Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	58157
Gene name Gene Name - the full gene name approved by the HGNC.	Neuroglobin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NGB
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	14q24.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing

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miRTarBase ID	miRNA	Experiments	Reference
MIRT756133	hsa-miR-320a	Luciferase reporter assay, Western blotting, qRT-PCR	34584546
MIRT1184061	hsa-miR-1184	CLIP-seq
MIRT1184062	hsa-miR-1205	CLIP-seq
MIRT1184063	hsa-miR-1207-3p	CLIP-seq
MIRT1184064	hsa-miR-1237	CLIP-seq
MIRT1184065	hsa-miR-1248	CLIP-seq
MIRT1184066	hsa-miR-1254	CLIP-seq
MIRT1184067	hsa-miR-1301	CLIP-seq
MIRT1184068	hsa-miR-28-5p	CLIP-seq
MIRT1184069	hsa-miR-3116	CLIP-seq
MIRT1184070	hsa-miR-3127-5p	CLIP-seq
MIRT1184071	hsa-miR-3130-3p	CLIP-seq
MIRT1184072	hsa-miR-3139	CLIP-seq
MIRT1184073	hsa-miR-3150b-3p	CLIP-seq
MIRT1184074	hsa-miR-3156-3p	CLIP-seq
MIRT1184075	hsa-miR-3158-5p	CLIP-seq
MIRT1184076	hsa-miR-3200-5p	CLIP-seq
MIRT1184077	hsa-miR-34a	CLIP-seq
MIRT1184078	hsa-miR-34c-5p	CLIP-seq
MIRT1184079	hsa-miR-3664-5p	CLIP-seq
MIRT1184080	hsa-miR-378	CLIP-seq
MIRT1184081	hsa-miR-378b	CLIP-seq
MIRT1184082	hsa-miR-378c	CLIP-seq
MIRT1184083	hsa-miR-378d	CLIP-seq
MIRT1184084	hsa-miR-378e	CLIP-seq
MIRT1184085	hsa-miR-378f	CLIP-seq
MIRT1184086	hsa-miR-378h	CLIP-seq
MIRT1184087	hsa-miR-378i	CLIP-seq
MIRT1184088	hsa-miR-3918	CLIP-seq
MIRT1184089	hsa-miR-422a	CLIP-seq
MIRT1184090	hsa-miR-4301	CLIP-seq
MIRT1184091	hsa-miR-4431	CLIP-seq
MIRT1184092	hsa-miR-449a	CLIP-seq
MIRT1184093	hsa-miR-449b	CLIP-seq
MIRT1184094	hsa-miR-4522	CLIP-seq
MIRT1184095	hsa-miR-4649-3p	CLIP-seq
MIRT1184096	hsa-miR-4660	CLIP-seq
MIRT1184097	hsa-miR-4689	CLIP-seq
MIRT1184098	hsa-miR-4757-5p	CLIP-seq
MIRT1184099	hsa-miR-4761-3p	CLIP-seq
MIRT1184100	hsa-miR-4784	CLIP-seq
MIRT1184101	hsa-miR-4793-3p	CLIP-seq
MIRT1184102	hsa-miR-483-3p	CLIP-seq
MIRT1184103	hsa-miR-5047	CLIP-seq
MIRT1184104	hsa-miR-532-3p	CLIP-seq
MIRT1184105	hsa-miR-544	CLIP-seq
MIRT1184106	hsa-miR-661	CLIP-seq
MIRT1184107	hsa-miR-663b	CLIP-seq
MIRT1184108	hsa-miR-708	CLIP-seq
MIRT2053380	hsa-miR-1324	CLIP-seq
MIRT2053381	hsa-miR-3189-5p	CLIP-seq
MIRT2053382	hsa-miR-4436a	CLIP-seq
MIRT2282598	hsa-miR-3074-5p	CLIP-seq
MIRT2282599	hsa-miR-548ag	CLIP-seq
MIRT2282600	hsa-miR-548ai	CLIP-seq
MIRT2282601	hsa-miR-548m	CLIP-seq
MIRT2391534	hsa-miR-1912	CLIP-seq
MIRT2391535	hsa-miR-3184	CLIP-seq
MIRT2391536	hsa-miR-423-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005344	Function	Oxygen carrier activity	TAS	11029004
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0015671	Process	Oxygen transport	NAS	11029004
GO:0015671	Process	Oxygen transport	TAS
GO:0019825	Function	Oxygen binding	IEA
GO:0020037	Function	Heme binding	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
605304	14077	ENSG00000165553

Protein

UniProt ID

Q9NPG2

Protein name

Neuroglobin (Nitrite reductase) (EC 1.7.-.-)

Protein function

Monomeric globin with a bis-histidyl six-coordinate heme-iron atom through which it can bind dioxygen, carbon monoxide and nitric oxide (PubMed:11473128, PubMed:12962627, PubMed:24699645). Could help transport oxygen and increase its availabilit

PDB

1OJ6 , 4MPM , 7VQG , 8GRZ , 8WUB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00042	Globin	5 → 114	Globin	Domain

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in brain, the strongest expression is seen in the frontal lobe, the subthalamic nucleus and the thalamus. {ECO:0000269|PubMed:11029004}.

Sequence

MERPEPELIRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLFQYNCRQFSSPEDCLSSPE
FLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHRAVGVKLSSFSTVGESLLYMLEKC
LGPAFTPATRAAWSQLYGAVVQAMSRGWDGE

Sequence length

151

Interactions

View interactions

	Reactome
			Intracellular oxygen transport

NGB (neuroglobin)