Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5829
Gene name Gene Name - the full gene name approved by the HGNC.
Paxillin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PXN
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q24.23
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007346 hsa-miR-137 Luciferase reporter assay, qRT-PCR, Western blot 23275153
MIRT007346 hsa-miR-137 Luciferase reporter assay, qRT-PCR, Western blot 23275153
MIRT007346 hsa-miR-137 Luciferase reporter assay, qRT-PCR, Western blot 23275153
MIRT018650 hsa-miR-335-5p Microarray 18185580
MIRT023030 hsa-miR-124-3p Microarray 18668037
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001725 Component Stress fiber IDA 24036928
GO:0005515 Function Protein binding IPI 7561682, 9756887, 10604475, 10814581, 11035932, 12861019, 14665621, 14688263, 15572663, 16628223, 17082770, 18940607, 19167335, 19492042, 20489202, 21034468, 21173240, 21741599, 22270917, 22728435, 23393263, 23397142, 24694988, 24863063, 25795725, 26598620, 27880917, 31980649, 32296
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IDA
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602505 9718 ENSG00000089159
Protein
UniProt ID P49023
Protein name Paxillin
Protein function Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion.
PDB 1OW6 , 1OW7 , 1OW8 , 2K2R , 2O9V , 2VZD , 2VZG , 2VZI , 3GM1 , 3PY7 , 3RQE , 3RQF , 3RQG , 3U3F , 4EDN , 4R32 , 4XGZ , 4XH2 , 5UWH , 6IUI , 6PW8 , 6U4M , 6U4N , 7QB0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03535 Paxillin 44 253 Family
PF00412 LIM 358 413 LIM domain Domain
PF00412 LIM 417 472 LIM domain Domain
PF00412 LIM 476 531 LIM domain Domain
PF00412 LIM 535 590 LIM domain Domain
Sequence
Sequence length 591
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Chemokine signaling pathway
VEGF signaling pathway
Focal adhesion
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Shigellosis
Yersinia infection
Human cytomegalovirus infection
Human papillomavirus infection
Human immunodeficiency virus 1 infection
Viral carcinogenesis
Proteoglycans in cancer
  GAB1 signalosome
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
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