Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5874
Gene name Gene Name - the full gene name approved by the HGNC.
RAB27B, member RAS oncogene family
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RAB27B
Synonyms (NCBI Gene) Gene synonyms aliases
C25KG
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q21.2
Summary Summary of gene provided in NCBI Entrez Gene.
Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005197 hsa-miR-30a-5p pSILAC 18668040
MIRT001512 hsa-miR-155-5p pSILAC 18668040
MIRT001512 hsa-miR-155-5p Proteomics;Other 18668040
MIRT023764 hsa-miR-1-3p Proteomics 18668040
MIRT005197 hsa-miR-30a-5p Proteomics;Other 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IEA
GO:0003924 Function GTPase activity ISS
GO:0003925 Function G protein activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603869 9767 ENSG00000041353
Protein
UniProt ID O00194
Protein name Ras-related protein Rab-27B (EC 3.6.5.2) (C25KG)
Protein function Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and sec
PDB 2F7S
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 11 183 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed primarily in testis.
Sequence
Sequence length 218
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Pancreatic secretion   Platelet degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Mental Depression Major depressive disorder N/A N/A GWAS
Metabolic Syndrome Metabolic syndrome N/A N/A GWAS
Neuroticism Neuroticism N/A N/A GWAS
Oligodendroglioma Oligodendroglioma N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 30627227, 33021972
Alzheimer Disease Stimulate 31460748
Attention Deficit Disorder with Hyperactivity Associate 19156173
Breast Neoplasms Associate 21304180, 23217148, 33845096
Carcinoma Hepatocellular Associate 22553406
Carcinoma Non Small Cell Lung Associate 30480360, 31173161, 35136028, 37077938
Carcinoma Pancreatic Ductal Associate 26418905
Carcinoma Renal Cell Associate 32379831, 37563650
Carcinoma Squamous Cell Associate 30480360
Central Nervous System Vascular Malformations Associate 39899936