Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5862
Gene name Gene Name - the full gene name approved by the HGNC.
RAB2A, member RAS oncogene family
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RAB2A
Synonyms (NCBI Gene) Gene synonyms aliases
LHX, RAB2
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q12.1-q12.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins,
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004140 hsa-miR-192-5p Microarray 16822819
MIRT020899 hsa-miR-155-5p Proteomics 18668040
MIRT022905 hsa-miR-124-3p Microarray 18668037
MIRT024358 hsa-miR-215-5p Microarray 19074876
MIRT004140 hsa-miR-192-5p Microarray 19074876
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IBA 21873635
GO:0000139 Component Golgi membrane TAS
GO:0003924 Function GTPase activity IDA 16034420, 17562788, 17684057
GO:0005515 Function Protein binding IPI 16189514, 17684057, 21516116, 25416956, 25473115, 28514442, 29892012, 31515488, 32296183
GO:0005525 Function GTP binding IDA 16034420
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
179509 9763 ENSG00000104388
Protein
UniProt ID P61019
Protein name Ras-related protein Rab-2A (EC 3.6.5.2)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, dr
PDB 1Z0A
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 8 169 Ras family Domain
Sequence
Sequence length 212
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  AMPK signaling pathway   Golgi Cisternae Pericentriolar Stack Reorganization
RAB geranylgeranylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Hypothyroidism Hypothyroidism GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Inhibit 27050411
Autistic Disorder Associate 26938441
Breast Neoplasms Associate 25417742, 25818297, 27255086, 32432324
Carcinogenesis Stimulate 25818297
Cell Transformation Neoplastic Associate 25818297
COVID 19 Associate 35970849, 37932299
Disease Associate 26938441
Gastrointestinal Stromal Tumors Associate 24133624
Glioblastoma Associate 34470582
Lung Neoplasms Associate 17369352