Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5803
Gene name Gene Name - the full gene name approved by the HGNC.	Protein tyrosine phosphatase receptor type Z1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PTPRZ1
Synonyms (NCBI Gene) Gene synonyms aliases	HPTPZ, HPTPzeta, PTP-ZETA, PTP18, PTPRZ, PTPZ, R-PTP-zeta-2, RPTPB, RPTPbeta, phosphacan
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q31.32
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternative

Show/Hide all(27)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022444	hsa-miR-124-3p	Microarray	18668037
MIRT025060	hsa-miR-181a-5p	Microarray	17612493
MIRT053463	hsa-miR-200c-3p	Microarray	23807165
MIRT1276598	hsa-miR-3529	CLIP-seq
MIRT1276599	hsa-miR-3667-5p	CLIP-seq
MIRT1276600	hsa-miR-379	CLIP-seq
MIRT1276601	hsa-miR-4451	CLIP-seq
MIRT1276602	hsa-miR-4650-3p	CLIP-seq
MIRT1276603	hsa-miR-548a-3p	CLIP-seq
MIRT1276604	hsa-miR-548e	CLIP-seq
MIRT1276605	hsa-miR-548f	CLIP-seq
MIRT1276606	hsa-miR-582-3p	CLIP-seq
MIRT1276607	hsa-miR-125a-3p	CLIP-seq
MIRT1276608	hsa-miR-3150a-5p	CLIP-seq
MIRT1276609	hsa-miR-3150b-5p	CLIP-seq
MIRT1276610	hsa-miR-3673	CLIP-seq
MIRT1276611	hsa-miR-3692	CLIP-seq
MIRT1276612	hsa-miR-3934	CLIP-seq
MIRT1276613	hsa-miR-4678	CLIP-seq
MIRT1276614	hsa-miR-4693-5p	CLIP-seq
MIRT1276615	hsa-miR-4703-3p	CLIP-seq
MIRT1276616	hsa-miR-493	CLIP-seq
MIRT1276617	hsa-miR-764	CLIP-seq
MIRT2081329	hsa-miR-133a	CLIP-seq
MIRT2081330	hsa-miR-133b	CLIP-seq
MIRT2081331	hsa-miR-3117-5p	CLIP-seq
MIRT2081332	hsa-miR-4704-5p	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
ELK1	Unknown	20224786
EPAS1	Unknown	20224786

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA	21873635
GO:0004725	Function	Protein tyrosine phosphatase activity	IDA	10706604
GO:0004725	Function	Protein tyrosine phosphatase activity	ISS
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	TAS	1323835
GO:0005178	Function	Integrin binding	IDA	19141530
GO:0005515	Function	Protein binding	IPI	10706604, 17681947, 19141530, 21969550
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IDA	19141530
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	8387522
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0007417	Process	Central nervous system development	TAS	8387522
GO:0007611	Process	Learning or memory	ISS
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0031226	Component	Intrinsic component of plasma membrane	ISS
GO:0031641	Process	Regulation of myelination	ISS
GO:0035335	Process	Peptidyl-tyrosine dephosphorylation	IBA	21873635
GO:0035335	Process	Peptidyl-tyrosine dephosphorylation	ISS
GO:0043524	Process	Negative regulation of neuron apoptotic process	ISS
GO:0048709	Process	Oligodendrocyte differentiation	ISS
GO:0048714	Process	Positive regulation of oligodendrocyte differentiation	ISS
GO:0070445	Process	Regulation of oligodendrocyte progenitor proliferation	ISS

MIM	HGNC	e!Ensembl
176891	9685	ENSG00000106278

Protein

UniProt ID

P23471

Protein name

Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2)

Protein function

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a r

PDB

3JXF , 3S97 , 5AWX , 5H08 , 8FN8 , 8FN9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00194	Carb_anhydrase	37 → 299	Eukaryotic-type carbonic anhydrase	Domain
PF00041	fn3	313 → 401	Fibronectin type III domain	Domain
PF00102	Y_phosphatase	1750 → 1991	Protein-tyrosine phosphatase	Domain
PF00102	Y_phosphatase	2048 → 2281	Protein-tyrosine phosphatase	Domain

Tissue specificity

TISSUE SPECIFICITY: Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regu

Sequence

MRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPK
QSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTVEINLTNDYRVSGGVSEMV
FKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALS
ILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPC
TDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSY
TGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTK
HEFLTDGYQDLGAILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPE
LIGTEEIIKEEEEGKDIEEGAIVNPGRDSATNQIRKKEPQISTTTHYNRIGTKYNEAKTN
RSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSASLND
GSKTVLRSPHMNLSGTAESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFIS
ENISQGYIFSSENPETITYDVLIPESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDI
TAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFP
TEVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQI
LNTTPAASSSDSALHATPVFPSVDVSFESILSSYDGAPLLPFSSASFSSELFRHLHTVSQ
ILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLY
KTLMFSQVEPPSSDAMMHARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQG
SLFSGPSHIPIPKSSLITPTASLLQPTHALSGDGEWSGASSDSEFLLPDTDGLTALNISS
PVSVAEFTYTTSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNK
LNASLQETSVSISSTKGMFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASGDTSL
KPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASDVDTLLKTVLP
AVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGL
TISYASEKYEPVLLKSESSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSID
EPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSVPIGNGHVAITAVS
PHRDGSVTSTKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIH
KCMSCSSYRESQEKVMNDSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQTGMDR
SPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAWAVLTSDEESGSGQGTSDSLN
ENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFHVSEAEASNSS
HESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPR
VISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGI
TADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAA
QGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQ
VLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAY
AKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEE
QYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTKLEKQFQLLSQSNIQQSDY
SAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLL
HTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLS
NEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAANRDGPMI
VHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
SLVSTRQEENPSTSLDSNGAALPDGNIAESLESLV

Sequence length

2315

Interactions

View interactions

	KEGG		Reactome
	Epithelial cell signaling in Helicobacter pylori infection		Other interleukin signaling

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	18186075, 22832403, 17579610

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Evidence	Source
Unknown
Ovarian cancer	Ovarian cancer	Conditional KD of IL6 in the OCCA xenograft model delays tumor growth	GWAS, CBGDA
Dementia	Dementia		GWAS

Show/Hide Text Mining Associations (26)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	26950848
Anxiety	Associate	38051303
Astrocytoma	Associate	15831233, 23349846, 27586084, 31381204, 36503484
Brain Neoplasms	Associate	34812554
Breast Neoplasms	Associate	17706593, 30497491
Carcinoid Tumor	Associate	38237798
Carcinoma Ductal	Associate	17706593
Carcinoma Ovarian Epithelial	Associate	25418856
Chromosome Deletion	Associate	23570448
Glioblastoma	Associate	1323835, 15831233, 15908427, 16582634, 20235875, 25135958, 27586084, 31381204, 33317554, 35883571, 38167429
Glioblastoma	Stimulate	20224786
Glioma	Associate	25135958, 25935522, 31381204, 33645009, 34812554
Heredodegenerative Disorders Nervous System	Associate	23570448
Hyperlysinemias	Associate	23570448
Lung Neoplasms	Associate	20639902, 34812554
Meningioma	Associate	20235875, 32968068
Multiple Myeloma	Associate	20574050
Neoplasms	Stimulate	20224786
Neoplasms	Inhibit	23226095
Neoplasms	Associate	26892443, 30497491, 31381204
Ovarian Neoplasms	Associate	25418856
Schizophrenia	Associate	17579610
Spinal Cord Injuries	Associate	19604403
Squamous Cell Carcinoma of Head and Neck	Inhibit	23226095
Triple Negative Breast Neoplasms	Associate	30497491
Wounds and Injuries	Associate	19604403

PTPRZ1 (protein tyrosine phosphatase receptor type Z1)