Gene Gene information from NCBI Gene database.
Entrez ID 5869
Gene name RAB5B, member RAS oncogene family
Gene symbol RAB5B
Synonyms (NCBI Gene)
-
Chromosome 12
Chromosome location 12q13.2
miRNA miRNA information provided by mirtarbase database.
1880
miRTarBase ID miRNA Experiments Reference
MIRT016752 hsa-miR-335-5p Microarray 18185580
MIRT019535 hsa-miR-340-5p Sequencing 20371350
MIRT020119 hsa-miR-130b-3p Sequencing 20371350
MIRT027918 hsa-miR-96-5p Sequencing 20371350
MIRT027977 hsa-miR-93-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
42
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IDA 17562788
GO:0003924 Function GTPase activity IEA
GO:0003924 Function GTPase activity TAS 1541686
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
179514 9784 ENSG00000111540
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61020
Protein name Ras-related protein Rab-5B (EC 3.6.5.2)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r
PDB 2HEI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 22 183 Ras family Domain
Sequence
Sequence length 215
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Ras signaling pathway
Mitophagy - animal
Endocytosis
Phagosome
Efferocytosis
Vasopressin-regulated water reabsorption
Salmonella infection
Amoebiasis
Tuberculosis
  Neutrophil degranulation
TBC/RABGAPs
Clathrin-mediated endocytosis
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
RAB5B-associated surfactant dysfunction disorder Uncertain significance rs2136490152 RCV001837728
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Ovarian Neoplasms Associate 19258477
Polycystic Ovary Syndrome Associate 25904635, 26975253, 27217259, 28068351, 31036605, 37223019