Gene Gene information from NCBI Gene database.
Entrez ID 5862
Gene name RAB2A, member RAS oncogene family
Gene symbol RAB2A
Synonyms (NCBI Gene)
LHXRAB2
Chromosome 8
Chromosome location 8q12.1-q12.2
Summary The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins,
miRNA miRNA information provided by mirtarbase database.
396
miRTarBase ID miRNA Experiments Reference
MIRT004140 hsa-miR-192-5p Microarray 16822819
MIRT020899 hsa-miR-155-5p Proteomics 18668040
MIRT022905 hsa-miR-124-3p Microarray 18668037
MIRT024358 hsa-miR-215-5p Microarray 19074876
MIRT004140 hsa-miR-192-5p Microarray 19074876
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
42
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IBA
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0000166 Function Nucleotide binding IEA
GO:0000421 Component Autophagosome membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
179509 9763 ENSG00000104388
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61019
Protein name Ras-related protein Rab-2A (EC 3.6.5.2)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, dr
PDB 1Z0A
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 8 169 Ras family Domain
Sequence
Sequence length 212
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  AMPK signaling pathway   Golgi Cisternae Pericentriolar Stack Reorganization
RAB geranylgeranylation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Vascular endothelial growth factor (VEGF) inhibitor response association rs2272620 RCV002254033
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Inhibit 27050411
Autistic Disorder Associate 26938441
Breast Neoplasms Associate 25417742, 25818297, 27255086, 32432324
Carcinogenesis Stimulate 25818297
Cell Transformation Neoplastic Associate 25818297
COVID 19 Associate 35970849, 37932299
Disease Associate 26938441
Gastrointestinal Stromal Tumors Associate 24133624
Glioblastoma Associate 34470582
Lung Neoplasms Associate 17369352