Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	5871
Gene name	Mitogen-activated protein kinase kinase kinase kinase 2
Gene symbol	MAP4K2
Synonyms (NCBI Gene)	BL44GCKRAB8IP
Chromosome	11
Chromosome location	11q13.1
Summary	The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-ce

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024097	hsa-miR-1-3p	Microarray	18668037
MIRT053659	hsa-miR-145-5p	Microarray	22942087
MIRT695548	hsa-miR-483-5p	HITS-CLIP	23313552
MIRT695540	hsa-miR-411-5p	HITS-CLIP	23313552
MIRT695547	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT695546	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT695545	hsa-miR-4732-3p	HITS-CLIP	23313552
MIRT695544	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT695543	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT695542	hsa-miR-6131	HITS-CLIP	23313552
MIRT695541	hsa-miR-193b-5p	HITS-CLIP	23313552
MIRT695540	hsa-miR-411-5p	HITS-CLIP	23313552
MIRT695539	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT695538	hsa-miR-548s	HITS-CLIP	23313552
MIRT695537	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT695536	hsa-miR-588	HITS-CLIP	23313552
MIRT695535	hsa-miR-4435	HITS-CLIP	23313552
MIRT695534	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT695533	hsa-miR-6843-3p	HITS-CLIP	23313552
MIRT695532	hsa-miR-6848-3p	HITS-CLIP	23313552
MIRT695531	hsa-miR-5096	HITS-CLIP	23313552
MIRT695530	hsa-miR-1303	HITS-CLIP	23313552
MIRT667483	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT626555	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT656474	hsa-miR-5693	HITS-CLIP	23824327
MIRT656473	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT656472	hsa-miR-3135b	HITS-CLIP	23824327
MIRT656471	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT656470	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT626555	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT656469	hsa-miR-3652	HITS-CLIP	23824327
MIRT656468	hsa-miR-4430	HITS-CLIP	23824327
MIRT656467	hsa-miR-5698	HITS-CLIP	23824327
MIRT626556	hsa-miR-645	HITS-CLIP	23824327
MIRT626555	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT545190	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT545189	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT545188	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT545187	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT545186	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT545185	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT545184	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT545183	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT545182	hsa-miR-646	PAR-CLIP	20371350
MIRT545181	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT545180	hsa-miR-633	PAR-CLIP	20371350
MIRT545179	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT545178	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT545176	hsa-miR-2054	PAR-CLIP	20371350
MIRT545190	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT545189	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT545188	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT545187	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT545186	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT545185	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT545184	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT545183	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT545182	hsa-miR-646	PAR-CLIP	20371350
MIRT545181	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT545180	hsa-miR-633	PAR-CLIP	20371350
MIRT545179	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT545178	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT545176	hsa-miR-2054	PAR-CLIP	20371350
MIRT545191	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT545190	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT545189	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT545188	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT545187	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT545186	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT545185	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT545184	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT545183	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT545182	hsa-miR-646	PAR-CLIP	21572407
MIRT545181	hsa-miR-5000-5p	PAR-CLIP	21572407
MIRT545180	hsa-miR-633	PAR-CLIP	21572407
MIRT545179	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT545178	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT545176	hsa-miR-2054	PAR-CLIP	21572407
MIRT695548	hsa-miR-483-5p	HITS-CLIP	23313552
MIRT695540	hsa-miR-411-5p	HITS-CLIP	23313552
MIRT695547	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT695546	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT695545	hsa-miR-4732-3p	HITS-CLIP	23313552
MIRT695544	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT695543	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT695542	hsa-miR-6131	HITS-CLIP	23313552
MIRT695541	hsa-miR-193b-5p	HITS-CLIP	23313552
MIRT695540	hsa-miR-411-5p	HITS-CLIP	23313552
MIRT695539	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT695538	hsa-miR-548s	HITS-CLIP	23313552
MIRT695537	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT695536	hsa-miR-588	HITS-CLIP	23313552
MIRT695535	hsa-miR-4435	HITS-CLIP	23313552
MIRT695534	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT695533	hsa-miR-6843-3p	HITS-CLIP	23313552
MIRT695532	hsa-miR-6848-3p	HITS-CLIP	23313552
MIRT695531	hsa-miR-5096	HITS-CLIP	23313552
MIRT695530	hsa-miR-1303	HITS-CLIP	23313552
MIRT667483	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT626555	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT656474	hsa-miR-5693	HITS-CLIP	23824327
MIRT656473	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT656472	hsa-miR-3135b	HITS-CLIP	23824327
MIRT656471	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT656470	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT626555	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT656469	hsa-miR-3652	HITS-CLIP	23824327
MIRT656468	hsa-miR-4430	HITS-CLIP	23824327
MIRT656467	hsa-miR-5698	HITS-CLIP	23824327
MIRT626556	hsa-miR-645	HITS-CLIP	23824327
MIRT626555	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT545190	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT545189	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT545188	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT545187	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT545186	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT545185	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT545184	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT545183	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT545182	hsa-miR-646	PAR-CLIP	20371350
MIRT545181	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT545180	hsa-miR-633	PAR-CLIP	20371350
MIRT545179	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT545178	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT545176	hsa-miR-2054	PAR-CLIP	20371350
MIRT545190	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT545189	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT545188	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT545187	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT545186	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT545185	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT545184	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT545183	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT545182	hsa-miR-646	PAR-CLIP	20371350
MIRT545181	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT545180	hsa-miR-633	PAR-CLIP	20371350
MIRT545179	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT545178	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT545176	hsa-miR-2054	PAR-CLIP	20371350
MIRT545191	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT545190	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT545189	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT545188	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT545187	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT545186	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT545185	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT545184	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT545183	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT545182	hsa-miR-646	PAR-CLIP	21572407
MIRT545181	hsa-miR-5000-5p	PAR-CLIP	21572407
MIRT545180	hsa-miR-633	PAR-CLIP	21572407
MIRT545179	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT545178	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT545176	hsa-miR-2054	PAR-CLIP	21572407
MIRT1129405	hsa-miR-1225-3p	CLIP-seq
MIRT1129406	hsa-miR-1908	CLIP-seq
MIRT1129407	hsa-miR-2117	CLIP-seq
MIRT1129408	hsa-miR-3151	CLIP-seq
MIRT1129409	hsa-miR-3168	CLIP-seq
MIRT1129410	hsa-miR-3180	CLIP-seq
MIRT1129411	hsa-miR-3180-3p	CLIP-seq
MIRT1129412	hsa-miR-3196	CLIP-seq
MIRT1129413	hsa-miR-331-3p	CLIP-seq
MIRT1129414	hsa-miR-342-5p	CLIP-seq
MIRT1129415	hsa-miR-374c	CLIP-seq
MIRT1129416	hsa-miR-4651	CLIP-seq
MIRT1129417	hsa-miR-4664-5p	CLIP-seq
MIRT1129418	hsa-miR-4706	CLIP-seq
MIRT1129419	hsa-miR-4749-5p	CLIP-seq
MIRT1129420	hsa-miR-4768-5p	CLIP-seq
MIRT1129421	hsa-miR-495	CLIP-seq
MIRT1129422	hsa-miR-524-3p	CLIP-seq
MIRT1129423	hsa-miR-525-3p	CLIP-seq
MIRT1129424	hsa-miR-608	CLIP-seq
MIRT1129425	hsa-miR-655	CLIP-seq
MIRT1129426	hsa-miR-663	CLIP-seq
MIRT1129427	hsa-miR-939	CLIP-seq
MIRT2036912	hsa-miR-105	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS	8643544
GO:0000166	Function	Nucleotide binding	IEA
GO:0002376	Process	Immune system process	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	11784851
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	11784851, 21044950
GO:0005524	Function	ATP binding	IDA	11784851
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006468	Process	Protein phosphorylation	IDA	11784851
GO:0006903	Process	Vesicle targeting	IEA
GO:0006955	Process	Immune response	TAS	7515885
GO:0007254	Process	JNK cascade	TAS	7477268
GO:0008349	Function	MAP kinase kinase kinase kinase activity	IBA
GO:0008349	Function	MAP kinase kinase kinase kinase activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0031435	Function	Mitogen-activated protein kinase kinase kinase binding	IPI	17584736
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IDA	11784851
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0043507	Process	Positive regulation of JUN kinase activity	IDA	17584736
GO:0045087	Process	Innate immune response	IEA
GO:0046330	Process	Positive regulation of JNK cascade	IDA	17584736
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
603166	6864	ENSG00000168067

Q12851

Protein name

Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)

Protein function

Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	16 → 273	Protein kinase domain	Domain
PF00780	CNH	492 → 790	CNH domain	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined. {ECO:0000269|PubMed:7515885}.

Sequence

MALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQ
EITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREA
LKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAP
EVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKT
RWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPE
DCELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLG
KEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDPPAEEP
LSSPPGTLPPPPSGPNSSPLLPTAWATMKQREDPERSSCHGLPPTPKVHMGACFSKVFNG
CPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHRCSWLYCVNNVL
LSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQ
CRVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKE
LPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIPPEGIPGSAQQVIQVDRDTILVSFE
RCVRIVNMQGEPTATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITD
ETRIFRVLGAHRDIILESIPTDNPEAHSNLYILTGHQSTY

Sequence length

820

Interactions

View interactions

	KEGG
	MAPK signaling pathway

MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2)