Gene Gene information from NCBI Gene database.
Entrez ID 5814
Gene name Purine rich element binding protein B
Gene symbol PURB
Synonyms (NCBI Gene)
PURBETA
Chromosome 7
Chromosome location 7p13
Summary This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of euka
miRNA miRNA information provided by mirtarbase database.
2055
miRTarBase ID miRNA Experiments Reference
MIRT030938 hsa-miR-21-5p Microarray 18591254
MIRT049459 hsa-miR-92a-3p CLASH 23622248
MIRT036639 hsa-miR-935 CLASH 23622248
MIRT036203 hsa-miR-320b CLASH 23622248
MIRT469877 hsa-miR-3940-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II ISS
GO:0000900 Function MRNA regulatory element binding translation repressor activity ISS
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608887 9702 ENSG00000146676
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96QR8
Protein name Transcriptional regulator protein Pur-beta (Purine-rich element-binding protein B)
Protein function Transcriptional regulator which can act as an activator or a repressor. Represses the transcription of ACTA2 in fibroblasts and smooth muscle cells via its ability to interact with the purine-rich strand of a MCAT- containing element in the 5' f
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04845 PurA 31 279 PurA ssDNA and RNA-binding protein Family
Tissue specificity TISSUE SPECIFICITY: Expressed in myocardium of heart failure patients. {ECO:0000269|PubMed:12933792}.
Sequence
Sequence length 312
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR I DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CLONAL HEMATOPOIESIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations