Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	58513
Gene name	Epidermal growth factor receptor pathway substrate 15 like 1
Gene symbol	EPS15L1
Synonyms (NCBI Gene)	EPS15R
Chromosome	19
Chromosome location	19p13.11

222

Show/Hide all (222)

miRTarBase ID	miRNA	Experiments	Reference
MIRT514105	hsa-miR-3609	PAR-CLIP	20371350
MIRT514106	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT514104	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT514103	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT514102	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT514101	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT514100	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT514099	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT514098	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT514097	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT514096	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT514095	hsa-miR-4803	PAR-CLIP	20371350
MIRT514094	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT514093	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT514092	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT514091	hsa-miR-329-5p	PAR-CLIP	20371350
MIRT514089	hsa-miR-4257	PAR-CLIP	20371350
MIRT514090	hsa-miR-759	PAR-CLIP	20371350
MIRT514087	hsa-miR-2467-3p	PAR-CLIP	20371350
MIRT514088	hsa-miR-6801-5p	PAR-CLIP	20371350
MIRT514086	hsa-miR-3678-3p	PAR-CLIP	20371350
MIRT514105	hsa-miR-3609	PAR-CLIP	21572407
MIRT514106	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT514104	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT514103	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT514102	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT514101	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT514100	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT514099	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT514098	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT514097	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT514096	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT514095	hsa-miR-4803	PAR-CLIP	21572407
MIRT514094	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT514093	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT514092	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT514091	hsa-miR-329-5p	PAR-CLIP	21572407
MIRT514089	hsa-miR-4257	PAR-CLIP	21572407
MIRT514090	hsa-miR-759	PAR-CLIP	21572407
MIRT514087	hsa-miR-2467-3p	PAR-CLIP	21572407
MIRT514088	hsa-miR-6801-5p	PAR-CLIP	21572407
MIRT514086	hsa-miR-3678-3p	PAR-CLIP	21572407
MIRT514105	hsa-miR-3609	PAR-CLIP	21572407
MIRT514106	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT514104	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT514103	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT514102	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT514101	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT514100	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT514099	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT514098	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT514097	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT514096	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT514095	hsa-miR-4803	PAR-CLIP	21572407
MIRT514094	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT514093	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT514092	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT514091	hsa-miR-329-5p	PAR-CLIP	21572407
MIRT514089	hsa-miR-4257	PAR-CLIP	21572407
MIRT514090	hsa-miR-759	PAR-CLIP	21572407
MIRT514087	hsa-miR-2467-3p	PAR-CLIP	21572407
MIRT514088	hsa-miR-6801-5p	PAR-CLIP	21572407
MIRT514086	hsa-miR-3678-3p	PAR-CLIP	21572407
MIRT514105	hsa-miR-3609	PAR-CLIP	23446348
MIRT514106	hsa-miR-548ah-5p	PAR-CLIP	23446348
MIRT514104	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT514103	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT514102	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT514101	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT514100	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT514099	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT514098	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT514097	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT514096	hsa-miR-4796-3p	PAR-CLIP	23446348
MIRT514095	hsa-miR-4803	PAR-CLIP	23446348
MIRT514094	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT514093	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT514092	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT514091	hsa-miR-329-5p	PAR-CLIP	23446348
MIRT514089	hsa-miR-4257	PAR-CLIP	23446348
MIRT514090	hsa-miR-759	PAR-CLIP	23446348
MIRT514087	hsa-miR-2467-3p	PAR-CLIP	23446348
MIRT514088	hsa-miR-6801-5p	PAR-CLIP	23446348
MIRT514086	hsa-miR-3678-3p	PAR-CLIP	23446348
MIRT451007	hsa-miR-6779-3p	PAR-CLIP	23592263
MIRT451006	hsa-miR-4292	PAR-CLIP	23592263
MIRT451005	hsa-miR-6791-5p	PAR-CLIP	23592263
MIRT451004	hsa-miR-5739	PAR-CLIP	23592263
MIRT451003	hsa-miR-3192-5p	PAR-CLIP	23592263
MIRT451002	hsa-miR-1233-3p	PAR-CLIP	23592263
MIRT451001	hsa-miR-558	PAR-CLIP	23592263
MIRT450999	hsa-miR-6804-5p	PAR-CLIP	23592263
MIRT451000	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT450998	hsa-miR-4306	PAR-CLIP	23592263
MIRT450997	hsa-miR-4644	PAR-CLIP	23592263
MIRT450996	hsa-miR-885-3p	PAR-CLIP	23592263
MIRT450995	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT450994	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT450993	hsa-miR-8085	PAR-CLIP	23592263
MIRT450992	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT450991	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT450990	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT514105	hsa-miR-3609	PAR-CLIP	20371350
MIRT514106	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT514104	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT514103	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT514102	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT514101	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT514100	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT514099	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT514098	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT514097	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT514096	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT514095	hsa-miR-4803	PAR-CLIP	20371350
MIRT514094	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT514093	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT514092	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT514091	hsa-miR-329-5p	PAR-CLIP	20371350
MIRT514089	hsa-miR-4257	PAR-CLIP	20371350
MIRT514090	hsa-miR-759	PAR-CLIP	20371350
MIRT514087	hsa-miR-2467-3p	PAR-CLIP	20371350
MIRT514088	hsa-miR-6801-5p	PAR-CLIP	20371350
MIRT514086	hsa-miR-3678-3p	PAR-CLIP	20371350
MIRT514105	hsa-miR-3609	PAR-CLIP	21572407
MIRT514106	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT514104	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT514103	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT514102	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT514101	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT514100	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT514099	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT514098	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT514097	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT514096	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT514095	hsa-miR-4803	PAR-CLIP	21572407
MIRT514094	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT514093	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT514092	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT514091	hsa-miR-329-5p	PAR-CLIP	21572407
MIRT514089	hsa-miR-4257	PAR-CLIP	21572407
MIRT514090	hsa-miR-759	PAR-CLIP	21572407
MIRT514087	hsa-miR-2467-3p	PAR-CLIP	21572407
MIRT514088	hsa-miR-6801-5p	PAR-CLIP	21572407
MIRT514086	hsa-miR-3678-3p	PAR-CLIP	21572407
MIRT514105	hsa-miR-3609	PAR-CLIP	21572407
MIRT514106	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT514104	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT514103	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT514102	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT514101	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT514100	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT514099	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT514098	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT514097	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT514096	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT514095	hsa-miR-4803	PAR-CLIP	21572407
MIRT514094	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT514093	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT514092	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT514091	hsa-miR-329-5p	PAR-CLIP	21572407
MIRT514089	hsa-miR-4257	PAR-CLIP	21572407
MIRT514090	hsa-miR-759	PAR-CLIP	21572407
MIRT514087	hsa-miR-2467-3p	PAR-CLIP	21572407
MIRT514088	hsa-miR-6801-5p	PAR-CLIP	21572407
MIRT514086	hsa-miR-3678-3p	PAR-CLIP	21572407
MIRT514105	hsa-miR-3609	PAR-CLIP	23446348
MIRT514106	hsa-miR-548ah-5p	PAR-CLIP	23446348
MIRT514104	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT514103	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT514102	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT514101	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT514100	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT514099	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT514098	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT514097	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT514096	hsa-miR-4796-3p	PAR-CLIP	23446348
MIRT514095	hsa-miR-4803	PAR-CLIP	23446348
MIRT514094	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT514093	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT514092	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT514091	hsa-miR-329-5p	PAR-CLIP	23446348
MIRT514089	hsa-miR-4257	PAR-CLIP	23446348
MIRT514090	hsa-miR-759	PAR-CLIP	23446348
MIRT514087	hsa-miR-2467-3p	PAR-CLIP	23446348
MIRT514088	hsa-miR-6801-5p	PAR-CLIP	23446348
MIRT514086	hsa-miR-3678-3p	PAR-CLIP	23446348
MIRT451007	hsa-miR-6779-3p	PAR-CLIP	23592263
MIRT451006	hsa-miR-4292	PAR-CLIP	23592263
MIRT451005	hsa-miR-6791-5p	PAR-CLIP	23592263
MIRT451004	hsa-miR-5739	PAR-CLIP	23592263
MIRT451003	hsa-miR-3192-5p	PAR-CLIP	23592263
MIRT451002	hsa-miR-1233-3p	PAR-CLIP	23592263
MIRT451001	hsa-miR-558	PAR-CLIP	23592263
MIRT450999	hsa-miR-6804-5p	PAR-CLIP	23592263
MIRT451000	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT450998	hsa-miR-4306	PAR-CLIP	23592263
MIRT450997	hsa-miR-4644	PAR-CLIP	23592263
MIRT450996	hsa-miR-885-3p	PAR-CLIP	23592263
MIRT450995	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT450994	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT450993	hsa-miR-8085	PAR-CLIP	23592263
MIRT450992	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT450991	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT450990	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT967320	hsa-miR-34a	CLIP-seq
MIRT967321	hsa-miR-34c-5p	CLIP-seq
MIRT967322	hsa-miR-4280	CLIP-seq
MIRT967323	hsa-miR-449a	CLIP-seq
MIRT967324	hsa-miR-449b	CLIP-seq
MIRT967325	hsa-miR-452	CLIP-seq
MIRT967326	hsa-miR-4676-3p	CLIP-seq
MIRT967327	hsa-miR-4738-3p	CLIP-seq
MIRT967328	hsa-miR-4795-5p	CLIP-seq
MIRT967329	hsa-miR-548g	CLIP-seq
MIRT967330	hsa-miR-600	CLIP-seq
MIRT2221092	hsa-miR-4428	CLIP-seq
MIRT2524803	hsa-miR-1915	CLIP-seq
MIRT2524804	hsa-miR-2276	CLIP-seq
MIRT2524805	hsa-miR-4668-3p	CLIP-seq
MIRT2524806	hsa-miR-4726-3p	CLIP-seq
MIRT2524807	hsa-miR-548c-3p	CLIP-seq
MIRT2524808	hsa-miR-605	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	16159959, 18200045, 19262564, 25416956, 32203420, 32296183, 33961781, 35271311, 35914814
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0006897	Process	Endocytosis	IBA
GO:0006897	Process	Endocytosis	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016197	Process	Endosomal transport	IBA
GO:0030132	Component	Clathrin coat of coated pit	IBA
GO:0030132	Component	Clathrin coat of coated pit	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	IBA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0046872	Function	Metal ion binding	IEA
GO:0048488	Process	Synaptic vesicle endocytosis	IEA
GO:0098793	Component	Presynapse	IEA

MIM	HGNC	e!Ensembl
616826	24634	ENSG00000127527

Q9UBC2

Protein name

Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)

Protein function

Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12763	EF-hand_4	17 → 93	Cytoskeletal-regulatory complex EF hand	Family
PF12763	EF-hand_4	122 → 218	Cytoskeletal-regulatory complex EF hand	Family
PF12763	EF-hand_4	273 → 365	Cytoskeletal-regulatory complex EF hand	Family

Sequence

MAAPLIPLSQQIPTGNSLYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLA
DPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLNLSMPPPKFHDTSSPLMVTPPSAEAH
WAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD
RDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRKKTVFPGAVPVLPASPPPKDSLRSTP
SHGSVSSLNSTGSLSPKHSLKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVK
EIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVP
PSERGTPGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSE
VQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSL
KTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEI
NQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDP
FKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGADPFKGDPFQNDPFAEQQTTSTDPFGG
DPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKG
SDPFGTLDPFGSGSFNSAEGFADFSQMSKPPPSGPFTSSLGGAGFSDDPFKSKQDTPALP
PKKPAPPRPKPPSGKSTPVSQLGSADFPEAPDPFQPLGADSGDPFQSKKGFGDPFSGKDP
FVPSSAAKPSKASASGFADFTSVS

Sequence length

864

Interactions

View interactions

	KEGG		Reactome
	Endocytosis		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

EPS15L1 (epidermal growth factor receptor pathway substrate 15 like 1)