Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5799
Gene name Gene Name - the full gene name approved by the HGNC.	Protein tyrosine phosphatase receptor type N2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PTPRN2
Synonyms (NCBI Gene) Gene synonyms aliases	IA-2beta, IAR, ICAAR, PTPRP, R-PTP-N2
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q36.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protei

Show/Hide all(142)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002430	hsa-miR-335-5p	Review	19935707
MIRT002430	hsa-miR-335-5p	Luciferase reporter assay, Microarray	18185580
MIRT002430	hsa-miR-335-5p	Microarray;Other	18185580
MIRT712260	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT712259	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT712258	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT712257	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT712256	hsa-miR-676-5p	HITS-CLIP	19536157
MIRT712255	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT712254	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT712253	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT712252	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT712251	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT712260	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT712259	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT712258	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT712257	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT712256	hsa-miR-676-5p	HITS-CLIP	19536157
MIRT712255	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT712254	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT712253	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT712252	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT712251	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT712258	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT712257	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT712256	hsa-miR-676-5p	HITS-CLIP	19536157
MIRT712255	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT712254	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT712253	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT712252	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT712251	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT712260	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT712259	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT712258	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT712257	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT712256	hsa-miR-676-5p	HITS-CLIP	19536157
MIRT712255	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT712254	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT712253	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT712252	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT712251	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT443096	hsa-miR-4311	PAR-CLIP	22100165
MIRT443094	hsa-miR-5680	PAR-CLIP	22100165
MIRT443093	hsa-miR-371b-5p	PAR-CLIP	22100165
MIRT443092	hsa-miR-373-5p	PAR-CLIP	22100165
MIRT443091	hsa-miR-616-5p	PAR-CLIP	22100165
MIRT443090	hsa-miR-371a-5p	PAR-CLIP	22100165
MIRT443089	hsa-miR-372-5p	PAR-CLIP	22100165
MIRT443088	hsa-miR-7110-3p	PAR-CLIP	22100165
MIRT443087	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT712260	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT712259	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT712258	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT712257	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT712256	hsa-miR-676-5p	HITS-CLIP	19536157
MIRT712255	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT712254	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT712253	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT712252	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT712251	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT712260	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT712259	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT712258	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT712257	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT712256	hsa-miR-676-5p	HITS-CLIP	19536157
MIRT712255	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT712254	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT712253	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT712252	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT712251	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT712258	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT712257	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT712256	hsa-miR-676-5p	HITS-CLIP	19536157
MIRT712255	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT712254	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT712253	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT712252	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT712251	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT712260	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT712259	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT712258	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT712257	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT712256	hsa-miR-676-5p	HITS-CLIP	19536157
MIRT712255	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT712254	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT712253	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT712252	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT712251	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT443096	hsa-miR-4311	PAR-CLIP	22100165
MIRT443094	hsa-miR-5680	PAR-CLIP	22100165
MIRT443093	hsa-miR-371b-5p	PAR-CLIP	22100165
MIRT443092	hsa-miR-373-5p	PAR-CLIP	22100165
MIRT443091	hsa-miR-616-5p	PAR-CLIP	22100165
MIRT443090	hsa-miR-371a-5p	PAR-CLIP	22100165
MIRT443089	hsa-miR-372-5p	PAR-CLIP	22100165
MIRT443088	hsa-miR-7110-3p	PAR-CLIP	22100165
MIRT443087	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT1276339	hsa-miR-100	CLIP-seq
MIRT1276340	hsa-miR-582-3p	CLIP-seq
MIRT1276341	hsa-miR-99a	CLIP-seq
MIRT1276342	hsa-miR-99b	CLIP-seq
MIRT1276343	hsa-miR-3144-5p	CLIP-seq
MIRT1276344	hsa-miR-4426	CLIP-seq
MIRT1276345	hsa-miR-4532	CLIP-seq
MIRT1276346	hsa-miR-4534	CLIP-seq
MIRT1276347	hsa-miR-4647	CLIP-seq
MIRT1276348	hsa-miR-4648	CLIP-seq
MIRT1276349	hsa-miR-4654	CLIP-seq
MIRT1276350	hsa-miR-4662b	CLIP-seq
MIRT1276351	hsa-miR-4769-5p	CLIP-seq
MIRT1276352	hsa-miR-4802-5p	CLIP-seq
MIRT1276353	hsa-miR-765	CLIP-seq
MIRT2307252	hsa-miR-1202	CLIP-seq
MIRT2307253	hsa-miR-1237	CLIP-seq
MIRT2307254	hsa-miR-1248	CLIP-seq
MIRT2307255	hsa-miR-146b-3p	CLIP-seq
MIRT2307256	hsa-miR-150	CLIP-seq
MIRT2307257	hsa-miR-3157-3p	CLIP-seq
MIRT2307258	hsa-miR-3173-5p	CLIP-seq
MIRT2307259	hsa-miR-3194-5p	CLIP-seq
MIRT2307260	hsa-miR-3972	CLIP-seq
MIRT2307261	hsa-miR-4314	CLIP-seq
MIRT2307262	hsa-miR-4667-5p	CLIP-seq
MIRT2307263	hsa-miR-4695-3p	CLIP-seq
MIRT2307264	hsa-miR-4700-5p	CLIP-seq
MIRT2307265	hsa-miR-4707-5p	CLIP-seq
MIRT2307266	hsa-miR-4713-5p	CLIP-seq
MIRT2307267	hsa-miR-532-3p	CLIP-seq
MIRT2307268	hsa-miR-637	CLIP-seq
MIRT2307269	hsa-miR-874	CLIP-seq
MIRT2307270	hsa-miR-942	CLIP-seq
MIRT2307253	hsa-miR-1237	CLIP-seq
MIRT2307254	hsa-miR-1248	CLIP-seq
MIRT2307256	hsa-miR-150	CLIP-seq
MIRT2689107	hsa-miR-1915	CLIP-seq
MIRT2689108	hsa-miR-4459	CLIP-seq
MIRT2307266	hsa-miR-4713-5p	CLIP-seq
MIRT2689109	hsa-miR-4726-3p	CLIP-seq
MIRT2689110	hsa-miR-4779	CLIP-seq
MIRT2307267	hsa-miR-532-3p	CLIP-seq
MIRT2689111	hsa-miR-665	CLIP-seq
MIRT2307270	hsa-miR-942	CLIP-seq

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	TAS	8798755
GO:0005886	Component	Plasma membrane	TAS	8798755
GO:0006470	Process	Protein dephosphorylation	TAS	8798755
GO:0006629	Process	Lipid metabolic process	IEA
GO:0007269	Process	Neurotransmitter secretion	IEA
GO:0007269	Process	Neurotransmitter secretion	ISS
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030141	Component	Secretory granule	IBA
GO:0030141	Component	Secretory granule	IEA
GO:0030658	Component	Transport vesicle membrane	IEA
GO:0030667	Component	Secretory granule membrane	IEA
GO:0030667	Component	Secretory granule membrane	ISS
GO:0030672	Component	Synaptic vesicle membrane	IEA
GO:0030672	Component	Synaptic vesicle membrane	ISS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0035773	Process	Insulin secretion involved in cellular response to glucose stimulus	IBA
GO:0035773	Process	Insulin secretion involved in cellular response to glucose stimulus	IEA
GO:0035773	Process	Insulin secretion involved in cellular response to glucose stimulus	ISS
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0045202	Component	Synapse	IBA
GO:0045202	Component	Synapse	IEA
GO:0051046	Process	Regulation of secretion	IBA
GO:0101003	Component	Ficolin-1-rich granule membrane	TAS

MIM	HGNC	e!Ensembl
601698	9677	ENSG00000155093

Protein

UniProt ID

Q92932

Protein name

Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60]

Protein function

Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preve

PDB

2QEP , 4HTI , 4HTJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14948	RESP18	59 → 144	RESP18 domain	Family
PF11548	Receptor_IA-2	509 → 597	Protein-tyrosine phosphatase receptor IA-2	Family
PF00102	Y_phosphatase	770 → 1004	Protein-tyrosine phosphatase	Domain

Tissue specificity

TISSUE SPECIFICITY: Highest levels in brain and pancreas (PubMed:8798755, PubMed:8954911). Lower levels in trachea, prostate, stomach and spinal cord (PubMed:8798755). {ECO:0000269|PubMed:8798755, ECO:0000269|PubMed:8954911}.

Sequence

MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRLGCLLEEGLCGASEACVNDGVFGR
CQKVPAMDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRP
EASSPARPSKHSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRP
PAEGDDRFSESILTYVAHTSALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRH
HLMAALSAYAAQRPPAPPGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSS
TGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGES
GEQADGPKATLRGDSFPDDGVQDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARP
LDMERKKSEHPESSLSSEEETAGVENVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGP
SKEEQSLPAGAQEALSDGLQLEVQPSEEEARGYIVTDRDPLRPEEGRRLVEDVARLLQVP
SSAFADVEVLGPAVTFKVSANVQNVTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKL
KFLPPQAEQEDSTKFIALTLVSLACILGVLLASGLIYCLRHSSQHRLKEKLSGLGGDPGA
DATAAYQELCRQRMATRPPDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQ
SNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVL
TYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCV
VIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNET
RTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDM
VLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ

Sequence length

1015

Interactions

View interactions

	KEGG		Reactome
	Type I diabetes mellitus		Neutrophil degranulation

Show/Hide Unknown Diseases (12)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alzheimer disease	Alzheimer's disease or family history of Alzheimer's disease	N/A	N/A	GWAS
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	N/A	N/A	GWAS
Anxiety Disorder	Anxiety	N/A	N/A	GWAS
Breast Cancer	Breast cancer in childhood cancer survivors, Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy	N/A	N/A	GWAS
Colorectal Cancer	Colorectal cancer	N/A	N/A	GWAS
Dementia	Dementia	N/A	N/A	GWAS
Diabetes	Glycaemic response to GLP-1 agonist treatment in type 2 diabetes (HbA1c reduction)	N/A	N/A	GWAS
Hyperopia	Hyperopia	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Ovarian cancer	Epithelial ovarian cancer	N/A	N/A	GWAS
Pelvic Organ Prolapse	Pelvic organ prolapse	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (44)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	21731750
Astrocytoma	Associate	27586084
Atherosclerosis	Associate	36457109
Autistic Disorder	Associate	32291385
Breast Neoplasms	Associate	40352186
Carcinoma Hepatocellular	Associate	28514750
Cardiovascular Diseases	Associate	34895303
Colorectal Neoplasms	Associate	34311674
Depressive Disorder	Associate	34341332
Diabetes Gestational	Associate	35721735
Diabetes Mellitus Type 1	Associate	30890718, 8798755
Disease	Associate	37884635
Dyggve Melchior Clausen syndrome	Associate	40352186
Embolic Stroke	Associate	32172663
Endometrial Hyperplasia	Associate	21731750
Glioblastoma	Associate	27586084, 39505178
Glioma	Associate	36650953
Glomerulonephritis IGA	Associate	22318827
Hearing Loss Noise Induced	Associate	33242228, 38212800
Infertility Male	Associate	31103287, 37628668
Insulin Resistance	Associate	39180924
Joint Diseases	Associate	30779748
Leiomyosarcoma	Associate	22419440, 33436720
Lung Diseases	Associate	26425700
Lung Injury	Associate	33658578
Lymphoma T Cell Cutaneous	Associate	28694326
Marfan Syndrome	Associate	34895303
Metabolic Diseases	Associate	30890718
Mitochondrial Diseases	Associate	30958317
Myopia	Associate	37884635
Neoplasms	Associate	18616821, 23280481, 28236344, 30890718, 31221986
Neoplasms Squamous Cell	Associate	18616821
Neurologic Manifestations	Associate	33139705
Obesity	Associate	28207535, 29976977, 30890718
Parkinson Disease	Associate	30958317
Prostatic Neoplasms	Associate	31221986
Pulmonary Disease Chronic Obstructive	Associate	30765504
Renal Insufficiency Chronic	Associate	24253112
Respiratory Tract Diseases	Associate	35163587
Schizophrenia	Associate	27474348
Smoke Inhalation Injury	Associate	37628668
Squamous Cell Carcinoma of Head and Neck	Associate	28236344
Stroke	Associate	32172663
Vascular Diseases	Associate	28693373

PTPRN2 (protein tyrosine phosphatase receptor type N2)