Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	58513
Gene name Gene Name - the full gene name approved by the HGNC.	Epidermal growth factor receptor pathway substrate 15 like 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	EPS15L1
Synonyms (NCBI Gene) Gene synonyms aliases	EPS15R
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.11

Show/Hide all(222)

miRTarBase ID	miRNA	Experiments	Reference
MIRT514105	hsa-miR-3609	PAR-CLIP	20371350
MIRT514106	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT514104	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT514103	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT514102	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT514101	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT514100	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT514099	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT514098	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT514097	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT514096	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT514095	hsa-miR-4803	PAR-CLIP	20371350
MIRT514094	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT514093	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT514092	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT514091	hsa-miR-329-5p	PAR-CLIP	20371350
MIRT514089	hsa-miR-4257	PAR-CLIP	20371350
MIRT514090	hsa-miR-759	PAR-CLIP	20371350
MIRT514087	hsa-miR-2467-3p	PAR-CLIP	20371350
MIRT514088	hsa-miR-6801-5p	PAR-CLIP	20371350
MIRT514086	hsa-miR-3678-3p	PAR-CLIP	20371350
MIRT514105	hsa-miR-3609	PAR-CLIP	21572407
MIRT514106	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT514104	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT514103	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT514102	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT514101	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT514100	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT514099	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT514098	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT514097	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT514096	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT514095	hsa-miR-4803	PAR-CLIP	21572407
MIRT514094	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT514093	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT514092	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT514091	hsa-miR-329-5p	PAR-CLIP	21572407
MIRT514089	hsa-miR-4257	PAR-CLIP	21572407
MIRT514090	hsa-miR-759	PAR-CLIP	21572407
MIRT514087	hsa-miR-2467-3p	PAR-CLIP	21572407
MIRT514088	hsa-miR-6801-5p	PAR-CLIP	21572407
MIRT514086	hsa-miR-3678-3p	PAR-CLIP	21572407
MIRT514105	hsa-miR-3609	PAR-CLIP	21572407
MIRT514106	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT514104	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT514103	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT514102	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT514101	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT514100	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT514099	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT514098	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT514097	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT514096	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT514095	hsa-miR-4803	PAR-CLIP	21572407
MIRT514094	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT514093	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT514092	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT514091	hsa-miR-329-5p	PAR-CLIP	21572407
MIRT514089	hsa-miR-4257	PAR-CLIP	21572407
MIRT514090	hsa-miR-759	PAR-CLIP	21572407
MIRT514087	hsa-miR-2467-3p	PAR-CLIP	21572407
MIRT514088	hsa-miR-6801-5p	PAR-CLIP	21572407
MIRT514086	hsa-miR-3678-3p	PAR-CLIP	21572407
MIRT514105	hsa-miR-3609	PAR-CLIP	23446348
MIRT514106	hsa-miR-548ah-5p	PAR-CLIP	23446348
MIRT514104	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT514103	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT514102	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT514101	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT514100	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT514099	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT514098	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT514097	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT514096	hsa-miR-4796-3p	PAR-CLIP	23446348
MIRT514095	hsa-miR-4803	PAR-CLIP	23446348
MIRT514094	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT514093	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT514092	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT514091	hsa-miR-329-5p	PAR-CLIP	23446348
MIRT514089	hsa-miR-4257	PAR-CLIP	23446348
MIRT514090	hsa-miR-759	PAR-CLIP	23446348
MIRT514087	hsa-miR-2467-3p	PAR-CLIP	23446348
MIRT514088	hsa-miR-6801-5p	PAR-CLIP	23446348
MIRT514086	hsa-miR-3678-3p	PAR-CLIP	23446348
MIRT451007	hsa-miR-6779-3p	PAR-CLIP	23592263
MIRT451006	hsa-miR-4292	PAR-CLIP	23592263
MIRT451005	hsa-miR-6791-5p	PAR-CLIP	23592263
MIRT451004	hsa-miR-5739	PAR-CLIP	23592263
MIRT451003	hsa-miR-3192-5p	PAR-CLIP	23592263
MIRT451002	hsa-miR-1233-3p	PAR-CLIP	23592263
MIRT451001	hsa-miR-558	PAR-CLIP	23592263
MIRT450999	hsa-miR-6804-5p	PAR-CLIP	23592263
MIRT451000	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT450998	hsa-miR-4306	PAR-CLIP	23592263
MIRT450997	hsa-miR-4644	PAR-CLIP	23592263
MIRT450996	hsa-miR-885-3p	PAR-CLIP	23592263
MIRT450995	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT450994	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT450993	hsa-miR-8085	PAR-CLIP	23592263
MIRT450992	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT450991	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT450990	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT514105	hsa-miR-3609	PAR-CLIP	20371350
MIRT514106	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT514104	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT514103	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT514102	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT514101	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT514100	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT514099	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT514098	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT514097	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT514096	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT514095	hsa-miR-4803	PAR-CLIP	20371350
MIRT514094	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT514093	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT514092	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT514091	hsa-miR-329-5p	PAR-CLIP	20371350
MIRT514089	hsa-miR-4257	PAR-CLIP	20371350
MIRT514090	hsa-miR-759	PAR-CLIP	20371350
MIRT514087	hsa-miR-2467-3p	PAR-CLIP	20371350
MIRT514088	hsa-miR-6801-5p	PAR-CLIP	20371350
MIRT514086	hsa-miR-3678-3p	PAR-CLIP	20371350
MIRT514105	hsa-miR-3609	PAR-CLIP	21572407
MIRT514106	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT514104	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT514103	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT514102	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT514101	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT514100	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT514099	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT514098	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT514097	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT514096	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT514095	hsa-miR-4803	PAR-CLIP	21572407
MIRT514094	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT514093	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT514092	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT514091	hsa-miR-329-5p	PAR-CLIP	21572407
MIRT514089	hsa-miR-4257	PAR-CLIP	21572407
MIRT514090	hsa-miR-759	PAR-CLIP	21572407
MIRT514087	hsa-miR-2467-3p	PAR-CLIP	21572407
MIRT514088	hsa-miR-6801-5p	PAR-CLIP	21572407
MIRT514086	hsa-miR-3678-3p	PAR-CLIP	21572407
MIRT514105	hsa-miR-3609	PAR-CLIP	21572407
MIRT514106	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT514104	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT514103	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT514102	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT514101	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT514100	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT514099	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT514098	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT514097	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT514096	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT514095	hsa-miR-4803	PAR-CLIP	21572407
MIRT514094	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT514093	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT514092	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT514091	hsa-miR-329-5p	PAR-CLIP	21572407
MIRT514089	hsa-miR-4257	PAR-CLIP	21572407
MIRT514090	hsa-miR-759	PAR-CLIP	21572407
MIRT514087	hsa-miR-2467-3p	PAR-CLIP	21572407
MIRT514088	hsa-miR-6801-5p	PAR-CLIP	21572407
MIRT514086	hsa-miR-3678-3p	PAR-CLIP	21572407
MIRT514105	hsa-miR-3609	PAR-CLIP	23446348
MIRT514106	hsa-miR-548ah-5p	PAR-CLIP	23446348
MIRT514104	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT514103	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT514102	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT514101	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT514100	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT514099	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT514098	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT514097	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT514096	hsa-miR-4796-3p	PAR-CLIP	23446348
MIRT514095	hsa-miR-4803	PAR-CLIP	23446348
MIRT514094	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT514093	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT514092	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT514091	hsa-miR-329-5p	PAR-CLIP	23446348
MIRT514089	hsa-miR-4257	PAR-CLIP	23446348
MIRT514090	hsa-miR-759	PAR-CLIP	23446348
MIRT514087	hsa-miR-2467-3p	PAR-CLIP	23446348
MIRT514088	hsa-miR-6801-5p	PAR-CLIP	23446348
MIRT514086	hsa-miR-3678-3p	PAR-CLIP	23446348
MIRT451007	hsa-miR-6779-3p	PAR-CLIP	23592263
MIRT451006	hsa-miR-4292	PAR-CLIP	23592263
MIRT451005	hsa-miR-6791-5p	PAR-CLIP	23592263
MIRT451004	hsa-miR-5739	PAR-CLIP	23592263
MIRT451003	hsa-miR-3192-5p	PAR-CLIP	23592263
MIRT451002	hsa-miR-1233-3p	PAR-CLIP	23592263
MIRT451001	hsa-miR-558	PAR-CLIP	23592263
MIRT450999	hsa-miR-6804-5p	PAR-CLIP	23592263
MIRT451000	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT450998	hsa-miR-4306	PAR-CLIP	23592263
MIRT450997	hsa-miR-4644	PAR-CLIP	23592263
MIRT450996	hsa-miR-885-3p	PAR-CLIP	23592263
MIRT450995	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT450994	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT450993	hsa-miR-8085	PAR-CLIP	23592263
MIRT450992	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT450991	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT450990	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT967320	hsa-miR-34a	CLIP-seq
MIRT967321	hsa-miR-34c-5p	CLIP-seq
MIRT967322	hsa-miR-4280	CLIP-seq
MIRT967323	hsa-miR-449a	CLIP-seq
MIRT967324	hsa-miR-449b	CLIP-seq
MIRT967325	hsa-miR-452	CLIP-seq
MIRT967326	hsa-miR-4676-3p	CLIP-seq
MIRT967327	hsa-miR-4738-3p	CLIP-seq
MIRT967328	hsa-miR-4795-5p	CLIP-seq
MIRT967329	hsa-miR-548g	CLIP-seq
MIRT967330	hsa-miR-600	CLIP-seq
MIRT2221092	hsa-miR-4428	CLIP-seq
MIRT2524803	hsa-miR-1915	CLIP-seq
MIRT2524804	hsa-miR-2276	CLIP-seq
MIRT2524805	hsa-miR-4668-3p	CLIP-seq
MIRT2524806	hsa-miR-4726-3p	CLIP-seq
MIRT2524807	hsa-miR-548c-3p	CLIP-seq
MIRT2524808	hsa-miR-605	CLIP-seq

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	16159959, 18200045, 19262564, 25416956, 32203420, 32296183, 33961781, 35271311, 35914814
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0006897	Process	Endocytosis	IBA
GO:0006897	Process	Endocytosis	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016197	Process	Endosomal transport	IBA
GO:0030132	Component	Clathrin coat of coated pit	IBA
GO:0030132	Component	Clathrin coat of coated pit	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	IBA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0046872	Function	Metal ion binding	IEA
GO:0048488	Process	Synaptic vesicle endocytosis	IEA
GO:0098793	Component	Presynapse	IEA

MIM	HGNC	e!Ensembl
616826	24634	ENSG00000127527

Protein

UniProt ID

Q9UBC2

Protein name

Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)

Protein function

Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12763	EF-hand_4	17 → 93	Cytoskeletal-regulatory complex EF hand	Family
PF12763	EF-hand_4	122 → 218	Cytoskeletal-regulatory complex EF hand	Family
PF12763	EF-hand_4	273 → 365	Cytoskeletal-regulatory complex EF hand	Family

Sequence

MAAPLIPLSQQIPTGNSLYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLA
DPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLNLSMPPPKFHDTSSPLMVTPPSAEAH
WAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD
RDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRKKTVFPGAVPVLPASPPPKDSLRSTP
SHGSVSSLNSTGSLSPKHSLKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVK
EIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVP
PSERGTPGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSE
VQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSL
KTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEI
NQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDP
FKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGADPFKGDPFQNDPFAEQQTTSTDPFGG
DPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKG
SDPFGTLDPFGSGSFNSAEGFADFSQMSKPPPSGPFTSSLGGAGFSDDPFKSKQDTPALP
PKKPAPPRPKPPSGKSTPVSQLGSADFPEAPDPFQPLGADSGDPFQSKKGFGDPFSGKDP
FVPSSAAKPSKASASGFADFTSVS

Sequence length

864

Interactions

View interactions

	KEGG		Reactome
	Endocytosis		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma	N/A	N/A	GWAS
Multiple Sclerosis	Multiple sclerosis	N/A	N/A	GWAS
Split-Hand-Foot Malformation	split hand-foot malformation	N/A	N/A	GenCC
Systemic lupus erythematosus	Systemic lupus erythematosus	N/A	N/A	GWAS

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Neoplasms	Associate	33275145, 36366450

EPS15L1 (epidermal growth factor receptor pathway substrate 15 like 1)