Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5868
Gene name Gene Name - the full gene name approved by the HGNC.
RAB5A, member RAS oncogene family
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RAB5A
Synonyms (NCBI Gene) Gene synonyms aliases
RAB5
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p24.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006150 hsa-miR-101-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21915098
MIRT006150 hsa-miR-101-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21915098
MIRT006150 hsa-miR-101-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21915098
MIRT006150 hsa-miR-101-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21915098
MIRT006150 hsa-miR-101-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21915098
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001726 Component Ruffle IEA
GO:0003924 Function GTPase activity IBA 21873635
GO:0003924 Function GTPase activity IDA 15378032, 17562788, 24891604
GO:0005515 Function Protein binding IPI 7957092, 9697774, 10491193, 11870209, 15016378, 15207266, 15328530, 15377662, 15378032, 16034420, 16525121, 16902405, 17562788, 17581628, 18034774, 21300063, 21378754, 21988832, 22431521, 23182941, 23382462, 24891604, 25107275, 26005850, 26496610, 28514442, 29568061, 31980649, 32296
GO:0005525 Function GTP binding IDA 15378032
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
179512 9783 ENSG00000144566
Protein
UniProt ID P20339
Protein name Ras-related protein Rab-5A (EC 3.6.5.2)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r
PDB 1N6H , 1N6I , 1N6K , 1N6L , 1N6N , 1N6O , 1N6P , 1N6R , 1R2Q , 1TU3 , 1TU4 , 3MJH , 4Q9U , 7BL1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 22 183 Ras family Domain
Sequence
Sequence length 215
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ras signaling pathway
Mitophagy - animal
Endocytosis
Phagosome
Efferocytosis
Vasopressin-regulated water reabsorption
Amyotrophic lateral sclerosis
Pathways of neurodegeneration - multiple diseases
Salmonella infection
Amoebiasis
Tuberculosis
  Synthesis of PIPs at the plasma membrane
TBC/RABGAPs
Clathrin-mediated endocytosis
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Prevention of phagosomal-lysosomal fusion
Factors involved in megakaryocyte development and platelet production
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Schizophrenia Schizophrenia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abnormalities Drug Induced Associate 18535180
Adenocarcinoma of Lung Associate 35017116
Adenoma Stimulate 12034881
Alzheimer Disease Associate 10880397, 18535180, 20655510
Alzheimer Disease Stimulate 20847427, 21669283
Amyotrophic Lateral Sclerosis Associate 29469808
Amyotrophic Lateral Sclerosis 2 Juvenile Associate 30224357
Atherosclerosis Associate 28899395, 35059464
Breast Neoplasms Associate 21895870, 25755726, 27023526, 30659094, 34741021, 38470169
Calcinosis Cutis Associate 26110570