Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5869
Gene name Gene Name - the full gene name approved by the HGNC.
RAB5B, member RAS oncogene family
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RAB5B
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q13.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016752 hsa-miR-335-5p Microarray 18185580
MIRT019535 hsa-miR-340-5p Sequencing 20371350
MIRT020119 hsa-miR-130b-3p Sequencing 20371350
MIRT027918 hsa-miR-96-5p Sequencing 20371350
MIRT027977 hsa-miR-93-5p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003924 Function GTPase activity IBA 21873635
GO:0003924 Function GTPase activity IDA 17562788
GO:0005515 Function Protein binding IPI 10491193, 17562788, 18445495, 25605758, 27314038, 32814053
GO:0005525 Function GTP binding IEA
GO:0005768 Component Endosome IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
179514 9784 ENSG00000111540
Protein
UniProt ID P61020
Protein name Ras-related protein Rab-5B (EC 3.6.5.2)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r
PDB 2HEI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 22 183 Ras family Domain
Sequence
Sequence length 215
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ras signaling pathway
Mitophagy - animal
Endocytosis
Phagosome
Efferocytosis
Vasopressin-regulated water reabsorption
Salmonella infection
Amoebiasis
Tuberculosis
  Neutrophil degranulation
TBC/RABGAPs
Clathrin-mediated endocytosis
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Autoimmune diseases Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2 rs869025224 30595370
Diabetes mellitus Diabetes Mellitus, Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
31152121
Hypothyroidism Hypothyroidism rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912
View all (22 more)
30595370
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma, Childhood asthma 30929738, 31619474, 31036433 ClinVar, GWAS
Polycystic Ovary Syndrome Polycystic Ovary Syndrome GWAS
Gastroesophageal Reflux Disease Gastroesophageal Reflux Disease GWAS
Psoriasis Psoriasis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Ovarian Neoplasms Associate 19258477
Polycystic Ovary Syndrome Associate 25904635, 26975253, 27217259, 28068351, 31036605, 37223019